An assessment of health status among medical research volunteers who served in the Project Whitecoat program at Fort Detrick, Maryland.

Abstract:

:Between 1954 and 1973, more than 2000 men entering military service as conscientious objectors participated in Project Whitecoat as medical research volunteers for the Army's biological warfare defense program. An assessment of self-reported, current health status among 358 "exposed" individuals and 164 unexposed control subjects found no conclusive evidence that receipt of investigational agents was related to adverse health outcomes. No differences in current overall health, current exercise levels, self-reported symptoms, and self-reported medical conditions were seen between the study groups. Possible associations were seen between exposure to antibiotics or other biological agents and self-reported asthma (13.0% vs. 2.4%, relative risk [RR] = 6.00, 95% confidence interval [CI] = 1.03-34.90, p = 0.050), as well as between receipt of tularemia vaccine(s) and self-reported asthma (13.3% vs. 2.4%, RR = 6.15, 95% CI = 1.03-36.70, p = 0.049) and increased frequency/severity of headaches (35.6% vs. 18.3%, RR = 2.46, 95% CI = 0.99-6.15, p = 0.074). However, the size of the population under study was insufficient to assert with confidence that these statistical associations are real.

journal_name

Mil Med

journal_title

Military medicine

authors

Pittman PR,Norris SL,Coonan KM,McKee KT Jr

doi

10.7205/milmed.170.3.183

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

183-7

issue

3

eissn

0026-4075

issn

1930-613X

journal_volume

170

pub_type

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