The diagnostic value of miR-92a, -143, and -145 expression levels in patients with colorectal adenocarcinoma from Romania.


:MicroRNAs (miRNAs) refers to a small, short non-coding RNA of endogenous class. They have shown to have an increasingly altered expression in many types of cancer, including colorectal cancer (CRC).In the present study, miRNA TaqManMGB and qRT-PCR was used to quantify the expression and clinical significance of 3 mature human miRNA in 82 pairs of colorectal adenocarcinoma tissues and normal adjacent tissue samples (NATS) collected from patients of the south-east part of Romania. Differences between CRC and NATS were analyzed using Wilcoxon test, while correlations between miRNAs expression levels and clinicopathological features were examined using non-parametric tests. In addition, the ability of selected miRNAs to function as biomarkers and, as potential indicators in CRC prognosis was also examined.When the miRNA expression was compared in CRC related NATS, miR-143, and miR-145 were significantly underexpressed (4.99 ± -1.02 vs -5.66 ± -1.66, P < .001; -4.85 ± -0.59 vs -9.27 ± -1.51, P < .001, respectively), while the pattern of miR-92a was significantly overexpressed (-5.55 ± -2.83 vs -4.92 ± -2.44, P < .001). Moreover, the expression levels of selected miRNAs were identified to be correlated with gradual increases in fold change expression with the depth of tumor invasion, lymph node invasion, and maximal increases with distant metastasis. Furthermore, the receiver operating characteristic analysis demonstrated that potential diagnostic of miR-143, miR-145, and miR-92a in discriminating CRC from NATS, with the area under the curve of 0.74, 0.85, and 0.84 respectively. The Kaplan-Meier and the log-rank test showed that a high level of miR-92a and low levels of miR-143 and miR-145 predicted poor survival rate in our cohorts.In conclusion, we can summarize that miR-145 and miR-143 are decreased, while miR-92 is increased in CRC compared to NATS, and associated with different stages of CRC pathogenesis. Thus, the expression of selected miRNAs can represent potential diagnostic and prognostic tools in patients with CRC from Romania.


Medicine (Baltimore)




Brînzan C,Aşchie M,Cozaru G,Dumitru E,Mitroi A




Has Abstract


2020-08-28 00:00:00
















  • Cytokines concentrations in aqueous humor of eyes with uveal melanoma.

    abstract::Uveal melanoma (UM) is the major intraocular malignancy in adults, of which the molecular biology is still unknown. Therefore, this study was designed to determine the aqueous concentrations of angiogenic, inflammatory, and chemotactic cytokines in eyes with UM.Aqueous humor samples were collected from 38 patients wit...


    pub_type: 杂志文章


    authors: Cheng Y,Feng J,Zhu X,Liang J

    更新日期:2019-02-01 00:00:00

  • Comparison of efficacy and safety of combination therapy with statins and omega-3 fatty acids versus statin monotherapy in patients with dyslipidemia: A systematic review and meta-analysis.

    abstract:OBJECTIVE:Dyslipidemia is a major risk factor for the development of cardiovascular disease. Both statins and omega-3 fatty acids demonstrate beneficial effects on lipid concentrations. The goal was to evaluate the safety and efficacy of combination therapy with statins and omega-3 fatty acids. METHODS:We performed a ...


    pub_type: 杂志文章,meta分析


    authors: Choi HD,Chae SM

    更新日期:2018-12-01 00:00:00

  • Triglyceride to HDL-cholesterol ratio as an independent risk factor for the poor development of coronary collateral circulation in elderly patients with ST-segment elevation myocardial infarction and acute total occlusion.

    abstract::To determine the prognostic role of triglyceride (TG) to high-density lipoprotein cholesterol (HDL) ratio for poorly developed coronary collateral circulation (CCC) in elderly patients with ST-segment elevation myocardial infarction (STEMI) and acute total occlusion (ATO).As a retrospective case-control study, elderly...


    pub_type: 杂志文章


    authors: Liu GY,Meng XX,Zhang Z

    更新日期:2018-09-01 00:00:00

  • Anatomical structure responsible for direction changing bilateral gaze-evoked nystagmus in patients with unilateral cerebellar infarction.

    abstract::The direction-changing bilateral gaze-evoked nystagmus (GEN) (BGEN) is a more specific sign for a gaze-holding deficit than unilateral GEN (UGEN) in a central lesion. We sought to clarify which cerebellar structure is responsible for the generation of BGEN compared with UGEN.We studied 47 cases of UGEN or BGEN associa...


    pub_type: 杂志文章


    authors: Lee H,Kim HA

    更新日期:2020-04-01 00:00:00

  • Relationship between skeletal muscle mass and liver fibrosis markers for patients with hepatitis C virus related liver disease.

    abstract::We aimed to elucidate the relationship between serum liver fibrosis markers (Mac-2 binding protein glycosylation isomer (M2BPGi), FIB-4 index, aspartate aminotransferase to platelet ratio index and hyaluronic acid), and skeletal muscle mass and to investigate factors linked to skeletal muscle mass loss (SMML) in patie...


    pub_type: 杂志文章


    authors: Takata R,Nishikawa H,Enomoto H,Iwata Y,Ishii A,Miyamoto Y,Ishii N,Yuri Y,Hasegawa K,Nakano C,Nishimura T,Yoh K,Aizawa N,Sakai Y,Ikeda N,Takashima T,Iijima H,Nishiguchi S

    更新日期:2017-12-01 00:00:00

  • Correlation of left atrial wall thickness and atrial remodeling in atrial fibrillation: Study based on low-dose-ibutilide-facilitated catheter ablation.

    abstract::Atrial remodeling plays a significant role during the progression of atrial fibrillation (AF). Left atrial wall thickness (LAT) is a subjective and easily acquirable indicator referring to structural remodeling. Therefore, we aimed to investigate the association between LAT and atrial remodeling substrate, and to expl...


    pub_type: 杂志文章


    authors: Zuo K,Li K,Liu M,Li J,Liu X,Liu X,Zhong J,Yang X

    更新日期:2019-04-01 00:00:00

  • Efficacy and safety of endovascular coiling vs surgical clipping for patients with ruptured carotid-ophthalmic aneurysm: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Carotid-ophthalmic aneurysms are relatively rare, and represent 1% of all intracranial aneurysms. Generally, endovascular coiling and surgical clipping are the 2 most commonly used methods to treat ruptured carotid-ophthalmic aneurysms, it provides the most favorable outcome for a patient. This study aims to...


    pub_type: 杂志文章


    authors: Feng GJ,Gao F,Huang XY,Hati P,Yang XP,Wu HX

    更新日期:2020-11-20 00:00:00

  • Multiple ectopic hepatocellular carcinomas in the pancreas: A case report.

    abstract:RATIONALE:Ectopic liver tissue can develop at various sites near the liver. Ectopic hepatocellular carcinomas (HCCs) arising from ectopic liver tissue have a rare clinical incidence. A very rare case has been observed to have metastasis after operation. PATIENT CONCERNS:We report an extremely rare case with multiple m...


    pub_type: 杂志文章


    authors: Li Z,Wu X,Wen T,Li C,Peng W

    更新日期:2017-07-01 00:00:00

  • Plate fixation versus intramedullary nail or Knowles pin fixation for displaced midshaft clavicle fractures: A meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Plate fixation and intramedullary nail/Knowles pin fixation methods are commonly used to treat displaced midshaft clavicle fractures. However, the differences between these 2 methods are unclear. OBJECTIVE:This meta-analysis aimed to compare plate fixation and intramedullary nail/Knowles pin fixation for di...


    pub_type: 杂志文章,meta分析


    authors: Li L,Yang X,Xing F,Jiang J,Tang X

    更新日期:2020-09-25 00:00:00

  • Effectiveness of cognitive behavioral therapy on kinesiophobia and oral health-related quality of life in patients with temporomandibular disorders, study protocol for a randomized controlled trial.

    abstract:BACKGROUND:Temporomandibular disorders (TMD) is a common physical and psychological disease in dental department. Pain and mandibular limitation are the main reasons for patients to seek oral treatment. However, the presence of kinesiophobia, patients often catastrophize pain, so as to avoid mandibular movement, which ...


    pub_type: 杂志文章


    authors: Zhang Q,Zhang J,Ran W,Yu S,Jin Y

    更新日期:2020-11-20 00:00:00

  • Sexual dream and family relationships in frequent sexual dreamers and healthy volunteers.

    abstract::Early life family relationships affect the sexuality in adulthood, and these influences might be reflected in sexual dreams. The present study was designed to investigate the exact associations between family relationships and sexual dream experience. We therefore invited 62 frequent sexual dreamers (dreamers) and 104...


    pub_type: 杂志文章


    authors: Shao X,Wang C,Jia Y,Wang W

    更新日期:2020-09-04 00:00:00

  • Dietary Habits Are Associated With School Performance in Adolescents.

    abstract::Several studies suggest that dietary habits are associated with poor academic performance. However, few studies have evaluated these relations after adjusting for numerous confounding factors. This study evaluated the frequency of various diet items (fruit, soft drinks, fast foods, instant noodles, confections, vegeta...


    pub_type: 杂志文章


    authors: Kim SY,Sim S,Park B,Kong IG,Kim JH,Choi HG

    更新日期:2016-03-01 00:00:00

  • High-energy focused extracorporeal shock wave therapy for bone marrow edema syndrome of the hip: A retrospective study.

    abstract::The objective of this retrospective study was to evaluate the efficacy of high-energy focused extracorporeal shock wave therapy (HF-ESWT) on painful bone marrow edema syndrome (BMES) of the hip and shorten the natural course of disease.Thirty-four consecutive patients with BMES of the hip were treated with HF-ESWT in ...


    pub_type: 杂志文章


    authors: Zhang L,Cui Y,Liang D,Guan J,Liu Y,Chen X

    更新日期:2020-04-01 00:00:00

  • Percutaneous versus open pedicle screw instrumentation in treatment of thoracic and lumbar spine fractures: A systematic review and meta-analysis.

    abstract:BACKGROUND:To assess the safety and efficacy of percutaneous short-segment pedicle instrumentation compared with conventionally open short-segment pedicle instrumentation and provide recommendations for using these procedures to treat thoracolumbar fractures. METHODS:The Medline database, Cochrane database of Systemat...


    pub_type: 杂志文章,meta分析,评审


    authors: Tian F,Tu LY,Gu WF,Zhang EF,Wang ZB,Chu G,Ka H,Zhao J

    更新日期:2018-10-01 00:00:00

  • Major influence of postoperative complications on costs of cytoreductive surgery and HIPEC in patients with colorectal peritoneal metastases.

    abstract::Complications after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) result in impaired short- and long-term outcomes. However, financial consequences of complications after CRS and HIPEC in a European health care setting are unknown. This study aims to assess the consequences of compl...


    pub_type: 杂志文章


    authors: Simkens GA,Rovers KP,van Oudheusden TR,Nienhuijs SW,Rutten HJ,de Hingh IH

    更新日期:2018-03-01 00:00:00

  • Effect of prediabetes on the long-term all-cause mortality of patients undergoing percutaneous coronary intervention: A protocol for systematic review and meta analysis.

    abstract:BACKGROUND:Prediabetes is an abnormal metabolic state that develops prior to the onset of diabetes with proven to common comorbid states of coronary artery disease. However, whether prediabetes worsens prognosis after percutaneous coronary intervention remains controversial. The aim of this study is to summarize previo...


    pub_type: 杂志文章,meta分析


    authors: Shi R,Diao KY,Shi K,Gao Y,Huang S,Guo YK,Yang ZG

    更新日期:2020-08-14 00:00:00

  • Bacteremic and nonbacteremic pneumococcal pneumonia. A prospective study.

    abstract::We prospectively identified cases of pneumococcal pneumonia and used stringent criteria to stratify them into bacteremic and nonbacteremic cases. Although patients were distributed among racial groups in proportion to all patients seen at this medical center, the proportion of African-Americans with bacteremic disease...


    pub_type: 杂志文章


    authors: Musher DM,Alexandraki I,Graviss EA,Yanbeiy N,Eid A,Inderias LA,Phan HM,Solomon E

    更新日期:2000-07-01 00:00:00

  • Signet ring cell carcinoma of early gastric cancer, is endoscopic treatment really risky?

    abstract::Signet ring cell carcinoma (SRC) is a poorly differentiated cancer of the stomach. Generally, poorly differentiated cancer is believed to show poor prognosis and aggressive behavior. Recently, however, there is debate on the aggressiveness of SRC in early gastric cancer (EGC). We therefore studied postoperation biopsi...


    pub_type: 杂志文章


    authors: Kang SH,Kim JS,Moon HS,Lee ES,Kim SH,Sung JK,Lee BS,Jeong HY

    更新日期:2017-08-01 00:00:00

  • CD4/CD8 dual-positive mycosis fungoides: A case report and literature review.

    abstract:RATIONALE:Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. It appears as patches, plaques, and tumors depending on the stage of the disease, which presents a chronic progressive course. Compared to CD4/CD8 MF, CD4/CD8 dual-positive MF is an uncommon immune phenotype. PATIENT CONCERNS:A 36-year-old ...


    pub_type: 杂志文章,评审


    authors: Ding X,Chen J,Kuai L,Xing M,Ru Y,Luo Y,Luo Y,Zhou M,Li B,Li X

    更新日期:2020-10-16 00:00:00

  • High plasma fibrinogen is correlated with poor response to trastuzumab treatment in HER2 positive breast cancer.

    abstract::Some of HER-2 positive breast cancer patients failed to trastuzumab treatment. Recent reports have indicated the correlation between plasma coagulation parameters and clinical characteristics in breast cancer. The aim of this study was to analyze the role of coagulation parameters in trastuzumab treated patients. Coag...


    pub_type: 杂志文章


    authors: Liu YL,Lu Q,Liang JW,Xia Y,Zhang W,Hu BQ,Shang FF,Ji YR,Wang J,Wang Q,Liang B

    更新日期:2015-02-01 00:00:00

  • A controlled study on the efficacy and quality of life of laparoscopic intersphincteric resection (ISR) and extralevator abdominoperineal resection (ELAPE) in the treatment of extremely low rectal cancer.

    abstract:BACKGROUND:The aim of this study is to compare the postoperative quality of life (QoL) and survival outcomes in lower rectal cancer (LRC) patients who undergo either laparoscopic- intersphincteric resection or extralevator abdominoperineal excision (L-ELAPE) after long-course neoadjuvant chemoradiation therapy (nCRT). ...


    pub_type: 杂志文章


    authors: Yang W,Huang L,Chen P,Yang Y,Liu X,Wang C,Yu Y,Yang L,Wang Z,Zhou Z

    更新日期:2020-05-29 00:00:00

  • Comparison of psychiatric disturbances in patients with multiple sclerosis and neuromyelitis optica.

    abstract::Although both multiple sclerosis (MS) and neuromyelitis optica (NMO) are demyelinating diseases, their psychiatric disturbances may differ given differences in the neurological manifestations. We used subjective and objective measurements to compare the psychiatric disturbances in patients with MS and NMO.Psychiatric ...


    pub_type: 杂志文章


    authors: Shin JS,Kwon YN,Choi Y,Lee JY,Lee YI,Hwang JH,Choi SH,Kim SM

    更新日期:2019-09-01 00:00:00

  • Bortezomib combined with lenalidomide as the first-line treatment for the rare synchronous occurrence of multiple myeloma and pulmonary adenocarcinoma: A case report.

    abstract:BACKGROUND:Simultaneous multiple myeloma (MM) and pulmonary adenocarcinoma is a rare occurrence, and thus, treatment is a challenge. This study reports on 1 such case of MM with concurrent lung cancer, where an accurate diagnosis was made and the patient underwent treatment for both cancers. CASE SUMMARY:A 68-year-old...


    pub_type: 杂志文章


    authors: Zuo W,Zhu X,Yang J,Mei Z,Deng M,Lin Q,Song Y,Yin Q

    更新日期:2017-01-01 00:00:00

  • Impact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia.

    abstract::This study investigated the effects of the presence of type 2 diabetes mellitus (T2D) and/or chronic liver disease (CLD) on the incidence and prognosis of dementia during a 10-year period in Korea using a nationwide population-based dataset from the Korea National Health Insurance Service.To assess the impact of T2D a...


    pub_type: 杂志文章


    authors: Kim HM,Lee YH,Han K,Lee BW,Kang ES,Kim J,Cha BS

    更新日期:2017-11-01 00:00:00

  • Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:This study will examine the effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells (HLCBC). METHODS:This study will search electronic bibliographic databases available in PUBMED, EMBASE, Cochrane Library, Scopus, Cumulative Index to Nursing and Allied Health Literature, China Biolog...


    pub_type: 杂志文章,meta分析


    authors: Li J,Liu ZY,Yu HB,Xue Q,Qu XS

    更新日期:2020-06-05 00:00:00

  • Infective endocarditis caused by slow-growing, fastidious, Gram-negative bacteria.

    abstract::In a review of endocarditis caused by fastidious, slow-growing gram-negative rods, similarities in the spectrum of disease overshadow differences among cases grouped by specific organisms. Cardiobacterium hominis, Actinobacillus actinomycetemcomitans and Haemophilus species usually seed previously damaged cardiac valv...


    pub_type: 杂志文章


    authors: Ellner JJ,Rosenthal MS,Lerner PI,McHenry MC

    更新日期:1979-03-01 00:00:00

  • Acupotomy combined with massage for cervical spondylotic radiculopathy: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Cervical spondylotic radiculopathy (CSR) is a clinical syndrome of radial neck and shoulder pain. Both Massage and Acupotomy have been widely used in the treatment of CSR, in China and achieved satisfied efficacy. Therefore, the aim of this study is to systematically evaluate the clinical efficacy of acupoto...


    pub_type: 杂志文章


    authors: Dai W,Wang X,Xie R,Zhuang M,Chang X,Jin Z,Yin H,Feng M,Wei X,Yu J,Zhu L

    更新日期:2020-08-07 00:00:00

  • Systemic strongyloidiasis in patients infected with the human immunodeficiency virus. A report of 3 cases and review of the literature.

    abstract::We report 3 cases of systemic strongyloidiasis in HIV-infected individuals and review 11 additional cases reported in the English-language literature. Systemic strongloidiasis is a rare and potentially fatal complication of late-stage HIV disease. A combination of gastrointestinal and respiratory symptoms in an HIV-in...


    pub_type: 杂志文章,评审


    authors: Celedon JC,Mathur-Wagh U,Fox J,Garcia R,Wiest PM

    更新日期:1994-09-01 00:00:00

  • Effect of the international pharmacy education programs: A pilot evaluation based on Kirkpatrick's model.

    abstract::Globalization has attracted much attention to universities over the past decade. The aim of this study was to evaluate the effect of the United States-China international pharmacy education programs (IPEP) in China.Kirkpatrick's model of evaluation was used to evaluate IPEP from reaction and learning levels. In the re...


    pub_type: 杂志文章


    authors: Yi ZM,Zhou LY,Yang L,Yang L,Liu W,Zhao RS,Zhai SD

    更新日期:2020-07-02 00:00:00

  • Efficacy and safety of different doses of azilsartan medoxomil in patients with hypertension: A protocol of a network meta-analysis.

    abstract:BACKGROUND:Hypertension is one of the most common chronic diseases and an increasingly public-health challenge worldwide. Previous meta-analyses evaluated the effects of azilsartan medoxomil compared to placebo or other antihypertensive drugs in patients with hypertension. However, it is still unclear which dose of azi...


    pub_type: 杂志文章


    authors: Zhang Y,Yu H,Shao K,Luo X,Wang J,Chen G

    更新日期:2019-09-01 00:00:00