Abstract:
:This case is of an unusual florid reactive CD4+ T Cell lymphocytosis involving lymph node (LN) and overshadowing residual B chronic lymphocytic leukemia (CLL). A 65 year old female with a 9 year history of untreated B-CLL presented with weight loss, splenomegaly and lymphadenopathy. B-CLL was confirmed on the basis of peripheral blood lymphocytosis, bone marrow trephine findings and flow cytometry analysis. However, the LN biopsy showed appearances of a diffuse small lymphocytic population mimicking a leukemic T-cell infiltrate. Immunophenotyping and molecular analysis demonstrated the major cell population to be reactive CD4 positive T lymphocytes.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Busmanis I,Hussein S,Feleppa F,Rockman S,Begley CGdoi
10.3109/10428199309148519subject
Has Abstractpub_date
1993-01-01 00:00:00pages
153-6issue
1-2eissn
1042-8194issn
1029-2403journal_volume
9pub_type
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journal_title:Leukemia & lymphoma
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