Solid Organ Transplant Is Associated With Increased Morbidity and Mortality in Patients Undergoing One or Two-level Anterior Cervical Decompression and Fusion.


STUDY DESIGN:Retrospective database review OBJECTIVE.: The aim of this study was to analyze the implications of solid organ transplant (SOT) on postoperative outcomes following elective one or two-level anterior cervical discectomy and fusion (ACDF). SUMMARY OF BACKGROUND DATA:Although SOTs have been associated with increased morbidity, postoperative outcomes in SOT recipients undergoing cervical spinal surgery are not well studied. METHODS:A retrospective database review of Medicare patients younger than 85 years who underwent an elective one to two-level ACDF from 2006-2013 was conducted. Following our exclusion criteria, patients were then divided into the following groups: those with a prior history of kidney, liver, heart or lung transplant (SOT group) and non-SOT patients. Both groups were compared for hospital length of stay, 90-day major medical complications, 90-day hospital readmission, 1-year surgical site infection (SSI), 1-year revision ACDF, and 1-year mortality. RESULTS:A total of 992 (0.5%) SOT recipients (1,144 organs) were identified out of 199,288 ACDF patients. SOT recipients had a significantly longer length of stay (2.32 vs. 5.22 days, p<0.001), higher rate of major medical complications (8.2% vs. 4.5%; OR 1.85, 95% CI 1.45-2.33, p<0.001) and hospital readmission (19.5% vs. 7.5%, OR 2.05, 95% CI 1.74-2.41, p<0.001). In addition, SOT patients had increased mortality within one year of surgery (5.8% vs. 1.3%; OR 3.01, 95% CI 2.26-3.94, p<0.001) compared to non-SOT patients. SOT was not independently associated with SSI (OR 1.25, 95% CI 0.85-1.75, p=0.230), and there was no significant difference in revision rate (0.9% vs. 0.5%; OR 1.54, 95% CI 0.73-2.82, p=0.202) between both groups. CONCLUSION:SOT is independently associated with longer hospital stay, increased rate of major medical complications, hospital readmission and mortality. Spine surgeons should be aware of the higher rates of morbidity and mortality in these patients and take it into consideration when developing patient-specific treatment plans. LEVEL OF EVIDENCE:3.


Spine (Phila Pa 1976)




Labaran LA,Harris AB,Puvanesarajah V,Amin R,Raad M,Jain A,Hassanzadeh H




Has Abstract


2020-02-01 00:00:00
















  • Isokinetic trunk and lifting strength measurements: variability as an indicator of effort.

    abstract::This study examines the hypothesis that force/distance curve variability distinguishes submaximal from maximal efforts in isokinetic trunk and lifting strength tests. Thirty normal subjects were tested on the Cybex Trunk Extension/Flexion (TEF) and Liftask (LT) machines during maximal (100%) and submaximal (50%) effor...


    pub_type: 杂志文章


    authors: Hazard RG,Reid S,Fenwick J,Reeves V

    更新日期:1988-01-01 00:00:00

  • Atlantoaxial instability in Lesch-Nyhan syndrome.

    abstract:STUDY DESIGN:A clinical case report of two brothers with Lesch-Nyhan syndrome found to have atlantoaxial instability is reported. OBJECTIVES:To report the clinical and radiologic findings and the operative outcome in these patients. SUMMARY OF BACKGROUND DATA:Both patients had biochemically proven Lesch-Nyhan syndrom...


    pub_type: 杂志文章


    authors: Shewell PC,Thompson AG

    更新日期:1996-03-15 00:00:00

  • Perioperative Neurologic Complications in Adult Spinal Deformity Surgery: Incidence and Risk Factors in 564 Patients.

    abstract:STUDY DESIGN:Prognostic study-case controlled. OBJECTIVE:Describe the rate of neurologic complications in adult spinal deformity surgery and describe the effect of these complications on clinical outcomes. SUMMARY OF BACKGROUND DATA:The incidence of neurologic complications and the risk factors for neurologic complic...


    pub_type: 杂志文章


    authors: Kim HJ,Iyer S,Zebala LP,Kelly MP,Sciubba D,Protopsaltis TS,Gupta M,Neuman BJ,Mundis GM,Ames CP,Smith JS,Hart R,Burton D,Klineberg EO,International Spine Study Group (ISSG).

    更新日期:2017-03-15 00:00:00

  • Commonly adopted postures and their effect on the lumbar spine.

    abstract::The activity of the erector spinae muscles and the changes in lumbar curvature were measured in 11 subjects in a range of commonly adopted postures to see if there were any consistent trends. Surface electrodes were used to measure back muscle activity and lumbar curvature was measured using electronic inclinometers. ...


    pub_type: 杂志文章


    authors: Dolan P,Adams MA,Hutton WC

    更新日期:1988-02-01 00:00:00

  • Principles for selecting fusion levels in adult spinal deformity with particular attention to lumbar curves and double major curves.

    abstract:STUDY DESIGN:Review article. OBJECTIVES:To identify decision-making principles for selecting fusion levels in adult spinal deformity, with particular attention to lumbar curves and double major curves. SUMMARY OF BACKGROUND DATA:Although numerous articles have been published on the selection of fusion levels for adol...


    pub_type: 杂志文章,评审


    authors: Kuklo TR

    更新日期:2006-09-01 00:00:00

  • Clinical efficacy of spinal instrumentation in lumbar degenerative disc disease.

    abstract::In review of 871 lumbar fusion procedures performed during the last 8 years, the theoretical advantages of lumbar spinal instrumentation are not borne out in simple discogenic disease. Four groups of 30-35 patients without previous surgery who underwent fusion by different techniques were matched for age, sex, length ...


    pub_type: 杂志文章


    authors: Zucherman J,Hsu K,Picetti G 3rd,White A,Wynne G,Taylor L

    更新日期:1992-07-01 00:00:00

  • Continuous irrigation in pyogenic spondylitis accompanied by iliopsoas abscess.

    abstract:STUDY DESIGN:A retrospective assessment of 12 patients with pyogenic spondylitis accompanied by iliopsoas abscess treated by continuous irrigation with our new method between March 2003 and July 2005. OBJECTIVES:To present our method of treatment and to evaluate outcomes of 12 patients undergoing it. SUMMARY OF BACKG...


    pub_type: 杂志文章


    authors: Tofuku K,Koga H,Yone K,Komiya S

    更新日期:2007-06-15 00:00:00

  • Historical Perspective: Henry H. Bohlman (1937-2010): The Father of Contemporary Spine Surgery.

    abstract::The incredible career of Henry H. Bohlman, MD, spanned over four decades at University Hospitals Case Medical Center. He was an innovator and pioneer, designing several techniques for the management of several spinal pathologies while advocating the anterior approach to the spine. Dr. Bohlman's legacy is preserved in ...


    pub_type: 传,历史文章,杂志文章


    authors: Abola MV,Knapik DM,Gordon ZL,Furey CG,Marcus RE

    更新日期:2016-10-15 00:00:00

  • Pedicle diameter determined by computed tomography. Its relevance to pedicle screw fixation in the lumbar spine.

    abstract::Intraoperative technical complications of pedicle screw fixation include screw cutout or maldirection and pedicle fracture. The aims of this study were 1) to use computed tomography to determine the average pedicle diameter; and 2) to compare these measurements with the outer diameter measurements of commonly used ped...


    pub_type: 杂志文章


    authors: Bernard TN Jr,Seibert CE

    更新日期:1992-06-01 00:00:00

  • Pulmonary embolism in spine surgery: a comparison of combined anterior/posterior approach versus posterior approach surgery.

    abstract:STUDY DESIGN:retrospective review. OBJECTIVE:to determine if Anterior/Posterior Combined approach spine surgery is associated with an increased risk of pulmonary embolism (PE) compared to Posterior Only approach surgery. SUMMARY OF BACKGROUND DATA:combined anterior/posterior approach spine surgery is associated with ...


    pub_type: 杂志文章


    authors: Kim HJ,Kepler C,Cunningham M,Rawlins B,Boachie-Adjei O

    更新日期:2011-01-15 00:00:00

  • Feasibility and Accuracy of Thoracolumbar Minimally Invasive Pedicle Screw Placement With Augmented Reality Navigation Technology.

    abstract:STUDY DESIGN:Cadaveric laboratory study. OBJECTIVE:To assess the feasibility and accuracy of minimally invasive thoracolumbar pedicle screw placement using augmented reality (AR) surgical navigation. SUMMARY OF BACKGROUND DATA:Minimally invasive spine (MIS) surgery has increasingly become the method of choice for a w...


    pub_type: 杂志文章


    authors: Elmi-Terander A,Nachabe R,Skulason H,Pedersen K,Söderman M,Racadio J,Babic D,Gerdhem P,Edström E

    更新日期:2018-07-15 00:00:00

  • Surgical mystery: where is the missing pituitary rongeur tip?

    abstract:STUDY DESIGN:Case report. OBJECTIVE:We report the unusual case of a patient who was referred to our institution after she sustained an intraoperative injury to the common iliac vein during posterior lumbar discectomy at L5-S1 with a pituitary rongeur. There was only minimal bleeding with spontaneous hemostasis and no ...


    pub_type: 杂志文章


    authors: Bydon A,Xu R,Conte JV,Gokaslan ZL,Brinker JA,Witham TF,Yassari R

    更新日期:2010-08-01 00:00:00

  • Spinal stability and intersegmental muscle forces. A biomechanical model.

    abstract::The human spinal column, devoid of musculature, is incapable of carrying normal physiologic loads. In an in vitro experiment, the effect of simulated intersegmental muscle forces on spinal instability was investigated. Intact and sequentially injured fresh lumbar functional spinal units were subjected to three-dimensi...


    pub_type: 杂志文章


    authors: Panjabi M,Abumi K,Duranceau J,Oxland T

    更新日期:1989-02-01 00:00:00

  • Automatic localization of target vertebrae in spine surgery: clinical evaluation of the LevelCheck registration algorithm.

    abstract:STUDY DESIGN:A 3-dimensional-2-dimensional (3D-2D) image registration algorithm, "LevelCheck," was used to automatically label vertebrae in intraoperative mobile radiographs obtained during spine surgery. Accuracy, computation time, and potential failure modes were evaluated in a retrospective study of 20 patients. OB...


    pub_type: 杂志文章


    authors: Lo SF,Otake Y,Puvanesarajah V,Wang AS,Uneri A,De Silva T,Vogt S,Kleinszig G,Elder BD,Goodwin CR,Kosztowski TA,Liauw JA,Groves M,Bydon A,Sciubba DM,Witham TF,Wolinsky JP,Aygun N,Gokaslan ZL,Siewerdsen JH

    更新日期:2015-04-15 00:00:00

  • Roy-Camille plates in unstable spinal conditions. A preliminary report.

    abstract::From 1979 to 1982, 21 consecutive patients with posttraumatic or pathologic fractures of the spine were treated at the University of Sherbrooke by Roy-Camille plates to provide stabilization. Ten burst fractures and 11 fracture-dislocations were treated in this manner. Nine patients had complete paraplegia, 6 had vari...


    pub_type: 杂志文章


    authors: Kinnard P,Ghibely A,Gordon D,Trias A,Basora J

    更新日期:1986-03-01 00:00:00

  • Minimally Effective Dose of Bone Morphogenetic Protein in Minimally Invasive Lumbar Interbody Fusions: Six Hundred Ninety Patients in a Dose-Finding Longitudinal Cohort Study.

    abstract:STUDY DESIGN:Retrospective longitudinal cohort. OBJECTIVE:We sought to demonstrate the minimally effective bone morphogenetic protein (BMP) dose to achieve fusion in minimally invasive transforaminal lumbar interbody fusions. SUMMARY OF BACKGROUND DATA:Multiple studies have been conducted, which used a wide range of ...


    pub_type: 杂志文章


    authors: Lytle EJ,Slavnic D,Tong D,Bahoura M,Govila L,Gonda R,Houseman C,Soo TM

    更新日期:2019-07-15 00:00:00

  • Double-blind evaluation of collagenase injections for herniated lumbar discs.

    abstract::A randomized clinical trial of 30 patients with refractory lumbar disc disease with evidence of a herniation at a single intervertebral space on the myelogram is presented. Collagenase or a saline placebo was injected into the affected disc. Lack of pain reduction or lack of functional improvement was considered a the...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Bromley JW,Varma AO,Santoro AJ,Cohen P,Jacobs R,Berger L

    更新日期:1984-07-01 00:00:00

  • A Dose-Response Curve for a Gram-Negative Spinal Implant Infection Model in Rabbits.

    abstract:STUDY DESIGN:A randomized complete block animal spinal implant infection model with internal control. OBJECTIVE:The aim of this study was to develop a spinal implant animal infection model to simulate postoperative gram-negative wound infection. SUMMARY OF BACKGROUND DATA:Implant-associated surgical site infections (...


    pub_type: 杂志文章


    authors: Laratta JL,Shillingford JN,Hardy N,Lehman RA,Lenke LG,Riew KD

    更新日期:2017-11-01 00:00:00

  • Spinal deformity in idiopathic juvenile osteoporosis.

    abstract::Idiopathic juvenile osteoporosis is an unusual condition appearing in the prepubertal child who is otherwise normal. Characteristically, the condition is of variable severity and of limited duration and always affect the spine. One of the major complications of idiopathic juvenile osteoporosis has been residual kyphos...


    pub_type: 杂志文章


    authors: Jones ET,Hensinger RN

    更新日期:1981-01-01 00:00:00

  • Three-dimensional computed tomography-based, personalized drill guide for posterior cervical stabilization at C1-C2.

    abstract:STUDY DESIGN:Cadaver and preliminary clinical study. OBJECTIVES:To enhance the precision of screw positions for posterior transarticular fixations according to Magerl at C1-C2. SUMMARY OF BACKGROUND DATA:The vertebral arteries are at risk during the Magerl operation and may be damaged in up to 4.1% of cases. Even int...


    pub_type: 杂志文章


    authors: Goffin J,Van Brussel K,Martens K,Vander Sloten J,Van Audekercke R,Smet MH

    更新日期:2001-06-15 00:00:00

  • Bone biomarkers as tools in osteoporosis management.

    abstract::Biochemical tests that can index bone turnover rate in the patient are increasingly being used in the study and management of osteoporosis. Markers of bone formation and resorption are reviewed here, including their molecular basis, relative strengths and weaknesses in clinical performance, and future potential. A bon...


    pub_type: 杂志文章,评审


    authors: Eyre DR

    更新日期:1997-12-15 00:00:00

  • The effect of infliximab, a monoclonal antibody against TNF-alpha, on disc herniation resorption: a randomized controlled study.

    abstract:STUDY DESIGN:Randomized, controlled study. OBJECTIVE:To evaluate the effect of infliximab on herniated nucleus pulposus (HNP) resorption. SUMMARY OF BACKGROUND DATA:Although the effects of tumor necrosis factor alpha (TNF-alpha) on HNP resorption are not fully understood, TNF-alpha appears to be an essential mediator...


    pub_type: 杂志文章,随机对照试验


    authors: Autio RA,Karppinen J,Niinimäki J,Ojala R,Veeger N,Korhonen T,Hurri H,Tervonen O

    更新日期:2006-11-01 00:00:00

  • Total sacrectomy and reconstruction for huge sacral tumors.

    abstract::The authors carried out successful total sacrectomy in three cases, two with giant cell tumors and one with a chordoma. The anterior and posterior approach is feasible for resecting huge sacral tumors en bloc, but it is important to reconstruct the continuity between the pelvic ring and spinal column using spinal inst...


    pub_type: 杂志文章


    authors: Tomita K,Tsuchiya H

    更新日期:1990-11-01 00:00:00

  • Two Doses of Tranexamic Acid Reduce Blood Transfusion in Complex Spine Surgery: A Prospective Randomized Study.

    abstract:STUDY DESIGN:Prospective, double-blinded, randomized controlled study. OBJECTIVE:To determine whether the use of 2 doses of tranexamic acid (TXA) can reduce perioperative blood loss and blood transfusions in low-risk adult patients undergoing complex laminectomy. SUMMARY OF BACKGROUND DATA:Complex laminectomy (multil...


    pub_type: 杂志文章,随机对照试验


    authors: Raksakietisak M,Sathitkarnmanee B,Srisaen P,Duangrat T,Chinachoti T,Rushatamukayanunt P,Sakulpacharoen N

    更新日期:2015-12-01 00:00:00

  • Adjacent level load transfer following vertebral augmentation in the cadaveric spine.

    abstract:STUDY DESIGN:In vitro biomechanics. OBJECTIVE:To determine if osteoporotic vertebral compression fracture (VCF) augmentation increases adjacent level load transfer. SUMMARY OF BACKGROUND DATA:Osteoporotic VCF subsequent to augmentation may result from disease progression or increased adjacent level load transfer, or ...


    pub_type: 杂志文章


    authors: Kayanja MM,Evans K,Milks R,Lieberman IH

    更新日期:2006-10-01 00:00:00

  • The influence of distraction force on the intradiscal pressure gradient in the bridged lumbar spine: a biomechanical investigation using a calf model.

    abstract:STUDY DESIGN:A biomechanical calf cadaver study. OBJECTIVE:The purpose of this study was to determine the intradiscal pressure gradient of bridged healthy intervertebral segments in correlation with intraoperative distraction force. SUMMARY OF BACKGROUND DATA:Bisegmental dorsal stabilization and anatomic reduction is...


    pub_type: 杂志文章


    authors: Spiegl U,Pätzold R,Glasmacher S,Stephan D,Josten C,Bühren V,Gonschorek O,Augat P

    更新日期:2014-04-01 00:00:00

  • Laboratory testing of segmental spinal instrumentation versus traditional Harrington instrumentation for scoliosis treatment.

    abstract::The authors have tested 51 instrumented calf spines in vitro, using a scoliosis simulator, to evaluate the adequacy of fixation and nature of acute failure seen with various methods of scoliosis instrumentation. Tests were performed in compressive loading, rotation, and forward bending on the following instrumentation...


    pub_type: 杂志文章


    authors: Wenger DR,Carollo JJ,Wilkerson JA Jr,Wauters K,Herring JA

    更新日期:1982-05-01 00:00:00

  • Influence of the Preoperative Neurological Status on Survival After the Surgical Treatment of Symptomatic Spinal Metastases With Spinal Cord Compression.

    abstract:STUDY DESIGN:Consecutive case-series. OBJECTIVE:The main purpose of this study was to analyze the relationship between the preoperative neurological status and subsequent survival of patients undergoing surgical treatment for symptomatic spinal metastases. SUMMARY OF BACKGROUND DATA:The survival of cancer patients ha...


    pub_type: 杂志文章


    authors: Vanek P,Bradac O,Trebicky F,Saur K,de Lacy P,Benes V

    更新日期:2015-12-01 00:00:00

  • Primary sensory neurons with dichotomizing axons projecting to the facet joint and the sciatic nerve in rats.

    abstract:STUDY DESIGN:Dorsal root ganglion (DRG) neurons that have dichotomizing axons to the lumbar facet joint and to the sciatic nerve were investigated in rats using a double fluorescent labeling technique. OBJECTIVES:To clarify the existence of DRG neurons with dichotomizing axons projecting to the lumbar facet joint and ...


    pub_type: 杂志文章


    authors: Sameda H,Takahashi Y,Takahashi K,Chiba T,Ohtori S,Moriya H

    更新日期:2001-05-15 00:00:00

  • Physiologic changes of nerve root during posterior lumbar discectomy.

    abstract:STUDY DESIGN AND OBJECTIVES:The effects of nerve root retraction in posterior discectomy on pressure, blood flow, and electrophysiologic changes of the nerve root were investigated. OBJECTIVES:This study was performed to assess the effects of nerve root retraction in posterior discectomy on pressure, blood flow, and e...


    pub_type: 杂志文章


    authors: Matsui H,Kitagawa H,Kawaguchi Y,Tsuji H

    更新日期:1995-03-15 00:00:00