Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications.

Abstract:

:Diabetes leads to complications in select organ systems primarily by disrupting the vasculature of the target organs. These complications include both micro- (cardiomyopathy, retinopathy, nephropathy, and neuropathy) and macro-(atherosclerosis) angiopathies. Bone marrow angiopathy is also evident in both experimental models of the disease as well as in human diabetes. In addition to vascular disruption, bone loss and increased marrow adiposity have become hallmarks of the diabetic bone phenotype. Emerging evidence now implicates enhanced marrow adipogenesis and changes to cellular makeup of the marrow in a novel mechanistic link between various secondary complications of diabetes. In this review, we explore the mechanisms of enhanced marrow adipogenesis in diabetes and the link between changes to marrow cellular composition, and disruption and depletion of reparative stem cells.

journal_name

Adipocyte

journal_title

Adipocyte

authors

Piccinin MA,Khan ZA

doi

10.4161/adip.32215

subject

Has Abstract

pub_date

2014-12-10 00:00:00

pages

263-72

issue

4

eissn

2162-3945

issn

2162-397X

pii

964540

journal_volume

3

pub_type

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