Effect of deletion of gene cluster involved in synthesis of Enterobacterial common antigen on virulence and immunogenicity of live attenuated Salmonella vaccine when delivering heterologous Streptococcus pneumoniae antigen PspA.

abstract：BACKGROUND:Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant destruction of the gingival tissue remain largely undefined. RESULTS:We report host-P. gingivalis interactions in primary human gingival fibroblast (HGF) c...

journal_title：BMC microbiology

authors： Urnowey S,Ansai T,Bitko V,Nakayama K,Takehara T,Barik S

更新日期：2006-03-08 00:00:00

abstract：BACKGROUND:Dispersal from Candida albicans biofilms that colonize catheters is implicated as a primary factor in the link between contaminated catheters and life threatening blood stream infections (BSI). Appropriate in vitro C. albicans biofilm models are needed to probe factors that induce detachment events. RESULTS...

journal_title：BMC microbiology

authors： Sellam A,Al-Niemi T,McInnerney K,Brumfield S,Nantel A,Suci PA

更新日期：2009-02-02 00:00:00

abstract：BACKGROUND:The development of vaccines and evaluation of novel treatment strategies for invasive group A streptococcal (iGAS) disease requires suitable models of human infection that can be monitored longitudinally and are preferably non-invasive. Bio-photonic imaging provides an opportunity to reduce use of animals in...

journal_title：BMC microbiology

authors： Lamb LE,Zhi X,Alam F,Pyzio M,Scudamore CL,Wiles S,Sriskandan S

更新日期：2018-06-19 00:00:00

abstract：BACKGROUND:Escherichia coli strains are commonly found in the gut microflora of warm-blooded animals. These strains can be assigned to one of the four main phylogenetic groups, A, B1, B2 and D, which can be divided into seven subgroups (A0, A1, B1, B22, B23, D1 and D2), according to the combination of the three genetic...

journal_title：BMC microbiology

authors： Carlos C,Pires MM,Stoppe NC,Hachich EM,Sato MI,Gomes TA,Amaral LA,Ottoboni LM

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to design and evaluate fluorescent in situ hybridization (FISH) probes for the single-cell detection and enumeration of lactic acid bacteria, in particular organisms belonging to the major phylogenetic groups and species of oral lactobacilli and to Abiotrophia/Granulicatella. R...

journal_title：BMC microbiology

authors： Quevedo B,Giertsen E,Zijnge V,Lüthi-Schaller H,Guggenheim B,Thurnheer T,Gmür R

更新日期：2011-01-19 00:00:00

abstract：BACKGROUND:Candida parapsilosis typically is a commensal of human skin. However, when host immune defense is compromised or the normal microflora balance is disrupted, C. parapsilosis transforms itself into an opportunistic pathogen. Candida-derived lipase has been identified as potential virulence factor. Even though ...

journal_title：BMC microbiology

authors： Nagy I,Filkor K,Németh T,Hamari Z,Vágvölgyi C,Gácser A

更新日期：2011-05-29 00:00:00

abstract：BACKGROUND:Hepatitis B virus (HBV), because of its error-prone viral polymerase, has a high mutation rate leading to widespread substitutions, deletions, and insertions in the HBV genome. Deletions may significantly change viral biological features complicating the progression of liver diseases. However, the clinical c...

journal_title：BMC microbiology

authors： Zhang D,Dong P,Zhang K,Deng L,Bach C,Chen W,Li F,Protzer U,Ding H,Zeng C

更新日期：2012-12-28 00:00:00

abstract：BACKGROUND:Microorganisms of different species interact in several ecological niches, even causing infection. During the infectious process, a biofilm of single or multispecies can develop. Aspergillus fumigatus and Staphyloccocus aureus are etiologic agents that can cause infectious keratitis. We analyzed in vitro sin...

journal_title：BMC microbiology

authors： Ramírez Granillo A,Canales MG,Espíndola ME,Martínez Rivera MA,de Lucio VM,Tovar AV

更新日期：2015-02-15 00:00:00

abstract：BACKGROUND:Bartonella henselae is a Gram-negative bacterium transmitted to humans by a scratch from cat in the presence of ectoparasites. Humans infected with B. henselae can result in various clinical diseases including local lymphadenopathy and more serious systemic disease such as persistent bacteremia and endocardi...

journal_title：BMC microbiology

authors： Zheng X,Ma X,Li T,Shi W,Zhang Y

更新日期：2020-04-10 00:00:00

abstract：BACKGROUND:Quorum sensing is a communication system that regulates gene expression in response to population density and often regulates virulence determinants. Deletion of the luxR homologue vjbR highly attenuates intracellular survival of Brucella melitensis and has been interpreted to be an indication of a role for ...

journal_title：BMC microbiology

authors： Weeks JN,Galindo CL,Drake KL,Adams GL,Garner HR,Ficht TA

更新日期：2010-06-08 00:00:00

abstract：BACKGROUND:The aminoglycoside antibiotic gentamicin was supposed to induce a crosstalk between the Cpx- and the Arc-two-component systems (TCS). Here, we investigated the physical interaction of the respective TCS components and compared the results with their respective gene expression and protein abundance. The findi...

journal_title：BMC microbiology

authors： Ćudić E,Surmann K,Panasia G,Hammer E,Hunke S

更新日期：2017-09-18 00:00:00

abstract：BACKGROUND:Invasive aspergillosis (IA) is a major cause of infectious morbidity and mortality in immune compromised patients. Studies on the pathogenesis of IA have been limited by the difficulty to monitor disease progression in real-time. For real-time monitoring of the infection, we recently engineered a bioluminesc...

journal_title：BMC microbiology

authors： Ibrahim-Granet O,Jouvion G,Hohl TM,Droin-Bergère S,Philippart F,Kim OY,Adib-Conquy M,Schwendener R,Cavaillon JM,Brock M

更新日期：2010-04-08 00:00:00

abstract：BACKGROUND:Lyme borrelia genotypes differ in their capacity to cause disseminated disease. Gene array analysis was employed to profile the host transcriptome induced by Borrelia burgdorferi strains with different capacities for causing disseminated disease in the blood of C3H/HeJ mice during early infection. RESULTS:B...

journal_title：BMC microbiology

authors： Petzke MM,Iyer R,Love AC,Spieler Z,Brooks A,Schwartz I

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:A common assumption of microorganisms is that laboratory stocks will remain genetically and phenotypically constant over time, and across laboratories. It is becoming increasingly clear, however, that mutations can ruin strain integrity and drive the divergence or "domestication" of stocks. Since its discove...

journal_title：BMC microbiology

authors： Carroll SM,Xue KS,Marx CJ

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:The microbiological diagnosis of bacterial vaginosis is usually made using Nugent's criteria, a useful but rather laborious scoring system based on counting bacterial cell types on Gram stained slides of vaginal smears. Ison and Hay have simplified the score system to three categories and added a fourth cate...

journal_title：BMC microbiology

authors： Verhelst R,Verstraelen H,Claeys G,Verschraegen G,Van Simaey L,De Ganck C,De Backer E,Temmerman M,Vaneechoutte M

更新日期：2005-10-14 00:00:00

abstract：BACKGROUND:Many chronic diseases, such as non-healing wounds are characterized by prolonged inflammation and respond poorly to conventional treatment. Bacterial biofilms are a major impediment to wound healing. Persistent infection of the skin allows the formation of complex bacterial communities termed biofilm. Bacter...

journal_title：BMC microbiology

authors： Secor PR,James GA,Fleckman P,Olerud JE,McInnerney K,Stewart PS

更新日期：2011-06-21 00:00:00

abstract：BACKGROUND:Cysteine has a crucial role in cellular physiology and its synthesis is tightly controlled due to its reactivity. However, little is known about the sulfur metabolism and its regulation in clostridia compared with other firmicutes. In Clostridium perfringens, the two-component system, VirR/VirS, controls the...

journal_title：BMC microbiology

authors： André G,Haudecoeur E,Monot M,Ohtani K,Shimizu T,Dupuy B,Martin-Verstraete I

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Chlortetracycline (CTC) is one of the commercially important tetracyclines (TCs) family product and is mainly produced by Streptomyces. CTC is still in a great demand due to its broad-spectrum activity against pathogens. Engineering transcriptional control allows the cell to allocate its valuable resources t...

journal_title：BMC microbiology

authors： Kong L,Liu J,Zheng X,Deng Z,You D

更新日期：2019-12-10 00:00:00

abstract：BACKGROUND:Neisseria gonorrhoeae is an obligate human pathogen that causes significant worldwide morbidity. N. gonorrhoeae expresses lipooligosaccharide (LOS), a phase variable molecule that plays an important role during pathogenesis of the organism. Alteration in the structure of gonococcal LOS correlates with altere...

journal_title：BMC microbiology

authors： Patrone JB,Stein DC

更新日期：2007-01-26 00:00:00

abstract：BACKGROUND:Nucleotide sugar transporters (NSTs) play an essential role in translocating nucleotide sugars into the lumen of the endoplasmic reticulum and Golgi apparatus to be used as substrates in glycosylation reactions. This intracellular transport is an essential step in the biosynthesis of glycoconjugates. RESULT...

journal_title：BMC microbiology

authors： Baptista CG,Rodrigues EC,Morking P,Klinke A,Zardo ML,Soares MJ,de Aguiar AM,Goldenberg S,Ramos AS

更新日期：2015-11-21 00:00:00

abstract：BACKGROUND:Although the most widely accepted mechanism of action for polymyxins is related to bacterial lysis via disruption, we hypothesized that this antimicrobial drug class could have other effects on Pseudomonas aeruginosa planktonic and sessile cells. Little is known regarding oxidative burst and zeta potential (...

journal_title：BMC microbiology

authors： Lima MR,Ferreira GF,Nunes Neto WR,Monteiro JM,Santos ÁRC,Tavares PB,Denadai ÂML,Bomfim MRQ,Dos Santos VL,Marques SG,de Souza Monteiro A

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:Meiotic cells undergo two rounds of nuclear division and generate gametes. Previous studies have indicated that a number of transcription factors modulate the transcriptome in successive waves during meiosis and spore formation in fission yeast. However, the mechanisms underlying the post-transcriptional reg...

journal_title：BMC microbiology

authors： Togashi N,Yamashita A,Sato M,Yamamoto M

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Fibronectin-binding protein A (FnBPA) mediates adhesion of Staphylococcus aureus to fibronectin, fibrinogen and elastin. We previously reported that S. aureus strain P1 encodes an FnBPA protein where the fibrinogen/elastin-binding domain (A domain) is substantially divergent in amino acid sequence from the a...

journal_title：BMC microbiology

authors： Loughman A,Sweeney T,Keane FM,Pietrocola G,Speziale P,Foster TJ

更新日期：2008-05-08 00:00:00

abstract：BACKGROUND:Bacterial nucleoid consists of genome DNA, RNA, and hundreds of nucleoid-associated proteins (NAPs). Escherichia coli nucleoid is compacted towards the stationary phase, replacing most log-phase NAPs with the major stationary-phase nucleoid protein, Dps. In contrast, Staphylococcus aureus nucleoid sustains t...

journal_title：BMC microbiology

authors： Ushijima Y,Ohniwa RL,Morikawa K

更新日期：2017-10-02 00:00:00

abstract：BACKGROUND:Coxiella burnetii is the causative agent of Q-fever, a widespread zoonosis. Due to its high environmental stability and infectivity it is regarded as a category B biological weapon agent. In domestic animals infection remains either asymptomatic or presents as infertility or abortion. Clinical presentation i...

journal_title：BMC microbiology

authors： Panning M,Kilwinski J,Greiner-Fischer S,Peters M,Kramme S,Frangoulidis D,Meyer H,Henning K,Drosten C

更新日期：2008-05-19 00:00:00

abstract：BACKGROUND:A growing body of evidence suggests that Mycobacterium tuberculosis (Mtb) uses the host's cholesterol as a source of carbon and energy during infection. Strains defective in cholesterol transport or degradation exhibit attenuated growth in activated macrophages and diminished infectivity in animal models. Th...

journal_title：BMC microbiology

authors： Brzezinska M,Szulc I,Brzostek A,Klink M,Kielbik M,Sulowska Z,Pawelczyk J,Dziadek J

更新日期：2013-02-20 00:00:00

abstract：BACKGROUND:The naked mole-rat (NMR, Heterocephalus glaber) is being bred as a novel laboratory animal due to its unique biological characteristics, including longevity, cancer resistance, hypoxia tolerance, and pain insensitivity. It is expected that differences exist between the microbiota of wild NMRs and that of NMR...

journal_title：BMC microbiology

authors： Cong W,Xing J,Feng Y,Wang J,Fu R,Yue B,He Z,Lin L,Yang W,Cheng J,Sun W,Cui S

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:The genus Xanthomonas comprises several plant pathogenic bacteria affecting a wide range of hosts. Despite the economic, industrial and biological importance of Xanthomonas, the classification and phylogenetic relationships within the genus are still under active debate. Some of the relationships between pat...

journal_title：BMC microbiology

authors： Rodriguez-R LM,Grajales A,Arrieta-Ortiz ML,Salazar C,Restrepo S,Bernal A

更新日期：2012-03-23 00:00:00

abstract：BACKGROUND:Iron is an essential nutrient but can be toxic at high intracellular concentrations and organisms have evolved tightly regulated mechanisms for iron uptake and homeostasis. Information on iron management mechanisms is available for organisms living at circumneutral pH. However, very little is known about how...

journal_title：BMC microbiology

authors： Osorio H,Martínez V,Nieto PA,Holmes DS,Quatrini R

更新日期：2008-11-24 00:00:00

abstract：BACKGROUND:Sinorhizobium meliloti is an agriculturally important model symbiont. There is an ongoing need to update and improve its genome annotation. In this study, we used a high-throughput pyrosequencing approach to sequence the transcriptome of S. meliloti, and search for new bacterial genes missed in the previous ...

journal_title：BMC microbiology

authors： Mao C,Evans C,Jensen RV,Sobral BW

更新日期：2008-05-02 00:00:00