当前位置： SCI文献检索 > Journal of Thoracic Disease期刊下所有文献 > Liquid biopsy is a valuable tool in the diagnosis and management of lung cancer.

Liquid biopsy is a valuable tool in the diagnosis and management of lung cancer.

Abstract：

:Liquid biopsy refers to the use of various body fluids to test for circulating biological elements derived from the tumor. Liquid biopsy has taken on an increasingly important role in lung cancer diagnosis, molecular characterization, surveillance, monitoring, and determining mechanisms of resistance. These assays can utilize various sources of cell-free DNA (cfDNA) including blood, pleural fluid, urine, and others to detect tumor associated alterations. With the increasing power of next-generation sequencing technologies and the development of assays such as digital droplet PCR, rare tumor alleles can be detected in cfDNA to determine key characteristics of the tumor. Current assays, while effective, are still challenged by limited sensitivity and capacity to single genes or small panels of genes, though this is rapidly expanding. Nevertheless, testing of cfDNA has been shown to be valuable in detecting resistance to targeted inhibitors, particularly for detection of T790M in EGFR and monitoring response to therapy. With the continued development of more powerful and sensitive assays, these techniques will empower clinicians to better characterize early stage disease and can be used in the screening of high-risk patients, which may eliminate the requirement for tissue diagnosis in some settings. That said, since the majority of these alterations are not specific to lung cancer, there will continue to be a need for tissue in at least the initial diagnosis. Used in conjugation with tissue sampling, these assays will assist the treating clinician and the pathologist to better characterize individual tumors, even in the setting of limited tissue.

journal_name

J Thorac Dis

journal_title

Journal of thoracic disease

authors

Cecchini MJ,Yi ES

doi

10.21037/jtd.2020.04.20

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

7048-7056

issue

11

eissn

2072-1439

issn

2077-6624

pii

jtd-12-11-7048

journal_volume

12

pub_type

杂志文章,评审

相关文献

Journal of Thoracic Disease文献大全
  • Limiting the risk of cardiac toxicity with esophageal-sparing intensity modulated radiotherapy for locally advanced lung cancers.

    abstract：BACKGROUND:Intensity modulated radiotherapy (IMRT) is routinely utilized in the treatment of locally advanced non-small cell lung cancer (NSCLC). RTOG 0617 found that overall survival was impacted by increased low (5 Gy) and intermediate (30 Gy) cardiac doses. We evaluated the impact of esophageal-sparing IMRT on cardi...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2016.03.64

    authors： Woodford K,Panettieri V,Ruben JD,Senthi S

    更新日期：2016-05-01 00:00:00

  • The benefits of digital drainage system versus traditional drainage system after robotic-assisted pulmonary lobectomy.

    abstract：Background:Postoperative air leaks are the most common complication after a pulmonary resection. There is no data in the literature comparing the traditional and digital chest drainage system after a robotic-assisted pulmonary lobectomy. Methods:This was a retrospective, correlational study. Medical records from 182 e...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2019.11.69

    authors： Jacobsen K,Talbert S,Boyer JH

    更新日期：2019-12-01 00:00:00

  • Outcome of shorter treatment duration in non-cavitary nodular bronchiectatic Mycobacterium avium complex lung disease.

    abstract：Background:The recommended treatment duration for non-cavitary nodular bronchiectatic (NC-NB) Mycobacterium avium complex (MAC) lung disease (LD) is at least 12 months after culture conversion, but evidence supporting this is limited. This study investigated whether treatment for less than 12 months after culture conve...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2020.01.39

    authors： Park YE,Chong YP,Kim YJ,Kim OH,Kwon BS,Shim TS,Jo KW

    更新日期：2020-03-01 00:00:00

  • Right lung upper lobe carcinoma radical excision plus superior vena cava angioplasty.

    abstract：:An elderly male patient was found to be with "nodule in upper lobe of right lung" during his health examination, although without any symptom. Chest CT at admission showed that the nodules were close to the superior vena cava, and CT reconstruction displayed an adipose space between the nodules and the superior vena c...

    journal_title：Journal of thoracic disease

    pub_type：

    doi：10.3978/j.issn.2072-1439.2013.11.22

    authors： Peng GL,Yin WQ,Zhang X,He JX

    更新日期：2013-12-01 00:00:00

  • Minimized extracorporeal circulation in non-coronary surgery.

    abstract：:Minimally invasive extracorporeal circulation (MiECC) technology is characterized by improved biocompatibility due to closed-loop design, minimized priming, and markedly reduced artificial surface. Despite well-evidenced clinical advantages in coronary surgery, MiECC penetration in complex open-heart surgery is low. C...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章,评审

    doi：10.21037/jtd.2019.02.04

    authors： Liebold A,Albrecht G

    更新日期：2019-06-01 00:00:00

  • Thoracoscopic segmentectomy with simple routine bronchoscopic inflation for intersegmental plane identification: short and mid-term outcomes compared with lobectomy.

    abstract：Background:The technical concepts of thoracoscopic segmentectomy are still evolving. In this study we present a simple bronchoscopy-based intersegmental demarcation technique with short- and mid-term outcomes compared between thoracoscopic segmentectomy and lobectomy. Methods:All 105 consecutive patients with lung can...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd-20-656

    authors： Helminen O,Valo J,Andersen H,Lautamäki A,Räsänen J,Sihvo E

    更新日期：2020-06-01 00:00:00

  • Statistical modelling for thoracic surgery using a nomogram based on logistic regression.

    abstract：:A well-developed clinical nomogram is a popular decision-tool, which can be used to predict the outcome of an individual, bringing benefits to both clinicians and patients. With just a few steps on a user-friendly interface, the approximate clinical outcome of patients can easily be estimated based on their clinical a...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2016.07.91

    authors： Liu RZ,Zhao ZR,Ng CS

    更新日期：2016-08-01 00:00:00

  • Transmanubrial osteomuscular sparing approach for resection of cervico-thoracic lesions.

    abstract：Background:To review our experience of transmanubrial osteomuscular sparing approach (TMA) for resection of various lesions involving the thoracic inlet and to prove the feasibility and safety of the approach. Methods:Retrospective review of 58 consecutive cases, from April 2007 to January 2016, with surgical resectio...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2017.08.99

    authors： Pan X,Gu C,Wang R,Zhao H,Yang J,Shi J

    更新日期：2017-09-01 00:00:00

  • Epidemiological aspects of obstructive sleep apnea.

    abstract：:Obstructive sleep apnea (OSA) is probably the most common respiratory disorder, with recent data from the United States and Europe suggesting that between 14% and 49% of middle-aged men have clinically significant OSA. The intimate relationship between OSA and obesity means that its prevalence will only increase as th...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章,评审

    doi：10.3978/j.issn.2072-1439.2015.04.52

    authors： Garvey JF,Pengo MF,Drakatos P,Kent BD

    更新日期：2015-05-01 00:00:00

  • Prognostic significance of CT-determined emphysema in patients with small cell lung cancer.

    abstract：Background:Although emphysema and small cell lung cancer (SCLC) are prevalent in smokers, no previous study has investigated the prognostic impact of computed tomography (CT)-determined emphysema in SCLC. This study was undertaken to analyze the prognostic value of emphysema scores as determined by baseline CT scans in...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2018.01.97

    authors： Lee HY,Kim EY,Kim YS,Ahn HK,Kim YK

    更新日期：2018-02-01 00:00:00

  • CT findings of pulmonary nocardiosis: a report of 9 cases.

    abstract：Background:Pulmonary nocardiosis often occurs among immunocompromised patients, especially in those with impaired cell immunity related to AIDS and transplant. As the number of patients receiving transplant, the occurrence of pulmonary nocardiosis may also increase. Radiologic characteristics of this entity have not be...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2017.09.122

    authors： Liu B,Zhang Y,Gong J,Jiang S,Huang Y,Wang L,Xu J,Qiu C

    更新日期：2017-11-01 00:00:00

  • Long-term outcomes of multiple and single arterial off-pump coronary artery bypass grafting.

    abstract：Background:To compare the clinical outcomes between multiple arterial (MA) and single arterial (SA) off-pump coronary artery bypass grafting (OPCAB) when applied to left main coronary disease or three-vessel disease. Methods:A total of 537 patients with left main coronary disease or three-vessel disease underwent MA O...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2019.01.101

    authors： Zhu P,Chen A,Wang Z,Ye X,Zhou M,Liu J,Zhao Q

    更新日期：2019-03-01 00:00:00

  • A 20-year study on treating childhood infective endocarditis with valve replacement in a single cardiac center in China.

    abstract：BACKGROUND:Children with infective endocarditis (IE) have to undergo valve replacement instead of valve repair in China due to severe valve damage. The present study is to review our experience on surgical treatment of children with IE in reference to the incidence, pathologic status, diagnosis, surgical strategies and...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2016.06.15

    authors： Xiao J,Yin L,Lin Y,Zhang Y,Wu L,Wang Z

    更新日期：2016-07-01 00:00:00

  • Efficacy and safety of high-dose budesonide/formoterol in patients with bronchiolitis obliterans syndrome after allogeneic hematopoietic stem cell transplant.

    abstract：Background:Bronchiolitis obliterans syndrome (BOS) is a rare, progressive and irreversible airway disease associated with significant mortality after allogeneic hematopoietic stem-cell transplantation (HSCT). In this study, we investigated the therapeutic effect of high-dose budesonide/formoterol (320/9 µg bid) in pati...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd-19-3475

    authors： Kim KH,Lee J,Kim HJ,Lee S,Kim YJ,Lee JH,Rhee CK

    更新日期：2020-08-01 00:00:00

  • Clinical utility of robot-assisted transthoracic esophagectomy in advanced esophageal cancer after neoadjuvant chemoradiation therapy.

    abstract：Background:Although robot-assisted minimally-invasive esophagectomy (RAMIE) surgeries are expanding clinically, few studies have reported patients with locally-advanced esophageal cancer who underwent neoadjuvant chemoradiation therapy (nCRT). Methods:From 2013 to 2017, 219 patients with esophageal squamous cell carci...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2019.07.53

    authors： Yun JK,Lee IS,Gong CS,Kim BS,Kim HR,Kim DK,Park SI,Kim YH

    更新日期：2019-07-01 00:00:00

  • Use of efficient purse-string stapling technique for esophagogastric anastomosis in minimally invasive Ivor Lewis esophagectomy.

    abstract：:Minimally invasive esophagectomy (MIE) is increasingly accepted in the treatment of locoregional or advanced esophageal cancer. Laparoscopic-thoracoscopic Ivor-Lewis esophagectomy has been proved to be effective in treating middle and distal esophageal cancer, however, intrathoracic esophagogastric anastomosis is tech...

    journal_title：Journal of thoracic disease

    pub_type：

    doi：10.3978/j.issn.2072-1439.2013.12.10

    authors： Shen G,Pan SB,Wu M,Zhang S,Xu XF,Chen G

    更新日期：2013-12-01 00:00:00

  • Serum metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in lung carcinoma patients.

    abstract：Background:Assessment of serum extracellular matrix (ECM) metalloproteinase MMP-2 and tissue inhibitor of matrix metalloproteinase TIMP-2 concentrations in non-small cell lung carcinoma (NSCLC) patients considering TNM staging. Assessment of the prognostic value of MMP-2 and TIMP-2 concentrations in NSCLC patients. Me...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2017.11.128

    authors： Drzewiecka-Jędrzejczyk M,Wlazeł R,Terlecka M,Jabłoński S

    更新日期：2017-12-01 00:00:00

  • Good neurological recovery after rescue thrombolysis of presumed pulmonary embolism despite prior 100 minutes CPR.

    abstract：:We reported the case of a 70-year-old man who was admitted to neurologic wards for recurrent syncope for 3 years. Unfortunately, just 2 hours after his admission, he suddenly collapsed and failed to return of spontaneous circulation (ROSC) after a 100-minute standard cardiopulmonary resuscitation (CPR). Fortunately, h...

    journal_title：Journal of thoracic disease

    pub_type：

    doi：10.3978/j.issn.2072-1439.2014.12.23

    authors： Wu JP,Gu DY,Wang S,Zhang ZJ,Zhou JC,Zhang RF

    更新日期：2014-12-01 00:00:00

  • Combined thoracoscopic and laparoscopic minimally invasive esophagectomy.

    abstract：:With the improvement in thoracoscopic and laparoscopic surgery, thoracoscopic and laparoscopic esophagectomy (TLE), a minimally invasive approach, has attracted increasing attention as an alternative to open three-field esophagectomy. From June 2012 to October 2013, 90 patients underwent laparoscopic and thoracoscopic...

    journal_title：Journal of thoracic disease

    pub_type：

    doi：10.3978/j.issn.2072-1439.2014.02.04

    authors： Zeng F,He B,Wang Y,Xue Y,Cong W

    更新日期：2014-02-01 00:00:00

  • Airway complications after lung transplantation: benefit of a conservative bronchoscopy strategy.

    abstract：Background:After lung transplantation (LT), between 2% and 25% of bronchial anastomoses develop complications requiring therapeutic intervention. The status of healing of both bronchial anastomoses and downhill airways are well described by the French consensual MDS standardized grading system (Macroscopic, Diameter, S...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2020.03.21

    authors： Patoir A,Luchez A,Tiffet O,Vercherin P,Grima R,Tronc F,Philit F,Mornex JF,Vergnon JM,Maury JM

    更新日期：2020-05-01 00:00:00

  • A phase I dose escalation study of S-1 with concurrent radiotherapy in elderly patients with esophageal cancer.

    abstract：BACKGROUND:Concurrent chemoradiotherapy (CRT) with 5-fluorouracil (5-FU) and cisplatin (CDDP) are often associated with significant incidence of toxic effects in elderly patients with esophageal cancer. This phase I trial was designed to determine the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of S-1...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2016.02.70

    authors： Ji Y,Qiu G,Sheng L,Sun X,Zheng Y,Chen M,Du X

    更新日期：2016-03-01 00:00:00

  • Detection, classification, and management of rejection after lung transplantation.

    abstract：:Rejection is a major complication following lung transplantation. Acute cellular rejection, lymphocytic bronchiolitis, and antibody-mediated rejection (AMR) are all risk factors for the subsequent development of chronic lung allograft dysfunction (CLAD). Acute cellular rejection and lymphocytic bronchiolitis have well...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章,评审

    doi：10.21037/jtd.2019.03.83

    authors： Parulekar AD,Kao CC

    更新日期：2019-09-01 00:00:00

  • Lentivirus vector-mediated Rho guanine nucleotide dissociation inhibitor 2 overexpression induces beta-2 adrenergic receptor desensitization in airway smooth muscle cells.

    abstract：BACKGROUND:Beta-2 adrenergic receptor (β2AR) downregulation is critical to asthma rescue therapy; however, tolerance, also known as β2AR or bronchodilator desensitization, mechanisms potentially resulting in life-threatening rescue treatment failure remain poorly understood. METHODS:Airway smooth muscle cells (ASMCs) ...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.3978/j.issn.2072-1439.2013.10.07

    authors： Ni S,Zhang Y,Wang H,Zhou J,Ding L,Liu H

    更新日期：2013-10-01 00:00:00

  • Could thymomectomy be a reasonable option for non-myasthenic thymoma patients?

    abstract：Background:Complete resection is the mainstay of treatment for thymoma, but few studies have investigated the extent of resection on normal thymus. Extended thymectomy is considered the treatment of choice for myasthenic patients with thymoma, while the optimal therapy for non-myasthenic patients is still a matter of d...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2017.09.109

    authors： Tassi V,Ceccarelli S,Zannori C,Gili A,Daddi N,Bellezza G,Ascani S,Liberati AM,Puma F

    更新日期：2017-10-01 00:00:00

  • Non-intercostal access for video-assisted thoracic surgery-analysis of technical advantages and disadvantages.

    abstract：Background:Video-assisted thoracoscopic surgery (VATS) lobectomy has become an accepted method for the treatment of early-stage non-small-cell lung cancer (NSCLC). The standard VATS approach is an intercostal one which is often followed by postoperative pain due to injury of the intercostal nerve. The non-intercostal t...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd.2018.09.139

    authors： Zieliński M,Gwozdz P,Wilkojc M,Kosinski S,Fryzlewicz E,Nabialek T,Pankowski J,Kwiatkowski R

    更新日期：2018-11-01 00:00:00

  • Radical resection of right upper lung cancer using uniportal video-assisted thoracic surgery with non-intubated anesthesia.

    abstract：BACKGROUND:Presently, the clinical effect of radical video-assisted thoracic surgery (VATS) is equal to that of traditional open chest surgery and has received worldwide recognition of its advantages: less trauma and faster recovery. In the attempt to further the advancement of minimally invasive surgery the operative ...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.3978/j.issn.2072-1439.2015.12.51

    authors： Wang W,Peng G,Guo Z,Liang L,Dong Q,He J,Yin W

    更新日期：2015-12-01 00:00:00

  • Combining targeted agents and hypo- and hyper-fractionated radiotherapy in NSCLC.

    abstract：:Radical radiotherapy remains the cornerstone of treatment for patients with unresectable locally advanced non small cell lung cancer (NSCLC) either as single modality treatment for poor performance status patients or with sequential or concomitant chemotherapy for good performance status patients. Advances in understa...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章,评审

    doi：10.3978/j.issn.2072-1439.2013.12.05

    authors： McDonald F,Popat S

    更新日期：2014-04-01 00:00:00

  • Transcatheter aortic valve resection: new mechanical devices.

    abstract：Background:To improve periprocedural outcomes of transcatheter aortic valve implantation (TAVI), transcatheter mechanical resection devices were tested for prior ablation of the aortic cusps. Methods:Three mechanical transcatheter resection devices were tested in a series of native porcine (n=30) and reassembled calci...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd-20-2036

    authors： Dai H,Lutter G,Frank D,Freitag-Wolf S,Topal A,Haneya A,Sathananthan J,Puehler T

    更新日期：2020-11-01 00:00:00

  • The utility of three-dimensional computed tomography for prediction of tumor invasiveness in clinical stage IA lung adenocarcinoma.

    abstract：Background:It is critical to have an accurate measurement of solid tumor size in order to predict the invasiveness of small lung adenocarcinomas. Some lesions cannot be measured accurately via High-resolution computed tomography (HRCT) due to their irregular shape and unclear borders. For this reason, we evaluated the ...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.21037/jtd-20-2131

    authors： Kawaguchi Y,Nakao M,Omura K,Iwamoto N,Ozawa H,Kondo Y,Ichinose J,Matsuura Y,Okumura S,Mun M

    更新日期：2020-12-01 00:00:00

  • Video-assisted thoracoscopic surgery tracheal resection and carinal reconstruction for tracheal adenoid cystic carcinoma.

    abstract：:We report a case of video-assisted thoracoscopic surgery (VATS) tracheal resection and carinal reconstruction in a patient with tracheal tumor. The patient presented with adenoid cystic carcinoma (ACC) of the distal trachea, extending along the right main bronchus with carinal invasion. The reconstruction procedure wa...

    journal_title：Journal of thoracic disease

    pub_type： 杂志文章

    doi：10.3978/j.issn.2072-1439.2016.01.45

    authors： He J,Wang W,Li J,Yin W,Xu X,Peng G,Chen Y,He P

    更新日期：2016-01-01 00:00:00