A review of immunogenicity and tolerability of live attenuated Hepatitis A vaccine in children.

Abstract:

:Changing epidemiology of Hepatitis A virus (HAV) has led to an increased susceptibility of adolescents and adults to the infection. Vaccination can remarkably reduce the incidence and associated morbidity of HAV infection. This review is focused on the safety and efficacy of H2 strain derived live attenuated Hepatitis A vaccine. We found the vaccine to be highly immunogenic with minimal or negligible safety issues. Moreover, a single dose of live attenuated vaccine persists a long term immune response and can be a preferred option for developing countries. In 2014, Indian Academy of Paediatrics (IAP) also updated their recommendations for H2 vaccine as a single dose as against the previous 2 dose schedule. A focused approach to include the vaccine in national immunization program should be explored.

journal_name

Hum Vaccin Immunother

authors

Rao S,Mao JS,Motlekar S,Fangcheng Z,Kadhe G

doi

10.1080/21645515.2016.1216286

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

3160-3165

issue

12

eissn

2164-5515

issn

2164-554X

journal_volume

12

pub_type

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