Women successfully treated for severe intrahepatic cholestasis of pregnancy do not have increased risks for adverse perinatal outcomes.

Abstract:

:Intrahepatic cholestasis of pregnancy (ICP) increases adverse perinatal outcome (APO) incidence. Whether successful treatment of severe ICP reduces APO risk is unclear.This retrospective, single-center study in China enrolled consecutive women with ICP who had term delivery (≥37 weeks, singleton) between August 2013 and June 2016. Patients were divided into the mild ICP (serum bile acids (SBA) ≤40 μmol/L throughout pregnancy) and severe ICP (SBA >40 μmol/L during pregnancy but fell after ursodeoxycholate therapy) groups. Baseline characteristics, laboratory investigations, and maternal and neonatal outcomes were assessed. Logistic regression was used to identify factors associated with meconium staining of amniotic fluid (MSAF) and APOs.Seventy-three patients were included (mild ICP group, n=47; severe ICP group, n=26). Pruritus was more common in the severe ICP group (65.4% vs 40.4%; P <.05), but other baseline characteristics were similar. Compared with the mild ICP group, the severe ICP group had higher SBA at first visit and peak value, higher direct bilirubin before delivery and 4 days postpartum, and lower gamma-glutamyltransferase at peak value, before delivery and 4 days postpartum (P <.05). Other laboratory parameters, type of delivery, hemorrhage, and liver function abnormality were similar between groups, although the severe ICP group had longer duration of hepatic dysfunction (P <.05). Birth weight was lower in the mild ICP group (P <.05), but other fetal outcomes were similar between groups. Logistic regression identified no factors (including SBA group) associated with APOs or MSAF.Women successfully treated for severe ICP do not have increased risks for APOs.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Yang J,Chen C,Liu M,Zhang S

doi

10.1097/MD.0000000000016214

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

e16214

issue

27

eissn

0025-7974

issn

1536-5964

pii

00005792-201907050-00045

journal_volume

98

pub_type

杂志文章

相关文献

MEDICINE文献大全
  • Extrapulmonary tuberculosis in patients with human immunodeficiency virus infection.

    abstract::The annual number of cases of culture-proven extrapulmonary tuberculosis (TB) at our hospital increased from 47 cases in 1983 to 113 cases in 1988. At least 43% (199) of 464 consecutive patients with extrapulmonary TB during this 6-year period were infected with the human immunodeficiency virus (HIV); since HIV serolo...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/00005792-199111000-00004

    authors: Shafer RW,Kim DS,Weiss JP,Quale JM

    更新日期:1991-11-01 00:00:00

  • Impact of neurological diseases on family planning: A single-center experience.

    abstract::This cross-sectional study aimed to assess the impact of epilepsy, myasthenia gravis (MG), and multiple sclerosis (MS) on pregnancy and family planning decision-making in a cohort of Saudi women. Women with epilepsy, MG, and MS were recruited consecutively at the time of their follow-up visits at a neurology clinic. D...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022978

    authors: Alanazy MH,Asiri A,Edrees MF,Abuzinadah AR

    更新日期:2020-10-30 00:00:00

  • Nucleobindin 2 expression is an independent prognostic factor for bladder cancer.

    abstract::Nucleobindin 2 (NUCB2) has been reported to play an important role in both tumorigenesis and cancer progression. This study aimed to examine the clinical significance of NUCB2 expression urothelial carcinoma of the bladder (UCB).The expression level of NUCB2 and its correlation with clinicopathological parameters was ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019597

    authors: Cho JM,Moon KT,Lee HJ,Shin SC,Choi JD,Kang JY,Yoo TK

    更新日期:2020-03-01 00:00:00

  • Contradictions between DAPT and PRECISE-DAPT scores with the severity of coronary lesion in acute coronary syndrome.

    abstract::This study aimed to identify the correlation of contradiction between DAPT score and PRECISE-DAPT score with the severity of coronary lesion in acute coronary syndromes (ACS).In total, 458 patients with ACS after a percutaneous coronary intervention (PCI) who had tolerated 1-year uneventful dual antiplatelet therapy (...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019699

    authors: Bi S,Zhao Y,Peng Q,Liu W,Zhang G,Zhang C

    更新日期:2020-04-01 00:00:00

  • Effect of cognitive-behavioral therapy with music therapy in reducing physics test anxiety among students as measured by generalized test anxiety scale.

    abstract:BACKGROUND:The study determined the effect of cognitive-behavioral therapy (CBT) with music in reducing physics test anxiety among secondary school students as measured by generalized test anxiety scale. METHODS:Pre-test post-test randomized control trial experimental design was adopted in this study. A total of 83 se...

    journal_title:Medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/MD.0000000000016406

    authors: Ugwuanyi CS,Ede MO,Onyishi CN,Ossai OV,Nwokenna EN,Obikwelu LC,Ikechukwu-Ilomuanya A,Amoke CV,Okeke AO,Ene CU,Offordile EE,Ozoemena LC,Nweke ML

    更新日期:2020-04-01 00:00:00

  • Proximal Femoral Nail Antirotation Versus Reverse Less Invasive Stabilization System-distal Femur for Treating Proximal Femoral Fractures: A Meta-analysis.

    abstract::The aim of this study was to compare the effectiveness and safety of 2 surgical techniques that are used to treat proximal femoral fractures.A systematic literature search (up to December 2014) was conducted in Medline, Embase, PubMed, and The Cochrane Central Register of Controlled Trials to screen for studies compar...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000003168

    authors: Jiang X,Wang Y,Ma X,Ma J,Wang C,Zhang C,Han Z,Sun L,Lu B

    更新日期:2016-04-01 00:00:00

  • Inverted internal limiting membrane flap technique and an autologous platelet concentrate to treat an Nd: YAG laser-induced macular hole: A case report.

    abstract:RATIONALE:Nd:YAG laser-induced macular holes (MHs) feature more extensive anatomical defects and worse functional outcomes than idiopathic MHs. Although new treatment options for large refractory MHs have been suggested, the current literature on Nd:YAG laser-induced MHs suggests only conventional pars plana vitrectomy...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000018185

    authors: Yang YH,Chung YT,Kim BK,Moon JH,Mun SJ

    更新日期:2019-11-01 00:00:00

  • Cost-effectiveness analysis of neonatal screening of critical congenital heart defects in China.

    abstract:BACKGROUND:Pulse oximetry screening is a highly accurate tool for the early detection of critical congenital heart disease (CCHD) in newborn infants. As the technique is simple, noninvasive, and inexpensive, it has potentially significant benefits for developing countries. The aim of this study is to provide informatio...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000008683

    authors: Tobe RG,Martin GR,Li F,Moriichi A,Wu B,Mori R

    更新日期:2017-11-01 00:00:00

  • Fecal microbiota transplantation therapy for Parkinson's disease: A preliminary study.

    abstract::Imbalances in the gut microbiota mediate the progression of neurodegenerative diseases such as Parkinson's disease (PD). Fecal microbiota transplantation (FMT) is currently being explored as a potential therapy for PD. The objective of this study was to assess the efficacy and safety of FMT on PD. Fifteen PD patients ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000022035

    authors: Xue LJ,Yang XZ,Tong Q,Shen P,Ma SJ,Wu SN,Zheng JL,Wang HG

    更新日期:2020-08-28 00:00:00

  • Erratum: Evaluation of a combined posterior lateral and anteromedial approach in the treatment of terrible triad of the elbow: A retrospective study: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000007643.]. ...

    journal_title:Medicine

    pub_type: 杂志文章,已发布勘误

    doi:10.1097/MD.0000000000007827

    authors:

    更新日期:2017-08-11 00:00:00

  • Doege-Potter syndrome: A review of the literature including a new case report.

    abstract:RATIONALE:We reviewed 76 published cases of Doege-Potter syndrome, and non-islet cell tumor hypoglycemia (NICTH) secondary to a solitary fibrous tumor (SFT) between 1989 and 2016, to study disease pathogenesis, diagnosis, and treatment of this rare paraneoplastic disease. Further, we report 1 new case of a patient pres...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000007417

    authors: Han G,Zhang Z,Shen X,Wang K,Zhao Y,He J,Gao Y,Shan X,Xin G,Li C,Liu X

    更新日期:2017-07-01 00:00:00

  • Meta-analysis of serum lactate dehydrogenase and prognosis for osteosarcoma.

    abstract:BACKGROUNDS:A large number of studies have reported the relationships between serum lactate dehydrogenase (LDH) and prognosis of osteosarcoma. However, the result is still controversial and no consensus has been reached. Therefore, we performed a meta-analysis to evaluate the prognostic role of serum LDH in osteosarcom...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析,评审

    doi:10.1097/MD.0000000000010741

    authors: Fu Y,Lan T,Cai H,Lu A,Yu W

    更新日期:2018-05-01 00:00:00

  • Sexual behavior of female adolescents on the spread of HIV/AIDS and other STDs in Carriacou.

    abstract::This article explores information relating to female adolescents knowledge, attitudes, and behaviors toward human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs) in Carriacou. The authors aimed at finding out whether adolescent females in Carriacou receive adequate information about HIV and...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000004800

    authors: Patrice-Coy C,Johnson EJ,Boodram CAS

    更新日期:2016-09-01 00:00:00

  • Treatment of persistent postoperative hiccups with stellate ganglion block: Three case reports.

    abstract:RATIONALE:Although persistent postoperative hiccups can cause various problems (such as sleep disorders, depression, fatigue) for the patient, there has been little research on this topic. The purpose of this study is to determine the effectiveness of treating persistent postoperative hiccups with a stellate ganglion b...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000013370

    authors: Lee AR,Cho YW,Lee JM,Shin YJ,Han IS,Lee HK

    更新日期:2018-11-01 00:00:00

  • Pediatric tuina for the treatment of fever in children: A protocol for systematic review and meta-analysis.

    abstract:BACKGROUND:Infantile fever is a common symptom of the pediatric diseases, which is often caused by cold, food accumulation, or other pathogenic factors. Pediatric tuina is regarded as an acceptable non-pharmaceutical therapy for children with optimal effects, which has been widely used for infantile fever around China....

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021664

    authors: Chen LF,Yin M,Dong X,Zou JX,Wang BX,Chen J

    更新日期:2020-08-14 00:00:00

  • Relationship between ataxia and inferior cerebellar peduncle injury in patients with cerebral infarct.

    abstract:INTRODUCTION:The inferior cerebellar peduncle (ICP) is a major neural tract in the cerebellum and is involved in coordination of movement and proprioceptive; therefore, ICP injury can be accompanied by poor coordination of movement, including ataxia. In this study, using diffusion tensor tractography (DTT), we investig...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019344

    authors: Jang SH,Lee HD

    更新日期:2020-02-01 00:00:00

  • Carbon monoxide-releasing molecule-2 suppresses thrombomodulin and endothelial protein C receptor expression of human umbilical vein endothelial cells induced by lipopolysaccharide in vitro.

    abstract:OBJECTIVE:The aim of this study was to observe the counter-effect of carbon monoxide-releasing molecule-2 (CORM-2) on lipopolysaccharide (LPS)-suppressed thrombomodulin (TM) and endothelial protein C receptor (EPCR) expressions from human umbilical vein endothelial cell (HUVEC), and to reveal its mechanisms. METHODS:H...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006978

    authors: Meng X,Fei D,Liu M,Yang S,Song N,Jiang L,Kang K,Nan C,Luo Y,Pan S,Zhao M

    更新日期:2017-05-01 00:00:00

  • A rare case of deep cerebral venous thrombosis secondary to traumatic epidural hematoma: Case report.

    abstract:RATIONALE:Deep cerebral venous thrombosis (DCVT) is a rare disease, but always results in poor prognosis. PATIENT CONCERNS:We reported a 79-year-old female with coma after traumatic brain injury (TBI). DIAGNOSIS:The epidural hematoma was first diagnosed on non-contrast computerized tomography (CT). The hypodense area...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000011587

    authors: Zheng H,Xu W,Chen Y,Gai S,Chen G

    更新日期:2018-09-01 00:00:00

  • Fluctuations in the amplitude of ST-segment elevation in vasospastic angina: Two case reports.

    abstract:RATIONALE:ST-segment elevation localizes an ischemic lesion to the coronary artery supplying the area of the myocardium reflected by the electrocardiographic leads. Dynamic ST-segment elevation can be due to severe transmural ischemia secondary to a thrombus, vasospasm, or a tightly fixed coronary artery lesion or a co...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006334

    authors: Hung MJ

    更新日期:2017-03-01 00:00:00

  • Diagnostic accuracy of contrast-enhanced ultrasound in the detection of small renal masses: A protocol of systematic review and meta-analysis.

    abstract:BACKGROUND:The small renal masses (SRMs) were defined that the diameter of renal masses measured by enhanced image was ≤4 cm. The diagnostic accuracy of contrast-enhanced ultrasound (CEUS) for SRMs is apparently variable among previous studies. Hence, this study will evaluate the diagnostic accuracy of CEUS in the iden...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000021262

    authors: Wu JF,Wu C,Wang YL,Wang ZP

    更新日期:2020-07-17 00:00:00

  • Large dosage Huangqin (Scutellaria) and Huanglian (Rhizoma Coptidis) for T2DM: A protocol of systematic review and meta-analysis of randomized clinical trials.

    abstract:INTRODUCTION:Type 2 diabetes mellitus (T2DM) is a metabolic disease with widespread concern in the world. It has the characteristics of high incidence rate and high disability rate, which seriously affects economic and social development. large dose herb Rhizoma Coptidis (Huanglian) and Scutellaria (Huangqin) or compou...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000022032

    authors: Huang X,Wang L,Yue R,Ding N,Yang H

    更新日期:2020-09-18 00:00:00

  • Efficacy and Safety of Zoledronic Acid and Pamidronate Disodium in the Treatment of Malignant Skeletal Metastasis: A Meta-Analysis.

    abstract::Solid tumors frequently metastasize to bone. Two bisphosphonates have been investigated for bone metastases including pamidronate disodium and zoledronic acid.By searching the PubMed, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI) databases, we conducted a meta-analysis to determine the efficacy a...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000001822

    authors: Yang L,Du S

    更新日期:2015-10-01 00:00:00

  • Erratum: Association of Lifestyle-Related Comorbidities With Periodontitis: A Nationwide Cohort Study in Korea: Erratum.

    abstract::[This corrects the article DOI: 10.1097/MD.0000000000001567.]. ...

    journal_title:Medicine

    pub_type: 已发布勘误

    doi:10.1097/01.md.0000479543.97836.5d

    authors:

    更新日期:2016-01-15 00:00:00

  • Erector spinae plane block for multimodal analgesia after wide midline laparotomy: A case report.

    abstract:RATIONALE:The most commonly used regional techniques for analgesia following laparotomy thoracic epidural analgesia and paravertebral blocks are technically difficult to perform and carry a risk of severe complications. Recently, the erector spinae plane block (ESPB) has been reported to effectively treat neuropathic p...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000015654

    authors: Bang S,Chung J,Kwon W,Yoo S,Soh H,Lee SM

    更新日期:2019-05-01 00:00:00

  • Association between interleukin-8 gene -251 A/T polymorphism and the risk of coronary artery disease: A meta-analysis.

    abstract:BACKGROUND:The association between interleukin-8 (IL-8) gene polymorphism -251 A>T and susceptibility to coronary artery disease (CAD) has been investigated previously; however, results remain controversial. Thus, a meta-analysis was conducted to reassess the effects of this polymorphism on CAD risks. METHODS:The PubM...

    journal_title:Medicine

    pub_type: 杂志文章,meta分析

    doi:10.1097/MD.0000000000017866

    authors: Zhang Q,Lian Z,Zhang W,Cui Y,Wang W,Wu J,Chen Z,Wang W

    更新日期:2019-11-01 00:00:00

  • Congenital scoliosis in Smith-Magenis syndrome: a case report and review of the literature.

    abstract::The Smith-Magenis syndrome (SMS) is a complex and rare congenital condition that is characterized by minor craniofacial anomalies, short stature, sleep disturbances, behavioral, and neurocognitive abnormalities, as well as variable multisystemic manifestations. Little is reported about spinal deformity associated with...

    journal_title:Medicine

    pub_type: 杂志文章,评审

    doi:10.1097/MD.0000000000000705

    authors: Li Z,Shen J,Liang J,Sheng L

    更新日期:2015-05-01 00:00:00

  • Balance control, agility, eye-hand coordination, and sport performance of amateur badminton players: A cross-sectional study.

    abstract::In this study, balance performance, agility, eye-hand coordination, and sports performance were compared between amateur badminton players and active controls.Thirty young adult badminton players and 33 active controls participated in the study. Static single-leg standing balance (with eyes closed) was measured using ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000014134

    authors: Wong TKK,Ma AWW,Liu KPY,Chung LMY,Bae YH,Fong SSM,Ganesan B,Wang HK

    更新日期:2019-01-01 00:00:00

  • Tuberculosis-associated hemophagocytic lymphohistiocytosis with initial presentation of fever of unknown origin in a general hospital: An analysis of 8 clinical cases.

    abstract::The study aimed to investigate the clinical features and prognoses of patients with tuberculosis (TB) who had secondary hemophagocytic lymphohistiocytosis (HLH).Patients first presenting with fever of unknown origin, who were ultimately diagnosed with TB-associated secondary HLH, were assessed retrospectively. We summ...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000006575

    authors: Zhang Y,Liang G,Qin H,Li Y,Zeng X

    更新日期:2017-04-01 00:00:00

  • Can cervical vascular ultrasound combined with transcranial Doppler ultrasound accurately diagnose cerebral infarction?: A protocol for a systematic review and meta-analysis.

    abstract:BACKGROUND:The purpose of this study is to investigate the impact of cervical vascular ultrasound (CVU) combined transcranial Doppler ultrasound (TDU) in the diagnosis of cerebral infarction (CI). METHODS:The following electronic databases will be sought from PUBMED, EMBASE, Cochrane Library, PSYCINFO, Web of Science,...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000019997

    authors: Qin LW,Wang C,Feng XJ,Wang XH,Qin LH,Weeks C

    更新日期:2020-05-29 00:00:00

  • Economic and health impacts of infectious diseases in China: A protocol for systematic review and meta analysis.

    abstract:BACKGROUND:A worldwide concern has been raised that novel infectious diseases may outbreak rapidly with a limited response time due to globalization. Severe Acute Respiratory Syndrome, influenza A, Avian Influenza Virus, and Corona Virus Disease 2019 are acute respiratory diseases that have been affected by the movemen...

    journal_title:Medicine

    pub_type: 杂志文章

    doi:10.1097/MD.0000000000021249

    authors: Li M,Fan D,Wang X

    更新日期:2020-07-24 00:00:00