Application of cell-free DNA sequencing in characterization of bloodborne microbes and the study of microbe-disease interactions.

abstract：:Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant cancers with no effective targets and treatments. However, the molecular pathogenesis of HCC remains largely uncertain. The aims of our study were to find crucial genes involved in HCC through multidimensional methods and revealed potential mole...

journal_title：PeerJ

authors： Liu ZK,Zhang RY,Yong YL,Zhang ZY,Li C,Chen ZN,Bian H

更新日期：2019-08-08 00:00:00

abstract：:In recent years, the use of lectins for screening of potential biomarkers has gained increased importance in cancer research, given the development in glycobiology that highlights altered structural changes of glycans in cancer associated processes. Lectins, having the properties of recognizing specific carbohydrate m...

journal_title：PeerJ

authors： Hashim OH,Jayapalan JJ,Lee CS

更新日期：2017-09-07 00:00:00

abstract：BACKGROUND:In Burkina Faso, it is not uncommon for mothers to drink alcohol, even during pregnancy. We aimed to study the association between maternal alcohol consumption during pregnancy and the child's cognitive performance using the Kaufman Assessment Battery for Children, 2nd edition (KABC-II) and the Children's Ca...

journal_title：PeerJ

authors： Sanou AS,Diallo AH,Holding P,Nankabirwa V,Engebretsen IMS,Ndeezi G,Tumwine JK,Meda N,Tylleskar T,Kashala-Abotnes E

更新日期：2017-06-30 00:00:00

abstract：Background:High throughput DNA sequencing of bulk invertebrate samples or metabarcoding is becoming increasingly used to provide profiles of biological communities for environmental monitoring. As metabarcoding becomes more widely applied, new reference DNA barcodes linked to individual specimens identified by taxonomi...

journal_title：PeerJ

authors： Carew ME,Coleman RA,Hoffmann AA

更新日期：2018-06-13 00:00:00

abstract：:Synechocystis gathered momentum in modelling studies and biotechnological applications owing to multiple factors like fast growth, ability to fix carbon dioxide into valuable products, and the relative ease of genetic manipulation. Synechocystis physiology and metabolism, and consequently, the productivity of Synechoc...

journal_title：PeerJ

authors： Cordara A,Re A,Pagliano C,Van Alphen P,Pirone R,Saracco G,Branco Dos Santos F,Hellingwerf K,Vasile N

更新日期：2018-07-27 00:00:00

abstract：:Due to its remote and isolated location, Antarctica is home to a unique diversity of species. The harsh conditions have shaped a primarily highly adapted endemic fauna. This includes the notothenioid family Channichthyidae. Their exceptional physiological adaptations have made this family of icefish the focus of many ...

journal_title：PeerJ

authors： Kuhn T,Zizka VMA,Münster J,Klapper R,Mattiucci S,Kochmann J,Klimpel S

更新日期：2018-05-11 00:00:00

abstract：Background:Patellofemoral pain (PFP) is often reported as a diffuse pain at the front of the knee during knee-loading activities. A patient's description of pain location and distribution is commonly drawn on paper by clinicians, which is difficult to quantify, report and compare within and between patients. One way of...

journal_title：PeerJ

authors： Matthews M,Rathleff MS,Vicenzino B,Boudreau SA

更新日期：2018-03-08 00:00:00

abstract：:LIMKi 3 is a specific selective LIMK inhibitor against LIMK1 and LIMK2, while LIMK1 and LIMK2 are the main regulators of actin cytoskeleton to participate in many cell activities. However, the effect of LIMKi 3 in porcine oocyte meiosis is still unclear. The present study was designed to investigate the effects of LIM...

journal_title：PeerJ

authors： Jia RX,Duan X,Song SJ,Sun SC

更新日期：2016-10-12 00:00:00

abstract：:Introduction. Colorectal cancer is one of the most frequent cancers in the world and liver metastases are seen in up to 19% of patients with colorectal cancers. Detection of liver metastases is not only vital for sufficient treatment and survival, but also for a better estimation of prognosis. The aim of this study wa...

journal_title：PeerJ

authors： Achiam MP,Løgager VB,Skjoldbye B,Møller JM,Lorenzen T,Rasmussen VL,Thomsen HS,Mollerup TH,Okholm C,Rosenberg J

更新日期：2016-01-14 00:00:00

abstract：:This study aimed to characterize the antioxidant properties of Rama Forte persimmon, a tannin-rich fruit variety produced in Brazil. Extracts prepared with lyophilized pulps from fruits obtained in local markets were analyzed individually to evaluate the extent of antioxidant protection and investigate the antioxidant...

journal_title：PeerJ

authors： Dalvi LT,Moreira DC,Alonso A,de Avellar IGJ,Hermes-Lima M

更新日期：2018-07-25 00:00:00

abstract：Background:B-mode ultrasound is one of the most commonly used imaging techniques for evaluating thyroid nodules due to its noninvasive property and excellent performance in terms of discriminating between benign and malignant nodules. However, the accuracy of differential diagnosis strongly depends on the experience of...

journal_title：PeerJ

authors： Wang J,He X,Ma L,Li M,Sun L,Jiang J,Zhou Q

更新日期：2020-05-04 00:00:00

abstract：:Streptococcus pneumoniae remains the leading causative pathogen in pediatric pneumonia and bacteremia throughout the world. The invasive pneumococcal disease (IPD) is known as isolation of S. pneumoniae from a normally sterile site (e.g., blood, cerebrospinal fluid, synovial fluid, pericardial fluid, pleural fluid, or...

journal_title：PeerJ

authors： Chiu NC,Chi H,Peng CC,Chang HY,Huang DT,Chang L,Lei WT,Lin CY

更新日期：2017-01-25 00:00:00

abstract：:A strong argument can be made that the European Union has the most rigorous regulatory system for pesticides in the world, and that modern pesticide use poses fewer environmental threats than older regimes. Nevertheless, the impacts of pesticides on bees and other non-target organisms are much debated in Europe as els...

journal_title：PeerJ

authors： Goulson D,Thompson J,Croombs A

更新日期：2018-07-19 00:00:00

abstract：:According to current molecular evidence, the Chionaspis pinifoliae heterophyllae species complex has been recognized as 10 cryptic species. In this study, we construct potential distribution maps for seven cryptic species based on climatic variables. This was done to assess the main environmental factors that have con...

journal_title：PeerJ

authors： Zhao Q,Zhang H,Wei J

更新日期：2019-05-31 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two late onset neurodegenerative diseases, have been shown to share overlapping cellular pathologies and genetic origins. Studies suggest that a hexanucleotide repeat expansion in the first intron of the C9orf72 gene is the most common cause of fam...

journal_title：PeerJ

authors： Iyer S,Subramanian V,Acharya KR

更新日期：2018-10-17 00:00:00

abstract：Background:Among Buddhist or Taoist Taiwanese residents, burning incense is a common source of indoor particulate matter (PM), including PM10 and PM2.5, and can adversely affect the health status of patients with chronic obstructive pulmonary diseases (COPD). However, few studies have focused on the effects of intermit...

journal_title：PeerJ

authors： Guo SE,Chi MC,Lin CM,Yang TM

更新日期：2020-08-31 00:00:00

abstract：:In the field of invasion ecology, the determination of a species' environmental tolerance, is a key parameter in the prediction of its potential distribution, particularly in the context of global warming. In poikilothermic species such as insects, temperature is often considered the most important abiotic factor that...

journal_title：PeerJ

authors： Lefort MC,Brown S,Boyer S,Worner S,Armstrong K

更新日期：2014-11-25 00:00:00

abstract：:Aedes aegypti is the major vector of dengue, yellow fever and chikungunya viruses that put millions of people in endemic countries at risk. Mass rearing of this mosquito is crucial for strategies that use modified insects to reduce vector populations and transmission of pathogens, such as sterile insect technique or p...

journal_title：PeerJ

authors： Gonzales KK,Tsujimoto H,Hansen IA

更新日期：2015-05-05 00:00:00

abstract：:Complete chloroplast genome sequences have been very useful for understanding phylogenetic relationships in angiosperms at the family level and above, but there are currently large gaps in coverage. We report the chloroplast genome for Helwingia himalaica, the first in the distinctive family Helwingiaceae and only the...

journal_title：PeerJ

authors： Yao X,Liu YY,Tan YH,Song Y,Corlett RT

更新日期：2016-11-29 00:00:00

abstract：:Following a radiation incident, preliminary dose estimates made by γ-H2AX foci analysis can supplement the early triage of casualties based on clinical symptoms. Sample processing time is important when many individuals need to be rapidly assessed. A protocol was therefore developed for high sample throughput that req...

journal_title：PeerJ

authors： Moquet J,Barnard S,Rothkamm K

更新日期：2014-03-06 00:00:00

abstract：:A new species of freshwater crab, Fredius ibiapaba, is described and illustrated from a mid-altitude forested patch in Ipú (Ibiapaba plateau, Ceará, northeastern Brazil), between 635 to 782 m. The new species can be separated from its congeners by the morphology of its first gonopod: proximal half remarkably swollen, ...

journal_title：PeerJ

authors： Santos LC,Tavares M,Silva JRF,Cervini M,Pinheiro AP,Santana W

更新日期：2020-06-29 00:00:00

abstract：:Burkholderia pseudomallei, the causative agent of melioidosis, is intrinsically resistant to many conventional antibiotics. Therefore, alternative antimicrobial agents such as antimicrobial peptides (AMPs) are extensively studied to combat this issue. Our study aims to identify and understand the mode of action of the...

journal_title：PeerJ

authors： Lee LF,Mariappan V,Vellasamy KM,Lee VS,Vadivelu J

更新日期：2016-10-25 00:00:00

abstract：Background:Sepsis represents a significant healthcare problem worldwide and causes a high number of deaths every year but remains to be fully understood. During and after sepsis, the host immune response is complex and involves an initial excessive host inflammatory response to infection that is closely related to tiss...

journal_title：PeerJ

authors： Wan R,Li L,Xing C,Peng R,Gao L

更新日期：2019-06-17 00:00:00

abstract：:Carrot is an important root vegetable crop abundant in bioactive compounds including carotenoids, vitamins, and dietary fibers. Carrot intake and its products are gradually growing owing to its high antioxidant activity. Auxins are a class of plant hormones that control many processes of plant growth and development. ...

journal_title：PeerJ

authors： Khadr A,Wang GL,Wang YH,Zhang RR,Wang XR,Xu ZS,Tian YS,Xiong AS

更新日期：2020-12-08 00:00:00

abstract：Background:Guanylurea is the main transformation product of the antidiabetic drug metformin, which is one of the most prescribed pharmaceuticals worldwide. Due to the high rate of microbial degradation of metformin in sewage treatment plants, guanylurea occurs in higher concentrations in surface waters than its parent ...

journal_title：PeerJ

authors： Jacob S,Knoll S,Huhn C,Köhler HR,Tisler S,Zwiener C,Triebskorn R

更新日期：2019-07-11 00:00:00

abstract：Background:As the most frequently occurred tumor in biliary tract, cholangiocarcinoma (CCA) is mainly characterized by its late diagnosis and poor outcome. It is therefore urgent to identify specific genes and pathways associated with its progression and prognosis. Materials and Methods:The differentially expressed ge...

journal_title：PeerJ

authors： Liu J,Liu W,Li H,Deng Q,Yang M,Li X,Liang Z

更新日期：2019-10-31 00:00:00

abstract：Background:Epidemiological surveillance of HIV infection in Japan involves two technical problems for directly applying a classical backcalculation method, i.e., (i) all AIDS cases are not counted over time and (ii) people diagnosed with HIV have received antiretroviral therapy, extending the incubation period. The pre...

journal_title：PeerJ

authors： Nishiura H

更新日期：2019-01-15 00:00:00

abstract：BACKGROUND:Aspergillus niger, along with many other lignocellulolytic fungi, has been widely used as a commercial workhorse for cellulase production. A fungal cellulase system generally includes three major classes of enzymes i.e., β-glucosidases, endoglucanases and cellobiohydrolases. Cellobiohydrolases (CBH) are vita...

journal_title：PeerJ

authors： Woon JS,Mackeen MM,Illias RM,Mahadi NM,Broughton WJ,Murad AMA,Abu Bakar FD

更新日期：2017-10-12 00:00:00

abstract：:Irruptions of small consumer populations, driven by pulsed resources, can lead to adverse effects including the decline of indigenous species or increased disease spread. Broad-scale pest management to combat such effects benefits from forecasting of irruptions and an assessment of the optimal control conditions for m...

journal_title：PeerJ

authors： Holland EP,Binny RN,James A

更新日期：2018-12-20 00:00:00

abstract：:Sex reversal is a complex biological phenomenon exhibited by Cynoglossus semilaevis. Some genetic females may irreversibly convert to pseudomales, thus increasing aquaculture costs because males grow much more slowly than females. In this study, an integrative analysis of transcriptome and proteome was performed to co...

journal_title：PeerJ

authors： Ye Z,Wang W,Zhang Y,Wang L,Cui Y,Li H

更新日期：2020-03-19 00:00:00