Comparative efficacy of vitamin supplements on prevention of major cardiovascular disease: Systematic review with network meta-analysis.

Abstract:

BACKGROUND:Vitamins are commonly used in the prevention of major cardiovascular disease. However, the efficacy and optimum choice remain controversial. OBJECTIVE:To compare and rank the relative efficacy among all available vitamin preparations for cardiovascular disease through a network meta-analysis. METHODS:Eligible studies were identified by searching PubMed, Embase, Medline, Cochrane library and Web of Science for randomized controlled trials. A random effects model was applied within a frequentist framework. RESULTS:Forty-two articles (45 comparisons, 384,248 participants), including nine vitamin interventions, were identified. Vitamin D had the highest probability of being ranked best in effectiveness (0.84 [0.72, 0.98]) on prevention of cardiovascular events. With regard to reducing death of cardiovascular disease rate, vitamin E was considered better efficacy. CONCLUSIONS:Vitamin B, D and E could reduce the incidence of cardiovascular events to varying degrees. At the same time, the combination of vitamins can not show improvement on the efficacy.

authors

Han J,Zhao C,Cai J,Liang Y

doi

10.1016/j.ctcp.2020.101142

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

101142

eissn

1744-3881

issn

1873-6947

pii

S1744-3881(19)30988-0

journal_volume

39

pub_type

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