The influence on spinal cord evoked potentials of chymopapain applied to the rat lumbar spine canal.

Abstract:

:Electrically evoked compound action potentials were used to quantify the neurophysiologic abnormalities caused by application of chymopapain into the lumbar spinal canal in rats. A branch of the sciatic nerve was stimulated with voltage impulses of constant amplitude (40 V) and duration (0.1 msec) at the right external malleolus. The responses were recorded at the dorsal root entry zone L1. The authors used different doses of chymopapain (low dose = 100 IU, middle dose = 250 IU, and high dose = 500 IU). The control rats were subjected to exactly the same stimulus and recording procedures, but the test solution was a corresponding volume of isotonic saline. The prolongation of the latency of the electrically evoked potential due to chymopapain is very clear at the doses of 250 IU and 500 IU, being about 10 to 15% relative to the mean latency before application of the drug. This study indicates that locally applied chymopapain has a dose-dependent effect on nerve conduction properties.

journal_name

Spine (Phila Pa 1976)

journal_title

Spine

authors

Wehling P,Pak MA,Cleveland SJ,Schulitz KP

doi

10.1097/00007632-198901000-00013

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

65-7

issue

1

eissn

0362-2436

issn

1528-1159

journal_volume

14

pub_type

杂志文章

相关文献

SPINE文献大全
  • Small intestinal submucosa as a potential bioscaffold for intervertebral disc regeneration.

    abstract:STUDY DESIGN:To evaluate the capacity of porcine small intestine submucosa to support the in vitro proliferation of human disc cells and the synthesis of extracellular matrix that could restore the biochemical properties of the disc. OBJECTIVE:To evaluate if porcine small intestine submucosa is a potential bioactive s...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000238684.04792.eb

    authors: Le Visage C,Yang SH,Kadakia L,Sieber AN,Kostuik JP,Leong KW

    更新日期:2006-10-01 00:00:00

  • Facet joint asymmetry as a radiologic feature of lumbar intervertebral disc herniation in children and adolescents.

    abstract:STUDY DESIGN:This study compared the incidence of facet joint asymmetry between adult and juvenile patients with lumbar intervertebral disc herniation. OBJECTIVES:To determine the different distribution of the facet joint asymmetry between the adult and juvenile patients. SUMMARY OF BACKGROUND DATA:As early as 1967, ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199709010-00012

    authors: Ishihara H,Matsui H,Osada R,Ohshima H,Tsuji H

    更新日期:1997-09-01 00:00:00

  • Metastatic pancreatic endocrine tumor presenting as thoracic spinal cord compression.

    abstract:STUDY DESIGN:A case report. OBJECTIVE:The authors present a rare case of metastatic nonfunctioning neuroendocrine tumor of the pancreas presenting as thoracic spinal cord compression. SUMMARY OF BACKGROUND DATA:Pancreatic endocrine tumors (PETs) are a slow-growing subset of pancreatic tumors. They can be classified a...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181cb4730

    authors: Eads TA,Hattab EM,Rodgers RB

    更新日期:2010-05-15 00:00:00

  • The Impact of COVID-19 pandemic on Spine Surgeons: An Asia Pacific Spine Society (APSS) Survey.

    abstract:STUDY DESIGN:Cross-sectional survey. OBJECTIVE:The aim of this study was to investigate the impact of COVID-19 pandemic on the clinical practices of spine surgeons within the Asia Pacific region. SUMMARY OF BACKGROUND DATA:COVID-19 pandemic had changed spine surgeons' clinical practices and their concerns toward pers...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000003622

    authors: Chan CYW,Chiu CK,Cheung JPY,Cheung PWH,Gani SMA,Kwan MK

    更新日期:2020-09-15 00:00:00

  • Anatomical gender differences in cervical vertebrae of size-matched volunteers.

    abstract:STUDY DESIGN:Clinical literature consistently identifies women as more susceptible to trauma-related neck pain, commonly resulting from soft tissue cervical spine injury. Structural gender differences may explain altered response to dynamic loading in women leading to increased soft tissue distortion and greater injury...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318160462a

    authors: Stemper BD,Yoganandan N,Pintar FA,Maiman DJ,Meyer MA,DeRosia J,Shender BS,Paskoff G

    更新日期:2008-01-15 00:00:00

  • Human nucleus pulposis can respond to a pro-inflammatory stimulus.

    abstract:STUDY DESIGN:Disc tissue obtained from patients undergoing surgery for scoliosis, lumbar radiculopathy, and discogenic pain was cultured under basal and lipopolysaccharide-stimulated conditions and the medium analyzed for production of a range of pro-inflammatory mediators. OBJECTIVES:This study was conducted to confi...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000103341.45133.F3

    authors: Burke JG,G Watson RW,Conhyea D,McCormack D,Dowling FE,Walsh MG,Fitzpatrick JM

    更新日期:2003-12-15 00:00:00

  • Complications and outcomes of pedicle subtraction osteotomies for fixed sagittal imbalance.

    abstract:STUDY DESIGN:Radiographic analysis, outcomes analysis (pain scale, Oswestry, SRS-24), and accumulation of complications. Outcomes and complications collected prospectively. Radiographic analysis performed retrospectively. OBJECTIVES:To assess the benefits and stress complications of pedicle subtraction osteotomies for...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.BRS.0000090891.60232.70

    authors: Bridwell KH,Lewis SJ,Edwards C,Lenke LG,Iffrig TM,Berra A,Baldus C,Blanke K

    更新日期:2003-09-15 00:00:00

  • Johann Peter Frank (1745-1821) and the Pathogenesis of Back Pain.

    abstract::: Johann Peter Frank (1745-1821) is generally known as one of the founders of the modern Hygiene and Public Health. It is less known his contribution in investigating the pathogenesis of spinal disorders. In his "De Vertebralis Columnae in Morbis Dignitate" (1791), Frank first proposed to use the Latin term "rhachialg...

    journal_title:Spine

    pub_type: 历史文章,杂志文章

    doi:10.1097/BRS.0000000000003074

    authors: Riva MA,Anghilieri FM,Belingheri M,Zatti G

    更新日期:2019-10-01 00:00:00

  • Radiation exposure to the spine surgeon in lumbar and thoracolumbar fusions with the use of an intraoperative computed tomographic 3-dimensional imaging system.

    abstract:STUDY DESIGN:A prospective clinical research article. OBJECTIVE:The primary goals were to determine (1) radiation exposure to the spine surgeon with the use of an intraoperative 3-dimensional imaging system and (2) to define the safe distance from the computed tomographic scanner. SUMMARY OF BACKGROUND:Intraoperative...

    journal_title:Spine

    pub_type: 临床试验,杂志文章

    doi:10.1097/BRS.0b013e31825786d8

    authors: Abdullah KG,Bishop FS,Lubelski D,Steinmetz MP,Benzel EC,Mroz TE

    更新日期:2012-08-01 00:00:00

  • Comparison of results of total disc replacement in postdiscectomy patients versus patients with no previous lumbar surgery.

    abstract:STUDY DESIGN:Data for this study were collected as part of a prospective Food and Drug Administration regulated IDE trial for the ProDisc total disc replacement. OBJECTIVE:The purpose of the study was to compare the results of total disc replacement (TDR) in patients with previous discectomy to patients who had no suc...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31817bd2f0

    authors: Leahy M,Zigler JE,Ohnmeiss DD,Rashbaum RF,Sachs BL

    更新日期:2008-07-01 00:00:00

  • Gender- and region-dependent local facet joint kinematics in rear impact: implications in whiplash injury.

    abstract:STUDY DESIGN:Localized facet joint kinematics resulting from whiplash acceleration were analyzed in the dynamic domain during the time of cervical S-curvature using intact head and neck specimens and a pendulum mini-sled loading apparatus. OBJECTIVES:To determine the effects of gender, impact severity, cervical level,...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000134563.10718.a7

    authors: Stemper BD,Yoganandan N,Pintar FA

    更新日期:2004-08-15 00:00:00

  • Extrusion of expandable stacked interbody device for lumbar fusion: case report of a complication.

    abstract:STUDY DESIGN:A case report. OBJECTIVE:We report on the device failure of a polyetherether-ketone expandable cage device with posterior migration of one of its components. SUMMARY OF BACKGROUND DATA:Posterior migration of transforaminal lumbar interbody fusion cage devices has been reported with static devices, and ou...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e318257f14d

    authors: Kim PD,Baron EM,Levesque M

    更新日期:2012-08-15 00:00:00

  • Lack of association between the promoter polymorphisms of MMP-3 and IL-6 genes and adolescent idiopathic scoliosis: a case-control study in a Chinese Han population.

    abstract:STUDY DESIGN:Case-control study. OBJECTIVE:This study is to replicate the association between the promoter polymorphisms of matrix metalloproteinase (MMP)-3 (-1171 5A/6A rs3025058) and interleukin (IL)-6 genes (-174G/C rs1800795) and adolescent idiopathic scoliosis (AIS) in a Chinese Han population. SUMMARY OF BACKGR...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e3181c6ba13

    authors: Liu Z,Tang NL,Cao XB,Liu WJ,Qiu XS,Cheng JC,Qiu Y

    更新日期:2010-08-15 00:00:00

  • Mechanical stability of thoracolumbar pedicle screw fixation. The effect of crosslinks.

    abstract:STUDY DESIGN:Pedicle screw fixation for unstable thoracolumbar spine injuries is relatively new. The effect of one or two crosslinks on rotational and lateral bending stiffness was studied. OBJECTIVE:To determine the rotational and bending stiffness values of thoracolumbar fractures fixed by the AO's internal fixation...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199707150-00007

    authors: Lynn G,Mukherjee DP,Kruse RN,Sadasivan KK,Albright JA

    更新日期:1997-07-15 00:00:00

  • The spondylolytic vertebra and its adjacent segment. Mobility measured before and after posterolateral fusion.

    abstract:STUDY DESIGN:By using roentgen stereophotogrammetric analysis in six patients having tantalum indicators implanted at a preoperative external fixation test, the mobility in the spondylolytic lumbosacral level and its adjacent segment could be studied before fusion and during the course of postoperative fusion consolida...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199702150-00012

    authors: Axelsson P,Johnsson R,Strömqvist B

    更新日期:1997-02-15 00:00:00

  • Lumbar spinal fusion using recombinant human bone morphogenetic protein in the canine. A comparison of three dosages and two carriers.

    abstract:STUDY DESIGN:A randomized, prospective and controlled animal study. OBJECTIVE:To evaluate lumbar spinal fusion using recombinant human bone morphogenetic protein 2 in a canine model. SUMMARY OF BACKGROUND DATA:Spinal fusion using autogenous bone grafting is associated with donor site morbidity and a nonunion rate of ...

    journal_title:Spine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00007632-199910010-00002

    authors: David SM,Gruber HE,Meyer RA Jr,Murakami T,Tabor OB,Howard BA,Wozney JM,Hanley EN Jr

    更新日期:1999-10-01 00:00:00

  • Impact of smoking on complication and pseudarthrosis rates after single- and 2-level posterolateral fusion of the lumbar spine.

    abstract:STUDY DESIGN:Retrospective study. OBJECTIVE:To study the impact of smoking status on postoperative complications and pseudarthrosis in adult patients undergoing posterolateral fusion (PLF) of the lumbar spine. SUMMARY OF BACKGROUND DATA:Results of studies analyzing the impact of smoking on complication and pseudarthr...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000000527

    authors: Bydon M,De la Garza-Ramos R,Abt NB,Gokaslan ZL,Wolinsky JP,Sciubba DM,Bydon A,Witham TF

    更新日期:2014-10-01 00:00:00

  • Evaluation of spinal missile injuries with respect to bullet trajectory, surgical indications and timing of surgical intervention: a new guideline.

    abstract:STUDY DESIGN:Analysis of the patients with spinal missile injury (SMI). OBJECTIVE:Choosing the optimum treatment for SMI with respect to bullet trajectory, evaluation of surgical indications, and timing of surgical intervention. SUMMARY OF BACKGROUND DATA:A few guidelines were reported for the management of SMI. But ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0b013e31818579a7

    authors: Duz B,Cansever T,Secer HI,Kahraman S,Daneyemez MK,Gonul E

    更新日期:2008-09-15 00:00:00

  • Guidelines for management of scoliosis in Rett syndrome patients based on expert consensus and clinical evidence.

    abstract:STUDY DESIGN:Modified Delphi technique. OBJECTIVE:To develop guidelines for the clinical management of scoliosis in Rett syndrome through evidence review and consensus expert panel opinion. SUMMARY OF BACKGROUND DATA:Rett syndrome is a rare disorder and clinical expertise is thus with small case series. Scoliosis is ...

    journal_title:Spine

    pub_type: 杂志文章,实务指引

    doi:10.1097/BRS.0b013e3181a95ca4

    authors: Downs J,Bergman A,Carter P,Anderson A,Palmer GM,Roye D,van Bosse H,Bebbington A,Larsson EL,Smith BG,Baikie G,Fyfe S,Leonard H

    更新日期:2009-08-01 00:00:00

  • Beneficial influence of titanium mesh cage on infection healing and spinal reconstruction in hematogenous septic spondylitis: a retrospective analysis of surgical outcome of twenty-five consecutive cases and review of literature.

    abstract:STUDY DESIGN:Single institution, single surgeon retrospective review. OBJECTIVE:To investigate if the use of titanium mesh cage on the site of infection could be beneficial for successful outcome of the operative treatment for pyogenic spondylitis. SUMMARY OF BACKGROUND DATA:There is a controversy concerning the opti...

    journal_title:Spine

    pub_type: 杂志文章,评审

    doi:10.1097/BRS.0b013e318187875e

    authors: Korovessis P,Repantis T,Iliopoulos P,Hadjipavlou A

    更新日期:2008-10-01 00:00:00

  • Management of symptomatic lumbar pseudarthrosis with anteroposterior fusion. A functional and radiographic outcome study.

    abstract:STUDY DESIGN:An independent retrospective review of 37 patients undergoing 39 anteroposterior lumbar fusions for lumbar pseudarthrosis repair between 1984 and 1990. OBJECTIVES:To evaluate radiographically and functionally the results of the combined anteroposterior fusion for the management of symptomatic lumbar pseud...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200001010-00021

    authors: Albert TJ,Pinto M,Denis F

    更新日期:2000-01-01 00:00:00

  • A biomechanical study of regional endplate strength and cage morphology as it relates to structural interbody support.

    abstract:STUDY DESIGN:An in vitro biomechanical investigation to quantify the endplates resistance to compressive loads, in the thoracic and lumbar spine. Comparisons were made to determine the regional strength of the endplate, the optimal size and geometry of interbody support, and the effects of endplate removal on structura...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000143623.18098.e5

    authors: Lowe TG,Hashim S,Wilson LA,O'Brien MF,Smith DA,Diekmann MJ,Trommeter J

    更新日期:2004-11-01 00:00:00

  • The effect of muscle relaxant on the paraspinal muscle blood flow: a randomized controlled trial in patients with chronic low back pain.

    abstract:STUDY DESIGN:A randomized controlled trial. OBJECTIVE:To investigate the effect of muscle relaxant for muscle blood flow at the trunk muscle in patients with chronic low back pain (LBP). SUMMARY OF BACKGROUND DATA:Paraspinal muscle function is widely believed to play a role and considered to be of etiologic significa...

    journal_title:Spine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/BRS.0b013e318166e051

    authors: Sakai Y,Matsuyama Y,Nakamura H,Katayama Y,Imagama S,Ito Z,Okamoto A,Ishiguro N

    更新日期:2008-03-15 00:00:00

  • Spondylolysis associated with Arnold-Chiari malformation and syringomyelia. A report of two cases.

    abstract:STUDY DESIGN:This is a report of two cases. OBJECTIVE:To document the occurrence and association of spondylolysis and Arnold-Chiari malformation Type I. SUMMARY OF BACKGROUND DATA:The association of spinal dysraphism has been reported with Arnold-Chiari Type II, but not with Arnold-Chiari Type I. METHODS:The senior ...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199710150-00026

    authors: Bowen JD,Malanga GA

    更新日期:1997-10-15 00:00:00

  • Temporary Iliac Fixation to Salvage an Acute L4 Chance Fracture: Following Pedicle Screw Fixation for Adolescent Idiopathic Scoliosis.

    abstract:STUDY DESIGN:A case report. OBJECTIVE:The aim of this study was to describe a technique of temporary distal fixation to the ilium to salvage an acute L4 fracture following a T3-L4 kyphoscoliosis correction. SUMMARY OF BACKGROUND DATA:Pedicle fracture is a possible complication in pedicle screw fixation for scoliosis,...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/BRS.0000000000001786

    authors: Kato S,Lewis SJ

    更新日期:2017-03-01 00:00:00

  • Complete segmental resection of the spine, including the spinal cord, for telangiectatic osteosarcoma: a report of 2 cases.

    abstract:STUDY DESIGN:Two case reports of telangiectatic osteosarcoma treated with complete segmental resection of the spine, including the spinal cord. OBJECTIVES:To report the en bloc tumor excision, including the spinal cord, for telangiectatic osteosarcoma, and discuss the indication of cord transection and influence after...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/01.brs.0000200132.59292.4b

    authors: Murakami H,Tomita K,Kawahara N,Oda M,Yahata T,Yamaguchi T

    更新日期:2006-02-15 00:00:00

  • An international comparison of back surgery rates.

    abstract:SUMMARY OF BACKGROUND DATA:Although high geographic variation in back surgery rates within the United States have been documented, international comparisons have not been published. METHODS:The authors compared rates of back surgery in eleven developed countries to determine if back surgery rates are higher: 1) in the...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199405310-00001

    authors: Cherkin DC,Deyo RA,Loeser JD,Bush T,Waddell G

    更新日期:1994-06-01 00:00:00

  • Relationship between subjective neck disorders and cervical spine mobility and motion-related pain in male machine operators.

    abstract:STUDY DESIGN:In a single blinded procedure, quantified cervical clinical tests were performed on machine operators with and without subjective reports of neck pain. OBJECTIVES:To evaluate whether subjective reports of neck pain are associated with limited and painful cervical spine mobility. SUMMARY OF BACKGROUND DAT...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199707010-00015

    authors: Hagen KB,Harms-Ringdahl K,Enger NO,Hedenstad R,Morten H

    更新日期:1997-07-01 00:00:00

  • Thoracic and lumbar spine in diastrophic dysplasia: a clinical and magnetic resonance imaging analysis.

    abstract:STUDY DESIGN:Cross-sectional study to evaluate the thoracic and lumbar spine in patients with diastrophic dysplasia (DD). OBJECTIVES:To find the causative factors behind the spinal deformities and restricted mobility of the spine. SUMMARY OF BACKGROUND DATA:Typical findings in this skeletal dysplasia are short-limbed...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-200101150-00014

    authors: Remes V,Tervahartiala P,Poussa M,Peltonen J

    更新日期:2001-01-15 00:00:00

  • A complication of spinal decompression. A case report.

    abstract:STUDY DESIGN:This case study is designed to report the previously unreported specific complication of acute cauda equina compression after decompression surgery for spinal stenosis. OBJECTIVES:To inform others of the possibility of such a complication; to suggest a possible mechanism for this situation, namely hourgla...

    journal_title:Spine

    pub_type: 杂志文章

    doi:10.1097/00007632-199511001-00017

    authors: Woods DA,Wilson-MacDonald J

    更新日期:1995-11-15 00:00:00