Abstract:
:Waldenstrom macroglobulinemia (WM) is a lymphoplasmacytic lymphoma that presents with symptomatic anemia, thrombocytopenia, constitutional symptoms, extramedullary disease and rarely hyperviscosity syndrome. The presence of both IgM monoclonal protein and ≥10% monoclonal lymphoplasmacytic cells is required for the diagnosis. MyD88 is present in 67-90% of patients but is not pathognomonic for WM. Many patients who fulfill the criteria of WM are asymptomatic and do not require treatment. Recent advances in the understanding of the biology of WM have paved the way for new treatment options. The use of novel agents with or without rituximab enables the use of effective chemotherapy-free regiments upfront and in the relapsed setting. New targeted treatments such as venetoclax and CXCR4 antagonists are being investigated.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Vaxman I,Gertz Mdoi
10.1080/10428194.2020.1711901subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1292-1304issue
6eissn
1042-8194issn
1029-2403journal_volume
61pub_type
杂志文章abstract::Nine patients with prolonged (> 2 years) chronic phase chronic myeloid leukaemia (CML) were investigated for the presence of T-cell involvement in the leukemic clone. Pure populations of peripheral blood T-cell populations were obtained by culturing separated mononuclear cells in the presence of pokeweed mitogen and I...
journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.3109/10428199309145886
更新日期:1993-06-01 00:00:00
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journal_title:Leukemia & lymphoma
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doi:10.1080/10428194.2017.1352089
更新日期:2018-04-01 00:00:00
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journal_title:Leukemia & lymphoma
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doi:10.1080/10428190500353877
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journal_title:Leukemia & lymphoma
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doi:10.3109/10428199809092694
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journal_title:Leukemia & lymphoma
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doi:10.1080/10428194.2020.1775210
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,评审
doi:10.3109/10428194.2010.487622
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abstract::Considering conflicting data on CDKN2A/B deletion in ALL, this study to assess its prognostic significance as an independent marker in a total of 96 pediatric B and T-ALL cases was planned. The overall frequency of CDKN2A/B deletion was 44% (n = 43) with 36% (30/83) in B-ALL and 100% (13/13) in T-ALL. CDKN2A/B deletio...
journal_title:Leukemia & lymphoma
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doi:10.1080/10428194.2018.1482542
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,评审
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更新日期:2006-07-01 00:00:00
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journal_title:Leukemia & lymphoma
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doi:10.3109/10428194.2013.784969
更新日期:2013-12-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,评审
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更新日期:2005-02-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.3109/10428194.2015.1023799
更新日期:2015-01-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.1080/10428194.2020.1832667
更新日期:2020-10-15 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2014-12-01 00:00:00
abstract::The combination of mitoxantrone (MIT), etoposide (ETP), and cytarabine (Ara-C) (MEC) is a frequently used salvage therapy for acute leukemia, but has been associated with severe myelosuppression. Therefore, we investigated the miniMEC regimen with reduced doses of AraC and MIT. Thirteen ALL and 44 AML patients, all re...
journal_title:Leukemia & lymphoma
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doi:10.3109/10428194.2016.1153087
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journal_title:Leukemia & lymphoma
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doi:10.3109/10428199109067623
更新日期:1991-01-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.3109/10428190009065839
更新日期:2000-10-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
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journal_title:Leukemia & lymphoma
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doi:10.3109/10428199309148519
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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