Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval.

abstract：:Although prostate cancer (CaP) is the most frequently diagnosed malignant tumor and the second leading cause of cancer deaths in American men, the mechanisms explaining the development and progression of CaP remain largely unknown. Recent studies have shown that some aberrantly expressed microRNAs (miRNAs) are involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi XB,Xue L,Yang J,Ma AH,Zhao J,Xu M,Tepper CG,Evans CP,Kung HJ,deVere White RW

更新日期：2007-12-11 00:00:00

abstract：:We are interested in tracking changes in large-scale data by periodically creating an agglomerative clustering and examining the evolution of clusters (communities) over time. We examine a large real-world data set: the NEC CiteSeer database, a linked network of >250,000 papers. Tracking changes over time requires a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopcroft J,Khan O,Kulis B,Selman B

更新日期：2004-04-06 00:00:00

abstract：:A human collagenase inhibitor (CI) of Mr 28,500 has been extensively characterized in skin fibroblasts and identified in a variety of connective tissues. Because human alveolar macrophages synthesize and secrete both a collagenase and CI that are immunologically and functionally identical to their counterparts in fibr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Shavit Z,Teitelbaum SL,Stricklin GP,Eisen AZ,Kahn AJ,Welgus HG

更新日期：1985-08-01 00:00:00

abstract：:MicroRNAs are predicted to regulate approximately 30% of all human genes by targeting sequences in their 3' UTR. Polymorphisms in 3' UTR of several genes have been reported to affect gene expression, but the mechanism is not fully understood. Here, we demonstrate that 829C-->T, a naturally occurring SNP, near the miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mishra PJ,Humeniuk R,Mishra PJ,Longo-Sorbello GS,Banerjee D,Bertino JR

更新日期：2007-08-14 00:00:00

abstract：:Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator for antioxidant and anti-inflammation enzymes that binds to its endogenous inhibitor protein, Kelch-like ECH (erythroid cell-derived protein with CNC homology)-associated protein 1, in the cytoplasm under normal conditions. Various e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SB,Pandita RK,Eskiocak U,Ly P,Kaisani A,Kumar R,Cornelius C,Wright WE,Pandita TK,Shay JW

更新日期：2012-10-23 00:00:00

abstract：:Complementation of the plasmin fragments of reduced-carbamoylmethylated (Cam) human somatotropin (hGH) with those of reduced-carbamoylmethylated human chorionic somatomammotropin (hCS) have been investigated. It was found that the recombinant obtained by noncovalent interaction of [Cys(Cam)53]hGH-(1-134) with [Cys(Cam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li CH

更新日期：1978-04-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) plays an essential role in regulating emotion, including inhibiting fear when danger has passed. The extinction of fear, however, is labile and a number of factors, including stress, cause extinguished fear to relapse. Here we show that fear relapse in rats limits single-unit activi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustino TF,Fitzgerald PJ,Ressler RL,Maren S

更新日期：2019-04-23 00:00:00

abstract：:Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and proliferation, two cellular processes that do not occur simultaneously--a phenomenon called "migration-proliferation dichotomy." We previously showed that epidermal growth factor (EGF) signaling is skewed to favor migration over prolif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhandari D,Lopez-Sanchez I,To A,Lo IC,Aznar N,Leyme A,Gupta V,Niesman I,Maddox AL,Garcia-Marcos M,Farquhar MG,Ghosh P

更新日期：2015-09-01 00:00:00

abstract：:Recently, single molecule-based superresolution fluorescence microscopy has surpassed the diffraction limit to improve resolution to the order of 20 nm or better. These methods typically use image fitting that assumes an isotropic emission pattern from the single emitters as well as control of the emitter concentratio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backlund MP,Lew MD,Backer AS,Sahl SJ,Grover G,Agrawal A,Piestun R,Moerner WE

更新日期：2012-11-20 00:00:00

abstract：:Epilepsy, a disease characterized by abnormal brain activity, is a disabling and potentially life-threatening condition for nearly 1% of the world population. Unfortunately, modulation of brain excitability using available antiepileptic drugs can have serious side effects, especially in the developing brain, and some ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraban SC,Southwell DG,Estrada RC,Jones DL,Sebe JY,Alfaro-Cervello C,García-Verdugo JM,Rubenstein JL,Alvarez-Buylla A

更新日期：2009-09-08 00:00:00

abstract：:Certain chemical systems which differ greatly in many of their chemical properties may nevertheless exhibit stereochemically isomorphic behavior, i.e., they may be stereochemically correspondent. Two such systems are spirocyclic pentacoordinate molecules and molecules of the type Ar(2)ZX. The consequences of stereoche...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gust D,Finocchiaro P,Mislow K

更新日期：1973-12-01 00:00:00

abstract：:Capsaicin (CP), the pungent component of chili pepper, acts on sensory neurons to convey the sensation of pain. The CP receptor, vanilloid receptor 1 (VR1), has been shown to be highly expressed by nociceptive neurons in dorsal root and trigeminal ganglia. We demonstrate here that the dendritic cell (DC), a key cell t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu S,Srivastava P

更新日期：2005-04-05 00:00:00

abstract：:The sterol regulatory element-binding protein (SREBP) family of transcription factors controls the biosynthesis of cholesterol and other lipids, and lipid synthesis is critical for cell growth and proliferation. We were, therefore, interested in the expression and activity of SREBPs during the cell cycle. We found tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bengoechea-Alonso MT,Punga T,Ericsson J

更新日期：2005-08-16 00:00:00

abstract：:Rad51 is a core component of the eukaryotic homologous recombination machinery and is responsible for key mechanistic steps during strand invasion. Higher order oligomers of Rad51 display a remarkable degree of structural variation, forming rings, compressed filaments, and elongated filaments. It is unclear whether Ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robertson RB,Moses DN,Kwon Y,Chan P,Chi P,Klein H,Sung P,Greene EC

更新日期：2009-08-04 00:00:00

abstract：:Although it is accepted that regulatory T cells (T regs) contribute to cancer progression, most studies in the field consider nonantigen-specific suppression. Here, we show the presence of tumor antigen-specific CD4(+) T regs in the blood of patients with metastatic melanoma. These CD4(+) T regs recognize a broad rang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vence L,Palucka AK,Fay JW,Ito T,Liu YJ,Banchereau J,Ueno H

更新日期：2007-12-26 00:00:00

abstract：:The liver plays a critical role in inducing systemic immune tolerance, for example, during limiting hypersensitivity to food allergy and in rendering acceptance of allotransplant or even hepatotropic pathogens. We investigated the unknown mechanisms of liver tolerance by using an established hepatitis B virus (HBV)-ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu L,Yin W,Sun R,Wei H,Tian Z

更新日期：2013-10-15 00:00:00

abstract：:Endosomal cargo travels through a dynamic vesicle network en route to degradation by lysosomes or recycling through the Golgi apparatus back to the cell surface. Rab5 is a key determinant of the early endosomes by organizing effector proteins in specific subdomains and mediating early endosome fusion. We find that ear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antignani A,Youle RJ

更新日期：2008-06-10 00:00:00

abstract：:We image macroscopic transient pores in mechanically stretched giant vesicles. Holes open above a critical radius r(c1), grow up to a radius r(c2), and close. We interpret the upper limit r(c2) by a relaxation of the membrane tension as the holes expand. The closing of the holes is caused by a further relaxation of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sandre O,Moreaux L,Brochard-Wyart F

更新日期：1999-09-14 00:00:00

abstract：:A fibroblast growth regulator, which inhibits the growth and division of proliferating fibroblasts, has been isolated from medium conditioned by exposure to density-inhibited mouse 3T3 cells. This partially purified preparation of the growth-inhibitory activity, termed FGR-s, contained two major polypeptides (Mrs, 10,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu YM,Barry JM,Wang JL

更新日期：1984-04-01 00:00:00

abstract：:Femtosecond and subfemtosecond time scales typically rule electron dynamics at metal surfaces. Recent advance in experimental techniques permits now remarkable precision in the description of these processes. In particular, shorter time scales, smaller system sizes, and spin-dependent effects are current targets of in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muiño RD,Sánchez-Portal D,Silkin VM,Chulkov EV,Echenique PM

更新日期：2011-01-18 00:00:00

abstract：:We report the heavy chain variable region sequences from the cDNAs of five previously described monoclonal cell lines producing human antibodies specific for the human immunodeficiency virus type 1 and detail the molecular characteristics, germ-line origins, and extent of somatic mutation among these antibodies. Three...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andris JS,Johnson S,Zolla-Pazner S,Capra JD

更新日期：1991-09-01 00:00:00

abstract：:Initiation of DNA replication has been observed in vitro with a DNA-membrane complex extracted from Bacillus subtilis. Antibiotics known to interfere with various aspects of initiation inhibited DNA synthesis significantly in vitro, whereas a mutant resistant to one inhibitor failed to respond to its presence. The inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benjamin P,Firshein W

更新日期：1983-10-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA)-modulin is a brain protein of Mr 16,500 that down-regulates the high-affinity binding site for GABA which is located in crude synaptic membranes. This protein can be phosphorylated in vitro by the catalytic subunit of cAMP-dependent protein kinase and by a partially purified preparation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise BC,Guidotti A,Costa E

更新日期：1983-02-01 00:00:00

abstract：:When an unusually high frequency of an allele is encountered in a population, "founder effect" is often invoked as an explanation. As usually used, the term implies the disproportionate increase through chance (rather than selection) of an allele contributed to the population by a particular ancestor. While genetic th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson EA,Neel JV

更新日期：1978-03-01 00:00:00

abstract：:The lateral mobility of individual murine polyoma virus-like particles (VLPs) bound to live cells and artificial lipid bilayers was studied by single fluorescent particle tracking using total internal reflection fluorescence microscopy. The particle trajectories were analyzed in terms of diffusion rates and modes of m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ewers H,Smith AE,Sbalzarini IF,Lilie H,Koumoutsakos P,Helenius A

更新日期：2005-10-18 00:00:00

abstract：:Ciliary Neurotrophic Factor (CNTF) was first characterized as a trophic factor for motor neurons in the ciliary ganglion and spinal cord, leading to its evaluation in humans suffering from motor neuron disease. In these trials, CNTF caused unexpected and substantial weight loss, raising concerns that it might produce ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lambert PD,Anderson KD,Sleeman MW,Wong V,Tan J,Hijarunguru A,Corcoran TL,Murray JD,Thabet KE,Yancopoulos GD,Wiegand SJ

更新日期：2001-04-10 00:00:00

abstract：:People who are more avoidant of pathogens are more politically conservative, as are nations with greater parasite stress. In the current research, we test two prominent hypotheses that have been proposed as explanations for these relationships. The first, which is an intragroup account, holds that these relationships ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tybur JM,Inbar Y,Aarøe L,Barclay P,Barlow FK,de Barra M,Becker DV,Borovoi L,Choi I,Choi JA,Consedine NS,Conway A,Conway JR,Conway P,Adoric VC,Demirci DE,Fernández AM,Ferreira DC,Ishii K,Jakšić I,Ji T,van Leeuwen

更新日期：2016-11-01 00:00:00

abstract：:Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein. To examine the physical basis for the apparent disproportion between LDL cholesterol and apoB characteristic of this syndrome, we used density...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng B,Thompson GR,Sniderman AD,Forte TM,Krauss RM,Kwiterovich PO Jr

更新日期：1983-11-01 00:00:00

abstract：:We determined the crystal structure of the Escherichia coli nucleoid-associated HUalphabeta protein by x-ray diffraction and observed that the heterodimers form multimers with octameric units in three potential arrangements, which may serve specialized roles in different DNA transaction reactions. It is of special imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo F,Adhya S

更新日期：2007-03-13 00:00:00

abstract：:We examined the MLL genomic translocation breakpoint in acute myeloid leukemia of infant twins. Southern blot analysis in both cases showed two identical MLL gene rearrangements indicating chromosomal translocation. The rearrangements were detectable in the second twin before signs of clinical disease and the intensit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Megonigal MD,Rappaport EF,Jones DH,Williams TM,Lovett BD,Kelly KM,Lerou PH,Moulton T,Budarf ML,Felix CA

更新日期：1998-05-26 00:00:00