Abstract：
:In this work, we provide an answer to the question formulated by Albert Eschenmoser: "How would you envisage the bridge between potentially primordial geochemistry that had been disordered and one that gradually became self-organizing?" Analysis of the free-energy profiles of some of the key reactions leading to formation of nucleotides and their oligomers shows that, whereas the first part of the pathway, up to nucleotides, is energy-driven, in the second low-energy part entropic control in the form of structural compatibility becomes more important. We suggest that the birth of modern metabolism requires structural compatibility, which is enabled by the commensurability of the thermodynamics of the synthetic steps with the stabilizing effect of those intermolecular interactions that play a key role in dictating entropic control of these reactions.
journal_name
Astrobiologyjournal_title
Astrobiologyauthors
Šponer JE,Šponer J,Di Mauro Edoi
10.1089/ast.2018.1978subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1117-1122issue
9eissn
1531-1074issn
1557-8070journal_volume
19pub_type
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