Abstract：
Background:To improve periprocedural outcomes of transcatheter aortic valve implantation (TAVI), transcatheter mechanical resection devices were tested for prior ablation of the aortic cusps. Methods:Three mechanical transcatheter resection devices were tested in a series of native porcine (n=30) and reassembled calcified human valves (n=54). The resection time, the resected valve area, the number of released cusps, and the degree of surrounding tissue damage were measured. Afterwards, postmortem transapical-transcatheter-resections of the aortic valve in two humans were performed. Results:In the native porcine hearts, the Aesculap II device demonstrated significantly shorter resection time compared to the R&R II and the Randstad devices (6.5±2.0 vs. 28.6±24.1 vs. 23.3±14.4 sec; P=0.001). However, it created more lesions in the surrounding tissue (P=0.002). The R&R II achieved a smaller number of resected cusps than the other two devices (2.7±0.7 vs. 1.1±0.7 vs. 2.4±0.5; P<0.001, respectively). It also resected a smaller area of the aortic valve (306.5±149.2 vs. 106.7±29.6 vs. 256.8±81.3 mm2; P=0.09) but a larger mean area of the resected fragments (110.3±41.5 vs. 160.7±29.6 vs. 111.5±43.9 mm2; P=0.01). The resection of the reassembled human valves demonstrated the same results between the devices regarding resection time (P=0.001) and resected area (P=0.016), but not fragment sizes (P=0.610). Finally, transapical-transcatheter-resection of aortic valve was performed in two cadavers. Conclusions:Transcatheter aortic valve resection is feasible with variable aortic leaflet resection times and mild risk of lesions of the surrounding tissue.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Dai H,Lutter G,Frank D,Freitag-Wolf S,Topal A,Haneya A,Sathananthan J,Puehler Tdoi
10.21037/jtd-20-2036subject
Has Abstractpub_date
2020-11-01 00:00:00pages
6586-6597issue
11eissn
2072-1439issn
2077-6624pii
jtd-12-11-6586journal_volume
12pub_type
杂志文章abstract：Background:Aspirin therapy improves saphenous vein graft (SVG) patency in patients undergoing coronary artery bypass graft (CABG), however, its use in the pre-operative period remains controversial. Therefore, we conducted a systematic review and meta-analysis of randomized-controlled trials (RCTs) to update the eviden...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.05.187
更新日期：2018-06-01 00:00:00
abstract：Background:Previous retrospective study suggested that acute lung injury (ALI) is frequent (78.49%) in patients undergoing aortic dissection surgery, and accompanied by a number of untoward consequences, and even induces death. Methods:This prospective single-center cross-sectional study, registered in the ClinicalTri...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.06.140
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:The aim of the present study was to determine the safety and feasibility of the use of laryngeal mask airway (LMA) for non-endotracheal intubated anesthesia for patients with pectus excavatum (PE) undergoing thoracoscopic Nuss procedure. METHODS:Between July 2015 and December 2015, 30 selected patients with...
journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.07.52
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.03.123
更新日期：2018-04-01 00:00:00
abstract：:Every patient undergoing curative treatment for primary lung cancer is a candidate for metachronous lung cancer, with a reported risk of 5% per year. The majority of cases are stage I patients. Patients who undergo resection for lung cancer should be followed regularly. A metachronous lung cancer that develops as bila...
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doi：10.3978/j.issn.2072-1439.2013.04.16
更新日期：2013-06-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.04.137
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journal_title：Journal of thoracic disease
pub_type：
doi：10.21037/jtd.2018.05.20
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.05.122
更新日期：2018-06-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2014.05.12
更新日期：2014-06-01 00:00:00
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journal_title：Journal of thoracic disease
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更新日期：2020-03-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.05.12
更新日期：2019-05-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.08.15
更新日期：2017-09-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2010.12.03
更新日期：2011-03-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.06.85
更新日期：2018-07-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.09.66
更新日期：2016-10-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type：
doi：10.3978/j.issn.2072-1439.2013.11.15
更新日期：2013-12-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2020.01.10
更新日期：2020-04-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.08.68
更新日期：2018-09-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.03.46
更新日期：2016-05-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2017.11.06
更新日期：2017-12-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2019.10.62
更新日期：2019-11-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.12.66
更新日期：2018-12-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2016.03.56
更新日期：2016-05-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.3978/j.issn.2072-1439.2012.03.15
更新日期：2012-06-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2018.11.32
更新日期：2019-02-01 00:00:00
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journal_title：Journal of thoracic disease
pub_type： 杂志文章
doi：10.21037/jtd.2018.11.77
更新日期：2018-12-01 00:00:00
abstract：:Cases of tracheobronchial foreign body aspiration are frequently encountered emergency cases of childhood; and, delays in its recognition and treatment do result in serious morbidity and mortality. Diagnosis mainly relies on taking history which should indicate what the foreign body is, when it has been aspirated and ...
journal_title：Journal of thoracic disease
pub_type： 杂志文章,评审
doi：10.21037/jtd.2016.12.69
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