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Mitral valve prolapse: an underestimated cause of sudden cardiac death-a current review of the literature.

Abstract：

:Mitral valve prolapse (MVP) is a common valve abnormality in general population. Despite the general belief of a benign disorder, several articles since the 1980s report sudden cardiac death (SCD) in MVP patients, with a substantial percentage of asymptomatic young individuals. The problem is to detect those patients at increased risk and implement methods that are suitable to prevent cardiac arrest. This review investigates the correlation between MVP and SCD, the understanding of the pathophysiology, the strategies for detecting those at risk and treatment options. A complete literature survey was performed using PubMed database search to gather available information regarding MVP and SCD. A total of 33 studies met selection criteria for inclusion in the review. MVP is an underrated cause of arrhythmic SCD. The subset of patients with malignant MVP who may be at greater risk for SCD is characterized by young women with bileaflet MVP, biphasic or inverted T waves in the inferior leads, and frequent complex ventricular ectopic activity with documented ventricular bigeminy or ventricular tachycardia (VT) and premature ventricular contractions (PVCs) configurations of outflow tract alternating with fascicular origin or papillary muscle. MVP is a common condition in the general population and is often encountered in asymptomatic individuals. The existing literature continues to generate significant controversy regarding the association of MVP with ventricular arrhythmias and SCD. Early echocardiography and cardiac magnetic resonance (CMR) are essential, as is a greater understanding of the potential electrophysiological processes of primary arrhythmogenesis and the evaluation of the genetic substrate.

journal_name

J Thorac Dis

journal_title

Journal of thoracic disease

authors

Spartalis M,Tzatzaki E,Spartalis E,Athanasiou A,Moris D,Damaskos C,Garmpis N,Voudris V

doi

10.21037/jtd.2017.11.14

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

5390-5398

issue

12

eissn

2072-1439

issn

2077-6624

pii

jtd-09-12-5390

journal_volume

9

pub_type

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