HuR expression in adipose tissue mediates energy expenditure and acute thermogenesis independent of UCP1 expression.

abstract：:We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel 'hunger factor': a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity. Conversely, neutralization of ACBP/DBI by systemic injectio...

journal_title：Adipocyte

authors： Sica V,Martins I,Motiño O,Bravo-San Pedro JM,Kroemer G

更新日期：2020-12-01 00:00:00

abstract：:Subcutaneous (SAT) and visceral (VAT) adipose tissues have distinct metabolic phenotypes. We hypothesized that the extracellular matrix (ECM) regulates depot-specific differences in adipocyte metabolic function in murine obesity. VAT and SAT preadipocytes from lean or obese mice were subject to adipogenic differentiat...

journal_title：Adipocyte

authors： Strieder-Barboza C,Baker NA,Flesher CG,Karmakar M,Patel A,Lumeng CN,O'Rourke RW

更新日期：2020-12-01 00:00:00

abstract：:The quality and nutritional value of beef is closely linked to its content of intramuscular fat (IMF). The differentiation of preadipocytes and the deposition of lipid droplets in the adipocytes are the key to regulate the IMF content. The differentiation of adipocytes is regulated by a series of transcription factors...

journal_title：Adipocyte

authors： Liu L,Wu J,Gao Y,Lv Y,Xue J,Qin L,Xiao C,Hu Z,Zhang L,Luo X,Wang Y,Cao Y,Cao Y,Zhang G

更新日期：2020-12-01 00:00:00

abstract：:Secreted frizzled-related protein (SFRP) 4 is an extracellular antagonist of Wnt signalling that regulates adipogenesis, and is highly in the visceral adipose tissue of obese individuals. However, it is still unclear how exactly SFRP4 regulates the secretion of adipokines in the adipose tissue in vivo, an event that i...

journal_title：Adipocyte

authors： Zhang Y,Guan H,Fu Y,Wang X,Bai L,Zhao S,Liu E

更新日期：2020-12-01 00:00:00

abstract：:The advanced glycosylation end product receptor (RAGE) acts as a recognition receptor and interacts with different types of ligands that form and accumulate in the tissues and circulation, such as diabetes, inflammation, insulin resistance, and obesity. In these environments, RAGE is expressed on the surface of variou...

journal_title：Adipocyte

authors： Feng Z,Zhu L,Wu J

更新日期：2020-12-01 00:00:00

abstract：:Adipocyte sizes from adipose tissue of mature animals form a bimodal distribution, thus reporting mean cell size is misleading. The objectives of this study were to develop a robust method for testing bimodality of porcine adipocytes, describe the size distribution with an informative metric, and statistically test hy...

journal_title：Adipocyte

authors： Testroet ED,Sherman P,Yoder C,Testroet A,Reynolds C,O'Neil M,Lei SM,Beitz DC,Baas TJ

更新日期：2017-04-03 00:00:00

abstract：:Dysregulation of adipose tissue metabolism is associated with multiple metabolic disorders. One such disease, known as Dunnigan-type familial partial lipodystrophy (FPLD2) is characterized by defective fat metabolism and storage. FPLD2 is caused by a specific subset of mutations in the LMNA gene. The mechanisms by whi...

journal_title：Adipocyte

authors： Davies SJ,Ryan J,O'Connor PBF,Kenny E,Morris D,Baranov PV,O'Connor R,McCarthy TV

更新日期：2017-10-02 00:00:00

abstract：:Due to the epidemic rise of obesity prevalence, adipose tissue (AT) research is of major interest. Our aim was to study specificity of the most-common Cre/loxP approach for inducible gene manipulation of AT in mice (AdipoqCre-ERT2). We used mice with tamoxifen-sensitive Cre recombinase controlled by the adiponectin pr...

journal_title：Adipocyte

authors： Lindhorst A,Bechmann I,Gericke M

更新日期：2020-12-01 00:00:00

abstract：:Adipose-derived stem cells represent a reliable adult stem cell source thanks to their abundance, straightforward isolation, and broad differentiation abilities. Consequently, human adipose-derived stem cells (hASCs) have been used in vitro for several innovative cellular therapy and regenerative medicine applications...

journal_title：Adipocyte

authors： Arrizabalaga JH,Nollert MU

更新日期：2017-07-03 00:00:00

abstract：:The radioprotective 105 (RP105)/MD-1 complex is a member of the Toll-like receptor (TLR) family of proteins. We have previously reported that this complex cooperates with the essential lipopolysaccharide (LPS) receptor TLR4/MD-2 complex and plays a crucial role in LPS responses by B cells. Recent evidences suggest tha...

journal_title：Adipocyte

authors： Nagai Y,Watanabe Y,Takatsu K

更新日期：2013-04-01 00:00:00

abstract：:Obesity has become a global health-threat for every age group. It is well known that young mice (10-12 weeks of age) fed a western-type diet (WD) become obese and develop higher cholesterol levels and liver steatosis whereas insulin sensitivity is reduced. Less is known, however, about the effect of a WD on advanced-a...

journal_title：Adipocyte

authors： Vercalsteren E,Vranckx C,Frederix L,Lox M,Lijnen HR,Scroyen I,Hemmeryckx B

更新日期：2019-12-01 00:00:00

abstract：:Obesity is linked to adipose tissue hypertrophy (increased adipocyte cell size) and hyperplasia (increased cell number). Comparative analyses of gene datasets allowed us to identify 1426 genes which may represent common adipose phenotype in humans and mice. Among them we identified several adipocyte-specific genes dys...

journal_title：Adipocyte

authors： Berger E,Héraud S,Mojallal A,Lequeux C,Weiss-Gayet M,Damour O,Géloën A

更新日期：2015-01-26 00:00:00

abstract：:Diabetes leads to complications in select organ systems primarily by disrupting the vasculature of the target organs. These complications include both micro- (cardiomyopathy, retinopathy, nephropathy, and neuropathy) and macro-(atherosclerosis) angiopathies. Bone marrow angiopathy is also evident in both experimental ...

journal_title：Adipocyte

authors： Piccinin MA,Khan ZA

更新日期：2014-12-10 00:00:00

abstract：:Brown adipose tissue (BAT) is important in monitoring energy homeostasis and cancer cachexia. Different from white adipose tissue, BAT is characterized by the presence of a large number of mitochondria in adipocytes. Translocator protein 18 kDa (TSPO), a critical transporter, is expressed in the outer membrane of mito...

journal_title：Adipocyte

authors： Niu N,Xing H,Wang X,Ding J,Hao Z,Ren C,Ba J,Zheng L,Fu C,Zhao H,Huo L

更新日期：2020-12-01 00:00:00

abstract：:It has been postulated that the protective effects of lower body subcutaneous adipose tissue (LBSAT) occur via its ability to sequester surplus lipid and thus serve as a "metabolic sink." However, the mechanisms that mediate this protective function are unknown thus this study addresses this postulate. Ad libitum, cho...

journal_title：Adipocyte

authors： Cox-York K,Wei Y,Wang D,Pagliassotti MJ,Foster MT

更新日期：2014-12-20 00:00:00

abstract：:The adipose tissue represents a critical and predominant site for the interaction between metabolic and inflammatory responses during health and disease. In the white adipose tissue microenvironment, macrophages/adipocytes cross-talk have been shown to influence the metabolic and inflammatory states of both cell types...

journal_title：Adipocyte

authors： Alnaeeli M,Noguchi CT

更新日期：2015-01-07 00:00:00

abstract：:Adipose tissue development is dependent on multiple signaling mechanisms and cell-cell interactions that regulate adipogenesis, angiogenesis and extracellular remodeling. The Notch signaling pathway is an important cell-fate determinant whose role in adipogenesis is not clearly defined. To address this issue, we exami...

journal_title：Adipocyte

authors： Urs S,Turner B,Tang Y,Rostama B,Small D,Liaw L

更新日期：2012-01-01 00:00:00

abstract：:A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for ...

journal_title：Adipocyte

authors： Chiazza F,Challa TD,Lucchini FC,Konrad D,Wueest S

更新日期：2015-07-17 00:00:00

abstract：:There is a current debate in the literature on whether human fat derived from the supraclavicular region should be classified as brown, or as the white fat-derived less potent, brite/beige. This commentary addresses whether the existing classification defined in mice is sufficient to describe the types of thermogenic ...

journal_title：Adipocyte

authors： Scheele C,Larsen TJ,Nielsen S

更新日期：2014-01-01 00:00:00

abstract：:Adenosine A1 receptor-deficient mice develop a phenotype of insulin resistance and grow fat. Participating pathophysiological pathways are not understood in detail yet, as discussed in our recent manuscript. This commentary further explores possible pathophysiological mechanisms with emphasis on the roles of the adipo...

journal_title：Adipocyte

authors： Faulhaber-Walter R

更新日期：2012-04-01 00:00:00

abstract：:The CRISPR/Cas9 system is a powerful tool to generate a specific loss-of-function phenotype by gene knockout (KO). However, this approach is challenging in primary human cells. In this technical report, we present a reliable protocol to achieve a functional KO in the genome of human adipose stem/progenitor cells (ASCs...

journal_title：Adipocyte

authors： Mandl M,Ritthammer H,Ejaz A,Wagner SA,Hatzmann FM,Baumgarten S,Viertler HP,Zwierzina ME,Mattesich M,Schiller V,Rauchenwald T,Ploner C,Waldegger P,Pierer G,Zwerschke W

更新日期：2020-12-01 00:00:00

abstract：:Alternative splicing (AS) is a mechanism by which multiple mRNA transcripts are generated from a single gene. According to recent reports approximately 95-100% of human multi-exon genes undergo AS. This increases the amount of functionally different protein isoforms, and in some cases leads to metabolic diseases. Here...

journal_title：Adipocyte

authors： Kaminska D,Pihlajamäki J

更新日期：2013-07-01 00:00:00

abstract：:Alternative splicing is well known to be tissue-specific. Although several genes have been shown to undergo alternative splicing in adipocytes, little is known about the mechanism that regulates alternative splicing during adipogenesis. We recently reported that Sam68-/- mice exhibit a lean phenotype and are protected...

journal_title：Adipocyte

authors： Huot ME,Richard S

更新日期：2012-10-01 00:00:00

abstract：:The post-translational modification of protein by acetylation has been emerging as a prevalent modification in enzymes that catalyze intermediary metabolism. However, the dynamics of protein acetylation during adipocyte differentiation that involves a major shift in cellular metabolism is not known. In this study, we ...

journal_title：Adipocyte

authors： Xu Z,Ande SR,Mishra S

更新日期：2013-01-01 00:00:00

abstract：:Adipose stromal/progenitor cells (ASCs) can differentiate into adipocytes in the course of adipogenesis. This process is governed by systemic factors and signals of the adipose stem cell niche. ASCs isolated from fat tissues and amplified in vitro provide an essential and reliable model system to study adipogenesis. H...

journal_title：Adipocyte

authors： Ejaz A,Hatzmann FM,Hammerle S,Ritthammer H,Mattesich M,Zwierzina M,Waldegger P,Zwerschke W

更新日期：2019-12-01 00:00:00

abstract：:Adipocyte progenitors, known as adipose stromal cells (ASC), can become mobilized, recruited by tumors, and contribute to cancer progression. Mechanisms underlying ASC trafficking have remained obscure. We recently reported that CXCL1 expressed by cancer cells chemoattracts ASC expressing CXCR1 in obesity. As a candid...

journal_title：Adipocyte

authors： Zhang Y,Kolonin MG

更新日期：2016-08-12 00:00:00

abstract：:Insulin plays an important role during adipogenic differentiation of animal preadipocytes and the maintenance of mature phenotypes. However, its role and mechanism in dedifferentiation of adipocyte remains unclear. This study investigated the effects of insulin on dedifferentiation of mice adipocytes, and the potentia...

journal_title：Adipocyte

authors： Zang L,Kothan S,Yang Y,Zeng X,Ye L,Pan J

更新日期：2020-12-01 00:00:00

abstract：:Maintaining natural feeding rhythms with time-restricted feeding (TRF), without altering nutritional intake, prevents and reverses diet-induced obesity (DIO) and its associated metabolic disorders in mice. TRF has a direct effect on animal adiposity, causes an alteration of adipokine signaling, and diminishes white ad...

journal_title：Adipocyte

authors： Chaix A,Zarrinpar A

更新日期：2015-04-20 00:00:00

abstract：:Adipogenesis is regulated by a complex cascade of transcriptional factors, among them KLF4. This factor was previously shown to be necessary for adipose differentiation. We found that GSK3β activity was required for Klf4 and Klf5 expression during adipogenesis. In addition, retinoic acid inhibited Klf4 and Klf5 expres...

journal_title：Adipocyte

authors： Cervantes-Camacho C,Beltrán-Langarica A,Ochoa-Uribe AK,Marsch-Moreno M,Ayala-Sumuano JT,Velez-delValle C,Kuri-Harcuch W

更新日期：2015-01-20 00:00:00

abstract：:We recently discovered a novel signaling pathway involving activin receptor-like kinase 7 (ALK7), one of the type I transforming growth factor-β receptors. ALK7 and activated Smads 2, 3, and 4 inhibit the master regulators of adipogenesis, CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated...

journal_title：Adipocyte

authors： Yogosawa S,Izumi T

更新日期：2013-10-01 00:00:00