Abstract:
Background:We aimed to investigate the expressions of miR-21 and miR-210 in the breast cancer tissue and their correlation with clinicopathological features and prognosis. Methods:A retrospective analysis was performed on 68 patients with breast cancer treated surgically in Wuhan General Hospital of Guangzhou Military in 2014-2015. The breast cancer tissue and the adjacent normal tissue were collected from the patients. Quantitative real-time PCR (qRT-PCR) was used to detect the expression levels of miR-21 and miR-210 in the breast cancer and adjacent normal tissues. Results:According to qRT-PCR, the expression levels of miR-210 and miR-21 in the breast cancer tissue were significantly higher than those in the adjacent normal tissue (P<0.05), which were significantly correlated with lymph node metastasis, clinical staging and differentiation of patients (P<0.05). miR-21 and miR-210 were significantly positive correlated in both breast cancer tissues and adjacent normal tissues (r=0.7014, 0.7502, P<0.001). The survival rate in the miR-210 high expression group was significantly lower than that in the miR-210 low expression group (P<0.05), whereas there was no significant difference between the miR-21 high and low expression groups. Conclusion:miR-21 and miR-210 are highly expressed in the breast cancer tissue and significantly correlated with lymph node metastasis, clinical staging and differentiation. miR-210, the up-regulated expression of which is related to the poor prognosis of patients with breast cancer, may be a potential prognostic indicator for breast cancer, which can be used to judge the prognosis.
journal_name
Iran J Public Healthjournal_title
Iranian journal of public healthauthors
Wu Xsubject
Has Abstractpub_date
2020-01-01 00:00:00pages
21-29issue
1eissn
2251-6085issn
2251-6093journal_volume
49pub_type
杂志文章abstract:BACKGROUND:Chinese medical workers suffer from a high incidence of mental health problems, resulting in reduced efficiency, increased medical malpractice, rising medical costs, and other issues. The effective alleviation of mental health problems among medical workers is therefore an important focus of research and soc...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
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abstract:BACKGROUND:P Cesarean delivery rates have been increasing throughout the world. Parallel to the developments in the world the cesarean rate in Turkey has risen to 48.1% in 2013. Some of the social factors were related with cesarean births. The purpose of this study was to determine cesarean birth rates and to find out ...
journal_title:Iranian journal of public health
pub_type: 杂志文章
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abstract:BACKGROUND:Scleroderma is a chronic connective tissue disease of unknown etiology. Vitamin D and parathyroid hormone (PTH) that play particular functions in calcium and phosphate homeostasis may be involved in the etiology of this disorder. Klotho, the co-receptor of the fibroblast growth factor 23 (FGF-23), can interf...
journal_title:Iranian journal of public health
pub_type: 杂志文章
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journal_title:Iranian journal of public health
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2017-03-01 00:00:00
abstract:Background:This population-based study aimed at investigating the prevalence and associated factors of over-weight /obesity and abdominal obesity in Iran. Methods:The study population consists of 2818 inhabitant of the urban and regional area of East-Azerbaijan, Iran in 2015. The weight, height and waist circumference...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:10.18502/ijph.v49i8.3874
更新日期:2020-08-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2015-10-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Considering the lack of data available on changes of physical activity over time in Iran, this study was designed to evaluate changes in physical activity levels among Iranian adults over a median 6.5 yr period. METHODS:In this population-based cohort study, 3515 participants, aged ≥ 20 yr (2100 females and...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Residents play an important role in the delivery of hospital care. They regularly work overnight, in emergency situations and with workload and stress which can affect their performance and quality of working life (QWL). This study explores the QWL and its contributory factors in residents working at hospita...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:Background:This study investigated how experiencing school violence affects depression and suicidal ideation in multicultural adolescents. Methods:Overall, 63444 adolescents from grades 7-12 (ages 12-18 yr) who participated in the 11th Korea Youth Risk Behavior Web-based Survey (KYRBS-XI) were enrolled from Jun 1 to J...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2019-02-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2019-10-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Exposure to mercury (Hg) as a heavy metal can cause health effects. The objective of this study was to assess occupational exposure to Hg in a chlor-alkali petrochemical industry in Iran by determining of Hg concentrations in air, blood and urine samples. METHODS:The study was performed on 50 exposed subjec...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2014-06-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章,评审
doi:
更新日期:2019-06-01 00:00:00
abstract:Background:The prevalence of Acute Myocardial Infarction (AMI) varies from region to region caused by seasonal climate changes and temperature variation. This study aimed to assess the relationship between changing meteorological conditions and incidence of AMI in Iran. Methods:This retrospective prevalence study was ...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Health locus of control (HLC) has been associated with a variety of ailments and health outcomes and designed to predict behaviors and cognitive processes relevant to mental and physical health. This study investigated the relationships between perceived health locus of control, self-esteem, and mental healt...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
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journal_title:Iranian journal of public health
pub_type: 杂志文章,评审
doi:
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Anxiety is one of the most common reactions that parents show while understanding their children's intellectual disability due to Down syndrome. Anxiety leads parents not to develop appropriate relations with their children, subsequently their psychological health are at risk. The present study was aimed to ...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2015-02-01 00:00:00
abstract::Coccidian protozoa of Cyclospora cayetanensis are obligate intracellular apicomplexan parasites that infect the mucosal epithelium of the small intestine of immunocompetent and immunocompromised persons. A 25- years old woman from around, Tehran with complaint of faintness and fatigue with HIV positive/AIDS confirmed ...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:An explosion of research has been done in discovering how human health is affected by environmental factors. I will discuss the impacts of environmental cancer causing factors and how they continue to cause multiple disruptions in cellular networking. Some risk factors may not cause cancer. Other factors ini...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract:Background:Non-Communicable disease (NCDs) is a killer of people that needs to urgent actions across the world. Scientific evidence is the critical arm for effective interventions. Therefore, we aimed to quantify the trend of four main NCDs' scientific publication in a 17-yr period, and reflect international collaborat...
journal_title:Iranian journal of public health
pub_type: 杂志文章,评审
doi:
更新日期:2018-07-01 00:00:00
abstract:Background:As dyslipidemia is a preventable risk factor for Coronary heart disease (CHD), precise estimation of its prevalence and determinants is crucial for proper development of health actions. This population-based study aimed at investigating the socioeconomic, dietary and psychological determinants of dyslipidemi...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:To examine the effects of soy [in the form of textured soy protein (TSP) and soy-nut] on body composition in elderly women with metabolic syndrome (MetS). METHODS:A 12-week randomized clinical trial was conducted on 75 women between 60-70 years of age with MetS in rural health clinics around Babol, Iran in ...
journal_title:Iranian journal of public health
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00