Abstract：
:Clostridium spp. are recovered from 25% of the blood culture positive with anaerobes. However, the clinical relevance of Clostridium bacteremia has been controverted in the literature, particularly for C. perfringens. We aimed to evaluate the clinical relevance of Clostridium bacteremia, either due to C. perfringens or other Clostridium species, and to identify the risk factors of mortality in these patients. A retrospective cohort study was conducted from January 2010 to April 2018. All the patients with at least one blood culture positive with any Clostridium species were included. Eighty-one patients with a least one blood culture positive with any Clostridium species were included. Seventy patients (86.4%) fulfilled the criteria for clinically relevant bacteremia. Bacteremia due to C. perfringens tended to be less clinically relevant than other Clostridium species but this was not statistically significant (76% vs 91.2%, P = 0.09). In case of clinically relevant bacteremia, the 30-day mortality rate was 31.4%. In multivariate analysis, adequate empiric antimicrobial therapy was significantly associated with survival (P = 0.03). In conclusion, bacteremia due to C. perfringens or other Clostridium species is usually clinically relevant. This finding was also supported by an improved survival at 30 days when adequate empiric antimicrobial therapy was administered.
journal_name
Anaerobejournal_title
Anaerobeauthors
Stabler S,Titécat M,Duployez C,Wallet F,Loïez C,Bortolotti P,Faure E,Faure K,Kipnis E,Dessein R,Le Guern Rdoi
10.1016/j.anaerobe.2020.102202subject
Has Abstractpub_date
2020-06-01 00:00:00pages
102202eissn
1075-9964issn
1095-8274pii
S1075-9964(20)30058-5journal_volume
63pub_type
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