Pharmacotherapy options in pulmonary alveolar proteinosis.

abstract：:The International Continence Society has defined overactive bladder (OAB) as urinary urgency, with or without urge urinary incontinence, usually with urinary frequency and nocturia. Approximately 17% of men and women in the US report OAB symptoms, which can affect quality of life. Trospium chloride, which has recently...

journal_title：Expert opinion on pharmacotherapy

authors： Zinner NR

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Fesoterodine is a newly approved drug for the treatment of overactive bladder syndrome. OBJECTIVE:The aim of this study was to review the preclinical and clinical data on fesoterodine. METHODS:The study involved a search of the Medline database and the proceedings volumes of urological congresses. RESULTS...

journal_title：Expert opinion on pharmacotherapy

authors： Michel MC

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:Asthma is the most common chronic disease in childhood, affecting approximately 10% of all children, and is the leading cause of hospitalization in developed countries. In this paper we aimed to review the evidence on chemical pharmacotherapy for long-term treatment of pediatric asthma, according to the la...

journal_title：Expert opinion on pharmacotherapy

authors： Vitale C,Maglio A,Pelaia C,Vatrella A

更新日期：2017-05-01 00:00:00

abstract：INTRODUCTION:Chronic constipation is a global problem affecting all ages and associated with considerable morbidity and significant financial burden for society. Though formerly defined on the basis of a single symptom, infrequent defecation; constipation is now viewed as a syndrome encompassing several complaints such...

journal_title：Expert opinion on pharmacotherapy

authors： Quigley EM,Neshatian L

更新日期：2016-01-01 00:00:00

abstract：:Peglyated liposomal doxorubicin was developed to maintain or enhance the demonstrated antineoplastic effects of doxorubicin, while improving the toxicity profile associated with this important cytotoxic agent. Accumulating clinical data have confirmed the activity of pegylated liposomal doxorubicin in cancers of the b...

journal_title：Expert opinion on pharmacotherapy

authors： Markman M

更新日期：2006-08-01 00:00:00

abstract：INTRODUCTION:Despite intensified insulin treatment, many persons with type 1 diabetes (T1D) do not achieve glycemic and metabolic targets. Consequently, non-insulin chemical therapies that improve glycemic control and metabolic parameters without increasing the risk of adverse events (including hypoglycemia) are of int...

journal_title：Expert opinion on pharmacotherapy

authors： Frandsen CS,Dejgaard TF,Madsbad S,Holst JJ

更新日期：2018-06-01 00:00:00

abstract：:Overactive bladder (OAB) is a common problem. Affected individuals suffer decreased quality of life and productivity. The mainstay of pharmacological treatment of OAB is antimuscarinic agents. Tolterodine was the first antimuscarinic drug designed specifically for treating OAB. Compared with the immediate-release (IR)...

journal_title：Expert opinion on pharmacotherapy

authors： Chung DE,Te AE

更新日期：2009-09-01 00:00:00

abstract：:HIV-1/highly active antiretroviral therapy-associated lipodystrophy syndrome (HALS) is presently the most common long-term adverse effect limiting the doubtless efficacy of antiretroviral therapy. It has a great impact on the quality of life of patients, it is stigmatising and its psychologically devastating consequen...

journal_title：Expert opinion on pharmacotherapy

authors： del Mar Gutierrez M,Mateo G,Domingo P

更新日期：2007-08-01 00:00:00

abstract：:Glycosuria is being increasingly recognised as not only a symptom but also as a novel therapeutic approach in the management of type 2 diabetes mellitus (T2DM). This is accomplished through sodium glucose co-transporter 2 (SGLT2) inhibitors. Consequently, the safety and efficacy of these new agents have been thoroughl...

journal_title：Expert opinion on pharmacotherapy

authors： Pafili K,Papanas N

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:During the past decade, there have been significant advances in the pharmacotherapies for the treatment of diabetic macular edema (DME). Among the presently available treatment options, anti-vascular endothelial growth factors (anti-VEGF) agents are the most favored agents due to their efficacy and safety....

journal_title：Expert opinion on pharmacotherapy

authors： Agarwal A,Parriott J,Demirel S,Argo C,Sepah YJ,Do DV,Nguyen QD

更新日期：2015-01-01 00:00:00

abstract：:Chronic kidney diseases frequently advance to end-stage renal failure, and the number of patients affected is steadily increasing worldwide. At the molecular level, progression of renal insufficiency correlates closely with ongoing pathological matrix protein expansion (i.e., renal fibrosis), in a manner independent o...

journal_title：Expert opinion on pharmacotherapy

authors： Gaedeke J,Neumayer HH,Peters H

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Flecainide is a class Ic antiarrhythmic agent available in Europe since 1982. The clinical development program of flecainide provided good data on its antiarrhythmic effect for the prevention of ventricular and supraventricular arrhythmias. The Cardiac Arrhythmia Suppression Trial (CAST), conducted to test...

journal_title：Expert opinion on pharmacotherapy

authors： Apostolakis S,Oeff M,Tebbe U,Fabritz L,Breithardt G,Kirchhof P

更新日期：2013-02-01 00:00:00

abstract：INTRODUCTION:Hepatocellular carcinoma (HCC) is a frequent and severe complication of cirrhosis. Most HCC patients initially present with or progress to advanced stage disease and require systemic treatment. As hypervascularization is a major characteristic of HCC, antiangiogenic drugs have been tested. Areas covered: I...

journal_title：Expert opinion on pharmacotherapy

authors： Raoul JL,Gilabert M,Adhoute X,Edeline J

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Chronic spontaneous urticaria (CSU) refers to urticaria (wheals) or angioedema, which occur for a period of six weeks or longer without an apparent cause. The condition may impair the patient's quality of life. AREAS COVERED:Treatment for CSU is mainly symptomatic. Both AAAAI/ACAAI practice parameters and...

journal_title：Expert opinion on pharmacotherapy

authors： Hon KL,Li JTS,Leung AKC,Lee V

更新日期：2020-09-29 00:00:00

abstract：:Diabetes mellitus is the most common cause of blindness among working-age adults, with a prevalence of 7 - 8% of adults in the USA, and is one of the most common causes of renal failure requiring kidney transplant and the most common cause of non-traumatic lower limb amputation in developed nations [1] . The role of t...

journal_title：Expert opinion on pharmacotherapy

authors： Danis RP,Sheetz MJ

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. AREAS COVERED:Herein, the authors address the eff...

journal_title：Expert opinion on pharmacotherapy

authors： Dempsey JL,Johns A,Rosko AE,Lazarus HM

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Neratinib is an orally available, pan-HER inhibitor with clinical activity in patients with HER2-amplified and HER2-mutated breast cancer. Areas covered: A summary of publically available and relevant clinical data on neratinib. Expert opinion: Neratinib (N) is clearly distinct from lapatinib (L), a differ...

journal_title：Expert opinion on pharmacotherapy

authors： Prové A,Dirix L

更新日期：2016-11-01 00:00:00

abstract：:Thymomas and thymic carcinoma are rare neoplasms. Surgical resection is the cornerstone of effective therapy. Stage I disease is effectively treated by complete surgical resection. The role of radiation therapy in completely resected stage II disease remains controversial. Adjuvant radiation therapy is useful for loca...

journal_title：Expert opinion on pharmacotherapy

authors： Papadopoulos KP,Thomas CR Jr

更新日期：2005-06-01 00:00:00

abstract：:At least two factors relating to pain management using oral analgesics suggest that combination strategies merit consideration: many pains arise from more than one physiological cause and current analgesics have adverse effect profiles that might be reduced by combination with another agent in smaller doses or with le...

journal_title：Expert opinion on pharmacotherapy

authors： Raffa RB,Clark-Vetri R,Tallarida RJ,Wertheimer AI

更新日期：2003-10-01 00:00:00

abstract：:Phosphorus binders are used in patients with kidney failure because of the incomplete removal of phosphorus with dialysis and the inability to exclude phosphorus from the diet. Aluminium was the initial phosphorus binder used, but was replaced by calcium-containing binders because of the development of aluminium toxic...

journal_title：Expert opinion on pharmacotherapy

authors： Bleyer AJ

更新日期：2003-06-01 00:00:00

abstract：INTRODUCTION:Treatment of unresectable or metastatic urothelial carcinoma (UC) has historically relied upon platinum-based chemotherapy and, more recently, immune checkpoint inhibitors. When tumors progress despite those therapies, remaining effective options are limited. AREAS COVERED:In this review, the authors revi...

journal_title：Expert opinion on pharmacotherapy

authors： Nauseef JT,Villamar DM,Lebenthal J,Vlachostergios PJ,Tagawa ST

更新日期：2020-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Prostate cancer is a common cancer and the role of adjuvant medical therapy continues to be investigated. An understanding of the use of adjuvant medical therapy is essential for the appropriate care of prostate cancer patients, especially for those with locally advanced or high-risk disease. A...

journal_title：Expert opinion on pharmacotherapy

authors： Sumey C,Flaig TW

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Historically, there were few effective and durable treatments for metastatic melanoma. Recently, mutation based targeted therapies have revolutionized treatment and outcomes for patients with metastatic melanoma. Specifically, inhibitors aimed at BRAF, NRAS, and C-KIT mutations are now commonly used in tre...

journal_title：Expert opinion on pharmacotherapy

authors： Turner MC,Rossfeld K,Salama AK,Tyler D,Beasley G

更新日期：2017-04-01 00:00:00

abstract：INTRODUCTION:Bipolar disorder is characterized by mood instability, which can be challenging to manage. First-line pharmacological approaches usually involve lithium, anticonvulsants and antipsychotics. Over the past fifteen years, several second-generation antipsychotics have demonstrated benefits for various phases o...

journal_title：Expert opinion on pharmacotherapy

authors： Janicak PG,Rado JT

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Dexmethylphenidate is a single-isomer stimulant medication approved for the treatment of attention deficit hyperactivity disorder (ADHD). Single-isomer drugs have the potential for decreased undesired effects and improved therapeutic efficacy. Stimulant medications have been the mainstay treatments for ADHD ...

journal_title：Expert opinion on pharmacotherapy

authors： Coury D

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of sodium glucose co-transporter 2 inhibitors in non-obese compared with obese patients with type 2 diabetes mellitus is unknown. METHODS:We conducted post hoc analyses of the results of a 52-week open-label study of Japanese type 2 diabetes mellitus patients treated with 100 or 200 ...

journal_title：Expert opinion on pharmacotherapy

authors： Inagaki N,Goda M,Yokota S,Maruyama N,Iijima H

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Tamoxifen is the established adjuvant treatment for postmenopausal women with hormone-sensitive breast cancer. OBJECTIVE:To determine whether the aromatase inhibitor anastrozole should replace tamoxifen as the adjuvant treatment in this cancer. METHODS:Two recent trials of anastrozole and tamoxifen as adju...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:In 1991, small cell lung cancer (SCLC) was reported as the first tumour type where colony stimulating factor (CSF) support was clinically effective. We reviewed 13 health services research studies that addressed CSF use as supportive care for SCLC. METHODS:Findings from American Society of Clinical Oncology...

journal_title：Expert opinion on pharmacotherapy

authors： Adams JR,Lyman GH,Djubegovic B,Feinglass J,Bennett CL

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:The management of thyroid cancer is difficult because the tumors comprise a wide range of biologic behaviors, from small papillary thyroid microcarcinomas that pose little or no threat to survival for the patient, to anaplastic thyroid cancers that are arguably the most lethal tumor. Although it may be diffi...

journal_title：Expert opinion on pharmacotherapy

authors： Sipos JA,Mazzaferri EL

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:There is at present no cure for multiple sclerosis (MS), and existing therapies are designed primarily to prevent lesion formation, decrease the rate and severity of relapses and delay the resulting disability by reducing levels of inflammation. OBJECTIVE:The aim of this review was to assess the treatment o...

journal_title：Expert opinion on pharmacotherapy

authors： Hartung HP

更新日期：2009-02-01 00:00:00