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A Theoretical Framework for Evolutionary Cell Biology.

Abstract：

:One of the last uncharted territories in evolutionary biology concerns the link with cell biology. Because all phenotypes ultimately derive from events at the cellular level, this connection is essential to building a mechanism-based theory of evolution. Given the impressive developments in cell biological methodologies at the structural and functional levels, the potential for rapid progress is great. The primary challenge for theory development is the establishment of a quantitative framework that transcends species boundaries. Two approaches to the problem are presented here: establishing the long-term steady-state distribution of mean phenotypes under specific regimes of mutation, selection, and drift and evaluating the energetic costs of cellular structures and functions. Although not meant to be the final word, these theoretical platforms harbor potential for generating insight into a diversity of unsolved problems, ranging from genome structure to cellular architecture to aspects of motility in organisms across the Tree of Life.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Lynch M,Trickovic B

doi

10.1016/j.jmb.2020.02.006

subject

Has Abstract

pub_date

2020-03-27 00:00:00

pages

1861-1879

issue

7

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(20)30156-X

journal_volume

432

pub_type

杂志文章,评审

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