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Cell-Penetrating Peptides Escape the Endosome by Inducing Vesicle Budding and Collapse.

Abstract：

:Cell-penetrating peptides (CPPs) are capable of delivering membrane-impermeable cargoes (including small molecules, peptides, proteins, nucleic acids, and nanoparticles) into the cytosol of mammalian cells and have the potential to revolutionize biomedical research and drug discovery. However, the mechanism of action of CPPs has remained poorly understood, especially how they escape from the endosome into the cytosol following endocytic uptake. We show herein that CPPs exit the endosome by inducing budding and collapse of CPP-enriched vesicles from the endosomal membrane. This mechanism provides a theoretical basis for designing CPPs and other delivery vehicles of improved efficiencies.

journal_name

ACS Chem Biol

journal_title

ACS chemical biology

authors

Sahni A,Qian Z,Pei D

doi

10.1021/acschembio.0c00478

subject

Has Abstract

pub_date

2020-09-18 00:00:00

pages

2485-2492

issue

9

eissn

1554-8929

issn

1554-8937

journal_volume

15

pub_type

杂志文章

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