Unique product quality considerations in vaccine development, registration and new program implementation in Malaysia.

abstract：:Changing epidemiology of Hepatitis A virus (HAV) has led to an increased susceptibility of adolescents and adults to the infection. Vaccination can remarkably reduce the incidence and associated morbidity of HAV infection. This review is focused on the safety and efficacy of H2 strain derived live attenuated Hepatitis...

journal_title：Human vaccines & immunotherapeutics

authors： Rao S,Mao JS,Motlekar S,Fangcheng Z,Kadhe G

更新日期：2016-12-01 00:00:00

abstract：:A new live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) has been developed based on innovative technology to give protection against JE with an improved immunogenicity and safety profile. In this phase 3, observer-blind study, 274 children aged 12-24 months were randomized 1:1 to receive one dose of...

journal_title：Human vaccines & immunotherapeutics

authors： Kim DS,Houillon G,Jang GC,Cha SH,Choi SH,Lee J,Kim HM,Kim JH,Kang JH,Kim JH,Kim KH,Kim HS,Bang J,Naimi Z,Bosch-Castells V,Boaz M,Bouckenooghe A

更新日期：2014-01-01 00:00:00

abstract：:Vaccination status is more often evaluated by up-to-date vaccination coverage rather than timeliness of immunization. Delaying vaccination may be dangerous during infancy. The aim of this study was to identify the importance of potentially dangerous vaccination delay (previously defined) and determinants of these dela...

journal_title：Human vaccines & immunotherapeutics

authors： Bailly AC,Gras P,Lienhardt JF,Requillart JC,Vié-le-Sage F,Martinot A,Dubos F

更新日期：2018-04-03 00:00:00

abstract：:Anti-vaccination movement has existed as long as the vaccines themselves, but its mode of action and social influences evolved over time. Such attitude with no doubt has negative impact on vaccination rates and eradication of infectious diseases. In this study, we used an online survey to examine vaccination attitudes...

journal_title：Human vaccines & immunotherapeutics

authors： Zarobkiewicz MK,Zimecka A,Zuzak T,Cieślak D,Roliński J,Grywalska E

更新日期：2017-11-02 00:00:00

abstract：:Pertussis is a highly contagious respiratory disease caused by Bordetella pertussis. However, after the introduction of the whole-cell pertussis vaccine (wP), the annual incidence rates of the disease progressively declined. Despite this result, the inclusion of wP in the national immunization schedule of infants and ...

journal_title：Human vaccines & immunotherapeutics

authors： Esposito S,Principi N

更新日期：2018-01-01 00:00:00

abstract：:The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that wer...

journal_title：Human vaccines & immunotherapeutics

authors： Park HL,Shim SH,Lee EY,Cho W,Park S,Jeon HJ,Ahn SY,Kim H,Nam JH

更新日期：2014-01-01 00:00:00

abstract：:The immune system becomes less effective with age, and older age is associated with an increased susceptibility to diseases and reduced responses to vaccination. Furthermore, some adult populations, such as those with diabetes mellitus, are at increased risk of acute hepatitis B virus (HBV) infection. Decreasing respo...

journal_title：Human vaccines & immunotherapeutics

authors： Van Der Meeren O,Crasta P,Cheuvart B,De Ridder M

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:In adults with a tetanus-prone injury, combined vaccines such as Tdap-IPV (REPEVAX®) can boost immunity against several diseases simultaneously. This Phase IIIb, parallel-group, open-label trial compared antibody responses to Tdap-IPV and tetanus monovalent vaccine (TMV; Vaccin Tétanique Pasteur® or Tetavax®...

journal_title：Human vaccines & immunotherapeutics

authors： Laurichesse H,Zimmermann U,Galtier F,Launay O,Duval X,Richard P,Sadorge C,Soubeyrand B

更新日期：2012-12-01 00:00:00

abstract：:The introduction of a serogroup A meningococcal conjugate vaccine in the African meningitis belt has been a remarkable success. Meningitis due to the serogroup A meningococcus, previously responsible for most epidemics, has fallen by 99% in vaccinated countries. Success must, however, not distract from the continuing ...

journal_title：Human vaccines & immunotherapeutics

authors： Stuart JM

更新日期：2018-05-04 00:00:00

abstract：:Objective: The objective of this study was to analyze the 100 most cited studies on vaccine.Methods: A comprehensive search of studies on vaccine was performed in the Web of Science Core Collection without year or language restrictions. The 100 top-cited studies were retrieved after screening abstracts or full-texts. ...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang Y,Quan L,Xiao B,Du L

更新日期：2019-01-01 00:00:00

abstract：:Higher-valent pneumococcal conjugate vaccines (PCVs) were licensed from 2009 in Europe; similar worldwide clinical effectiveness was observed for PCVs in routine use. Despite a proven medical need, PCV vaccination in Southern Europe remained suboptimal until 2015/16. We searched PubMed for manuscripts published betwee...

journal_title：Human vaccines & immunotherapeutics

authors： Moreira M,Castro O,Palmieri M,Efklidou S,Castagna S,Hoet B

更新日期：2017-06-03 00:00:00

abstract：:Sipuleucel-T, the first autologous active cellular immunotherapy approved by the United States Food and Drug Administration, is designed to stimulate an immune response to prostate cancer. Sipuleucel-T is manufactured by culturing a patient's peripheral blood mononuclear cells (including antigen presenting cells) with...

journal_title：Human vaccines & immunotherapeutics

authors： Wesley JD,Whitmore J,Trager J,Sheikh N

更新日期：2012-04-01 00:00:00

abstract：:Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination is recommended for all women during each pregnancy to prevent pertussis in young infants. However, data on the safety of this protective measure are limited and conflicting. To assess maternal and infant outcomes associated with administration of this vac...

journal_title：Human vaccines & immunotherapeutics

authors： Berenson AB,Hirth JM,Rahman M,Laz TH,Rupp RE,Sarpong KO

更新日期：2016-08-02 00:00:00

abstract：BACKGROUND:Health authorities recommend influenza vaccination to diabetic patients. Nevertheless, the vaccination coverage of adults was low in China. This study aimed to estimate influenza vaccination intentions and actual uptake among diabetic patients in China and identify the motivators and barriers associated with...

journal_title：Human vaccines & immunotherapeutics

authors： Ye L,Fang T,Cui J,Zhu G,Ma R,Sun Y,Li P,Li H,Dong H,Xu G

更新日期：2020-05-27 00:00:00

abstract：:Human papillomavirus (HPV) infection is common in women and also the main cause of cervical cancer. Based on a dynamic compartmental model, we aimed to evaluate the population impact and cost-effectiveness of strategies that combined cervical cancer screening and HPV schoolgirl vaccination for Chinese women. The effec...

journal_title：Human vaccines & immunotherapeutics

authors： Ma X,Harripersaud K,Smith K,Fairley CK,Zou H,Zou Z,Wang Y,Zhuang G,Zhang L

更新日期：2020-12-03 00:00:00

abstract：:Hollingsworth and Isturiz (1) have raised several questions about our earlier review of the use of pneumococcal conjugate (PCV) or polysaccharide (PPV) vaccine for older adults (i.e., ≥65 y of age). (2) They begin by citing two metaanalyses published in 2009 and 2013 that concluded that prevention of pneumococcal pneu...

journal_title：Human vaccines & immunotherapeutics

authors： Fedson DS

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Compare immune persistence from one dose of each of 3 different hepatitis A vaccines when given to school-age children: a domestic, live attenuated hepatitis A vaccine (H2 vaccine); a domestic inactivated hepatitis A vaccine (Healive®); and an imported, inactivated hepatitis A vaccine (Havrix®),. METHODS:Sch...

journal_title：Human vaccines & immunotherapeutics

authors： Zhang X,An J,Tu A,Liang X,Cui F,Zheng H,Tang Y,Liu J,Wang X,Zhang N,Li H

更新日期：2016-09-01 00:00:00

abstract：UNLABELLED:NmenB vaccine (4CMenB) is now available, but studies on the cost-effectiveness of vaccine introduction in a country outbreak situation are lacking. The aim of this study was to evaluate the cost-effectiveness of 4CMenB in the context of a hypothetical epidemic outbreak in Chile. We analyzed the direct and in...

journal_title：Human vaccines & immunotherapeutics

authors： Izquierdo G,Torres JP,Santolaya ME,Valenzuela MT,Vega J,Chomali M

更新日期：2015-01-01 00:00:00

abstract：:Immunization against pertussis, influenza, and rubella reduces morbidity and mortality in pregnant women and their offspring. Health care professionals (HCPs) caring for women perinatally are uniquely placed to reduce maternal vaccine preventable diseases (VPDs). Despite guidelines recommending immunization during the...

journal_title：Human vaccines & immunotherapeutics

authors： Webb H,Street J,Marshall H

更新日期：2014-01-01 00:00:00

abstract：:The present study evaluated the safety and immunogenicity of the 2013/2014 trivalent surface antigen inactivated subunit seasonal influenza virus vaccine Fluvirin® in healthy adults (18 - ≤ 60 years) and elderly (>60 years). The vaccine contained 15 µg haemagglutinin protein from each of influenza A/California/7/2009 ...

journal_title：Human vaccines & immunotherapeutics

authors： Roggelin L,Vinnemeier CD,Meyer S,Witte K,Marx L,Theeß W,Burchard GD,Rolling T,Cramer JP

更新日期：2015-01-01 00:00:00

abstract：:In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against related orthopoxviruses, including smallpox virus (variola virus). Over time, vaccinia virus (VACV) replaced cowpox virus as the smallpox vaccine,...

journal_title：Human vaccines & immunotherapeutics

authors： Verardi PH,Titong A,Hagen CJ

更新日期：2012-07-01 00:00:00

abstract：:Vaccine information of varying quality is available through many different sources. We describe the creation, release and utilization of ReadyVax, a new mobile smartphone app providing access to trustworthy, evidence-based vaccine information for a target audience of healthcare providers, pharmacists, and patients (in...

journal_title：Human vaccines & immunotherapeutics

authors： Bednarczyk RA,Frew PM,Salmon DA,Whitney E,Omer SB

更新日期：2017-05-04 00:00:00

abstract：:Although pancreatic cancer is but the eleventh most prevalent cancer in the US, it is predicted that of all the patients newly diagnosed with this disease in 2014, only 27% will still be alive at the end of the first year and only 6% will make it past 5 years. The choice of chemotherapy in the treatment of pancreatic ...

journal_title：Human vaccines & immunotherapeutics

authors： Hartley ML,Bade NA,Prins PA,Ampie L,Marshall JL

更新日期：2014-01-01 00:00:00

abstract：:The manner in which providers respond to parental concerns about the recommended childhood vaccination schedule is an area of increasing interest in pediatrics and medical ethics. Like many aspects of vaccination policy and practice, evaluating the reactions of providers to parental vaccine hesitancy--including the po...

journal_title：Human vaccines & immunotherapeutics

authors： Schwartz JL

更新日期：2013-12-01 00:00:00

abstract：:Monoclonal antibody preparations have demonstrated considerable clinical utility in the treatment of specific malignancies, as well as inflammatory and infectious diseases. Antibodies are conventionally delivered by passive administration, typically requiring costly large-scale laboratory development and production. A...

journal_title：Human vaccines & immunotherapeutics

authors： Muthumani K,Flingai S,Wise M,Tingey C,Ugen KE,Weiner DB

更新日期：2013-10-01 00:00:00

abstract：:The interesting article by Simas et. al. describes an outbreak case with over 600 individuals who exhibited neurological symptoms and which occurred in a town located at the northern region of Colombia in 2014. The community associated this event to the second-dose vaccination campaign against the Human Papillomavirus...

journal_title：Human vaccines & immunotherapeutics

authors： Idrovo AJ,Pinilla-Monsalve GD,Manrique-Hernández EF

更新日期：2019-01-01 00:00:00

abstract：:Group B streptococcus (GBS) is a leading bacterial cause of neonatal sepsis and meningitis in many countries as well as an important cause of disease in pregnant women. Currently, serotype-specific conjugate vaccines are being developed. We conducted an epidemiological analysis of health administrative data to estimat...

journal_title：Human vaccines & immunotherapeutics

authors： Hartley J,Li Y,Kunkel L,Crowcroft NS

更新日期：2019-01-01 00:00:00

abstract：:The combined diphtheria-tetanus-acellular pertussis-hepatitis B-poliomyelitis/Haemophilus influenza vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa, GlaxoSmithKline Vaccines) is used for primary vaccination of infants in a range of schedules world-wide. Antibody persistence after 4 DTPa-HBV-IPV/Hib doses in the first 2 y of...

journal_title：Human vaccines & immunotherapeutics

authors： Silfverdal SA,Assudani D,Kuriyakose S,Van Der Meeren O

更新日期：2014-01-01 00:00:00

abstract：:SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), is suspected to have been first contracted via animal-human interactions; it has further spread across the world by efficient human-to-human transmission. Recent reports of COVID-19 in companion animals (dogs and cats) and wild carnivores such as tigers hav...

journal_title：Human vaccines & immunotherapeutics

authors： Sharun K,Tiwari R,Patel SK,Karthik K,Iqbal Yatoo M,Malik YS,Singh KP,Panwar PK,Harapan H,Singh RK,Dhama K

更新日期：2020-12-01 00:00:00

abstract：:Intradermal immunization has become a forefront of vaccine improvement, both scientifically and commercially. Newer technologies are being developed to address the need to reduce the dose required for vaccination and to improve the reliability and ease of injection, which have been major hurdles in expanding the numbe...

journal_title：Human vaccines & immunotherapeutics

authors： Levin Y,Kochba E,Hung I,Kenney R

更新日期：2015-01-01 00:00:00