Lipid Profiling in Epicardial and Subcutaneous Adipose Tissue of Patients with Coronary Artery Disease.

abstract：:Serum protein profiling by mass spectrometry is a promising method for early detection of cancer. We have implemented a combined strategy based on matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) and statistical data analysis for serum protein profiling and applied it in a well-described breast...

journal_title：Journal of proteome research

authors： Callesen AK,Vach W,Jørgensen PE,Cold S,Tan Q,Depont Christensen R,Mogensen O,Kruse TA,Jensen ON,Madsen JS

更新日期：2008-04-01 00:00:00

abstract：:Recent studies have shown a remarkable degree of plasticity in the N-glycome of the model nematode Caenorhabditis elegans; ablation of glycosylation-relevant genes can result in radically altered N-glycan profiles despite only minor biological phenotypic effects. Up to four fucose residues and five different linkages ...

journal_title：Journal of proteome research

authors： Yan S,Jin C,Wilson IB,Paschinger K

更新日期：2015-12-04 00:00:00

abstract：:Endometrial cancer (EC) is the most frequent gynecological cancer. Tumor dissemination affecting ∼20% of EC patients is characterized at the primary carcinoma by epithelial-to-mesenchymal transition (EMT) associated with myometrial infiltration. At distant sites, the interaction of circulating tumor cells (CTCs) with ...

journal_title：Journal of proteome research

authors： Mariscal J,Fernandez-Puente P,Calamia V,Abalo A,Santacana M,Matias-Guiu X,Lopez-Lopez R,Gil-Moreno A,Alonso-Alconada L,Abal M

更新日期：2019-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a major liver malignancy possessing a high mortality rate and is particularly prevalent in China and Asia. While surgery is the most effective treatment for liver tumor, about 80% of HCC patients are inoperable at presentation and die early due to late diagnosis. For early cancer dete...

journal_title：Journal of proteome research

authors： Sun S,Xu MZ,Poon RT,Day PJ,Luk JM

更新日期：2010-01-01 00:00:00

abstract：:Adipose tissue is a major storage site for lipophilic environmental contaminants. The environmental metabolic disruptor hypothesis postulates that some pollutants can promote obesity or metabolic disorders by activating nuclear receptors involved in the control of energetic homeostasis. In this context, monoethylhexyl...

journal_title：Journal of proteome research

authors： Ellero-Simatos S,Claus SP,Benelli C,Forest C,Letourneur F,Cagnard N,Beaune PH,de Waziers I

更新日期：2011-12-02 00:00:00

abstract：:The gene transfer agent of Rhodobacter capsulatus (GTA) is a unique phage-like particle that exchanges genetic information between members of this same species of bacterium. Besides being an excellent tool for genetic mapping, the GTA has a number of advantages for biotechnological and nanoengineering purposes. To fac...

journal_title：Journal of proteome research

authors： Chen F,Spano A,Goodman BE,Blasier KR,Sabat A,Jeffery E,Norris A,Shabanowitz J,Hunt DF,Lebedev N

更新日期：2009-02-01 00:00:00

abstract：:Proteomic studies were performed to identify the protein species involved in copper (Cu) stress responses in common wheat. Two-week-old wheat seedlings were exposed to 100 μM CuSO4 treatment for 3 days. Growth of shoots and roots was markedly inhibited and lipid peroxidation was greatly increased. Cu was readily absor...

journal_title：Journal of proteome research

authors： Li G,Peng X,Xuan H,Wei L,Yang Y,Guo T,Kang G

更新日期：2013-11-01 00:00:00

abstract：:A proteoform family is a group of related molecular forms of a protein (proteoforms) derived from the same gene. We have previously described a strategy to identify proteoforms and elucidate proteoform families in complex mixtures of intact proteins. The strategy is based upon measurements of two properties for each p...

journal_title：Journal of proteome research

authors： Dai Y,Shortreed MR,Scalf M,Frey BL,Cesnik AJ,Solntsev S,Schaffer LV,Smith LM

更新日期：2017-11-03 00:00:00

abstract：:A metabonomic study was performed to investigate the biochemical perturbation of the serum samples from liver failure patients induced by hepatitis B virus (HBV; n=24) and control normal subjects (n=23). The serum metabonome was detected using gas chromatography-mass spectrometry (GC-MS) technique integrated with a co...

journal_title：Journal of proteome research

authors： Yu K,Sheng G,Sheng J,Chen Y,Xu W,Liu X,Cao H,Qu H,Cheng Y,Li L

更新日期：2007-07-01 00:00:00

abstract：:The world is currently facing the COVID-19 pandemic caused by the SARS-CoV-2 virus. The pandemic is causing the death of people around the world, and public and social health measures to slow or prevent the spread of COVID-19 are being implemented with the involvement of all members of society. Research institutions a...

journal_title：Journal of proteome research

authors： Barros RO,Junior FLCC,Pereira WS,Oliveira NMN,Ramos RM

更新日期：2020-11-06 00:00:00

abstract：:Mass spectrometry (MS) has become an accessible tool for whole proteome quantitation with the ability to characterize protein expression across thousands of proteins within a single experiment. A subset of MS quantification methods (e.g., SILAC and label-free) monitor the relative intensity of intact peptides, where t...

journal_title：Journal of proteome research

authors： O'Brien JJ,O'Connell JD,Paulo JA,Thakurta S,Rose CM,Weekes MP,Huttlin EL,Gygi SP

更新日期：2018-01-05 00:00:00

abstract：:Moving from macroscale preparative systems in proteomics to micro- and nanotechnologies offers researchers the ability to deeply profile smaller numbers of cells that are more likely to be encountered in clinical settings. Herein a recently developed microscale proteomic method, microdroplet processing in one pot for ...

journal_title：Journal of proteome research

authors： Weke K,Singh A,Uwugiaren N,Alfaro JA,Wang T,Hupp TR,O'Neill JR,Vojtesek B,Goodlett DR,Williams SM,Zhou M,Kelly RT,Zhu Y,Dapic I

更新日期：2021-01-25 00:00:00

abstract：:Russell and colleagues deserve credit for being the first to use a QconCAT standard to simultaneously quantify both the wild-type and mutant peptides of a protein (i.e., CYP2B6) ( J. Proteome Res. 2013, 12 (12), 5934-5942. DOI: 10.1021/pr400279u). However, the rationale of their study was entirely different from ours ...

journal_title：Journal of proteome research

authors： Shi J,Wang X,Zhu H,Jiang H,Wang D,Nesvizhskii A,Zhu HJ

更新日期：2019-03-01 00:00:00

abstract：:In the past few years, the focus of phosphoproteomics has shifted from merely qualitative to quantitative and targeted studies. Tryptic digestion is a critical step that directly affects quantification and that can be impaired by phosphorylation. Therefore, we systematically characterized the digestion efficiency of 1...

journal_title：Journal of proteome research

authors： Dickhut C,Feldmann I,Lambert J,Zahedi RP

更新日期：2014-06-06 00:00:00

abstract：:Skeletal muscle has emerged as an important secretory organ that produces so-called myokines, regulating energy metabolism via autocrine, paracrine, and endocrine actions; however, the nature and extent of the muscle secretome has not been fully elucidated. Mass spectrometry (MS)-based proteomics, in principle, allows...

journal_title：Journal of proteome research

authors： Deshmukh AS,Cox J,Jensen LJ,Meissner F,Mann M

更新日期：2015-11-06 00:00:00

abstract：:Ozonated autohemotherapy (O3-AHT) is a medical approach during which blood obtained from the patient is ozonated and injected back into the body. Despite an increasing number of evidence that O3-AHT is safe, this type of therapy remains controversial. To extend knowledge about the changes in blood evoked by O3-AHT, LC...

journal_title：Journal of proteome research

authors： Ciborowski M,Lipska A,Godzien J,Ferrarini A,Korsak J,Radziwon P,Tomasiak M,Barbas C

更新日期：2012-12-07 00:00:00

abstract：:We analyzed a unique rice (Oryza sativa L.) blast lesion mimic (blm) mutant for differentially expressed proteins in leaves of one- and two-week-old seedlings manifesting the lesion mimic phenotype. Gel-based one- and two-dimensional electrophoresis (1- and 2-DGE) was performed using leaves (blm and wild-type, WT) bef...

journal_title：Journal of proteome research

authors： Jung YH,Rakwal R,Agrawal GK,Shibato J,Kim JA,Lee MO,Choi PK,Jung SH,Kim SH,Koh HJ,Yonekura M,Iwahashi H,Jwa NS

更新日期：2006-10-01 00:00:00

abstract：:Birth weight is an important indicator of maternal and fetal health and a predictor of health in later life. However, the determinants of variance in birth weight are still poorly understood. We aimed to identify the biological pathways, which may be perturbed by environmental exposures, that are important in determin...

journal_title：Journal of proteome research

authors： Robinson O,Keski-Rahkonen P,Chatzi L,Kogevinas M,Nawrot T,Pizzi C,Plusquin M,Richiardi L,Robinot N,Sunyer J,Vermeulen R,Vrijheid M,Vineis P,Scalbert A,Chadeau-Hyam M

更新日期：2018-03-02 00:00:00

abstract：:A "one-pot" alternative method for processing proteins and isolating peptide mixtures from bacterial samples is presented for liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis and data reduction. The conventional in-solution digestion of the protein contents of bacteria is compared to a small disposab...

journal_title：Journal of proteome research

authors： Jabbour RE,Deshpande SV,Stanford MF,Wick CH,Zulich AW,Snyder AP

更新日期：2011-02-04 00:00:00

abstract：:Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identi...

journal_title：Journal of proteome research

authors： Cimmino F,Spano D,Capasso M,Zambrano N,Russo R,Zollo M,Iolascon A

更新日期：2007-07-01 00:00:00

abstract：:The physical, endocrine, and metabolic responses of livestock to road transport have been evaluated by conventional hematological and biochemistry parameters for more than 20 years. However, these measures are relatively insensitive to subtle metabolic adaptations. We applied NMR-based metabonomics to assess system-wi...

journal_title：Journal of proteome research

authors： Li J,Wijffels G,Yu Y,Nielsen LK,Niemeyer DO,Fisher AD,Ferguson DM,Schirra HJ

更新日期：2011-03-04 00:00:00

abstract：:Phytopathogenic fungi are one of the most damaging plant parasitic organisms, and can cause serious diseases and important yield losses in crops. The study of the biology of these microorganisms and the interaction with their hosts has experienced great advances in recent years due to the development of moderm, holist...

journal_title：Journal of proteome research

authors： Gonzalez-Fernandez R,Jorrin-Novo JV

更新日期：2012-01-01 00:00:00

abstract：:The phagosome is very important to host immunity and tissue homeostasis maintenance. The destiny of the phagosome is closely associated with the outcome of the pathogen within. Most pathogens are successfully delivered to the lysosome and destroyed via the fusion of the phagosome with the lysosome. Mycobacterium tube...

journal_title：Journal of proteome research

authors： He Y,Li W,Liao G,Xie J

更新日期：2012-05-04 00:00:00

abstract：:One application of 2D gel electrophoresis is to reveal differences in protein pattern between two or more groups of individuals, attributable to their group membership. Multivariate data analytical methods are useful in pinpointing the spots relevant for discrimination by focusing not only on single spot differences, ...

journal_title：Journal of proteome research

authors： Jensen KN,Jessen F,Jørgensen BM

更新日期：2008-03-01 00:00:00

abstract：:Mass-spectrometry-based proteomics has become the standard approach for identifying and quantifying proteins. A vital step consists of analyzing experimentally generated mass spectra to identify the underlying peptide sequences for later mapping to the originating proteins. We here present the latest developments in S...

journal_title：Journal of proteome research

authors： Barsnes H,Vaudel M

更新日期：2018-07-06 00:00:00

abstract：:This study presents a comparative proteomic analysis of the membrane subproteome of whole Arabidopsis seedlings using 2% Brij-58 or 60% methanol to enrich and solubilize membrane proteins for strong cation exchange fractionation and reversed-phase liquid chromatography-tandem mass spectrometry (LC-MS/MS). A total of 4...

journal_title：Journal of proteome research

authors： Mitra SK,Gantt JA,Ruby JF,Clouse SD,Goshe MB

更新日期：2007-05-01 00:00:00

abstract：:12-O-Tetradecanoyl-phorbol-13-acetate (TPA) is a plant derivative with multiple function as tumor promoter, differentiation revulsant or leukemia therapy drug. The molecular mechanism of its function is perplexing. Many studies have focused on the mechanism of TPA stimulation in tumor promotion of mouse models or term...

journal_title：Journal of proteome research

authors： Jiang P,Gan M,Huang H,Shen X,Wang S,Yao K

更新日期：2005-03-01 00:00:00

abstract：:Today's highly accurate spectra provided by modern tandem mass spectrometers offer considerable advantages for the analysis of proteomic samples of increased complexity. Among other factors, the quantity of reliably identified peptides is considerably influenced by the peptide identification algorithm. While most wide...

journal_title：Journal of proteome research

authors： Dorfer V,Pichler P,Stranzl T,Stadlmann J,Taus T,Winkler S,Mechtler K

更新日期：2014-08-01 00:00:00

abstract：:Natural disasters such as drought, extreme temperatures, and flooding can severely impact crop production. Understanding the metabolic response of crops threatened with these disasters provides insights into biological response mechanisms that can influence survival. In this study, a comparative analysis of GC-MS and ...

journal_title：Journal of proteome research

authors： Barding GA Jr,Béni S,Fukao T,Bailey-Serres J,Larive CK

更新日期：2013-02-01 00:00:00

abstract：:Salt stress is a major abiotic factor limiting maize yield. To characterize the mechanism underlying maize salt tolerance, we compared the seedling root proteomes of salt-tolerant Jing724 and salt-sensitive D9H. The germination rate and growth parameter values (weight and length) were higher for Jing724 than for D9H u...

journal_title：Journal of proteome research

authors： Luo M,Zhao Y,Wang Y,Shi Z,Zhang P,Zhang Y,Song W,Zhao J

更新日期：2018-01-05 00:00:00