Abstract：
PURPOSE:Complete surgical excision is the main factor for successful breast-conserving surgery in patients with ductal carcinoma in situ (DCIS) of the breast. Preoperative magnetic resonance imaging (MRI) may allow surgery optimization in this indication. From an economic standpoint, systematic preoperative MRI is associated with an extra cost, which may be offset by a decrease in the number of re-interventions. We performed an economic evaluation alongside IRCIS randomised controlled trial (NCT01112254) to determine whether systematic preoperative MRI in DCIS is a cost-effective strategy. METHODS:360 patients were included in IRCIS trial. Costs were assessed from the French national health insurance perspective. Resource use was prospectively collected during a 6-month period after randomisation. We estimated the mean cost per averted re-intervention. RESULTS:Despite extra costs due to MRI and additional biopsies, difference in total costs between arms was not statistically significant (mean cost of €9980 in MRI arm and €9682 in no MRI arm, cost difference: €298 [CI95% : -470; 1063]). There was a non-significant decrease in the rate of re-hospitalisations for positive or close margins (20% in MRI arm versus 27% in No MRI arm, difference -7% [CI95% : -17; 3]). At a willingness to pay of €500 to avert a re-intervention, the probability that MRI strategy is cost-effective was 93%. CONCLUSION:Systematic preoperative MRI in patients with DCIS of the breast may be a cost-effective strategy. However, the modest clinical benefit associated with such a strategy limits the interest for this procedure in routine practice given the current MRI techniques.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Kandel M,Dunant A,Balleyguier C,Bonastre Jdoi
10.1016/j.ejrad.2020.109058subject
Has Abstractpub_date
2020-08-01 00:00:00pages
109058eissn
0720-048Xissn
1872-7727pii
S0720-048X(20)30247-3journal_volume
129pub_type
杂志文章abstract：OBJECTIVES:To evaluate patient burden and preferences for MR colonography with a limited bowel preparation and automated carbon dioxide insufflation in comparison to conventional colonoscopy. METHODS:Symptomatic patients were consecutively recruited to undergo MR colonography with automated carbon dioxide insufflation...
journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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更新日期：2011-09-01 00:00:00
