Understanding and managing in-stent restenosis: a review of clinical data, from pathogenesis to treatment.

Abstract:

:The lumen diameter reduction after percutaneous coronary intervention (PCI) is well known as "restenosis". This phenomenon is due to vessel remodeling/recoil in case of no-stent strategy or, in case of stent employ, "neointimal proliferation" that consists in an excessive tissue proliferation in the luminal surface of the stent otherwise by a further new-occurring atherosclerotic process called "neoatherosclerosis". The exact incidence of in-stent restenosis (ISR) is not easy to determine caused by different clinical, angiographic and operative factors. In the pre-stent era the occurrence of restenosis ranged between 32-55% of all angioplasties, and drop to successively 17-41% in the bare metal stents (BMS) era. The advent of drug-eluting stent (DES), especially 2nd generation, and drug-coated balloon (DCB) further reduce restenosis rate until <10%. We here review the main characteristics of this common complication of coronary interventions, from its pathogenesis to the most appropriate treatment strategy.

journal_name

J Thorac Dis

authors

Buccheri D,Piraino D,Andolina G,Cortese B

doi

10.21037/jtd.2016.10.93

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

E1150-E1162

issue

10

eissn

2072-1439

issn

2077-6624

pii

jtd-08-10-E1150

journal_volume

8

pub_type

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