Porphyromonas: A neglected potential key genus in human microbiomes.

Abstract:

:Anaerobes form a large part of microbial communities, and have begun to be specifically studied in both healthy and pathologic contexts. Porphyromonas is one of the top ten anaerobic taxa in the microbiome (anaerobiome) in healthy subjects. However, to date, most studies focused on the deleterious role of P. gingivalis, the most widely described species. Interestingly, targeted metagenomics reveals Porphyromonas other than gingivalis (POTG), highlighting other species such as P. catoniae or P. pasteri as potential biomarkers in disease progression or pathogen colonization susceptibility. From the sparse data, it appears that the Porphyromonas genus may also be a relevant target of investigation in several pulmonary diseases. Moreover, deciphering cutaneous, gastric and oral microbiomes hint that Porphyromonas may be a genus of interest in non-pulmonary diseases. This review aims to summarize the major data on POTG and to report their impact on the various human microbiomes in different clinical states.

journal_name

Anaerobe

journal_title

Anaerobe

authors

Guilloux CA,Lamoureux C,Beauruelle C,Héry-Arnaud G

doi

10.1016/j.anaerobe.2020.102230

subject

Has Abstract

pub_date

2020-06-30 00:00:00

pages

102230

eissn

1075-9964

issn

1095-8274

pii

S1075-9964(20)30086-X

pub_type

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