Pulmonary tumor thrombotic microangiopathy: a systematic review.

abstract：:Most subtypes of pulmonary arterial hypertension (PAH) are characterized by a greater susceptibility to disease among females, although females with PAH appear to live longer after diagnosis. While this "estrogen paradoxȍ of enhanced female survival despite increased female susceptibility remains a mystery, recent pro...

journal_title：Pulmonary circulation

authors： Austin ED,Lahm T,West J,Tofovic SP,Johansen AK,Maclean MR,Alzoubi A,Oka M

更新日期：2013-04-01 00:00:00

abstract：:The aim of this study was to investigate whether a dual endothelin receptor antagonist bosentan modulates the kinetics of bone marrow-derived stem cells in inhibiting the development of pulmonary hypertension. Bone marrow chimeric mice, transplanted with enhanced green fluorescent protein (eGFP)-positive bone marrow m...

journal_title：Pulmonary circulation

authors： Kato T,Mitani Y,Masuya M,Maruyama J,Sawada H,Ohashi H,Ikeyama Y,Otsuki S,Yodoya N,Shinohara T,Miyata E,Zhang E,Katayama N,Shimpo H,Maruyama K,Komada Y,Hirayama M

更新日期：2020-05-14 00:00:00

abstract：:Riociguat is approved for the treatment of pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension. Some patients have difficulty swallowing tablets; therefore, 2 randomized, nonblinded, crossover studies compared the relative bioavailability of riociguat oral suspensions and immediate-releas...

journal_title：Pulmonary circulation

authors： Saleh S,Frey R,Becker C,Unger S,Wensing G,Mück W

更新日期：2016-03-01 00:00:00

abstract：:Rapid access to lung-derived cells from stable subjects is a major challenge in the pulmonary hypertension field, given the relative contraindication of lung biopsy. In these studies, we sought to demonstrate the importance of evaluating a cell type that actively participates in disease processes, as well as the poten...

journal_title：Pulmonary circulation

authors： Gaskill C,Marriott S,Pratap S,Menon S,Hedges LK,Fessel JP,Kropski JA,Ames D,Wheeler L,Loyd JE,Hemnes AR,Roop DR,Klemm DJ,Austin ED,Majka SM

更新日期：2016-12-01 00:00:00

abstract：:N-terminal pro B-type natriuretic peptide (NT-proBNP) is a product of cleavage of the cardiac prohormone pro B-type natriuretic peptide into its active form. It has proven to be a useful biomarker in left heart failure. However, studies examining the utility of serial measurements of NT-proBNP in pulmonary arterial hy...

journal_title：Pulmonary circulation

authors： Soon E,Doughty NJ,Treacy CM,Ross RM,Toshner M,Upton PD,Sheares K,Morrell NW,Pepke-Zaba J

更新日期：2011-04-01 00:00:00

abstract：:Inappropriate mechanical ventilation may induce hemodynamic alterations through cardiopulmonary interactions. The aim of this study was to explore the relationship between airway pressure and central venous pressure during the first 72 h of mechanical ventilation and its relevance to patient outcomes. We conducted a r...

journal_title：Pulmonary circulation

authors： Mao JY,Li DK,Ding X,Zhang HM,Long Y,Wang XT,Liu DW

更新日期：2020-11-25 00:00:00

abstract：: ...

journal_title：Pulmonary circulation

authors： Liu BY,Wu WC,Zeng QX,Liu ZH,Tian Y,Niu LL,Cheng XL,Luo Q,Zhao Z,An CH,Huang L,Wang H,He J,Xiong CM

更新日期：2019-07-03 00:00:00

abstract：:Vasculopathies, characterized by the formation of fragile and abnormal microvessels, are associated with the severity of many chronic lung diseases, including pulmonary fibrosis, emphysema/chronic obstructive pulmonary disease, systemic sclerosis, and hypertension. However, the study of human lung vasculature has been...

journal_title：Pulmonary circulation

authors： Gaskill C,Majka SM

更新日期：2017-03-27 00:00:00

abstract：:Carboxyl terminus of Hsc70-interacting protein (CHIP) is a 35-kDa cytoplasmic protein expressed in human striated muscle, brain, aortic smooth muscle, endothelial cells, and other tissues. Studies have confirmed that CHIP regulates cell growth, apoptosis, cell phenotype, metabolism, neurodegeneration, etc. However, wh...

journal_title：Pulmonary circulation

authors： Dong F,Zhang J

更新日期：2019-09-09 00:00:00

abstract：:Despite recent advances, the prognosis of pulmonary hypertension (PH) remains poor. While the initial insult in PH implicates the pulmonary vasculature, the functional state, exercise capacity, and survival of such patients are closely linked to right ventricular (RV) function. In the current study, we sought to inves...

journal_title：Pulmonary circulation

authors： Singh I,Rahaghi FN,Naeije R,Oliveira RKF,Vanderpool RR,Waxman AB,Systrom DM

更新日期：2019-07-01 00:00:00

abstract：:Right ventricular (RV) dysfunction in acute respiratory distress syndrome (ARDS) contributes to increased mortality. Our aim is to identify reproducible transthoracic echocardiography (TTE) parameters of RV dysfunction that can be used to predict outcomes in ARDS. We performed a retrospective single-center cohort pilo...

journal_title：Pulmonary circulation

authors： Shah TG,Wadia SK,Kovach J,Fogg L,Tandon R

更新日期：2016-06-01 00:00:00

abstract：:Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening condition characterized by single or recurrent pulmonary thromboemboli, which promote pulmonary vascular remodeling. MicroRNA (miRNA), is a small, noncoding RNA that is involved in multiple cell processes and functions and may partici...

journal_title：Pulmonary circulation

authors： Wang L,Guo LJ,Liu J,Wang W,Yuan JX,Zhao L,Wang J,Wang C

更新日期：2013-09-01 00:00:00

abstract：:The development of pulmonary arterial hypertension (PAH) in pediatric patients has been linked to the production of the arachidonic acid metabolite, thromboxane A(2) (TxA(2)). The present study evaluated the therapeutic effect of furegrelate sodium, a thromboxane synthase inhibitor, on the development of PAH in a neon...

journal_title：Pulmonary circulation

authors： Hirenallur-S DK,Detweiler ND,Haworth ST,Leming JT,Gordon JB,Rusch NJ

更新日期：2012-04-01 00:00:00

abstract：:The present study aimed to propose the pulmonary hypertension for predicting left ventricular dysfunction in adults after patent ductus arteriosus closure. A total of 183 patients (age ≥18 years) after patent ductus arteriosus occlusion were retrospectively collected in this study. In brief, pre-, post-procedure and s...

journal_title：Pulmonary circulation

authors： Chen PY,Luo DL,Li HZ,Fei HW,Huang T,Huang YG,Chen JM,Zhuang J,He PC,Zhang CJ

更新日期：2019-11-15 00:00:00

abstract：:Uncorrected atrial septal defect undergoes right ventricle chronic volume overload which may lead to pulmonary hypertension and Eisenmenger Syndrome. The soluble suppression of tumorigenicity-2 is a left ventricle strain biomarker; however, its role in right ventricle strain is unclear. This study aimed to investigate...

journal_title：Pulmonary circulation

authors： Pratama RS,Hartopo AB,Anggrahini DW,Dewanto VC,Dinarti LK

更新日期：2020-05-26 00:00:00

abstract：:In pulmonary hypertension, as in many other diseases, there is a need for a smarter approach to evaluating new treatments. The traditional randomized controlled trial has served medical science well, but constrains the development of treatments for rare diseases. A workshop was established to consider alternative clin...

journal_title：Pulmonary circulation

authors： Grieve AP,Chow SC,Curram J,Dawe S,Harnisch LO,Henig NR,Hung HM,Ivy DD,Kawut SM,Rahbar MH,Xiao S,Wilkins MR

更新日期：2013-01-01 00:00:00

abstract：:Despite the discovery more than 15 years ago that patients with hereditary pulmonary arterial hypertension (HPAH) inherit BMP type 2 receptor ( BMPR2) mutations, it is still unclear how these mutations cause disease. In part, this is attributable to the rarity of HPAH and difficulty obtaining tissue samples from patie...

journal_title：Pulmonary circulation

authors： Frump A,Prewitt A,de Caestecker MP

更新日期：2018-04-01 00:00:00

abstract：:Inhaled treprostinil (Tyvaso) has been shown to be a safe and effective addition to pulmonary arterial hypertension (PAH) oral therapies; however, the respiratory-related safety profile of inhaled treprostinil required further elucidation in the setting of routine clinical care. The objectives of this study were to ch...

journal_title：Pulmonary circulation

authors： Zamanian RT,Levine DJ,Bourge RC,De Souza SA,Rosenzweig EB,Alnuaimat H,Burger C,Mathai SC,Leedom N,DeAngelis K,Lim A,De Marco T

更新日期：2016-09-01 00:00:00

abstract：:Patients with pulmonary hypertension are more sedentary than the general population, but attitudes and experiences that may influence their exercise behaviour remain poorly understood. This study identified patterns of behaviour, attitudes towards exercise, barriers and enablers of exercise for people living with pulm...

journal_title：Pulmonary circulation

authors： Chia KSW,Brown K,Kotlyar E,Wong PKK,Faux SG,Shiner CT

更新日期：2020-11-16 00:00:00

abstract：:Pulmonary hypertension is recognized as a leading cause of morbidity and mortality in patients with sickle cell disease (SCD). We now report benchtop phenotyping from the explanted lungs of the first successful lung transplant in SCD. Pulmonary artery smooth muscle cells (PASMCs) cultured from the explanted lungs were...

journal_title：Pulmonary circulation

authors： Rogers NM,Yao M,Sembrat J,George MP,Knupp H,Ross M,Sharifi-Sanjani M,Milosevic J,St Croix C,Rajkumar R,Frid MG,Hunter KS,Mazzaro L,Novelli EM,Stenmark KR,Gladwin MT,Ahmad F,Champion HC,Isenberg JS

更新日期：2013-12-01 00:00:00

abstract：:Pulmonary hypertension currently has minimal guidelines for outpatient disease management. Congestive heart failure studies, however, have shown effectiveness of disease management plans in reducing all-cause mortality and all-cause and congestive heart failure-related hospital readmissions. Heart failure exacerbation...

journal_title：Pulmonary circulation

authors： Dolan J,Mandras S,Mehta JP,Navas V,Tarver J,Chakinala M,Rahaghi F

更新日期：2020-12-07 00:00:00

abstract：:Pathological alterations of inspiratory capacity (IC) have been observed in pulmonary hypertension. However, the clinical significance of IC in operable chronic thromboembolic pulmonary hypertension (CTEPH) without other pulmonary diseases remains unknown. CTEPH patients scheduled for pulmonary endarterectomy were pro...

journal_title：Pulmonary circulation

authors： Richter MJ,Gall H,Wittkämper G,Seeger W,Mayer E,Ghofrani HA,Guth S,Reichenberger F

更新日期：2017-04-01 00:00:00

abstract：:We aimed to evaluate the association between the presence of histologic chorioamnionitis (HC) and development of pulmonary hypertension (PH) during neonatal intensive care unit (NICU) stay. Data of preterm infants born at 32 weeks of gestation or less were reviewed. The development of PH and other respiratory outcomes...

journal_title：Pulmonary circulation

authors： Yum SK,Kim MS,Kwun Y,Moon CJ,Youn YA,Sung IK

更新日期：2018-04-01 00:00:00

abstract：:Pharmacokinetic studies with oral treprostinil demonstrate that three times daily (TID) dosing reduces peak-to-trough plasma trepostinil fluctuations compared with twice daily (BID) dosing. TID dosing may allow for faster titration, higher total daily doses, and potentially improve the tolerability of oral trepostinil...

journal_title：Pulmonary circulation

authors： Balasubramanian VP,Messick CR,Broderick M,Nelsen AC

更新日期：2018-04-01 00:00:00

abstract：:Insulin resistance is highly prevalent in pulmonary arterial hypertension (PAH) patients. However, the long-term impact of diabetes mellitus (DM) on survival in PAH is unclear. Insulin resistance and DM are associated with left ventricular steatosis and dysfunction, but whether the right ventricle (RV) might be affect...

journal_title：Pulmonary circulation

authors： Benson L,Brittain EL,Pugh ME,Austin ED,Fox K,Wheeler L,Robbins IM,Hemnes AR

更新日期：2014-06-01 00:00:00

abstract：:Radiotherapy as a primary treatment for thoracic malignancies induces deleterious effects, such as acute or subacute radiation-induced lung injury (RILI). Although the molecular etiology of RILI is controversial and likely multifactorial, a potentially important cellular target is the lung endothelial cytoskeleton tha...

journal_title：Pulmonary circulation

authors： Wang T,Mathew B,Wu X,Shimizu Y,Rizzo AN,Dudek SM,Weichselbaum RR,Jacobson JR,Hecker L,Garcia JG

更新日期：2016-06-01 00:00:00

abstract：:Pulmonary arterial dilatation associated with pulmonary hypertension may result in significant compression of local structures. Left main coronary artery and left recurrent laryngeal nerve compression have been described. Tracheobronchial compression from pulmonary arterial dilatation is rare in adults, and there are ...

journal_title：Pulmonary circulation

authors： Jaijee SK,Ariff B,Howard L,O'Regan DP,Gin-Sing W,Davies R,Gibbs JS

更新日期：2015-12-01 00:00:00

abstract：:Increased peripheral resistance of small distal pulmonary arteries is a hallmark signature of pulmonary hypertension (PH) and is believed to be the consequence of enhanced vasoconstriction to agonists, thickening of the arterial wall due to remodeling, and increased thrombosis. The elevation in arterial tone in PH is ...

journal_title：Pulmonary circulation

authors： Leblanc N,Forrest AS,Ayon RJ,Wiwchar M,Angermann JE,Pritchard HA,Singer CA,Valencik ML,Britton F,Greenwood IA

更新日期：2015-06-01 00:00:00

abstract：:Oral treprostinil (TRE) is a prostacylin that is approved for the treatment of patients with pulmonary arterial hypertension (PAH). Dosing is approved for two or three times daily (t.i.d.); however, adverse effects, including gastrointestinal-related symptoms, may limit the ability to reach optimal doses. We report ou...

journal_title：Pulmonary circulation

authors： Coons JC,Bunner C,Ishizawar DC,Risbano MG,Rivera-Lebron B,Mathier MA,Chan SY,Simon MA

更新日期：2018-01-01 00:00:00

abstract：:With the advancement of computed tomography pulmonary angiography, differentiating between acute and chronic thrombus in pulmonary embolism has become more feasible. However, whether pulmonary embolism with chronic thrombus contributes to a higher mortality than pulmonary embolism with acute thrombus remains undetermi...

journal_title：Pulmonary circulation

authors： Chang HY,Chang WT,Chen PW,Lin CC,Hsu CH

更新日期：2020-05-01 00:00:00