Perioperative change in lymphocyte count and prognosis in esophageal squamous cell carcinoma.

Abstract:

Background:Preoperative lymphocyte count (pre-LC) predicts the relapse and survival in patients with esophageal squamous cell carcinoma (ESCC), the clinical application of postoperative lymphocyte count (post-LC) change (LCc) remains unclear. Methods:A retrospective analysis of patients with newly diagnosed ESCC who received curative resection from 2008 to 2015 was conducted. Complete blood counts from preoperative within seven days to postoperative within seven days were analyzed. LCc was defined as LCc increased (post-LC higher than pre-LC) and LCc decreased (post-LC lower than pre-LC). LCc was evaluated for an association with disease-free survival (DFS). Results:A total of 677 patients who reach the standard were enrolled into the study. There were 579 (85.5%) male and 98 (14.5%) female patients with ESCC. The median age was 61 years (range, 39-84 years). In univariate analysis, LCc significantly correlated to DFS (P=0.006, HR =0.593, 95% CI: 0.409-0.862). In multivariate analysis (COX model), LCc was an independent prognostic factor for DFS (P=0.011, HR =0.617, 95% CI: 0.424-0.897). Conclusions:The dynamic change of LC after surgery may serve as a simple and new prognostic factor in patients with newly diagnosed ESCC.

journal_name

J Thorac Dis

authors

Song Q,Wu JZ,Wang S

doi

10.21037/jtd.2019.06.02

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

2332-2339

issue

6

eissn

2072-1439

issn

2077-6624

pii

jtd-11-06-2332

journal_volume

11

pub_type

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