The base pair-scale diffusion of nucleosomes modulates binding of transcription factors.

abstract：:A key component of scientific communication is sufficient information for other researchers in the field to reproduce published findings. For computational and data-enabled research, this has often been interpreted to mean making available the raw data from which results were generated, the computer code that generate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stodden V,Seiler J,Ma Z

更新日期：2018-03-13 00:00:00

abstract：:When the visual (striate) cortex (V1) is damaged in human subjects, cortical blindness results in the contralateral visual half field. Nevertheless, under some experimental conditions, subjects demonstrate a capacity to make visual discriminations in the blind hemifield (blindsight), even though they have no phenomena...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiskrantz L,Barbur JL,Sahraie A

更新日期：1995-06-20 00:00:00

abstract：:Escherichia coli glutamine synthetase (GS) was inactivated by a nonenzymic mixed-function oxidation system composed of ascorbate, O2, and Fe(III). Partial inactivation of GS by this system leads to the formation of hybrid GS molecules (dodecamers) composed of both active and inactive subunits. Subunit interactions in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura K,Stadtman ER

更新日期：1984-04-01 00:00:00

abstract：:Granulocytes generate a "respiratory burst" of NADPH oxidase-dependent superoxide anion (O(2)(-*)) production that is required for efficient clearance of bacterial pathogens. Hv1 mediates a voltage-gated H(+) channel activity that is proposed to serve a charge-balancing role in granulocytic phagocytes such as neutroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsey IS,Ruchti E,Kaczmarek JS,Clapham DE

更新日期：2009-05-05 00:00:00

abstract：:Mutations in Pink1, a gene encoding a Ser/Thr kinase with a mitochondrial-targeting signal, are associated with Parkinson's disease (PD), the most common movement disorder characterized by selective loss of dopaminergic neurons. The mechanism by which loss of Pink1 leads to neurodegeneration is not understood. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Y,Gehrke S,Imai Y,Huang Z,Ouyang Y,Wang JW,Yang L,Beal MF,Vogel H,Lu B

更新日期：2006-07-11 00:00:00

abstract：:Short interfering RNA (siRNA) is widely used for studying gene function and holds great promise as a tool for validating drug targets and treating disease. A critical assumption in these applications is that the effect of siRNA on cells is specific, i.e., limited to the specific knockdown of the target gene. In this a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Semizarov D,Frost L,Sarthy A,Kroeger P,Halbert DN,Fesik SW

更新日期：2003-05-27 00:00:00

abstract：:Observations from human microbiome studies are often conflicting or inconclusive. Many factors likely contribute to these issues including small cohort sizes, sample collection, and handling and processing differences. The field of microbiome research is moving from 16S rDNA gene sequencing to a more comprehensive gen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones MB,Highlander SK,Anderson EL,Li W,Dayrit M,Klitgord N,Fabani MM,Seguritan V,Green J,Pride DT,Yooseph S,Biggs W,Nelson KE,Venter JC

更新日期：2015-11-10 00:00:00

abstract：:The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood. Using Ubc13 conditional knockout mice, we show that somatic deletion of the Ubc13 gene cau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Yamamoto M,Akira S,Sun SC

更新日期：2009-12-08 00:00:00

abstract：:Sequence polymorphism of class II major histocompatibility complex-encoded molecules (Ia) not only accounts for the allelic variability in Ia structure relevant to T-lymphocyte responses but also seems to result in differential quantitative expression of particular Ia heterodimers. The contributions of different allel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braunstein NS,Germain RN

更新日期：1987-05-01 00:00:00

abstract：:The fetal genome regulates maternal physiology and behavior via its placenta, which produces hormones that act on the maternal hypothalamus. At the same time, the fetus itself develops a hypothalamus. In this study we show that many of the genes that regulate placental development also regulate the developing hypothal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broad KD,Keverne EB

更新日期：2011-09-13 00:00:00

abstract：:Astrocyte-elevated gene-1 (AEG-1) expression is increased in multiple cancers and plays a central role in Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Additionally, overexpression of AEG-1 protects primary and transformed human and rat cells from serum starvation-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emdad L,Lee SG,Su ZZ,Jeon HY,Boukerche H,Sarkar D,Fisher PB

更新日期：2009-12-15 00:00:00

abstract：:The major virulence determinant of the rodent malaria parasite, Plasmodium yoelii, has remained unresolved since the discovery of the lethal line in the 1970s. Because virulence in this parasite correlates with the ability to invade different types of erythrocytes, we evaluated the potential role of the parasite eryth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Otsuki H,Kaneko O,Thongkukiatkul A,Tachibana M,Iriko H,Takeo S,Tsuboi T,Torii M

更新日期：2009-04-28 00:00:00

abstract：:A two-dimensional model of the expansion of a crack in an elastic medium is considered in which friction depends on the slip rate and the modulus of cohesion depends on the speed of expansion of the crack. Elastic waves are neglected (quasi-static model). Under some conditions, the expansion of the crack is realized b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barenblatt GI,Keilis-Borok VI,Vishik MM

更新日期：1981-09-01 00:00:00

abstract：:Previous studies in Saccharomyces cerevisiae have defined an essential role for the Dbf4-Cdc7 kinase complex in the initiation of DNA replication presumably by phosphorylation of target proteins, such as the minichromosome maintenance (Mcm) complex. We have examined the phosphorylation of the Mcm complex by the Dfp1-H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JK,Seo YS,Hurwitz J

更新日期：2003-03-04 00:00:00

abstract：:U2 snRNP auxiliary factor 65 kDa (U2AF(65)) is a general splicing factor that contacts polypyrimidine (Py) tract and promotes prespliceosome assembly. In this report, we show that U2AF(65) stimulates alternative exon skipping in spinal muscular atrophy (SMA)-related survival motor neuron (SMN) pre-mRNA. A stronger 5' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho S,Moon H,Loh TJ,Jang HN,Liu Y,Zhou J,Ohn T,Zheng X,Shen H

更新日期：2015-08-11 00:00:00

abstract：:Highly pathogenic avian influenza A viruses of subtypes H5 and H7 are the causative agents of fowl plague in poultry. Influenza A viruses of subtype H5N1 also caused severe respiratory disease in humans in Hong Kong in 1997 and 2003, including at least seven fatal cases, posing a serious human pandemic threat. Between...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fouchier RA,Schneeberger PM,Rozendaal FW,Broekman JM,Kemink SA,Munster V,Kuiken T,Rimmelzwaan GF,Schutten M,Van Doornum GJ,Koch G,Bosman A,Koopmans M,Osterhaus AD

更新日期：2004-02-03 00:00:00

abstract：:The COVID-19 pandemic is a shocking reminder of how our world would look in the absence of vaccination. Fortunately, new technologies, the pace of understanding new and existing pathogens, and the increased knowledge of the immune system allow us today to develop vaccines at an unprecedented speed. Some of the vaccine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rappuoli R,De Gregorio E,Del Giudice G,Phogat S,Pecetta S,Pizza M,Hanon E

更新日期：2021-01-19 00:00:00

abstract：:Exposure of Escherichia coli to alkylating agents activates expression of AidB in addition to DNA repair proteins Ada, AlkA, and AlkB. AidB was recently shown to possess a flavin adenine dinucleotide (FAD) cofactor and to bind to dsDNA, implicating it as a flavin-dependent DNA repair enzyme. However, the molecular mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowles T,Metz AH,O'Quin J,Wawrzak Z,Eichman BF

更新日期：2008-10-07 00:00:00

abstract：:We report dynamic glycoprotein recognition of gels prepared by biomolecular imprinting using lectin and antibody molecules as ligands for tumor-specific marker glycoproteins. The glycoprotein-imprinted gels prepared with minute amounts of cross-linkers could dynamically recognize tumor-specific marker glycoproteins by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyata T,Jige M,Nakaminami T,Uragami T

更新日期：2006-01-31 00:00:00

abstract：:Basal ganglia-thalamocortical circuits are critical for motor control and motor learning. Classically, basal ganglia nuclei are thought to regulate motor behavior by increasing or decreasing cortical firing rates, and basal ganglia diseases are assumed to reflect abnormal overall activity levels. More recent studies s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kojima S,Kao MH,Doupe AJ

更新日期：2013-03-19 00:00:00

abstract：:Treatment of lymphocytes with inducers of interferon alpha (IFN-alpha) results in the production of corticotropin (ACTH) and endorphin-like activities. The pro-opiomelanocortin-derived hormones ACTH and alpha-, beta-, and gamma-endorphin and the structurally related hormones [Leu]- and [Met]enkephalin were therefore t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson HM,Smith EM,Torres BA,Blalock JE

更新日期：1982-07-01 00:00:00

abstract：:Recently, single molecule-based superresolution fluorescence microscopy has surpassed the diffraction limit to improve resolution to the order of 20 nm or better. These methods typically use image fitting that assumes an isotropic emission pattern from the single emitters as well as control of the emitter concentratio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backlund MP,Lew MD,Backer AS,Sahl SJ,Grover G,Agrawal A,Piestun R,Moerner WE

更新日期：2012-11-20 00:00:00

abstract：:Vesicles were constituted with glycophorin, the Sendai virus receptor of human erythrocytes, and loaded with calcein, a polar derivative of fluorescein, at self-quenching concentrations. On exposure to Sendai virus and mild hypo-osmotic stress, vesicles of the appropriate composition released a significant portion of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kundrot CE,Spangler EA,Kendall DA,MacDonald RC,MacDonald RI

更新日期：1983-03-01 00:00:00

abstract：:Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuruvilla AP,Shah R,Hochwald GM,Liggitt HD,Palladino MA,Thorbecke GJ

更新日期：1991-04-01 00:00:00

abstract：:Stem cells divide and differentiate to form all of the specialized cell types in a multicellular organism. In the Arabidopsis root, stem cells are maintained in an undifferentiated state by a less mitotically active population of cells called the quiescent center (QC). Determining how the QC regulates the surrounding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark NM,Fisher AP,Berckmans B,Van den Broeck L,Nelson EC,Nguyen TT,Bustillo-Avendaño E,Zebell SG,Moreno-Risueno MA,Simon R,Gallagher KL,Sozzani R

更新日期：2020-06-30 00:00:00

abstract：:The human immunodeficiency virus 1 (HIV-1) Tat protein suppresses antigen-induced, but not mitogen-induced, activation of human T cells when added to T-cell cultures [Viscidi, R. P., Mayur, K., Lederman, H. M. & Frankel, A. D. (1989) Science 246, 1606-1608]. This activity is potentially pertinent to the development of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gutheil WG,Subramanyam M,Flentke GR,Sanford DG,Munoz E,Huber BT,Bachovchin WW

更新日期：1994-07-05 00:00:00

abstract：:Defending cellular integrity against disturbances in intracellular concentrations of ATP ([ATP](i)) is predicated on coordinating the selection of substrates and their flux through metabolic pathways (metabolic signaling), ATP transfer from sites of production to utilization (energetic signaling), and the regulation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Stewart I,Tiyyagura SR,Lin JE,Kazerounian S,Pitari GM,Schulz S,Martin E,Murad F,Waldman SA

更新日期：2004-01-06 00:00:00

abstract：:Antibodies provide effective antiviral immunity despite the fact that viruses escape into cells when they infect. Here we show that antibodies remain attached to viruses after cell infection and mediate an intracellular immune response that disables virions in the cytosol. We have discovered that cells possess a cytos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mallery DL,McEwan WA,Bidgood SR,Towers GJ,Johnson CM,James LC

更新日期：2010-11-16 00:00:00

abstract：:A detailed conformational analysis of the known crystal structures of vitamin A, carotenoid, and xanthenoid derivatives has been made. These studies suggest that the visual chromophore 11-cis retinal and its isomers may each occur in several different conformational states, which would be expected to have different li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sundaralingam M,Beddell C

更新日期：1972-06-01 00:00:00

abstract：:We develop a potential landscape approach to quantitatively describe experimental data from a fibroblast cell line that exhibits a wide range of GFP expression levels under the control of the promoter for tenascin-C. Time-lapse live-cell microscopy provides data about short-term fluctuations in promoter activity, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sisan DR,Halter M,Hubbard JB,Plant AL

更新日期：2012-11-20 00:00:00