Prognostic value of neutrophil-to-lymphocyte ratio and its correlation with fluorine-18-fluorodeoxyglucose metabolic parameters in intrahepatic cholangiocarcinoma submitted to 90Y-radioembolization.

Abstract:

OBJECTIVE:The aim of this study was to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and its relationship with several metabolic parameters obtained through PET in intrahepatic cholangiocarcinoma (ICC) submitted to radioembolization with Y-microspheres (Y-radioembolization). METHODS:Records of 20 subjects affected by ICC and submitted to Y-radioembolization were retrospectively evaluated. In all cases, pretreatment NLR was carried out and fluorine-18-fluorodeoxyglucose (F-FDG) PET/CT was acquired with the calculation of the following metabolic parameters: maximum and mean standardized uptake value (SUVmax and SUVmean), metabolic total volume and total lesion glycolysis. After Y-radioembolization, all patients underwent regular imaging and laboratory follow-up. RESULTS:All patients presented F-FDG-avid hepatic tumors at pretreatment PET/CT examination. NLR significantly correlated with SUVmax (r = 0.64; P = 0.002) and SUVmean (r = 0.67; P = 0.001). After treatment with Y-microspheres, the mean OS resulted 12.5 ± 1.5 months. When the average pretreatment NLR value (i.e. 2.7) was used as a cutoff for patients' stratification, subjects with low NLR (<2.7) had a significantly longer OS than those with high NLR (>2.7). At Cox regression analysis including bilirubin, age, the presence of extrahepatic disease, hepatitis C virus/hepatitis B virus status and PET-derived parameters, only NLR resulted to be a significant predictor of OS (P = 0.01; hazard ratio = 13.1, 95% confidence interval = 1.6-102.7). CONCLUSION:NLR is correlated with SUVmax-mean values in ICC and resulted to be an easy available predictor of survival in patients submitted to treatment with Y-microspheres.

journal_name

Nucl Med Commun

authors

Filippi L,Di Costanzo GG,Tortora R,Pelle G,Saltarelli A,Marino Marsilia G,Cianni R,Schillaci O,Bagni O

doi

10.1097/MNM.0000000000001123

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

78-86

issue

1

eissn

0143-3636

issn

1473-5628

pii

00006231-202001000-00012

journal_volume

41

pub_type

杂志文章
  • Recovery of renal retention function by differentiating the Patlak-Rutland plot.

    abstract:INTRODUCTION:It has been suggested that renal retention function can be estimated by differentiation of the Patlak-Rutland plot. AIM:To evaluate the error resulting from this method. METHODS:A total of 5800 renograms were generated by convolving real input functions with artificial retention functions. Ten bi-exponen...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200405000-00012

    authors: Kuyvenhoven JD,Ham HR,Piepsz A

    更新日期:2004-05-01 00:00:00

  • Clinical implications of the differences between diagnostic 123I and post-therapy 131I scans.

    abstract:BACKGROUND:123I has been promoted for diagnostic imaging as a means of avoiding 'stunning'. It has also been suggested that the more favourable physical characteristics and consequent enhanced imaging resolution provided by 123I offers a more accurate diagnostic assessment of the extent of disease prior to therapy. Thi...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200402000-00006

    authors: Cohen JB,Kalinyak JE,McDougall IR

    更新日期:2004-02-01 00:00:00

  • 99Tcm-diastereomeric dimercaptosuccinic acid complexes: comparison of their biodistribution.

    abstract::The biodistribution of two stereoisomeric 99Tcm complexes derived from diastereomeric dimercaptosuccinic acids (DMSA), 99Tcm-dl-DMSA and 99Tcm-meso-DMSA, was examined in sarcoma 180 tumour-bearing mice. The biodistribution pattern of meso-complex was not significantly different from 99Tc(V)m-DMSA, a new tumour imaging...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198906000-00011

    authors: Awh OD,Kim JR,Shim SC

    更新日期:1989-06-01 00:00:00

  • Ga-68 DOTATATE PET/CT and F-18 FDG PET/CT in the evaluation of low and intermediate versus high-grade neuroendocrine tumors.

    abstract:OBJECTIVE:We investigated the role of Ga-68 DOTATATE PET/CT in comparison to F-18 FDG PET/CT in patients with low and intermediate versus high-grade neuroendocrine tumors (NETs). METHODS:We identified 81 patients who underwent Ga-68 DOTATATE PET/CT at our institution between May 2017 and December 2018 and met inclusio...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001255

    authors: You H,Kandathil A,Beg M,De Blanche L,Kazmi S,Subramaniam RM

    更新日期:2020-10-01 00:00:00

  • Management and evaluation of sodium [131I] iodide contamination after oral administration.

    abstract::Radioiodine therapy using oral administration of Iodine-131 (I) is a widespread employed strategy for the treatment of hyperthyroidism and thyroid cancer. Such a therapy requires well-trained staff, equipment and procedures regarding radiation safety. The aims of this work are to report an incidental experience of rad...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001276

    authors: Labbe E,Peyronnet D,Desmonts C,Vigne J

    更新日期:2020-11-01 00:00:00

  • Intraperitoneal 131I- and 111In-791T/36 monoclonal antibody in recurrent ovarian cancer: imaging and biodistribution.

    abstract::An examination of the biokinetics and biodistribution of i.p. administered 131I- or 111In-labelled 791T/36 antibody (1 mg) has been carried out in five patients with stage III/IV ovarian cancer. Blood kinetics and urinary excretion of the radiolabels were assayed. Scintigraphy was performed immediately following admin...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198908010-00006

    authors: Perkins AC,Pimm MV,Gie C,Marksman RA,Symonds EM,Baldwin RW

    更新日期:1989-08-01 00:00:00

  • A review of pediatric neuroendocrine tumors, their detection, and treatment by radioisotopes.

    abstract::Neuroendocrine tumors (NETs) are rare in childhood. Neuroblastoma is the most common pediatric extracranial solid tumor, occurring >90% in children younger than 5 years of age. Pheochromocytoma and paraganglioma are rare NETs, causing hypertension in 0.5-2% of hypertensive children. Gastroenteropancreatic NETs can occ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000001305

    authors: Haddad T,Fard-Esfahani A,Vali R

    更新日期:2021-01-01 00:00:00

  • 99Tcm-MAG3: a sensitive indicator for evaluating perfusion and rejection of renal transplants.

    abstract::Radionuclide renography has a role in evaluating perfusion of transplanted kidneys. In the course of rejection, cortical perfusion decreases before urinary excretion changes. Based on the facts that 99Tcm-MAG3 has different pharmacokinetics and shows a higher kidney-to-background count ratio than 99Tcm-DTPA, we postul...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:

    authors: Oriuchi N,Miyamoto K,Hoshino K,Imai J,Takahashi Y,Sakai S,Shimada A,Endo K

    更新日期:1997-05-01 00:00:00

  • Development of a conversion program to make SIMIND-generated SPECT data interfile acceptable to Xeleris.

    abstract::The Monte Carlo code SIMIND is used in nuclear medicine for research purposes, and also for testing the validity of various applications. Conversion of a SIMIND-generated interfile (header and image data file) is required to process the simulated image data on a Xeleris workstation. Currently there is no conversion pr...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000393

    authors: Pandey AK,Kumar JP,Aheer D,Sharma A,Hasan B,Patel C,Bal CS,Kumar R

    更新日期:2015-12-01 00:00:00

  • Evaluation of relative renal function for patients who had undergone simultaneous liver-kidney transplants using Tc-99m-MAG3 scintigraphy with attenuation correction from anatomical images and SPECT/CT.

    abstract:OBJECTIVE:Assessing the relative function of each of the three kidneys using nuclear scintigraphy with standard planar imaging in patients having undergone kidney transplant is problematic because of the different photon-attenuation factors associated with native versus transplanted kidneys. To address this, we applied...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328347e958

    authors: Palmer MR,Donohoe KJ,Francis JM,A Mandelbrot D

    更新日期:2011-08-01 00:00:00

  • Large variations occur in bone density measurements of children when using different software.

    abstract:BACKGROUND:Paediatric dual X-ray absorptiometry (DXA) studies present a number of technical problems. One of these is that the edge detection algorithms designed for the adult skeleton may fail for paediatric studies. Hologic provide alternative algorithms for low bone density studies. AIM:To assess low-density softwa...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200506000-00002

    authors: Simpson DE,Dontu VS,Stephens SE,Archbold LJ,Lowe V,O'Doherty MJ,Martin N,Coakley AJ

    更新日期:2005-06-01 00:00:00

  • Dosimetric evaluation and therapeutic response to internal radiation therapy of hepatocarcinomas using iodine-131-labelled lipiodol.

    abstract:OBJECTIVE:Vectorized internal radiation therapy using lipiodol-labelled with iodine-131 (131 I-lipiodol) is an effective treatment for inoperable hepatocellular carcinomas. However, few dosimetric data are available based on this approach. We have developed a dosimetric protocol based on scintiscan imaging and that is ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e32830439c6

    authors: Becker S,Laffont S,Vitry F,Rolland Y,Lecloirec J,Boucher E,Raoul JL,Herry JY,Bourguet P,Garin E

    更新日期:2008-09-01 00:00:00

  • Contribution of 99mTc-anti-carcinoembryonic antigen antibody and 99mTc-sestamibi scintimammography in the evaluation of high risk palpable breast lesions.

    abstract::Mammography is the screening test of choice for breast cancer. Its low specificity leads to a large number of unnecessary biopsies. Scintimammography, with either Tc-sestamibi (MIBI) or Tc-anti-carcinoembryonic antigen (CEA) Fab', has been proposed as a non-invasive test to lower the high false positive rate of mammog...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-200303000-00009

    authors: Sanidas EE,Koukouraki S,Velidaki A,Manios A,Stathopoulos E,De Bree E,Kafousi M,Kodogiannis E,Karkavitsas N,Tsiftsis DD

    更新日期:2003-03-01 00:00:00

  • Low versus high radioiodine dose in postoperative ablation of residual thyroid tissue in patients with differentiated thyroid carcinoma: a large randomized clinical trial.

    abstract:OBJECTIVES:Radioiodine ablation of thyroid tissue remains the cornerstone of treatment for patients with differentiated thyroid carcinoma after thyroidectomy. Selecting an optimal dose of radioiodine for successful ablation is a continuous challenge in these patients. METHODS:We compared the treatment response of 341 ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MNM.0b013e32834e306a

    authors: Fallahi B,Beiki D,Takavar A,Fard-Esfahani A,Gilani KA,Saghari M,Eftekhari M

    更新日期:2012-03-01 00:00:00

  • Deficiencies in product labelling instructions and quality control directions for 99mTc radiopharmaceuticals.

    abstract:OBJECTIVE:The aim of the study was to identify deficiencies in product labelling instructions for reconstitution and in the quality control directions detailed in the technical leaflets (TLs) or summary product characteristic (SPC) sheets of commonly used technetium labelling cold kits. MATERIALS AND METHODS:The recon...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000030

    authors: Buroni FE,Lodola L,Persico MG,Aprile C

    更新日期:2014-02-01 00:00:00

  • Combined 67Ga citrate and 99Tcm-human immunoglobulin imaging in human immunodeficiency virus-positive patients with fever of undetermined origin.

    abstract::Patients infected with the human immunodeficiency virus (HIV) suffer from serious and life-threatening infections. These patients often present with pyrexia but without localizing signs. Despite its high sensitivity in identifying focal infection 67Ga citrate scintigraphy lacks specificity; lymphoma and solid tumours ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199107000-00003

    authors: Buscombe JR,Miller RF,Lui D,Ell PJ

    更新日期:1991-07-01 00:00:00

  • 99Tcm-MIBI single photon emission tomography (SPET) for detecting myocardial ischaemia and necrosis in patients with significant coronary artery disease.

    abstract::The ability of 99Tcm-methoxyisobutylisonitrile (MIBI) single photon emission tomography (SPET) to detect myocardial ischaemia and necrosis was assessed in 56 patients (45 male, 11 female, aged 55 +/- 5 years), with clinically recognized ischaemic heart disease (IHD). All underwent coronary angiography (CA) and left ve...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199212000-00004

    authors: Sciammarella MG,Fragasso G,Gerundini P,Maffioli L,Cappelletti A,Margonato A,Savi A,Chierchia S

    更新日期:1992-12-01 00:00:00

  • A routine method for using sodium iodide to stabilize sodium pertechnetate [99Tcm] dispensed for the preparation of 99Tcm-exametazime.

    abstract::When preparing 99Tcm-exametazime, it is important to use sodium 99Tcm-pertechnetate that is less than 2 h old. The addition of sodium iodide (NaI) to 99Tcm-pertechnetate is known to extend this time to 6 h. This paper describes a technique for implementing this in routine practice. Sterile kits consisting of 440 micro...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199205000-00003

    authors: Millar AM

    更新日期:1992-05-01 00:00:00

  • 18F-FDG PET/CT findings of radiotherapy-related myocardial changes in patients with thoracic malignancies.

    abstract:OBJECTIVE:The purpose of this study was to investigate myocardial findings of F-fluorodeoxyglucose PET/computed tomography (F-FDG PET/CT) after thoracic radiotherapy. METHODS:F-Fluorodeoxyglucose PET/CT examination was performed in 38 patients at least 4 months after radiotherapy. Patients with known cardiac diseases,...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e328362f824

    authors: Unal K,Unlu M,Akdemir O,Akmansu M

    更新日期:2013-09-01 00:00:00

  • A new non-invasive test for the detection of compartment syndromes.

    abstract::Chronic exertional compartment syndrome (CECS) is currently diagnosed using invasive pressure measurements. We report the use of 99Tcm-methoxyisobutyl isonitrile (99Tcm-MIBI) scintigraphy as a new non-invasive method of diagnosis. Forty-six patients with suspected chronic compartment syndrome underwent graded treadmil...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199903000-00003

    authors: Edwards PD,Miles KA,Owens SJ,Kemp PM,Jenner JR

    更新日期:1999-03-01 00:00:00

  • Performance of two new solid-phase ligand assays for TSH using monoclonal antibodies.

    abstract::Three ligand assays for TSH using monoclonal antibodies, an IRMA, an ELISA and a DELFIA were compared with a standard DAB RIA technique. The IRMA proved to be superior in respect to sensitivity, precision, reproducibility and practicality. The highest sensitivity yet, was achieved by DELFIA. IRMA, ELISA and DELFIA are...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198504000-00003

    authors: Böttger I,Pabst HW,Senekowitsch R,Kriegel H

    更新日期:1985-04-01 00:00:00

  • Left ventricular function and the distribution of pulmonary and total blood volume in hypertensive and normotensive man.

    abstract::Using radionuclide methods the relationship between total and central blood volume and left ventricular function was studied in 12 patients with untreated essential hypertension and contrasted with the findings in eight normotensive subjects. The principal findings were of an increased stroke volume and end-diastolic ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198410000-00002

    authors: Mackay I,Nath K,Watson ML,Hannan WJ,Muir AL

    更新日期:1984-10-01 00:00:00

  • The early plasma concentration of 51Cr-EDTA in patients with cirrhosis and ascites: a comparison of three models.

    abstract:OBJECTIVES:The aim of the study was to determine which of three two-parameter fitting functions (exponential, linear-log, and negative-power function of time) most accurately models early chromium-51-EDTA (51Cr-EDTA) plasma concentration data prior to 120 min in patients with cirrhosis and ascites and understand how th...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000255

    authors: Wanasundara SN,Wesolowski MJ,Puetter RC,Burniston MT,Xirouchakis E,Giamalis IG,Babyn PS,Wesolowski CA

    更新日期:2015-04-01 00:00:00

  • Incremental value of 99mTc-MDP hybrid SPECT/CT over planar scintigraphy and SPECT in avascular necrosis of the femoral head.

    abstract:OBJECTIVE:The aim of the study was to evaluate the incremental value of technetium-99m-methylene diphosphonate (99mTc-MDP) single-photon emission tomography/computed tomography (SPECT/CT) over planar bone scintigraphy (BS) and SPECT in the diagnosis of avascular necrosis (AVN) of the femoral head. MATERIALS AND METHOD...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0000000000000357

    authors: Agarwal KK,Mukherjee A,Sharma P,Bal C,Kumar R

    更新日期:2015-10-01 00:00:00

  • Uptake of 2-[18F]fluoro-2-deoxy-D-glucose in uterine leiomyoma: imaging of four patients by coincidence positron emission tomography.

    abstract::Uterine leiomyomas, benign tumours of the human uterus, are the most common uterine neoplasm and are composed of smooth muscle with varying amounts of fibrous connective tissue. As a functional imaging modality, 2-[F]fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography can be used to obtain information about ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-200409000-00012

    authors: Ak I,Ozalp S,Yalçin OT,Zor E,Vardareli E

    更新日期:2004-09-01 00:00:00

  • Correlation of 99Tcm-sestamibi SPECT with coronary angiography in general hospital practice.

    abstract::One hundred and twenty-eight patients had a stress test with sestamibi injection and a coronarography within 2 months of the sestamibi study. Sestamibi studies were reconstructed using Hanning 0.65 and Wiener 1.0 filters; the latter improved the results significantly (P < 0.05). Significant correlations were found bet...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199301000-00006

    authors: Solot G,Hermans J,Merlo P,Chaudron JM,Luwaert R,Cheron P,Bodart F,Beauduin M

    更新日期:1993-01-01 00:00:00

  • Should the presence of other diseases exclude subjects as controls in studies of gallbladder response to cholecystokinin octapeptide (sincalide)? Scintigraphic results in patients with malignancies but no known gallbladder disease.

    abstract::Findings of hepatobiliary scintigraphy with intravenous cholecystokinin octapeptide (sincalide) were examined in 26 asymptomatic patients with various malignancies but no known pre-existing gallbladder disease, and normal hepatobiliary and gallbladder morphology on sonography. The maximum gallbladder ejection fraction...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-199606000-00010

    authors: Jacobson AF,Teefey SA

    更新日期:1996-06-01 00:00:00

  • Accuracy of gated equilibrium radioventriculography in measuring left ventricular function in dogs.

    abstract::To assess the precision of gated equilibrium radioventriculography in measuring changes in left ventricular stroke volume (LVSV), we studied five dogs each with a chronically implanted electromagnetic flowmeter on the ascending aorta. Per cent changes in left ventricular stroke counts (LVSC) were compared to those in ...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/00006231-198812000-00009

    authors: Valette H,Bourguignon MH,Apoil E,Moyse D,Wise RA,Buchanan JW,Wagner HN Jr,Syrota A

    更新日期:1988-12-01 00:00:00

  • The role of positron emission tomography following radiosurgical treatment of malignant lung lesions.

    abstract:OBJECTIVE:To establish response patterns in PET following stereotactic body radiotherapy (SBRT) of malignant lung lesions. METHODS:Patients with malignant lung lesions treated with SBRT were retrospectively reviewed. All patients received 40-52 Gy in three to five equal fractions. An independent, blinded radiologist r...

    journal_title:Nuclear medicine communications

    pub_type: 杂志文章

    doi:10.1097/MNM.0b013e3283512b08

    authors: Gill BS,Rivandi AH,Sandhu SP,Jensen LG,Nobiensky PD,Hoh CK,Sandhu AP

    更新日期:2012-06-01 00:00:00

  • Pentavalent 99Tcm-DMSA imaging in patients with bone metastases.

    abstract::Pentavalent 99Tcm-dimercaptosuccinic acid (99Tcm-(V)DMSA) has an established role in imaging medullary thyroid carcinoma. There have been case reports of uptake in bone metastases. Our aims were to compare 99Tcm-(V)DMSA with 99Tcm-hydroxymethylene diphosphonate (99Tcm-HDP) in bone metastases, to assess its value in im...

    journal_title:Nuclear medicine communications

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006231-199710000-00003

    authors: Lam AS,Kettle AG,O'Doherty MJ,Coakley AJ,Barrington SF,Blower PJ

    更新日期:1997-10-01 00:00:00