Abstract:
:A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.
journal_name
Adipocytejournal_title
Adipocyteauthors
Chiazza F,Challa TD,Lucchini FC,Konrad D,Wueest Sdoi
10.1080/21623945.2015.1071454subject
Has Abstractpub_date
2015-07-17 00:00:00pages
88-92issue
1eissn
2162-3945issn
2162-397Xpii
1071454journal_volume
5pub_type
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