Abstract:
:Breast cancer is one of the most common malignancies which appear during pregnancy. Since women are increasingly not giving birth until they are at a more advanced age, it can be assumed that the incidence of pregnancy-related breast cancers will continue to increase in the future. Because of pregnancy-induced changes and conservative diagnosis, these carcinomas are frequently not detected until they are at an advanced stage and thus generally require systemic adjuvant therapy. The available data on optimal chemotherapeutic management are limited. Particularly for the use of the target agent trastuzumab which could crucially contribute to improving the prognosis in the therapy of HER2-overexpressing breast cancer in non-pregnant women, there is a lack of definitive information regarding the profile of action and safety in pregnancy as well as with regard to any long-term effects on the child. Thirty-eight pregnancies on trastuzumab for the treatment of breast cancer were able to be analysed in the literature currently available. Information can be gained from this and conclusions can be drawn which can individualise and decisively improve therapeutic options in the future for the pregnant breast cancer patient.
journal_name
Geburtshilfe Frauenheilkdjournal_title
Geburtshilfe und Frauenheilkundeauthors
Goller SS,Markert UR,Fröhlich Kdoi
10.1055/a-0880-9295subject
Has Abstractpub_date
2019-06-01 00:00:00pages
618-625issue
6eissn
0016-5751issn
1438-8804pii
8809295journal_volume
79pub_type
杂志文章abstract::During the cancer check-up of a 46-year-old woman a PAP V was diagnosed in the cervical scrapings. The atypical cells of the abrasion specimens from the corpus uteri arouse strong suspicion of malignancy. Connected with the clinical data, this finding primarily indicated a metastatic involvement of the inner genitals....
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036064
更新日期:1987-12-01 00:00:00
abstract::A 20-year old woman, who underwent an intersex operation during infancy, was presented for evaluation of the gonads because of suspected true hermaphroditism. The phenotype was female with regular menstruations. Examination revealed an ovarian tumour of 8 cm on the left side and a normal right ovary. During the operat...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022897
更新日期:1993-05-01 00:00:00
abstract::The special anatomic approach and difficult cell collecting from all parts of the corpus uteri have so far prevented the development of an ideal instrument for an early detection of endometrial adenocarcinoma. During the past 9 years we examined several methods; this is a report of a long-term study on 2,500 smears wi...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036489
更新日期:1985-12-01 00:00:00
abstract::Cystometry and simultaneous cystometry and urethrometry were conducted in 81 incontinent female patients (46 Grade I, 35 Grade II, according to the Ingelman-Sundberg Scale). The tonometric criteria for stress incontinence were presented and discussed by statistically comparing the pressure parameters for continent and...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-11-01 00:00:00
abstract::Heterologous insemination is being established in increasing numbers in Anglo-Saxon, middle and north European countries, although some medical, legal and theological-ethical aspects are still not settled. Our experiences with this type of sterilisation in regard to marriage stability and psycho-physical development o...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-01-01 00:00:00
abstract::The capability of Doppler flow velocimetry to predict intrauterine growth retardation is well known. The increased morbidity and mortality rate of postterm newborns is also well known. The aim of our study was to examine if Doppler flow velocimetry is able to indicate foetal jeopardy in the postterm period. Flow veloc...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023595
更新日期:1993-09-01 00:00:00
abstract::From 1987 to 1991 a total of 5035 pelviscopies were done at the Kiel University Hospital of Gynaecology. More than 90% of these were surgical pelviscopies, whereas less than 10% were diagnostic procedures only. Serious complications requiring laparotomy or repeat pelviscopy or laparotomy within 4 weeks after the origi...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022285
更新日期:1996-09-01 00:00:00
abstract::This analysis covers 170 patients with teratomas from 1965-1978 in the Department of Obstetrics and Gynaecology of Heidelberg University. Malignant teratomas were found in two patients; in a special case, a "gliomatosis peritonei" was identified. The histological composition, the degree of maturity, grading and clinic...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037256
更新日期:1982-03-01 00:00:00
abstract::Polyglycolic acid sutures (Dexon) were compared to chromic catgut sutures in episiotomy repair. When polyglycolic acid sutures were used, the degree of postpartum perineal pain was approximately half as great, and the incidence of dehiscence of episiotomy was 3--5 times greater in the chromic catgut group. The cosmeti...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::In a prospective study 265 patients with threatened abortions were divided into 2 groups. One group of 134 patients received treatment with Oestradiol benzoat and hydroxyprogesterone capronat. The other group of 131 patients received no hormonal treatment. Of the group treated with hormones 40.7% of the women had an a...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 临床试验,杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract::A new tissue-selective prostaglandin E2-derivate, 16-Phenoxy-prostaglandin E2-methansulfonamide (SH B 286) developed by Pfizer, USA, and Schering, Germany, has been investigated as abortifacient using the intrauterine as well as intravenous route of application. Vital signs, intrauterine pressure, serum levels of ster...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-12-01 00:00:00
abstract::Holoprosencephaly is a malformation complex, in which the foetal forebrain (prosencephalon) fails to cleave. The aetiology of holoprosencephaly is heterogeneous. In the last years, a new malformation syndrome has been described, including holoprosencephaly, postaxial polydactyly, congenital heart defects and normal ka...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023813
更新日期:1992-12-01 00:00:00
abstract::In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be a...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0774-7924
更新日期:2019-04-01 00:00:00
abstract::During the last six years we observed four malaria relapses shortly after delivery. In three cases the relapse occurred subsequent to Caesarean section, and in one case shortly after normal uncomplicated delivery. Case histories revealed that these women had previously stayed in the tropical or subtropical zones. The ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036513
更新日期:1984-11-01 00:00:00
abstract::Instead of continuous CTG monitoring lasting from the onset of labor to delivery, various obstetricians recommend interval monitoring in cases designated "likely to be free of complications". This enables the mother to move freely from time to time without being permanently confronted by technological apparatus. In th...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036035
更新日期:1987-10-01 00:00:00
abstract::Seasonal variations in the incidence of the conception of multiple pregnancies are compared in the same population area in two centuries. 12,617 singleton and 101 twin pregnancies from 1803 to 1852 are compared to 63,967 singleton, 473 twin and 5 triplet pregnancies from 1965 to 1970. In both groups the percentage dec...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract::The authors report on a successful pregnancy in a young Turkish patient with p and anti-PP1Pk-antibodies. Anti-PP1Pk is considered to cause haemolytic diseases in the newborn and habitual abortions. The patient was treated via plasma exchange and substitution with intravenous immunoglobulin. At 31 weeks of gestation t...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023820
更新日期:1991-09-01 00:00:00
abstract::Basing on an observation made by the authors, the article describes the diagnostic and therapeutic criteria in primary non-Hodgkin lymphoma of the mamma. Despite high malignancy, especially of the lymphoblastic-centroblastic lymphoma and of the immunoblastic lymphoma (Stein, 1974), permanent healing can be achieved vi...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037156
更新日期:1982-10-01 00:00:00
abstract::The purpose of the present study is to determine differences in the postoperative character of pain between two study groups undergoing different techniques of hysterectomy. Therefore we examined 42 women. 21 women underwent combined laparoscopic and vaginal hysterectomy and 21 abdominal hysterectomies have been perfo...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022348
更新日期:1994-11-01 00:00:00
abstract::Gamete intrafallopian transfer (GIFT) was applied in 55 couples in 62 treatment cycles. The overall pregnancy rate was 38.7% (24 of 62), the highest incidence of pregnancy being obtained in the group of tubal adhesions (8 [47%] of 17), in cases of multifactorial infertility (7 [44%] of 16) and of unexplained infertili...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1026428
更新日期:1990-01-01 00:00:00
abstract::According to a judgement by the German Federal Court of 17 December 1991 the surgeon is legally bound to inform the patient before hand of the risk of a possible homologous blood transfusion during surgery. If the transfusion probability exceeds 5%, this obligation is really relevant, 228 patients with primary breast ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023526
更新日期:1995-10-01 00:00:00
abstract::To evaluate their physical efficiency, 14 healthy untrained women were examined during pregnancy weeks 16-20, 25-29 and 34-38 and 5 to 10 weeks post partum, by spiroergometry at various exercise levels on the bicycle ergometer. Besides the spiroergometric values, circulatory parameters were measured and serum analyses...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036184
更新日期:1986-03-01 00:00:00
abstract::From August 1988 to October 1990, 115 transabdominal placental biopsies were performed in the second (68%) and third trimenon (32%). The main indication (80%) was the detection of pathological ultrasonographic findings (foetal malformation, growth retardation, oligohydramnios and polyhydramnios). The success rate of c...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023686
更新日期:1991-02-01 00:00:00
abstract::The discussions on the pros and cons of obstetric screening for connatal infections have been going on for years. We, therefore, conducted a prevalence study of the most common connatal infections. HIV infection, rubella and syphilis were not subjects of this study. We analysed the relevance of these infections in 512...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026231
更新日期:1991-11-01 00:00:00
abstract:UNLABELLED:The paper is a review on the actual possibilities and indications of the transplacentar therapy of the fetus. At first some principles of the pharmacodynamics of the materno-placento-fetal unit are explained in order to enable an effective drug administration and reach therapeutic levels in the fetus. Common...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2007-1022783
更新日期:1995-02-01 00:00:00
abstract::By means of ultrasound and fetal electrocardiography the diagnosis of twin pregnancies can be made prenatally without any reservation; the diagnosis is even possible in the first half of pregnancy. Comparative analysis of two approximately equal collectives of in all 602 twin pregnancies--1,45% of all births in the ye...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract::Treatment with monoclonal antibodies (mabs) has become an established component of oncological therapy. The monoclonal antibodies available for this purpose are mainly administered intravenously in individually adapted doses according to body weight over longer treatment times. For other chronic diseases such as, for ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0034-1368173
更新日期:2014-04-01 00:00:00
abstract::Now that we know about the genetic production mechanisms of diseases of the trophoblast, interest is concentrated on the question which risk factors can produce a disposition in the patient - seen from a clinico-genetic angle - towards malignancy of a complete mole. Many years before the genetic interrelations became ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036215
更新日期:1985-02-01 00:00:00
abstract::This study investigates the possibilities to treat oligo-asthenozoospermia, a cause of sterility, by assisted conjugation. After completing acrosome reaction, normal motile spermatozoa are microinjected into mouse oocytes. After 2 hours of incubation time in medium with lactate and albumins, spermatozoa are put into d...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026552
更新日期:1988-09-01 00:00:00
abstract::A case of aplasia of the uterine cervix and partial atresia of the vagina in a 17 year old woman is reported. A hysterectomy was done and a new vagina created. The literature on the origin of the different parts of the female genital tract is reviewed and discussed. Interpretation of the embryologic origin of the diff...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-06-01 00:00:00