Effects of SFRP4 overexpression on the production of adipokines in transgenic mice.

abstract：:Obesity is a global problem and effective drug therapy treatment is still unavailable. Obesity develops due to an imbalance between energy intake and energy expenditure (EE). Understanding what happens to EE in obesity may be the key to developing new treatments for obesity. If EE in obesity can be elevated, it could ...

journal_title：Adipocyte

authors： Simonds SE,Cowley MA,Enriori PJ

更新日期：2012-07-01 00:00:00

abstract：:The notion that the obesogenic potential of high fat diets in rodents is attenuated when the protein:carbohydrate ratio is increased is largely based on studies using casein or whey as the protein source. We fed C57BL/6J mice high fat-high protein diets using casein, soy, cod, beef, chicken or pork as protein sources....

journal_title：Adipocyte

authors： Liisberg U,Myrmel LS,Fjære E,Rønnevik AK,Bjelland S,Fauske KR,Holm JB,Basse AL,Hansen JB,Liaset B,Kristiansen K,Madsen L

更新日期：2016-03-17 00:00:00

abstract：:Alternative splicing is well known to be tissue-specific. Although several genes have been shown to undergo alternative splicing in adipocytes, little is known about the mechanism that regulates alternative splicing during adipogenesis. We recently reported that Sam68-/- mice exhibit a lean phenotype and are protected...

journal_title：Adipocyte

authors： Huot ME,Richard S

更新日期：2012-10-01 00:00:00

abstract：:It has been postulated that the protective effects of lower body subcutaneous adipose tissue (LBSAT) occur via its ability to sequester surplus lipid and thus serve as a "metabolic sink." However, the mechanisms that mediate this protective function are unknown thus this study addresses this postulate. Ad libitum, cho...

journal_title：Adipocyte

authors： Cox-York K,Wei Y,Wang D,Pagliassotti MJ,Foster MT

更新日期：2014-12-20 00:00:00

abstract：:Sepsis is a systemic inflammatory response to infection, with no preventative strategies. In this study, we identify a role for habitual physical activity in the prevention of adipose tissue inflammation induced by a model of sepsis, lipopolysaccharide (LPS). Male C57BL/6J mice (8 weeks old) were housed with access to...

journal_title：Adipocyte

authors： Peppler WT,Anderson ZG,MacRae LM,MacPherson REK,Wright DC

更新日期：2017-01-02 00:00:00

abstract：:Adipogenesis is regulated by a complex cascade of transcriptional factors, among them KLF4. This factor was previously shown to be necessary for adipose differentiation. We found that GSK3β activity was required for Klf4 and Klf5 expression during adipogenesis. In addition, retinoic acid inhibited Klf4 and Klf5 expres...

journal_title：Adipocyte

authors： Cervantes-Camacho C,Beltrán-Langarica A,Ochoa-Uribe AK,Marsch-Moreno M,Ayala-Sumuano JT,Velez-delValle C,Kuri-Harcuch W

更新日期：2015-01-20 00:00:00

abstract：:Dysregulation of adipose tissue metabolism is associated with multiple metabolic disorders. One such disease, known as Dunnigan-type familial partial lipodystrophy (FPLD2) is characterized by defective fat metabolism and storage. FPLD2 is caused by a specific subset of mutations in the LMNA gene. The mechanisms by whi...

journal_title：Adipocyte

authors： Davies SJ,Ryan J,O'Connor PBF,Kenny E,Morris D,Baranov PV,O'Connor R,McCarthy TV

更新日期：2017-10-02 00:00:00

abstract：:Due to the epidemic rise of obesity prevalence, adipose tissue (AT) research is of major interest. Our aim was to study specificity of the most-common Cre/loxP approach for inducible gene manipulation of AT in mice (AdipoqCre-ERT2). We used mice with tamoxifen-sensitive Cre recombinase controlled by the adiponectin pr...

journal_title：Adipocyte

authors： Lindhorst A,Bechmann I,Gericke M

更新日期：2020-12-01 00:00:00

abstract：:The post-translational modification of protein by acetylation has been emerging as a prevalent modification in enzymes that catalyze intermediary metabolism. However, the dynamics of protein acetylation during adipocyte differentiation that involves a major shift in cellular metabolism is not known. In this study, we ...

journal_title：Adipocyte

authors： Xu Z,Ande SR,Mishra S

更新日期：2013-01-01 00:00:00

abstract：:Adipocyte progenitors, known as adipose stromal cells (ASC), can become mobilized, recruited by tumors, and contribute to cancer progression. Mechanisms underlying ASC trafficking have remained obscure. We recently reported that CXCL1 expressed by cancer cells chemoattracts ASC expressing CXCR1 in obesity. As a candid...

journal_title：Adipocyte

authors： Zhang Y,Kolonin MG

更新日期：2016-08-12 00:00:00

abstract：:Obesity is linked to adipose tissue hypertrophy (increased adipocyte cell size) and hyperplasia (increased cell number). Comparative analyses of gene datasets allowed us to identify 1426 genes which may represent common adipose phenotype in humans and mice. Among them we identified several adipocyte-specific genes dys...

journal_title：Adipocyte

authors： Berger E,Héraud S,Mojallal A,Lequeux C,Weiss-Gayet M,Damour O,Géloën A

更新日期：2015-01-26 00:00:00

abstract：:Alternative splicing (AS) is a mechanism by which multiple mRNA transcripts are generated from a single gene. According to recent reports approximately 95-100% of human multi-exon genes undergo AS. This increases the amount of functionally different protein isoforms, and in some cases leads to metabolic diseases. Here...

journal_title：Adipocyte

authors： Kaminska D,Pihlajamäki J

更新日期：2013-07-01 00:00:00

abstract：:Subcutaneous (SAT) and visceral (VAT) adipose tissues have distinct metabolic phenotypes. We hypothesized that the extracellular matrix (ECM) regulates depot-specific differences in adipocyte metabolic function in murine obesity. VAT and SAT preadipocytes from lean or obese mice were subject to adipogenic differentiat...

journal_title：Adipocyte

authors： Strieder-Barboza C,Baker NA,Flesher CG,Karmakar M,Patel A,Lumeng CN,O'Rourke RW

更新日期：2020-12-01 00:00:00

abstract：:A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for ...

journal_title：Adipocyte

authors： Chiazza F,Challa TD,Lucchini FC,Konrad D,Wueest S

更新日期：2015-07-17 00:00:00

abstract：:Diabetes leads to complications in select organ systems primarily by disrupting the vasculature of the target organs. These complications include both micro- (cardiomyopathy, retinopathy, nephropathy, and neuropathy) and macro-(atherosclerosis) angiopathies. Bone marrow angiopathy is also evident in both experimental ...

journal_title：Adipocyte

authors： Piccinin MA,Khan ZA

更新日期：2014-12-10 00:00:00

abstract：:Brown adipose tissue (BAT) is important in monitoring energy homeostasis and cancer cachexia. Different from white adipose tissue, BAT is characterized by the presence of a large number of mitochondria in adipocytes. Translocator protein 18 kDa (TSPO), a critical transporter, is expressed in the outer membrane of mito...

journal_title：Adipocyte

authors： Niu N,Xing H,Wang X,Ding J,Hao Z,Ren C,Ba J,Zheng L,Fu C,Zhao H,Huo L

更新日期：2020-12-01 00:00:00

abstract：:The advanced glycosylation end product receptor (RAGE) acts as a recognition receptor and interacts with different types of ligands that form and accumulate in the tissues and circulation, such as diabetes, inflammation, insulin resistance, and obesity. In these environments, RAGE is expressed on the surface of variou...

journal_title：Adipocyte

authors： Feng Z,Zhu L,Wu J

更新日期：2020-12-01 00:00:00

abstract：:Obesity has become a global health-threat for every age group. It is well known that young mice (10-12 weeks of age) fed a western-type diet (WD) become obese and develop higher cholesterol levels and liver steatosis whereas insulin sensitivity is reduced. Less is known, however, about the effect of a WD on advanced-a...

journal_title：Adipocyte

authors： Vercalsteren E,Vranckx C,Frederix L,Lox M,Lijnen HR,Scroyen I,Hemmeryckx B

更新日期：2019-12-01 00:00:00

abstract：:Insulin plays an important role during adipogenic differentiation of animal preadipocytes and the maintenance of mature phenotypes. However, its role and mechanism in dedifferentiation of adipocyte remains unclear. This study investigated the effects of insulin on dedifferentiation of mice adipocytes, and the potentia...

journal_title：Adipocyte

authors： Zang L,Kothan S,Yang Y,Zeng X,Ye L,Pan J

更新日期：2020-12-01 00:00:00

abstract：:This study investigated the effects of cold acclimation on circulating fibroblast growth factor 21 (FGF21) levels, as well as its production and signaling in classical brown and white adipose tissues. Male Wistar rats were cold (4°C) acclimatized for 7 days. Subsequently, liver, interscapular and aortic BAT (iBAT and ...

journal_title：Adipocyte

authors： Sepa-Kishi DM,Ceddia RB

更新日期：2018-01-01 00:00:00

abstract：:Adipose tissue development is dependent on multiple signaling mechanisms and cell-cell interactions that regulate adipogenesis, angiogenesis and extracellular remodeling. The Notch signaling pathway is an important cell-fate determinant whose role in adipogenesis is not clearly defined. To address this issue, we exami...

journal_title：Adipocyte

authors： Urs S,Turner B,Tang Y,Rostama B,Small D,Liaw L

更新日期：2012-01-01 00:00:00

abstract：:Non-drug strategy targeting adipocyte differentiation is critical for alleviating visceral obesity and its related diseases. However, whether and how low intensity pulsed ultrasound (LIPUS) could be used for inhibiting visceral adipocyte differentiation is not fully understood. In this study, we aim to investigate the...

journal_title：Adipocyte

authors： Xu T,Zhao K,Guo X,Tu J,Zhang D,Sun W,Kong X

更新日期：2019-12-01 00:00:00

abstract：:We recently identified acyl coenzyme A-binding protein (ACBP)/diazepam binding inhibitor (DBI) as a novel 'hunger factor': a protein that is upregulated in human or murine obesity and that, if administered to mice, causes hyperphagy, adipogenesis and obesity. Conversely, neutralization of ACBP/DBI by systemic injectio...

journal_title：Adipocyte

authors： Sica V,Martins I,Motiño O,Bravo-San Pedro JM,Kroemer G

更新日期：2020-12-01 00:00:00

abstract：:Maintaining natural feeding rhythms with time-restricted feeding (TRF), without altering nutritional intake, prevents and reverses diet-induced obesity (DIO) and its associated metabolic disorders in mice. TRF has a direct effect on animal adiposity, causes an alteration of adipokine signaling, and diminishes white ad...

journal_title：Adipocyte

authors： Chaix A,Zarrinpar A

更新日期：2015-04-20 00:00:00

abstract：:Growth hormone (GH) supplementation therapy to adults with GH deficiency has beneficial effects on adipose tissue lipid metabolism, improving thus adipocyte functional morphology and insulin sensitivity. However, molecular nature of these effects remains unclear. We therefore tested the hypothesis that lipid-mobilizin...

journal_title：Adipocyte

authors： Balaž M,Ukropcova B,Kurdiova T,Vlcek M,Surova M,Krumpolec P,Vanuga P,Gašperíková D,Klimeš I,Payer J,Wolfrum C,Ukropec J

更新日期：2014-12-17 00:00:00

abstract：:The adipose tissue represents a critical and predominant site for the interaction between metabolic and inflammatory responses during health and disease. In the white adipose tissue microenvironment, macrophages/adipocytes cross-talk have been shown to influence the metabolic and inflammatory states of both cell types...

journal_title：Adipocyte

authors： Alnaeeli M,Noguchi CT

更新日期：2015-01-07 00:00:00

abstract：:Current efforts to treat obesity and associated disorders focus on the stimulation of energy expenditure by increasing thermogenesis, for instance through activating brown adipose tissue or more recently "beige" or "brite" fat, a relatively novel type of adipose tissue with putative thermogenic potential. In this comm...

journal_title：Adipocyte

authors： Warner A,Mittag J

更新日期：2014-07-01 00:00:00

abstract：:Adenosine A1 receptor-deficient mice develop a phenotype of insulin resistance and grow fat. Participating pathophysiological pathways are not understood in detail yet, as discussed in our recent manuscript. This commentary further explores possible pathophysiological mechanisms with emphasis on the roles of the adipo...

journal_title：Adipocyte

authors： Faulhaber-Walter R

更新日期：2012-04-01 00:00:00

abstract：:The CRISPR/Cas9 system is a powerful tool to generate a specific loss-of-function phenotype by gene knockout (KO). However, this approach is challenging in primary human cells. In this technical report, we present a reliable protocol to achieve a functional KO in the genome of human adipose stem/progenitor cells (ASCs...

journal_title：Adipocyte

authors： Mandl M,Ritthammer H,Ejaz A,Wagner SA,Hatzmann FM,Baumgarten S,Viertler HP,Zwierzina ME,Mattesich M,Schiller V,Rauchenwald T,Ploner C,Waldegger P,Pierer G,Zwerschke W

更新日期：2020-12-01 00:00:00

abstract：:There is a current debate in the literature on whether human fat derived from the supraclavicular region should be classified as brown, or as the white fat-derived less potent, brite/beige. This commentary addresses whether the existing classification defined in mice is sufficient to describe the types of thermogenic ...

journal_title：Adipocyte

authors： Scheele C,Larsen TJ,Nielsen S

更新日期：2014-01-01 00:00:00