Induction of B-cell differentiation antigens in interferon- or phorbol ester-treated Daudi cells is impaired by inhibitors of ADP-ribosyltransferase.

abstract：:The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capital...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spence MM,Rubin SM,Dimitrov IE,Ruiz EJ,Wemmer DE,Pines A,Yao SQ,Tian F,Schultz PG

更新日期：2001-09-11 00:00:00

abstract：:We are investigating the feasibility of using the positive-strand RNA virus Sindbis virus and its defective interfering (DI) particles as vectors for introducing foreign genes into cells. In previous work we showed by deletion mapping of a cloned cDNA derived from one of the DI RNAs that only nucleotides at the 3' and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levis R,Huang H,Schlesinger S

更新日期：1987-07-01 00:00:00

abstract：:Absorbance changes in untreated intact leaf discs, produced upon excitation with high-intensity red light, were shown to be due to the photooxidation of cytochrome b-559. At low intensities (<100 W/m2), photooxidation was almost undetectable. Photooxidation occurred with a half-time of 4.3 sec and an extent of 0.64 mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canaani O,Havaux M

更新日期：1990-12-01 00:00:00

abstract：:Temporal integration in visual perception is thought to occur within cycles of occipital alpha-band (8-12 Hz) oscillations. Successive stimuli may be integrated when they fall within the same alpha cycle and segregated for different alpha cycles. Consequently, the speed of alpha oscillations correlates with the tempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wutz A,Melcher D,Samaha J

更新日期：2018-02-06 00:00:00

abstract：:The 33-amino-acid ankyrin motif comprises a beta-turn followed by two anti-parallel alpha-helices and a loop and tandem arrays of the motif pack in a linear fashion to produce elongated structures characterized by short-range interactions. In this article we use site-directed mutagenesis to investigate the kinetic unf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Werbeck ND,Rowling PJ,Chellamuthu VR,Itzhaki LS

更新日期：2008-07-22 00:00:00

abstract：:Geckos can run rapidly on walls and ceilings, requiring high friction forces (on walls) and adhesion forces (on ceilings), with typical step intervals of approximately 20 ms. The rapid switching between gecko foot attachment and detachment is analyzed theoretically based on a tape model that incorporates the adhesion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian Y,Pesika N,Zeng H,Rosenberg K,Zhao B,McGuiggan P,Autumn K,Israelachvili J

更新日期：2006-12-19 00:00:00

abstract：:We investigated the possibility of positive selection acting on members of the putative seven-pass chemoreceptor superfamily in Caenorhabditis elegans, which comprises approximately 1,300 genes encoding seven-pass G protein-coupled receptors (GPCRs). Using a maximum-likelihood approach, we conducted statistical tests ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas JH,Kelley JL,Robertson HM,Ly K,Swanson WJ

更新日期：2005-03-22 00:00:00

abstract：:Severe combined immunodeficient (SCID) mice display an increased sensitivity to ionizing radiation compared with the parental, C.B-17, strain due to a deficiency in DNA double-strand break repair. The catalytic subunit of DNA-dependent protein kinase (DNA-PKCS) has previously been identified as a strong candidate for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fried LM,Koumenis C,Peterson SR,Green SL,van Zijl P,Allalunis-Turner J,Chen DJ,Fishel R,Giaccia AJ,Brown JM,Kirchgessner CU

更新日期：1996-11-26 00:00:00

abstract：:We have detected a proteolytic mechanism in chloroplasts that selectively and rapidly degrades the imported small subunit of ribulose 1,5-bisphosphate carboxylase when pools of the chloroplast-synthesized large subunit are depleted. This degradation system is constitutively present and appears to be responsible for pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt GW,Mishkind ML

更新日期：1983-05-01 00:00:00

abstract：:A full-length placental alkaline phosphatase (PLAP) cDNA was used to identify and clone the PLAP-like Nagao isozyme gene from human genomic libraries. The entire nucleotide sequence of the gene reveals the existence of 11 exons interrupted by 10 small introns (76-427 base pairs). Putative regulatory sequences have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Millán JL,Manes T

更新日期：1988-05-01 00:00:00

abstract：:Forebrain cholinergic neurons play important roles as striatal local circuit neurons and basal telencephalic projection neurons. The genetic mechanisms that control development of these neurons suggest that most of them are derived from the basal telencephalon where Lhx8, a LIM-homeobox gene, is expressed. Here we rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Y,Marín O,Hermesz E,Powell A,Flames N,Palkovits M,Rubenstein JL,Westphal H

更新日期：2003-07-22 00:00:00

abstract：:Profilin2 (PFN2) is a target of the embryonic stem cell (ESC)-enriched miR-290 family of microRNAs (miRNAs) and an actin/dynamin-binding protein implicated in endocytosis. Here we show that the miR-290-PFN2 pathway regulates many aspects of ESC biology. In the absence of miRNAs, PFN2 is up-regulated in ESCs, with a re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sangokoya C,Blelloch R

更新日期：2020-08-25 00:00:00

abstract：:Benthic foraminifers inhabit a wide range of aquatic environments including open marine, brackish, and freshwater environments. Here we show that several different and diverse foraminiferal groups (miliolids, rotaliids, textulariids) and Gromia, another taxon also belonging to Rhizaria, accumulate and respire nitrates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piña-Ochoa E,Høgslund S,Geslin E,Cedhagen T,Revsbech NP,Nielsen LP,Schweizer M,Jorissen F,Rysgaard S,Risgaard-Petersen N

更新日期：2010-01-19 00:00:00

abstract：:Proteins need to be tightly regulated as they control biological processes in most normal cellular functions. The precise mechanisms of regulation are rarely completely understood but can involve binding of endogenous ligands and/or partner proteins at specific locations on a protein that can modulate function. Often,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludlow RF,Verdonk ML,Saini HK,Tickle IJ,Jhoti H

更新日期：2015-12-29 00:00:00

abstract：:Antibodies can be developed to directly inhibit almost any protein, but their inability to enter the cytosol limits inhibitory antibodies to membrane-associated or extracellular targets. Developing a cytosolic antibody delivery system would offer unique opportunities to directly inhibit and study intracellular protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang HH,Tsourkas A

更新日期：2019-10-29 00:00:00

abstract：:To relate transients of force by single kinesin molecules with the elementary steps of the ATPase cycle, we measured the time to force generation by kinesin after photorelease of ATP from caged ATP. Kinesin-coated beads were trapped by an infrared laser and brought onto microtubules fixed to a coverslip. Tension was a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higuchi H,Muto E,Inoue Y,Yanagida T

更新日期：1997-04-29 00:00:00

abstract：:The uncatalyzed reactions of O(2) (S = 1) with organic substrates (S = 0) are thermodynamically favorable but kinetically slow because they are spin-forbidden and the one-electron reduction potential of O(2) is unfavorable. In nature, many of these important O(2) reactions are catalyzed by metalloenzymes. In the case ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pau MY,Lipscomb JD,Solomon EI

更新日期：2007-11-20 00:00:00

abstract：:Treatment of myoblast cell lines with 3-deazaadenosine stimulates differentiation into myofibers. Myoblast clone L5/ 3B5 , which does not form myofibers after 6 days in fusion medium, was stimulated to form myofibers after 5 days of culture in fusion medium containing 50 microM 3-deazaadenosine. Myoblast clone L5/ 3C4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scarpa S,Strom R,Bozzi A,Aksamit RR,Backlund PS Jr,Chen J,Cantoni GL

更新日期：1984-05-01 00:00:00

abstract：:A study has been made of Cauchy's problem for a class of abstract parabolic differential equations. Our study is based upon a transformation that maps solutions of second-order abstract Cauchy problems into solutions of first-order. This is a preliminary report on some of the results obtained. These results include (1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson JA

更新日期：1971-09-01 00:00:00

abstract：:The electromechanochemical model has been reformulated to take account of the close connection between energy coupling and catalysis. In catalysis the protein is programmed to utilize thermal energy to produce local strains in the catalytic cavity and to generate conformational states that favor substrate --> product ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green DE,Ji S

更新日期：1973-03-01 00:00:00

abstract：:Transgenic mice expressing the Pim-1 kinase are predisposed to develop T-cell lymphomas with a long latency period of about 7-9 months. However, the exact functional basis of the oncogenic activity of Pim-1 remains obscure. C57BL/6 mice homozygous for the lpr mutation develop a well-described lymphoproliferative syndr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Möröy T,Grzeschiczek A,Petzold S,Hartmann KU

更新日期：1993-11-15 00:00:00

abstract：:Most of the activities of IFN-gamma are the result of STAT1-mediated transcriptional responses. In this study, we show that the BRCA1 tumor suppressor acts in concert with STAT1 to differentially activate transcription of a subset of IFN-gamma target genes and mediates growth inhibition by this cytokine. After IFN-gam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ouchi T,Lee SW,Ouchi M,Aaronson SA,Horvath CM

更新日期：2000-05-09 00:00:00

abstract：:The annual migration of ∼1.2 million wildebeest (Connochaetes taurinus) through the Serengeti Mara Ecosystem is the largest remaining overland migration in the world. One of the most iconic portions of their migration is crossing of the Mara River, during which thousands drown annually. These mass drownings have been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Subalusky AL,Dutton CL,Rosi EJ,Post DM

更新日期：2017-07-18 00:00:00

abstract：:Whereas target-specific drugs are available for treating ERBB2-overexpressing and hormone receptor-positive breast cancers, no tailored therapy exists for hormone receptor- and ERBB2-negative ("triple-negative") mammary carcinomas. Triple-negative tumors account for 15% of all breast cancers and frequently harbor defe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rottenberg S,Jaspers JE,Kersbergen A,van der Burg E,Nygren AO,Zander SA,Derksen PW,de Bruin M,Zevenhoven J,Lau A,Boulter R,Cranston A,O'Connor MJ,Martin NM,Borst P,Jonkers J

更新日期：2008-11-04 00:00:00

abstract：:Drug-target residence time (t = 1/k(off), where k(off) is the dissociation rate constant) has become an important index in discovering better- or best-in-class drugs. However, little effort has been dedicated to developing computational methods that can accurately predict this kinetic parameter or related parameters, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bai F,Xu Y,Chen J,Liu Q,Gu J,Wang X,Ma J,Li H,Onuchic JN,Jiang H

更新日期：2013-03-12 00:00:00

abstract：:URF13 is a mitochondrially encoded, integral membrane protein found only in maize carrying the cms-T cytoplasm. URF13 is associated with cytoplasmic male sterility, Texas type, and causes susceptibility to the fungal pathogens Bipolaris maydis race T and Phyllosticta maydis. URF13 is predicted to contain three transme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rhoads DM,Kaspi CI,Levings CS 3rd,Siedow JN

更新日期：1994-08-16 00:00:00

abstract：:Isolates of rhinovirus C (RV-C), a recently identified Enterovirus (EV) species, are the causative agents of severe respiratory infections among children and are linked to childhood asthma exacerbations. The RV-C have been refractory to structure determination because they are difficult to propagate in vitro. Here, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Hill MG,Klose T,Chen Z,Watters K,Bochkov YA,Jiang W,Palmenberg AC,Rossmann MG

更新日期：2016-08-09 00:00:00

abstract：:Comparative vertebrate genome sequencing offers a powerful method for detecting conserved regulatory sequences. We propose that the compact genome of the teleost Fugu rubripes is well suited for this purpose. The evolutionary distance of teleosts from other vertebrates offers the maximum stringency for such evolutiona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aparicio S,Morrison A,Gould A,Gilthorpe J,Chaudhuri C,Rigby P,Krumlauf R,Brenner S

更新日期：1995-02-28 00:00:00

abstract：:A 6.1-kilobase insertion into the rudimentary (r) gene was cloned and partially sequenced. The insertion consists of a 703-base-pair (bp) P element next to a 5.4-kilobase single-copy sequence. The normal position of the single-copy sequence is near the tip of the X chromosome. Upon insertion into the r gene, this chim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsubota SI,Huong DV

更新日期：1991-02-01 00:00:00

abstract：:In the central nervous system, myelin proteolipid protein isoforms (PLP and DM20) play an essential structural role in myelination. It has been shown in several species that myelination is impaired by molecular defects resulting from single base mutations in the PLP gene. We have used DNA amplification by polymerase c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pham-Dinh D,Popot JL,Boespflug-Tanguy O,Landrieu P,Deleuze JF,Boué J,Jollès P,Dautigny A

更新日期：1991-09-01 00:00:00