Multiple SCN5A variant enhancers modulate its cardiac gene expression and the QT interval.

abstract：:The intracellular activation of trypsinogen, which is both pH- and calcium-dependent, is an important early step in the development of acute pancreatitis. The cellular compartment in which trypsinogen activation occurs currently is unknown. We therefore investigated the site of intracellular trypsinogen activation by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherwood MW,Prior IA,Voronina SG,Barrow SL,Woodsmith JD,Gerasimenko OV,Petersen OH,Tepikin AV

更新日期：2007-03-27 00:00:00

abstract：:Angiogenin, a potent inducer of neovascularization in the chicken chorioallantoic membrane and rabbit cornea, promotes endothelial cell invasion of Matrigel basement membrane. A transformed bovine aortic endothelial cell line, GM 7373, is 5 times more invasive when cultured in the presence of 1 microgram of bovine ang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu G,Riordan JF,Vallee BL

更新日期：1994-12-06 00:00:00

abstract：:The rates of spontaneous mutation to 6-thioguanine resistance were determined in fibroblasts derived from normal and two Bloom syndrome individuals (GM 2548 and GM 1492). Two methods were utilized to determine the rates. Method I obtained the spontaneous mutation rate from the increase in the mutation frequency of a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren ST,Schultz RA,Chang CC,Wade MH,Trosko JE

更新日期：1981-05-01 00:00:00

abstract：:Dopaminergic and glutamatergic neurotransmissions in the striatum play an essential role in motor- and reward-related behaviors. Dysfunction of these neurotransmitter systems has been found in Parkinson's disease, schizophrenia, and drug addiction. Cyclin-dependent kinase 5 (CDK5) negatively regulates postsynaptic sig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chergui K,Svenningsson P,Greengard P

更新日期：2004-02-17 00:00:00

abstract：:The ubiquitous gasotransmitter hydrogen sulfide (H2S) has been recognized to play a crucial role in human health. Using cystathionine γ-lyase (CSE)-deficient mice, we demonstrate an unexpected role of H2S in Mycobacterium tuberculosis (Mtb) pathogenesis. We showed that Mtb-infected CSE-/- mice survive longer than WT m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rahman MA,Cumming BM,Addicott KW,Pacl HT,Russell SL,Nargan K,Naidoo T,Ramdial PK,Adamson JH,Wang R,Steyn AJC

更新日期：2020-03-24 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen K,Sabatini DM

更新日期：2018-09-18 00:00:00

abstract：:A number of recent studies have shown that iron dissolution in Fe-containing dust aerosol can be linked to source material (mineral or anthropogenic), mineralogy, and iron speciation. All of these factors need to be incorporated into atmospheric chemistry models if these models are to accurately predict the impact of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubasinghege G,Lentz RW,Scherer MM,Grassian VH

更新日期：2010-04-13 00:00:00

abstract：:Direct reciprocity and conditional cooperation are important mechanisms to prevent free riding in social dilemmas. However, in large groups, these mechanisms may become ineffective because they require single individuals to have a substantial influence on their peers. However, the recent discovery of zero-determinant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Wu B,Traulsen A,Nowak MA

更新日期：2014-11-18 00:00:00

abstract：:The tissue-specific transcriptional coactivator OCA-B is required for antigen-dependent B cell differentiation events, including germinal center formation. However, the identity of OCA-B target genes involved in this process is unknown. This study has used large-scale cDNA arrays to monitor changes in gene expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim U,Siegel R,Ren X,Gunther CS,Gaasterland T,Roeder RG

更新日期：2003-07-22 00:00:00

abstract：:Electronic nematicity, a correlated state that spontaneously breaks rotational symmetry, is observed in several layered quantum materials. In contrast to their liquid-crystal counterparts, the nematic director cannot usually point in an arbitrary direction (XY nematics), but is locked by the crystal to discrete direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida K,Tsujii M,Hosoi S,Mizukami Y,Ishida S,Iyo A,Eisaki H,Wolf T,Grube K,V Löhneysen H,Fernandes RM,Shibauchi T

更新日期：2020-03-24 00:00:00

abstract：:We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates. This delivery system has been found to be very effective for both the internalization and the expression of genetic material in cells that have many transferrin rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Cotten M,Foisner R,Birnstiel ML

更新日期：1991-05-15 00:00:00

abstract：:The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Schnetz-Boutaud NC,Weisenseel JP,Marnett LJ,Stone MP

更新日期：1999-06-08 00:00:00

abstract：:Junctions that mediate excitation-contraction (e-c) coupling are formed between the sarcoplasmic reticulum (SR) and either the surface membrane or the transverse (T) tubules in normal skeletal muscle. Two structural components of the junctions, the feet of the SR and the tetrads of T tubules, have been identified resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takekura H,Nishi M,Noda T,Takeshima H,Franzini-Armstrong C

更新日期：1995-04-11 00:00:00

abstract：:Modeling studies of terrestrial extrasolar planetary climates are now including the effects of ocean circulation due to a recognition of the importance of oceans for climate; indeed, the peak equator-pole ocean heat transport on Earth peaks at almost half that of the atmosphere. However, such studies have made the ass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cullum J,Stevens DP,Joshi MM

更新日期：2016-04-19 00:00:00

abstract：:Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is a newly recognized condition in children with recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These children and adult patients with severe hyperinflammation present with a constellation of symptoms that st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng MH,Zhang S,Porritt RA,Noval Rivas M,Paschold L,Willscher E,Binder M,Arditi M,Bahar I

更新日期：2020-10-13 00:00:00

abstract：:Olfactory transduction is thought to take place in the outer dendritic membrane of insect olfactory receptor neurons. Here we show that the outer dendritic plasma membrane of silkmoth olfactory receptor neurons seems to be exclusively equipped with a specific ion channel activated by low concentrations of the species-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zufall F,Hatt H

更新日期：1991-10-01 00:00:00

abstract：:The assembly of tiny magnetic particles in external magnetic fields is important for many applications ranging from data storage to medical technologies. The development of ever smaller magnetic structures is restricted by a size limit, where the particles are just barely magnetic. For such particles we report the dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehdizadeh Taheri S,Michaelis M,Friedrich T,Förster B,Drechsler M,Römer FM,Bösecke P,Narayanan T,Weber B,Rehberg I,Rosenfeldt S,Förster S

更新日期：2015-11-24 00:00:00

abstract：:An invariant substructure that forms two interlocked pairs of neighboring beta-strands occurs in essentially all known sandwich-like proteins. Eight conserved positions in these strands were recently shown to act as structural determinants. To test whether the residues at these invariant positions are conserved for me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson CJ,Wittung-Stafshede P

更新日期：2005-03-15 00:00:00

abstract：:The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apcher S,Daskalogianni C,Lejeune F,Manoury B,Imhoos G,Heslop L,Fåhraeus R

更新日期：2011-07-12 00:00:00

abstract：:ATP-dependent RNA ligases are agents of RNA repair that join 3'-OH and 5'-PO4 RNA ends. Naegleria gruberi RNA ligase (NgrRnl) exemplifies a family of RNA nick-sealing enzymes found in bacteria, viruses, and eukarya. Crystal structures of NgrRnl at three discrete steps along the reaction pathway-covalent ligase-(lysyl-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Unciuleac MC,Goldgur Y,Shuman S

更新日期：2015-11-10 00:00:00

abstract：:We have isolated, cloned, and expressed a male antennae-specific pheromone-degrading enzyme (PDE) [Antheraea polyphemus PDE (ApolPDE), formerly known as Sensillar Esterase] from the wild silkmoth, A. polyphemus, which seems essential for the rapid inactivation of pheromone during flight. The onset of enzymatic activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida Y,Leal WS

更新日期：2005-09-27 00:00:00

abstract：:Antibody against carcinoembryonic antigen (CEA) was conjugated with p-[1,2-dicarba-closo-[1-3H]do-decaboran(12)-2-yl] benzenediazonium ion by an azo-coupling reaction, resulting in 30 boron atoms per IgG molecule with no loss of antibody protein. Antibody immunoreactivity was not appreciably affected by this conjugati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldenberg DM,Sharkey RM,Primus FJ,Mizusawa E,Hawthorne MF

更新日期：1984-01-01 00:00:00

abstract：:Glucagon-like peptide 1 (GLP-1) is a hormone derived from the preproglucagon molecule and is secreted by intestinal L cells. It is the most potent stimulator of glucose-induced insulin secretion and also suppresses in vivo acid secretion by gastric glands. A cDNA for the GLP-1 receptor was isolated by transient expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorens B

更新日期：1992-09-15 00:00:00

abstract：:Two nucleases that catalyze the excision of photoproducts from UV-irradiated DNA have been extensively purified from M. luteus (M. lysodeikticus). The first enzyme, an endonuclease, has been purified 5000-fold and is free of conflicting nuclease activities. It introduces single-strand breaks into irradiated DNA but do...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan JC,Kushner SR,Grossman L

更新日期：1969-05-01 00:00:00

abstract：:Long-term synaptic plasticity requires both gene expression in the nucleus and local protein synthesis at synapses. The effector proteins that link molecular events in the cell body with local maintenance of synaptic strength are not known. We now show that treatment with serotonin (5-HT) that produces long-term facil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustetto M,Hegde AN,Si K,Casadio A,Inokuchi K,Pei W,Kandel ER,Schwartz JH

更新日期：2003-11-11 00:00:00

abstract：:Fungi produce numerous low molecular weight molecules endowed with a multitude of biological activities. However, mining the full-genome sequences of fungi indicates that their potential to produce secondary metabolites is greatly underestimated. Because most of the biosynthesis gene clusters are silent under laborato...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schroeckh V,Scherlach K,Nützmann HW,Shelest E,Schmidt-Heck W,Schuemann J,Martin K,Hertweck C,Brakhage AA

更新日期：2009-08-25 00:00:00

abstract：:The major late transcriptional unit of adenovirus type 2 has served as a model for studying transcription in eukaryotes. We report that pausing and premature termination are intrinsic to the transcription of this transcriptional unit by RNA polymerase II. In vivo and in isolated nuclei, transcription pauses at discret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maderious A,Chen-Kiang S

更新日期：1984-10-01 00:00:00

abstract：:In the cytoplasm of well-spread cultured normal fibroblasts, actin is organized into a network of cables that run the length of the cell just inside the adherent cell membrane. A diffuse matrix replaces the cables in fibroblasts that have become tumorigenic as a result of oncogenic transformation. We have found a simi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kopelovich L,Conlon S,Pollack R

更新日期：1977-07-01 00:00:00

abstract：:The suprachiasmatic nucleus (SCN), the master circadian clock in mammals, sends major output signals to the subparaventricular zone (SPZ) and further to the paraventricular nucleus (PVN), the neural mechanism of which is largely unknown. In this study, the intracellular calcium levels were measured continuously in cul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu YE,Enoki R,Oda Y,Huang ZL,Honma KI,Honma S

更新日期：2018-10-02 00:00:00

abstract：:The DNA from tumors of Nicotiana glauca initiated by strains of Agrobacterium rhizogenes was shown to contain sequences that are homologous to the root-inducing (Ri) plasmid of the bacterium. Two independently established tumor lines contained a similar portion of the Ri-plasmid. The Ri-plasmid also hybridized to DNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White FF,Ghidossi G,Gordon MP,Nester EW

更新日期：1982-05-01 00:00:00