[Are there genetic risk factors in the occurrence of choriocarcinoma?].

Abstract:

:Now that we know about the genetic production mechanisms of diseases of the trophoblast, interest is concentrated on the question which risk factors can produce a disposition in the patient - seen from a clinico-genetic angle - towards malignancy of a complete mole. Many years before the genetic interrelations became known, there had been discussions on blood relationship as a possible aetiological factor in the production of chorionic carcinoma. Since consanguinity in preceding generations can lead to a selection of certain genotypes, this question was reexamined on a limited patients material (10 patients with chorionic carcinoma and 11 with mole). The negative result of this study contradicts - similar to other recent publications on this subject - the hitherto frequently advanced hypothesis that homozygotism is responsible, for a recessive "onko" gen, for rendering a complete mole malignant. Recent investigations, for example, point to a close correlation between the presence of a Y chromosome in a complete mole, and malignancy.

authors

Brackertz M,Gille J,Schindler D

doi

10.1055/s-2008-1036215

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

103-6

issue

2

eissn

0016-5751

issn

1438-8804

journal_volume

45

pub_type

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