Abstract:
:The standard CHOP regimen may cure 30-40% of patients with advanced aggressive non-Hodgkin's lymphoma (ANHL). Mitoxantrone is an anthracenedione, which is active in NHL and its toxicity profile may be more favorable than doxorubicin with respect to alopecia, mucositis and cardiotoxicity. This study was designed to compare the effectiveness of an escalated dose of mitoxantrone with that of standard doxorubicin, used in the CHOP regimen in patients with ANHL. One hundred and forty three eligible patients with ANHL were randomized to receive 6 cycles of either CHOP (n = 71) or intensified CNOP (iCNOP) (n = 72), with mitoxantrone 20 mg/m2, i.v., d.1 instead of doxorubicin. Complete responders (CR) were again randomized either to receive interferon-alpha (IFN-alpha) maintenance (3 MU t.i.w., s.c.) or not. The CR rate was 70 vs. 76% for iCNOP and CHOP (p = 0.45), and the overall response rate was 81 vs. 83%, respectively (p = 0.71). The 5-year failure free survival (FFS) was 48 and 50% in the iCNOP and CHOP arm, respectively (p = 0.45), and the 5-year overall survival (OS) was 61 vs. 64% (p = 0.56). IFN-alpha did not prolong relapse free survival (p = 0.91). iCNOP produced less alopecia (p = 0.001) but more febrile episodes (p = 0.04) than CHOP, while requiring more frequent G-CSF support (p = 0.01). Two cases of acute myelogenous leukemia (AML) were recorded, both in the iCNOP arm (p = 0.14). In conclusion, iCNOP was equally effective to CHOP in patients with ANHL, producing more leukopenia and febrile episodes, but less alopecia. The development of two cases of secondary AML in th e iCNOP arm is of concern.
journal_name
Leuk Lymphomajournal_title
Leukemia & lymphomaauthors
Pangalis GA,Vassilakopoulos TP,Michalis E,Roussou P,Vrakidou E,Repousis P,Angelopoulou MK,Siakantaris MP,Korantzis J,Symeonidis A,Grigorakis V,Stefanoudakis E,Stamatellou M,Bourantas KL,Kalmantis T,Christopoulos G,Kokkinidoi
10.1080/1042819031000063471keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
635-44issue
4eissn
1042-8194issn
1029-2403journal_volume
44pub_type
临床试验,杂志文章,随机对照试验abstract::Two important syndromes of hemophagocytic lymphohistiocytosis (HLH) have to be considered in infants and young children with recurrent fever, organomegaly and cytopenias. Familial hemophagocytic lymphohistiocytosis (FHLH) is a genetically heterogeneous autosomal recessive disease with histiocytic and lymphocytic infil...
journal_title:Leukemia & lymphoma
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abstract::Even though HIV is associated with worse prognosis in many malignancies, the clinical course of myelodysplastic syndrome (MDS) in HIV + patients has not been well studied. Determining the clinical presentation and outcomes of MDS in these patients would be important for future diagnostic strategies, as anemia and othe...
journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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doi:10.3109/10428199309147373
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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doi:10.1080/1042819022386716
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journal_title:Leukemia & lymphoma
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abstract::The recurring translocation t(1;19) (q23;p13) with TCF3-PBX1 rearrangements are uncommon in adult acute lymphoblastic leukemia (ALL), and their prognostic impact remains to be described in the era of modern chemotherapies. We investigated 427 adult patients with newly diagnosed pre-B ALL, 16 (4%) had t(1;19)(q23;p13) ...
journal_title:Leukemia & lymphoma
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doi:10.1080/10428194.2020.1824071
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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更新日期:2010-09-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,多中心研究
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abstract::The cytomorphology and immunologic characteristics of cells obtained by fine-needle aspiration biopsy of 34 consecutive patients with abdominal lymphomas were analyzed. Nineteen patients had no previous diagnosis, while 15 had previously known or suspected lymphomas. On cytology 21 high-grade and 13 low-intermediate-g...
journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.3109/10428198909042461
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.1080/10428190802709438
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journal_title:Leukemia & lymphoma
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/10428199409049634
更新日期:1994-05-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.1080/1042819021000016096
更新日期:2002-11-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.3109/10428194.2011.574759
更新日期:2011-08-01 00:00:00
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journal_title:Leukemia & lymphoma
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doi:10.3109/10428194.2011.580475
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,评审
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,评审
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章
doi:10.3109/10428199709058337
更新日期:1997-12-01 00:00:00
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journal_title:Leukemia & lymphoma
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更新日期:1998-11-01 00:00:00
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journal_title:Leukemia & lymphoma
pub_type: 杂志文章,多中心研究
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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journal_title:Leukemia & lymphoma
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