N-Acetyl-L-Cysteine Reduces Fibrosis and Improves Muscle Function After Acute Compartment Syndrome Injury.


INTRODUCTION:Upon injury, skeletal muscle undergoes a multiphase process beginning with degeneration of the damaged tissue, which is accompanied by inflammation and finally regeneration. One consequence of an injured microenvironment is excessive production of reactive oxygen species, which results in attenuated regeneration and recovery of function ultimately leading to fibrosis and disability. The objective of this research was to test the potential of the antioxidant, N-Acetyl-L-Cysteine (NAC), as a mediator of reactive oxygen species damage that results from traumatic muscle injury in order to support repair and regeneration of wounded muscle tissue and improve function recovery. MATERIALS AND METHODS:Adult female Lewis rats were subjected to compartment syndrome injury as previously published by our group. Rats received intramuscular injections of NAC or vehicle at 24, 48, and 72 hours postinjury. Muscle function, tissue fibrosis, and the expression of myogenic and angiogenic markers were measured. RESULTS:Muscle function was significantly improved, and tissue fibrosis was significantly decreased in NAC-treated muscles. CONCLUSIONS:These results suggest that NAC treatment of skeletal muscle after injury may be a viable option for the prevention of long-term fibrosis and scar formation, facilitating recovery of muscle function.


Mil Med


Military medicine


Yosef B,Zhou Y,Mouschouris K,Poteracki J,Soker S,Criswell T




Has Abstract


2020-01-07 00:00:00




Suppl 1










  • Maintenance of water and food quality in the stabilization forces area of operations: German surveillance laboratories and the problem of expired field rations.

    abstract::The medical services of the German contingent of the Stabilization Forces in Bosnia maintain a high-standard-preventive health care system. Because knowledge about German food and water surveillance laboratories is not widespread, these and the methods used for sample examinations as well as their analytical capacitie...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Spieler P,Petersen H

    更新日期:2000-05-01 00:00:00

  • Receipt of disability through an outreach program for homeless veterans.

    abstract::Receipt of public support payments is associated with beneficial outcomes for homeless people with mental illness. The purpose of this study was to identify factors associated with receipt of Department of Veterans Affairs (VA) pension and compensation benefits among homeless veterans after their initial contact with ...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Chen JH,Rosenheck RA,Kasprow WJ,Greenberg G

    更新日期:2007-05-01 00:00:00

  • Conversion disorder presenting as multiple sclerosis.

    abstract::We describe a patient originally diagnosed with clinically definite multiple sclerosis whose actual diagnosis of conversion disorder was revealed when his examination was found to be fictitious, his radiological, electrophysiological, and biochemical tests were determined to be normal, and his symptoms were reversed t...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Russo MB,Brooks FR,Fontenot J,Dopler BM,Neely ET,Halliday AW

    更新日期:1998-10-01 00:00:00

  • Atrial fibrillation and electrical appliance injury.

    abstract::Electrocardiographic changes and cardiac arrhythmias have been reported frequently in patients suffering high tension (greater than 1,000 V) electrical injuries as well as low tension (less than 350 V) electrical injuries. An association of atrial fibrillation with low tension electrical injury from a household applia...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Shoenfeld P,Rupp J,Savage RW

    更新日期:1991-05-01 00:00:00

  • A Tale of Two Compulsions - Two Case Studies Using Accelerated Resolution Therapy (ART) for Obsessive Compulsive Disorder (OCD).

    abstract::Although research for accelerated resolution therapy (ART) has been predominately for post-traumatic stress disorder, ART has shown promise as a treatment for other behavioral health conditions as well. ART is a brief, trauma-focused, eye movement-based therapy that has been successfully utilized to treat a wide array...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Schimmels J,Waits W

    更新日期:2019-05-01 00:00:00

  • Hypnosis using a communication device to increase magnetic resonance imaging tolerance with a claustrophobic patient.

    abstract::This is a case report of a patient who prematurely terminated two previous magnetic resonance imaging procedures because of his highly claustrophobic condition. The patient was induced into a hypnotic trance twice before his third magnetic resonance imaging examination and he was given posthypnotic suggestions for dec...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Simon EP

    更新日期:1999-01-01 00:00:00

  • An Examination of Chronic Pain Indices and the Updated Posttraumatic Stress Disorder Checklist for Diagnostic and Statistical Manual of Mental-Disorders-Fifth Edition.

    abstract:INTRODUCTION:Chronic pain and post-traumatic stress disorder (PTSD) comorbidity is prevalent among veterans and is associated with increased levels of pain severity and pain-related disability. An improved understanding of the relationship between these co-occurring disorders, in addition to effective integrated treatm...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Lehinger E,Reed DE,Nabity P,Brackins N,Villarreal R,McGeary C,Blount T,Cobos B,Jaramillo C,Eapen BC,Pugh MJ,Potter J,Peterson A,Young-McCaughan S,Houle T,McGeary DD

    更新日期:2020-12-10 00:00:00

  • Is a Dental Health Risk Assessment predictive of dental health?

    abstract::A complete dental examination is the basis for identifying the dental readiness of Air Force Reserve Command members. Historically, these were done on an infrequent basis. Recently, an annual dental examination has been mandated for all military members. Current dental personnel manning and resources are not sufficien...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Callison GM

    更新日期:2005-01-01 00:00:00

  • Expanding the role of the nurse practitioner in the deployed setting.

    abstract::Today's military is experiencing rapid advances in technology and in manpower utilization. The Army Medical Department is redesigning the structure and function of deployable hospital systems as part of this effort. The transformation of deployable hospital systems requires that a critical analysis of manpower utiliza...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Dargis J,Horne T,Tillman-Ortiz S,Scherr D,Yackel EE

    更新日期:2006-08-01 00:00:00

  • The Israeli Defense Force experience with intraosseous access.

    abstract:INTRODUCTION:Obtaining vascular access is of paramount importance in trauma care. When peripheral venous access is indicated but cannot be obtained, the intraosseous route represents an alternative. The Bone Injection Gun (BIG) is the device used for intraosseous access by the Israeli Defense Force (IDF). The purpose o...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Nadler R,Gendler S,Chen J,Lending G,Abramovitch A,Glassberg E

    更新日期:2014-11-01 00:00:00

  • Caffeine Toxicity Due to Supplement Use in Caffeine--Naïve Individual: A Cautionary Tale.

    abstract::Thousands of military members self-medicate with dietary supplements containing unknown quantities of pharmacologically active compounds. These poorly regulated substances can cause real harm to the military population, especially when they contain stimulants such as caffeine. When taken regularly, caffeine has severa...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Lystrup RM,Leggit JC

    更新日期:2015-08-01 00:00:00

  • Longitudinal Relationship of Combat Exposure With Mental Health Diagnoses in the Military Health System.

    abstract:INTRODUCTION:Combat deployment is associated with mental and physical health disorders and functional impairment. Mental health (MH) diagnoses such as adjustment and anxiety disorders have received little research attention but may reflect important postdeployment sequelae. The purpose of this study was to investigate ...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Campbell MS,O'Gallagher K,Smolenski DJ,Stewart L,Otto J,Belsher BE,Evatt DP

    更新日期:2021-01-25 00:00:00

  • Exertional heatstroke: early recognition and outcome with aggressive combined cooling--a 12-year experience.

    abstract:OBJECTIVE:To determine the clinical outcomes of an aggressive combined cooling technique for exertional heatstroke in Thailand. METHODS:We analyzed patients who were diagnosed with exertional heatstroke between 1995 and 2007. Outcomes were assessed both in hospital and at 3 months follow-up. RESULTS:Twenty-eight case...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Sithinamsuwan P,Piyavechviratana K,Kitthaweesin T,Chusri W,Orrawanhanothai P,Wongsa A,Wattanathum A,Chinvarun Y,Nidhinandana S,Satirapoj B,Supasyndh O,Sriswasdi C,Prayoonwiwat W,Phramongkutklao Army Hospital Exertional Heatstro

    更新日期:2009-05-01 00:00:00

  • Variation in Bariatric Surgery Costs and Complication Rates in the Military Health System.

    abstract:INTRODUCTION:Within the Military Health System (MHS), facilities have struggled to meet minimum recommended volume thresholds for certain procedures. Understanding variations in complication rates and cost can help policymakers tailor policy to target improvement. Our objective was to quantify the variation in bariatri...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Luan WP,Leroux TC,Olsen C,Robb D,Skinner JS,Richard P

    更新日期:2020-08-14 00:00:00

  • A comparison of the effects of a high carbohydrate vs. a higher protein milk supplement following simulated mountain skirmishes.

    abstract::This study compared the effects of a higher protein supplement manufactured from milk vs. a commercially available higher carbohydrate supplement on serum markers of muscle damage, anaerobic exercise, choice reaction time, and body composition during 2 weekends of vigorous hikes with simulated mountain skirmishes. Thi...

    journal_title:Military medicine

    pub_type: 杂志文章,随机对照试验


    authors: Jimenez-Flores R,Heick J,Davis SC,Hall KG,Schaffner A

    更新日期:2012-06-01 00:00:00

  • Effectiveness of Eye Movement Desensitization and Reprocessing in German Armed Forces Soldiers With Post-Traumatic Stress Disorder Under Routine Inpatient Care Conditions.

    abstract:BACKGROUND:Post-traumatic stress disorder (PTSD) is one of the more commonly occurring mental disorders following potentially traumatizing events soldiers may encounter when deployed abroad. One of the first-line recommended treatment options is eye movement desensitization and reprocessing (EMDR). The number of studie...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Köhler K,Eggert P,Lorenz S,Herr K,Willmund G,Zimmermann P,Alliger-Horn C

    更新日期:2017-05-01 00:00:00

  • Effectiveness of Acceptance and Commitment Therapy in Increasing Resilience and Reducing Attrition of Injured US Navy Recruits.

    abstract:INTRODUCTION:US Navy recruits who have injuries preventing them from participating in intense physical conditioning are pulled out of boot camp training and receive treatment that includes daily physical therapy, pain medications, and psychoeducational groups. Graduation from boot camp for these recruits requires not o...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Udell CJ,Ruddy JL,Procento PM

    更新日期:2018-09-01 00:00:00

  • A comparison of postdeployment hospitalization incidence between active duty Vietnam and Persian Gulf War Veterans.

    abstract::Post-conflict hospitalization rates of active duty Marines deployed to the Persian Gulf War were compared with hospitalization rates of similar Marine Corps units returning from the Vietnam conflict. The aggregated Gulf War units exhibited lower hospitalization rates than their Vietnam counterparts. Examined separatel...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Blood CG,Aboumrad TL

    更新日期:2001-07-01 00:00:00

  • Determinants of dental insurance status for U.S. military families.

    abstract::This study explores what factors influence whether active duty U.S. military personnel enroll their families in Department of Defense (DoD) or non-DoD dental insurance plans. The data come from a 26-site, cross-sectional survey of U.S. service members conducted from April 1994 to January 1995. A prestratified, randoml...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Chisick MC,Poindexter FR

    更新日期:1998-12-01 00:00:00

  • NATO survey of mental health training in army recruits.

    abstract::To-date, there has been no international review of mental health resilience training during Basic Training nor an assessment of what service members perceive as useful from their perspective. In response to this knowledge gap, the North Atlantic Treaty Organization (NATO) Human Factors & Medicine Research & Technology...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Adler AB,Delahaij R,Bailey SM,Van den Berge C,Parmak M,van Tussenbroek B,Puente JM,Landratova S,Kral P,Kreim G,Rietdijk D,McGurk D,Castro CA

    更新日期:2013-07-01 00:00:00

  • Building strong and ready Army families: a multirisk reduction health promotion pilot study.

    abstract::A quasi-experimental prospective study was conducted to assess the stage of change progression and elimination of unhealthy behaviors among active duty Army soldiers and their spouses (N = 245) before and after attending a community-based wellness program. Significant differences in stage progression between the inter...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Niederhauser VP,Maddock J,LeDoux F,Arnold M

    更新日期:2005-03-01 00:00:00

  • Identifying classes of veterans with multiple risk factors.

    abstract::As researchers examine the efficacy of interventions that simultaneously target more than 1 symptom, it is important to identify ways to help guide research and program development. This study used electronic medical record data to examine the covariation of multiple risk factors regularly assessed among primary care ...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Funderburk JS,Kenneson A,Maisto SA

    更新日期:2014-10-01 00:00:00

  • Adrenocortical neoplasm disguised as a post-traumatic perinephric hematoma.

    abstract::Trauma and cancer are entities that are encountered frequently by surgeons and occasionally may exist simultaneously in certain patients. Illustrated here is the case of a man with a perinephric mass, discovered during evaluation for blunt abdominal trauma, which was originally thought to be a perinephric hematoma and...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Blake DP,Bessey PQ

    更新日期:1996-03-01 00:00:00

  • Traits associated with personality disorders and adjustment to military life: predictive validity of self and peer reports.

    abstract::This study demonstrated that traits and features associated with several types of personality disorders are related to work performance and the ability to conform to requirements of military life. The Schedule for Nonadaptive and Adaptive Personality and a peer nomination procedure were used to assess traits associate...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Fiedler ER,Oltmanns TF,Turkheimer E

    更新日期:2004-03-01 00:00:00

  • Joint Task Force Andrew: the 44th Medical Brigade mental health staff officer's after action review.

    abstract::The massive Department of Defense deployment in support of Hurricane Andrew relief cast the military medical departments in a new role. Military medical personnel were challenged to apply the traditional principles of combat medicine to a noncombat environment, within the continental United States, within an existing ...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Holsenbeck LS

    更新日期:1994-03-01 00:00:00

  • Are effort measures sensitive to cognitive impairment?

    abstract::The basic premise of symptom validity tests (SVTs) is that appropriate effort can be assessed because the designs of SVT measures are thought to be insensitive to all but the most extreme forms of impairment of memory. In patients with mild traumatic brain injury in particular, it is thought that failure on effort mea...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Willis PF,Farrer TJ,Bigler ED

    更新日期:2011-12-01 00:00:00

  • Fluticasone as Treatment for Cluster Headaches in a Navy Aircrew Member.

    abstract::Cluster headaches (CHs) are one of the most debilitating of all the identified headache syndromes. Their pathogenesis is poorly understood, which has made their treatment challenging. Various medicines and modalities have been put forth in an effort to minimize the symptoms, but none have proven to be consistently rel...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Andicochea CT,Blalack PM,Fulkerson JA,Kidd GA,Taylor BM

    更新日期:2015-10-01 00:00:00

  • A prospective study of the application of transfusions in a field hospital during the war in Croatia.

    abstract::Use of blood products are recommended worldwide as a substitution for whole blood. In the case of war wounds, because of their specificity, this is not possible. We studied prospectively the use of blood and blood products during management of the wounded in a field hospital during the war in Croatia. During a 6-month...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Horzic M,Bunoza D,Maric K,Poje A

    更新日期:1996-02-01 00:00:00

  • National electronic health record interoperability chronology.

    abstract::The federal initiative for electronic health record (EHR) interoperability began in 2000 and set the stage for the establishment of the 2004 Executive Order for EHR interoperability by 2014. This article discusses the chronology from the 2001 e-Government Consolidated Health Informatics (CHI) initiative through the cu...

    journal_title:Military medicine

    pub_type: 杂志文章


    authors: Hufnagel SP

    更新日期:2009-05-01 00:00:00

  • Derivation of candidates for the combat casualty critical care (C4) database.

    abstract:OBJECTIVE:To describe the development of the Combat Casualty Critical Care Database, a comprehensive database of critically injured combat casualties to identify potentially modifiable risk factors for morbidity and mortality in this population. METHODS:The Department of Defense's Joint Theater Trauma Registry was que...

    journal_title:Military medicine

    pub_type: 杂志文章,评审


    authors: Stewart IJ,Fang R,Cannon JW,Zonies DH,Morrow BD,Orman JA,Oliver JD,Abbott KC,Jones JA,Chung KK

    更新日期:2014-04-01 00:00:00