Abstract：
Background:To survey the prevalence of potential drug-drug interactions (DDIs) between anticancer drugs and non-anticancer drugs and evaluate the risk factors associated with these drug-drug interactions in China. Methods:All discharged patients in the Department of Oncology were collected from Jun to Dec in 2016 with the Hospital Information System of the Chinese people's Liberation Army General Hospital. Drugs were screened for interactions by Micromedex solutions database. Descriptive statistics were generated and logistic regression was used to identify the associated factors. Results:Among 6578 eligible patients, 1979 potential drug interactions were found in 1830 patients (27.82%). The most common drug-drug interaction was cisplatin and furosemide. Erlotinib was most likely to interact with various non-anticancer drugs. Most interactions were classified as pharmacodynamics (71.60%), major severity (97.02%) and were supported by fair documentation evidence (86.21%). In multivariate analysis, increasing number of medications, lung cancer and patients with stage IV had a higher risk for potential drug-drug interactions. Conclusion:Potential drug-drug interactions between antineoplastic drugs and non-antineoplastic drugs occur frequently in cancer patients of Chinese hospitals. Doctors should fully consider potential risk associated with DDIs. Further research should be performed to evaluate real clinical significance of these drug-drug interactions.
journal_name
Iran J Public Healthjournal_title
Iranian journal of public healthauthors
Wang W,Xiao B,Liu Z,Wang D,Zhu Msubject
Has Abstractpub_date
2019-03-01 00:00:00pages
435-443issue
3eissn
2251-6085issn
2251-6093journal_volume
48pub_type
杂志文章abstract：Background:To analyze and summarize the effect of continuous care on the life quality and control of asthma of pediatric patients with asthma discharged from multiple hospitals. Methods:Retrospective analysis was carried out on 172 pediatric patients with asthma aged between 6 and 11 yr old randomly selected from thos...
journal_title：Iranian journal of public health
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abstract：BACKGROUND:A few elements of soil are radioactive. Soil can transfer radionuclide into plants feeding human. Sometimes their levels are as high as to be concern of human healthy. Rice has an important share for Iranian foods especially in north of Iran. Therefore we decided to obtain radionuclides concentration emittin...
journal_title：Iranian journal of public health
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abstract：BACKGROUND:Scleroderma is a chronic connective tissue disease of unknown etiology. Vitamin D and parathyroid hormone (PTH) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. Klotho, the co-receptor of the fibroblast growth factor 23 (FGF-23), can interf...
journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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doi：
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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doi：
更新日期：2015-12-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2016-11-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2011-01-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
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journal_title：Iranian journal of public health
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doi：10.18502/ijph.v49i8.3897
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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journal_title：Iranian journal of public health
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更新日期：2018-10-01 00:00:00
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更新日期：2019-01-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章,评审
doi：
更新日期：2019-07-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
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更新日期：2020-04-01 00:00:00
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journal_title：Iranian journal of public health
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doi：
更新日期：2018-02-01 00:00:00
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journal_title：Iranian journal of public health
pub_type： 杂志文章
doi：
更新日期：2019-08-01 00:00:00
