Association of familial leukemia with HLA Cw3: is it real?

Abstract:

:A kindred with familial leukemia is described in which three members are affected by leukemia in three consecutive generations. One of these members had Philadelphia positive chronic myeloid leukemia (CML) and other two had precursor B acute lymphoblasticleukemia (ALL)--Philadelphia negative. All three of them shared a common haplotype A2, B55, Cw3. In addition, another member sharing same haplotype developed metastatic breast cancer. Phenomenon of anticipation is demonstrated in the affected family members. Possible causes of genetic susceptibility to leukemia especially the association of Cw3 with familial leukemia are discussed.

journal_name

Leuk Lymphoma

journal_title

Leukemia & lymphoma

authors

Kuruvilla J,Gupta V,Gill KS,Lipton JH

doi

10.1080/1042819021000035707

keywords:

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

309-11

issue

2

eissn

1042-8194

issn

1029-2403

journal_volume

44

pub_type

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