当前位置： SCI文献检索 > Multiple Sclerosis and Related Disorders期刊下所有文献 > A temporal analysis of bilateral gait coordination in people with multiple sclerosis.

A temporal analysis of bilateral gait coordination in people with multiple sclerosis.

Abstract：

BACKGROUND:Gait performance often dictates an individual's ability to navigate the dynamic environments of everyday living. With each stride, the lower extremities move through phases of stance, swing, and double support. Coordinating these motions with high accuracy and consistency is imperative to constraining the center of mass within the base of support, thereby maintaining balance. Gait abnormalities accompany neurodegeneration, impeding stride to stride cohesion and increasing the likelihood of a fall. This study sought to identify the temporal actions underlying bilateral coordination in people with multiple sclerosis (PwMS) and furthermore, how bilateral coordination is affected by gait speed augmentation in these individuals. METHODS:The Phase Coordination Index (PCI), a temporal analysis of left-right step pattern generations throughout the gait cycle was used to quantify bilateral coordination in twenty-nine neurotypical (21 females and 8 males) and twenty-seven PwMS (20 females and 7 males). PCI was acquired with inertial monitoring units while performing two-minute over ground gait trials while walking at a self-selected pace and at a fast pace. RESULTS:PwMS displayed significantly worse bilateral coordination compared to neurotypical adults regardless of gait speed. The poorer left-right stepping patterns generated by PwMS were derived from significant decreases in both phase (step) generation accuracy and consistency. In addition to demonstrating poorer bilateral coordination, PwMS walked more slowly than their neurotypical peers during each walking condition. CONCLUSION:PwMS exhibited poorer left-right coordinated stepping patterns during gait compared to neurotypical peers across walking conditions. Beyond the novelty of this examination, this assessment highlights PCI as a potential target for future rehabilitative interventions for PwMS and individualized rehabilitation strategies aimed at improving the health span and overall quality of life for PwMS.

journal_name

Mult Scler Relat Disord

journal_title

Multiple sclerosis and related disorders

authors

Richmond SB,Swanson CW,Peterson DS,Fling BW

doi

10.1016/j.msard.2020.102445

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

102445

eissn

2211-0348

issn

2211-0356

pii

S2211-0348(20)30520-4

journal_volume

45

pub_type

杂志文章

相关文献

Multiple Sclerosis and Related Disorders文献大全
  • Capillary leak syndrome in neuromyelitis optica treated with rituximab.

    abstract：:61-year-old woman with Neuromyelitis optica (NMO) diagnosis treated with rituximab was referred to our hospital with severe hypovolemic shock and anasarca. The laboratory findings showed marked hemoconcentration and a decrease in total serum protein. She developed a multiple organ failure and died three hours later. W...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.06.001

    authors： Fuentes Fernandez I,Hernandez-Clares R,Carreón Guarnizo E,Meca Lallana JE

    更新日期：2017-08-01 00:00:00

  • Evaluation of types of psychological disorders in patients with neuromyelitis optica spectrum disorder (NMOSD).

    abstract：BACKGROUND:Neuromyelitis Optica Spectrum Disorder (NMOSD), commonly characterized by affecting optic nerves and spinal cord can be regarded as one of uncommon diseases of the central nervous system. Although the evidence presented in the literature supports cognitive impairments, psychological aspects of the disease an...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102128

    authors： Ebadi Z,Saeedi R,Hashemi SN,Gheini MR,Sahraian MA,Naser Moghadasi A

    更新日期：2020-07-01 00:00:00

  • Optic neuropathy: A 15-year retrospective observational study.

    abstract：BACKGROUND:Optic neuropathies (ON) have several aetiologies and sometimes the diagnosis established ab initio is redefined after further investigations and/or new neurological events. We aim with this study to report clinical, paraclinical findings, treatment choices and disease course in patients admitted with a suspi...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102337

    authors： Alves JM,Seabra M,Braz L,Guimarães J

    更新日期：2020-09-01 00:00:00

  • Epidemiology and comorbidities of adult multiple sclerosis and neuromyelitis optica in Taiwan, 2001-2015.

    abstract：BACKGROUND:The epidemiology of multiple sclerosis (MS) and neuromyelitis optica (NMO) remains to be clarified or updated in many parts of Asia. This study aims to investigate the epidemiology and comorbidities of MS and NMO during 2001-2015 in Taiwan. METHODS:We conducted a retrospective nationwide population-based st...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102425

    authors： Fang CW,Wang HP,Chen HM,Lin JW,Lin WS

    更新日期：2020-10-01 00:00:00

  • Health-related quality of life in patients with longstanding 'benign multiple sclerosis'.

    abstract：BACKGROUND:We explored health-related quality of life (HRQoL) and psychosocial aspects in a cohort of patients with a history of longstanding benign MS (BMS). METHODS:Patients with BMS (EDSS≤3 after 20 years disease duration) were re-assessed 25-30 years post-MS symptom onset for: EDSS, HRQoL (MSQoL-54), depression (B...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2014.09.211

    authors： Bueno AM,Sayao AL,Yousefi M,Devonshire V,Traboulsee A,Tremlett H

    更新日期：2015-01-01 00:00:00

  • Differential diagnosis of multiple sclerosis and other inflammatory CNS diseases.

    abstract：:Multiple sclerosis (MS) is the most common acquired demyelinating disorder of the central nervous system (CNS). Diagnosing MS can be very challenging owing to its variable clinical features and lack of specific tests. Magnetic resonance imaging (MRI) is a key measure in this process. Although white matter lesions on b...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2019.101452

    authors： Wildner P,Stasiołek M,Matysiak M

    更新日期：2020-01-01 00:00:00

  • Management strategies for female patients of reproductive potential with multiple sclerosis: An evidence-based review.

    abstract：:Multiple sclerosis (MS) is an inflammatory, demyelinating, neurodegenerative, immune-mediated disease primarily diagnosed in early adulthood. Multiple sclerosis mostly impacts women of reproductive potential, with pregnancy and birth outcomes being major concerns for many patients. While there is ample evidence that t...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2019.04.003

    authors： Coyle PK,Oh J,Magyari M,Oreja-Guevara C,Houtchens M

    更新日期：2019-07-01 00:00:00

  • NFL and CXCL13 may reveal disease activity in clinically and radiologically stable MS.

    abstract：BACKGROUND:Cerebrospinal fluid (CSF) levels of neurofilament light (NFL), a biomarker of axonal damage, and CXCL13, a chemokine involved in B-cell regulation, are both associated with disease activity in multiple sclerosis (MS). OBJECTIVE:To explore the potential of NFL and CXCL13 to detect residual disease activity i...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102463

    authors： Novakova L,Axelsson M,Malmeström C,Zetterberg H,Blennow K,Svenningsson A,Lycke J

    更新日期：2020-11-01 00:00:00

  • Trial of intrathecal rituximab in progressive multiple sclerosis patients with evidence of leptomeningeal contrast enhancement.

    abstract：BACKGROUND:Leptomeningeal inflammation is associated with increased cortical damage and worse clinical outcomes in MS. It may be detected on contrast-enhanced T2-FLAIR imaging as focal leptomeningeal contrast-enhancement (LME). OBJECTIVE:To assess the safety of intrathecal (IT) rituximab in progressive MS (PMS) and to...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.02.013

    authors： Bhargava P,Wicken C,Smith MD,Strowd RE,Cortese I,Reich DS,Calabresi PA,Mowry EM

    更新日期：2019-05-01 00:00:00

  • The prevalence of cognitive impairment in patients with neuromyelitis optica spectrum disorders (NMOSD): A systematic review and meta-analysis.

    abstract：OBJECTIVE:To estimate pooled prevalence of cognitive impairment in neuromyelitis opticaspectrum disorders (NMOSD) cases. METHODS:We searched PubMed, Scopus, EMBASE, Web of Science, and google scholar. We also searched the gray literature including references of the included studies, and conference abstracts which were...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2021.102757

    authors： Moghadasi AN,Mirmosayyeb O,Mohammadi A,Sahraian MA,Ghajarzadeh M

    更新日期：2021-01-15 00:00:00

  • Prevalence of fatigue and its association with clinical features in progressive and non-progressive forms of Multiple Sclerosis.

    abstract：BACKGROUND:Fatigue is a complex and disabling symptom of Multiple Sclerosis (MS); however, there is conflicting evidence of the relationship between fatigue and clinical features of MS. Furthermore, few studies have considered these relationships specifically in a progressive MS population. AIMS:(1) estimate the preva...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.01.011

    authors： Rooney S,Wood L,Moffat F,Paul L

    更新日期：2019-02-01 00:00:00

  • Linking Cognitive Impairment to Neuroinflammation in Multiple Sclerosis using neuroimaging tools.

    abstract：:Multiple sclerosis (MS) is a complex chronic immune disease in the central nervous system, causing neurological disability among young and middle-aged adults. Impaired cognition is now emerging as a major clinical symptom being present in more than 50% of MS patients. Recent data support that neuroinflammation mediate...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2020.102622

    authors： Barros C,Fernandes A

    更新日期：2020-11-14 00:00:00

  • A case-control study of dietary salt intake in pediatric-onset multiple sclerosis.

    abstract：BACKGROUND:High salt intake may be associated with pro-inflammatory changes in the immune response, and increased clinical and MRI activity in adults with relapsing-remitting multiple sclerosis. OBJECTIVE:We sought to determine if dietary salt intake is associated with pediatric-onset MS risk in a multicenter, case-co...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.msard.2016.02.011

    authors： McDonald J,Graves J,Waldman A,Lotze T,Schreiner T,Belman A,Greenberg B,Weinstock-Guttman B,Aaen G,Tillema JM,Hart J,Lulu S,Ness J,Harris Y,Rubin J,Candee M,Krupp LB,Gorman M,Benson L,Rodriguez M,Chitnis T,Mar S

    更新日期：2016-03-01 00:00:00

  • 2017 McDonald criteria for multiple sclerosis: Earlier diagnosis with reduced specificity?

    abstract：BACKGROUND:McDonald criteria for multiple sclerosis (MS) diagnosis were revised in 2017. OBJECTIVE:Aim of our study was to evaluate and compare the sensitivity and specificity of 2017 and 2010 McDonald criteria in patients presenting with an initial demyelinating event (IDE). METHODS:We retrospectively identified pat...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.01.008

    authors： Gobbin F,Zanoni M,Marangi A,Orlandi R,Crestani L,Benedetti MD,Gajofatto A

    更新日期：2019-04-01 00:00:00

  • Neurosarcoidosis as an MS Mimic: The trials and tribulations of making a diagnosis.

    abstract：:The clinical presentation of neurosarcoidosis is varied as multiple levels of the neuraxis may be affected. When central nervous system involvement occurs, making an accurate diagnosis of the condition can be challenging, especially given the current definition for definite neurosarcoidosis requires histologic confirm...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2015.06.012

    authors： MacLean HJ,Abdoli M

    更新日期：2015-09-01 00:00:00

  • Unmet needs of multiple sclerosis patients in the community.

    abstract：BACKGROUND:There is no evidence that disease modifying therapies (DMTs) are beneficial in progressive (non-relapsing) MS. However, these patients may benefit from multidiscipliniary interventions, and require financial and community support. Non-pharmacological needs of MS patients may be overlooked during fund allocat...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.msard.2015.01.003

    authors： Lonergan R,Kinsella K,Fitzpatrick P,Duggan M,Jordan S,Bradley D,Hutchinson M,Tubridy N

    更新日期：2015-03-01 00:00:00

  • PER3 VNTR polymorphism in Multiple Sclerosis: A new insight to impact of sleep disturbances in MS.

    abstract：BACKGROUND:Multiple Sclerosis (MS) is a degenerative disease of central nervous system caused by an immune response against the myelin. About half of MS patients suffers from sleep disturbances. The circadian clock genes such as PER3 controls circadian rhythm and sleep. Due to the role of PER3 in sleep disturbances and...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2017.07.005

    authors： Golalipour M,Maleki Z,Farazmandfar T,Shahbazi M

    更新日期：2017-10-01 00:00:00

  • An extremely aggressive case of Marburg's disease treated with high dose cyclophosphamide. A case report.

    abstract：BACKGROUND:The acute, fulminant type of Multiple Sclerosis (MS), known as Marburg Disease, has been shown to have poor response to conventional acute treatments typically used for demyelinating diseases. METHODS:We report a 20 y/o postpartum female who was consulted to the Neurology service given findings of subacute ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.03.014

    authors： Avila-Ornelas J,Labat E,Alfonso G,Serrano C,Fiorito F

    更新日期：2019-06-01 00:00:00

  • Factors Associated with Prescribing Oral Disease Modifying Agents in Multiple Sclerosis: a Real-world Analysis of Electronic Medical Records.

    abstract：BACKGROUND:Little is known about the factors associated with the selection of Disease Modifying Agents (DMA) for the management of Multiple Sclerosis (MS) since the introduction of oral DMAs in 2010. OBJECTIVES:To examine the factors associated with initiation of oral DMAs in patients with MS using data from electroni...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102334

    authors： Earla JR,Hutton GJ,Thornton JD,Aparasu RR

    更新日期：2020-10-01 00:00:00

  • Update on the cardiovascular profile of fingolimod in the therapy of relapsing-remitting multiple sclerosis (MS).

    abstract：BACKGROUND:Fingolimod (FTY720) has been approved as the first oral representative of the class of sphingosine-1-phosphate (S1P) receptor modulators for the treatment of relapsing-remitting multiple sclerosis (MS). Besides inducing vaso-relaxation, fingolimod can also influence electrical conduction in the myocardium an...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2016.04.002

    authors： Meissner A,Limmroth V

    更新日期：2016-07-01 00:00:00

  • Forkhead box C1 gene variant causing glaucoma and small vessel angiopathy can mimic multiple sclerosis.

    abstract：:A 34-year old Caucasian female was initially diagnosed with multiple small-vessel strokes at age 20 years which were etiologically classified as secondary to anti-phospholipid antibody syndrome (APS) although she had no history or laboratory data to suggest APS. Based on her MRI of brain findings, one of her neurologi...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.04.004

    authors： Avasarala JR,Jones JR,Rogers CR

    更新日期：2018-05-01 00:00:00

  • Could Sars-Cov2 affect MS progression?

    abstract：:A long-term neurologic sequela arising from COVID-19 infection in multiple sclerosis (MS) patients could be related both to the increase of cytokines and the activation of NLRP3 inflammasome by the Sars-CoV2. These two mechanisms may cause a worsening of MS several months after the resolution of the infection. ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2020.102540

    authors： Di Stadio A,Romani L,Bernitsas E

    更新日期：2020-11-01 00:00:00

  • Correlation between the corpus callosum index and brain atrophy, lesion load, and cognitive dysfunction in multiple sclerosis.

    abstract：BACKGROUND:The corpus callosum index (CCI) can be easily and reliably obtained from conventional magnetic resonance imaging (MRI) and has been proposed as a possible marker of brain atrophy in MS. However, further validation of its correlation with volumetric measurements is still warranted. OBJECTIVE:To assess the co...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.01.015

    authors： Gonçalves LI,Dos Passos GR,Conzatti LP,Burger JLP,Tomasi GH,Zandoná MÉ,Azambuja LS,Gomes I,Franco A,Sato DK,Becker J

    更新日期：2018-02-01 00:00:00

  • Favorable outcome of interferon-beta associated thrombotic microangiopathy following treatment with corticosteroids, plasma exchange and rituximab: A case report.

    abstract：:Thrombotic microangiopathy (TMA) is a rare but increasingly recognized complication of interferon-beta therapy, which can be associated with serious sequelae. We report on a 53-year-old woman with a longstanding history of relapsing-remitting multiple sclerosis, who developed TMA after 15 years of high-dose treatment ...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2016.09.002

    authors： Gerischer LM,Siebert E,Janke O,Jungehuelsing GJ,Ruprecht K

    更新日期：2016-11-01 00:00:00

  • Cognitive and neuropsychiatric disorders among multiple sclerosis patients from Latin America: Results of the RELACCEM study.

    abstract：BACKGROUND:Cognitive impairment and psychiatric symptoms impact many aspects of the lives of people with multiple sclerosis [MS]. This literature is based largely on North American and Western European samples, and little is known about these aspects of MS disability in Latin America. OBJECTIVE:RELACCEM is a longitudi...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2013.10.007

    authors： Caceres F,Vanotti S,Benedict RH,RELACCEM Work Group.

    更新日期：2014-05-01 00:00:00

  • An overview of lipidomic analysis in different human matrices of multiple sclerosis.

    abstract：:Multiple sclerosis is a chronic inflammatory and neurodegenerative disease of the central nervous system, and it is one of the most common neurological cause of disability in young adults. It is known that several factors contribute to increase the risk of development and pathogenesis of multiple sclerosis, nonetheles...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,评审

    doi：10.1016/j.msard.2020.102189

    authors： Ferreira HB,Neves B,Guerra IM,Moreira A,Melo T,Paiva A,Domingues MR

    更新日期：2020-09-01 00:00:00

  • The 20-year history: Change of multiple sclerosis patient profile over 20 years.

    abstract：BACKGROUND:Patients attending multiple sclerosis (MS) clinics experience less disability compared to previous years. OBJECTIVE:This study was conducted retrospectively examining the patient records of our MS Clinic. The patient records in 1996 were compared to those in 2016. METHODS:Demographic data, duration of dise...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2019.05.002

    authors： Ozakbas S,Cinar BP,Kahraman T,Multiple Sclerosis Research Group.

    更新日期：2019-08-01 00:00:00

  • Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations.

    abstract：OBJECTIVE:To describe 2 atypical cases with Anti-MOG antibody related demyelinating syndrome. METHODOLOGY:Case series. RESULTS:We present two cases. Case 1 is an 18-year-old woman who presented with headache, blurred vision, and papilledema and was initially diagnosed with pseudotumor cerebri syndrome. CSF showed mil...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2018.10.003

    authors： Narayan RN,Wang C,Sguigna P,Husari K,Greenberg B

    更新日期：2019-01-01 00:00:00

  • Integration of the Extreme Gradient Boosting model with electronic health records to enable the early diagnosis of multiple sclerosis.

    abstract：BACKGROUND:Delayed multiple sclerosis (MS) diagnoses are not uncommon, an early diagnostic tool is urgently warranted. We aimed to develop an effective tool through electronic health records and machine learning techniques to early recognize MS patients from hospital visitors in China. METHODS:Two case sets were colle...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章

    doi：10.1016/j.msard.2020.102632

    authors： Wang R,Luo W,Liu Z,Liu W,Liu C,Liu X,Zhu H,Li R,Song J,Hu X,Han S,Qiu W

    更新日期：2020-11-18 00:00:00

  • Safety liver profile of teriflunomide versus interferon β in multiple sclerosis: Systematic review and indirect comparison meta-analysis.

    abstract：OBJECTIVES:To compare the liver safety profile of interferon β (IFN β) and teriflunomide in patients with multiple sclerosis. METHODS:A network meta-analysis was carried out following the Cochrane Collaboration methodology. All trials comparing all types of IFN β with teriflunomide, or disease-modifying drugs, or plac...

    journal_title：Multiple sclerosis and related disorders

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.msard.2018.09.014

    authors： Salas PAO,Parra CO,Florez CEP,Goez LM,Velez-van-Meerbeke A,Rodriguez JH

    更新日期：2018-11-01 00:00:00