Abstract：
:The prognostic value of the PCNA-proliferative fraction as compared to conventional clinical and histomorphological factors (FIGO-stage, tumour type, histological grading, lymph node status, size of residual tumour) was investigated in 81 ovarian cancer patients. Categorisation of PCNA-expression into tumours with low and high proliferative activity (< 20%/ > or = 20% according to laboratory standards) had the highest prognostic value. Categorisation on the basis of the median value (< or = 34%/> 34%) or classification of PCNA as a continuous variable did not prove advantageous. PCNA-proliferative fraction was significantly directly correlated with histological grading (p = 0.006). Tumours with a high PCNA expression had a greater frequency of macroscopically detectable residual tumours. In univariate survival analyses patients with highly proliferating tumours had a worse outcome than patients with tumour of low proliferation (PCNA or = 20%/20%, p = 0.012; PCNA < or = 34%/ > 34%, p = 0.08). The result was consistent in subgroup of FIGO III-tumours (p = 0.031, PCNA < 20%/> or = 20%), of FIGO l-tumours (p = 0.036, PCNA < 20%/> or = 20%), of carcinomas without post-operative residual tumour (p = 0.03 PCNA < 20%/> or = 20%) and also of FIGO III-tumour without residual tumours (p = 0.041 PCNA < 20%/> or = 20%). Multivariate survival analysis comprising all the patients revealed PCNA expression (< 20%/> or = 20%) as an independent prognostic factor second to the size of the residual tumour. In patients with FIGO III-tumours PCNA proves significant as an independent factor after the size of the residual tumour was removed from the model. Thus, PCNA provides additional information which may prove beneficial in determining prognostic estimates for ovarian cancer.
journal_name
Geburtshilfe Frauenheilkdjournal_title
Geburtshilfe und Frauenheilkundeauthors
Schönborn I,Minguillon C,Reles A,Bartel U,Lichtenegger Wdoi
10.1055/s-2007-1023268subject
Has Abstractpub_date
1996-07-01 00:00:00pages
357-64issue
7eissn
0016-5751issn
1438-8804journal_volume
56pub_type
杂志文章abstract：:A report is given of results and complications following postoperative irradiation in endometrial carcinoma via monitored high-dose afterloading therapy (iridium 192). Intravaginal irradiation was performed in all operated cases. In advanced cases or in cases with poor prognosis (deep infiltration of the myometrium, t...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1035941
更新日期：1986-10-01 00:00:00
abstract：:Background During cancer therapy, many patients suffer from malnutrition or vitamin deficiency. Treatment for nutrition-related deficiencies should therefore include nutritional therapy and possibly oral or intravenous substitution of micronutrients. Little information exists on multinutrient infusion therapies. The a...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/a-0754-2923
更新日期：2018-11-01 00:00:00
abstract：:The vasoconstrictive peptide (Ornithin-Vasopressin, experimental name POR 8) was tested regarding its usefulness in colposcopic diagnosis and differential diagnosis. In a concentration of 5 IE/2 ml of normal saline the compound resulted in good hemostasis in 88% of the cases. The differential diagnosis of the atypical...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1976-05-01 00:00:00
abstract：:Twin delivery is often complicated by breech presentation of the second twin. To investigate the influence of breech presentation of the second twin, we reviewed all 259 twin deliveries from the 18,404 deliveries at our institution over 11 years between 1978 to 1989. The neonatal morbidity of the second twin in breech...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1026381
更新日期：1990-11-01 00:00:00
abstract：:Therapeutic abortion is foremost a biological problem. The abrupt termination of the physiologic phenomenon of pregnancy is a sudden interference with the biology of the interaction between mother and fetus. Therapeutic abortion is also a psychological, a sociological and a political problem. Today therapeutic abortio...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1037102
更新日期：1983-04-01 00:00:00
abstract：:Introduction Obesity is a well-established risk factor for postmenopausal hormone-receptor positive breast cancer. The relationship between premenopausal breast cancer intrinsic subtypes and obesity is not completely elucidated; therefore, this systematic review was conducted to give an overview about the existing evi...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/a-1170-5004
更新日期：2020-06-01 00:00:00
abstract：:Following differentiated endocrinologic-gynecologic diagnosis auricular acupuncture was used in 15 women with oligoamenorrhea and 12 women with luteal body insufficiency who had come for hormone consultation because of sterility. In both groups the subsequent incidence of pregnancy was comparable to that achieved by d...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1035717
更新日期：1988-03-01 00:00:00
abstract：:Cervical smears of 554 women using IUDs were examined. The following criteria were evaluated: 1. Age distribution, 2. maturation index of the vaginal epithelium, 3. vaginal flora, 4. cytologic criteria of inflammation, 5. period of time between insertion of the IUD and the cytological examination, 6. final cytologic d...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1037354
更新日期：1981-03-01 00:00:00
abstract：:On account of the good prognosis for patients with breast cancer, improving or maintaining the quality of life in the aftercare period is becoming more and more important. In particular, the increasing usage of aromatase inhibitors in the past few years has led to an increased incidence of vaginal atrophy with symptom...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-0033-1350876
更新日期：2013-10-01 00:00:00
abstract：:The regular Huffman vaginoscope is fitted with an endotracheal sleeve to obtain a balloon vaginoscope. The balloon vaginoscope makes inspection of the cervix in children much easier, and facilitates the removal of foreign bodies from the vagina of children. Vaginoscopy can be learned easier with the balloon vaginoscop...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Gamete intrafallopian transfer (GIFT) was applied in 55 couples in 62 treatment cycles. The overall pregnancy rate was 38.7% (24 of 62), the highest incidence of pregnancy being obtained in the group of tubal adhesions (8 [47%] of 17), in cases of multifactorial infertility (7 [44%] of 16) and of unexplained infertili...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2007-1026428
更新日期：1990-01-01 00:00:00
abstract：:Marriage according to religious denomination is no longer important because of the philosophical changes in recent times. Reproductive behaviour is no longer dependant on religion for the same reasons. Faith in the naturalness and ordainment by God of the roles of the sexes is no longer prevalent. From 1960--1976 the ...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：:Introduction In recent decades, there has been a continuous rise in the average age at which women give birth. A maternal age of 35 years and above is considered an independent risk factor in pregnancy and birth, due to higher rates of intervention. This study investigates the influence of maternal age on birth proced...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/a-0859-0826
更新日期：2019-11-01 00:00:00
abstract：:Recently a number of authors have published their results of conservative treatment in tubal gestations. Numerous operative techniques have been described. This review tries to summarize the different operative approaches under special consideration of microsurgical techniques in regard to the authors experience. As a...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1036118
更新日期：1985-10-01 00:00:00
abstract：:In estradiol micro-crystalline suspension was injected into the ovary containing the corpus luteum in women who underwent hysterectomy. The same complete luteaolysis is in women who did not have hysterectomies was obtained. The conclusion is drawn that the prostaglandins which are formed in the uterus have no influenc...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1979-11-01 00:00:00
abstract：:At the hospital for women in Finkenau intra-uterine devices are used since 1965. At first plastic devices were used exclusively. It was assumed that the devices could stay for variable times. The present opinion that non-commper deivces have to be changed at regular intervals is in contradistinction to our first opini...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1979-05-01 00:00:00
abstract：:In 50 cases with an end-diastolic zero flow or reverse flow all antenatal and perinatal abnormalities have been recorded. The fetal outcome was registered. The percentage of highly dystrophic newborns (percentile less than 5) was 88%. The perinatal mortality counted up to 16% and the percentage of congenital malformat...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1026313
更新日期：1991-04-01 00:00:00
abstract：:This study investigates the possibilities to treat oligo-asthenozoospermia, a cause of sterility, by assisted conjugation. After completing acrosome reaction, normal motile spermatozoa are microinjected into mouse oocytes. After 2 hours of incubation time in medium with lactate and albumins, spermatozoa are put into d...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1026552
更新日期：1988-09-01 00:00:00
abstract：:In the Romano-Ward syndrome, an inherited form of abnormally prolonged QT duration is a matter for concern. The frequency-corrected QTc value in the ECG amounts to more than 0.44 s. Persons suffering from Romano-Ward syndrome are vitally endangered by attacks of arrhythmia, syncope and cardiac arrest which are trigger...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2007-1023666
更新日期：1993-03-01 00:00:00
abstract：:According to a judgement by the German Federal Court of 17 December 1991 the surgeon is legally bound to inform the patient before hand of the risk of a possible homologous blood transfusion during surgery. If the transfusion probability exceeds 5%, this obligation is really relevant, 228 patients with primary breast ...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2007-1023526
更新日期：1995-10-01 00:00:00
abstract：:In recent years, the effect of music interventions and music therapy has experienced increased attention in the literature. It has been shown that music has positive effects on cognitive and physical performance, such as concentration and endurance, as well as on psychological parameters, such as anxiety and relaxatio...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-0043-118414
更新日期：2017-09-01 00:00:00
abstract：:Surgery of the fallopian tubes has today developed into pelviscopic surgery. The development of suitable instruments such as the tube set, a new endocoagulation method were prerequisites for this development. Operative therapeutic pelviscopic surgery is a development past laparotomy. It is now possible to treat adhesi...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1977-11-01 00:00:00
abstract：:Pulsed Doppler velocimetry of the fetal aortic and pulmonary valves derived in the five-chamber-view and short-axis view were performed in 88 uncomplicated pregnancies between the 20th and 40th week of gestation. The maximal and mean velocities were assessed for both semilunar valves. Considering the valve diameters a...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2007-1023303
更新日期：1995-04-01 00:00:00
abstract：:Treatment with monoclonal antibodies (mabs) has become an established component of oncological therapy. The monoclonal antibodies available for this purpose are mainly administered intravenously in individually adapted doses according to body weight over longer treatment times. For other chronic diseases such as, for ...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-0034-1368173
更新日期：2014-04-01 00:00:00
abstract：:The specific disadvantage of the Vecchietti technique for construction of a vagina in cases of vaginal agenesis is the need for laparotomy. We describe an endoscopically assisted construction of a vagina by a variation of this method and report on the first five cases operated on without any complications and with goo...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2007-1023676
更新日期：1993-04-01 00:00:00
abstract：:The common separation of indications at the First University Clinic for Obstetrics and Gynecology in Vienna concerning the choice of extraction instrument in cases of operative termination of vaginal delivery out of vertex position is being demonstrated. When there is only a slight increase of resistance in the delive...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1975-12-01 00:00:00
abstract：:We investigated the clinical course in 35 healthy newborn with premature beats and studied the literature with regard to their frequency, pathogenesis, and therapy with the following results: Investigations with continuous monitoring or long-term ECG registration show a frequency of 7-25%. In literature, almost one-fo...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2008-1036652
更新日期：1985-11-01 00:00:00
abstract：:14 of the 16 German Federal "Lands" ("Bundesländer") participated in the first assessment in perinatal medicine in reunited Germany. A total of stored data representing 563,480 single births were used to calculate percentile values for birth weight, size (length) at birth and circumference of the head from the 23rd we...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：10.1055/s-2007-1023283
更新日期：1996-10-01 00:00:00
abstract：:Active immunotherapy is widely employed in the treatment of patients with habitual abortion, but it is comparable to the transfusion of blood or blood components with respect to possible complications such as undesirable immune responses and the possibility of transmitting infectious diseases. In fact, immunization wi...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章,评审
doi：10.1055/s-2008-1026255
更新日期：1991-12-01 00:00:00
abstract：:Seasonal fluctuations in the sex ratio of new borns are investigated. The largest predominance of male deliveries over female deliveries was found to be during the conception months May-June with an almost constant number of deliveries. The highest value was in June. Seasonal maximum of the male to female sex ratio is...
journal_title：Geburtshilfe und Frauenheilkunde
pub_type： 杂志文章
doi：
更新日期：1979-03-01 00:00:00
