HumCFS: a database of fragile sites in human chromosomes.

abstract：BACKGROUND:Rice false smut caused by Villosiclava virens is a devastating fungal disease that spreads in major rice-growing regions throughout the world. However, the genomic information for this fungal pathogen is limited and the pathogenic mechanism of this disease is still not clear. To facilitate genetic, molecular...

journal_title：BMC genomics

authors： Wang X,Liu Q,Wang H,Luo CX,Wang G,Luo M

更新日期：2013-12-16 00:00:00

abstract：BACKGROUND:Cardiorespiratory fitness (VO2max) is an excellent predictor of chronic disease morbidity and mortality risk. Guidelines recommend individuals undertake exercise training to improve VO2max for chronic disease reduction. However, there are large inter-individual differences between exercise training responses...

journal_title：BMC genomics

authors： Williams CJ,Williams MG,Eynon N,Ashton KJ,Little JP,Wisloff U,Coombes JS

更新日期：2017-11-14 00:00:00

abstract：BACKGROUND:Abnormalities of pre-mRNA splicing are increasingly recognized as an important mechanism through which gene mutations cause disease. However, apart from the mutations in the donor and acceptor sites, the effects on splicing of other sequence variations are difficult to predict. Loosely defined exonic and int...

journal_title：BMC genomics

authors： Lastella P,Surdo NC,Resta N,Guanti G,Stella A

更新日期：2006-09-22 00:00:00

abstract：BACKGROUND:In livestock species like the chicken, high throughput single nucleotide polymorphism (SNP) genotyping assays are increasingly being used for whole genome association studies and as a tool in breeding (referred to as genomic selection). To be of value in a wide variety of breeds and populations, the success ...

journal_title：BMC genomics

authors： Groenen MA,Megens HJ,Zare Y,Warren WC,Hillier LW,Crooijmans RP,Vereijken A,Okimoto R,Muir WM,Cheng HH

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:The effective use of mutant populations for reverse genetic screens relies on the population-wide characterization of the induced mutations. Genome- and population-wide characterization of the mutations found in fast neutron populations has been hindered, however, by the wide range of mutations generated and...

journal_title：BMC genomics

authors： Lemay MA,Torkamaneh D,Rigaill G,Boyle B,Stec AO,Stupar RM,Belzile F

更新日期：2019-08-06 00:00:00

abstract：BACKGROUND:Venomous animals incapacitate their prey using complex venoms that can contain hundreds of unique protein toxins. The realisation that many of these toxins may have pharmaceutical and insecticidal potential due to their remarkable potency and selectivity against target receptors has led to an explosion in th...

journal_title：BMC genomics

authors： Wood DL,Miljenović T,Cai S,Raven RJ,Kaas Q,Escoubas P,Herzig V,Wilson D,King GF

更新日期：2009-08-13 00:00:00

abstract：BACKGROUND:Haplotypes combine the effects of several single nucleotide polymorphisms (SNPs) with high linkage disequilibrium, which benefit the genome-wide association analysis (GWAS). In the haplotype association analysis, both haplotype alleles and blocks are tested. Haplotype alleles can be inferred with the same st...

journal_title：BMC genomics

authors： Chen H,Hao Z,Zhao Y,Yang R

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Boar taint is observed in a high proportion of uncastrated male pigs and is characterized by an unpleasant odor/flavor in cooked meat, primarily caused by elevated levels of androstenone and skatole. Androstenone is a steroid produced in the testis in parallel with biosynthesis of other sex steroids like tes...

journal_title：BMC genomics

authors： Grindflek E,Lien S,Hamland H,Hansen MH,Kent M,van Son M,Meuwissen TH

更新日期：2011-07-13 00:00:00

abstract：BACKGROUND:Quercetin is a polyphenol of great interest given its antioxidant activity and involvement in the immune response. Although quercetin has been well studied at the molecular level as a gene regulator and an activator of specific cellular pathways, not much attention has been given to its mechanism of action a...

journal_title：BMC genomics

authors： Atrahimovich D,Samson AO,Barsheshet Y,Vaya J,Khatib S,Reuveni E

更新日期：2019-07-23 00:00:00

abstract：BACKGROUND:Numerous human genes encode potentially active DNA transposases or recombinases, but our understanding of their functions remains limited due to shortage of methods to profile their activities on endogenous genomic substrates. RESULTS:To enable functional analysis of human transposase-derived genes, we comb...

journal_title：BMC genomics

authors： Henssen AG,Jiang E,Zhuang J,Pinello L,Socci ND,Koche R,Gonen M,Villasante CM,Armstrong SA,Bauer DE,Weng Z,Kentsis A

更新日期：2016-08-04 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression implicated in multiple cellular processes. Cyclic stretch of alveoli is characteristic of mechanical ventilation, and is postulated to be partly responsible for the lung injury and inflammation in ventilator-induced lung injury. We pro...

journal_title：BMC genomics

authors： Yehya N,Yerrapureddy A,Tobias J,Margulies SS

更新日期：2012-04-26 00:00:00

abstract：BACKGROUND:Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain. RESULTS:We have used array comparative genomic hybridization (aCGH)...

journal_title：BMC genomics

authors： Maydan JS,Lorch A,Edgley ML,Flibotte S,Moerman DG

更新日期：2010-01-25 00:00:00

abstract：BACKGROUND:In recent years, dozens of Arabidopsis and rice CCCH-type zinc finger genes have been functionally studied, many of which confer important traits, such as abiotic and biotic stress tolerance, delayed leaf senescence and improved plant architecture. Switchgrass (Panicum virgatum) is an important bioenergy cro...

journal_title：BMC genomics

authors： Yuan S,Xu B,Zhang J,Xie Z,Cheng Q,Yang Z,Cai Q,Huang B

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:Low iron bioavailability is a common feature of ocean surface water and therefore micro-algae developed original strategies to optimize iron uptake and metabolism. The marine picoeukaryotic green alga Ostreococcus tauri is a very good model for studying physiological and genetic aspects of the adaptation of ...

journal_title：BMC genomics

authors： Lelandais G,Scheiber I,Paz-Yepes J,Lozano JC,Botebol H,Pilátová J,Žárský V,Léger T,Blaiseau PL,Bowler C,Bouget FY,Camadro JM,Sutak R,Lesuisse E

更新日期：2016-05-03 00:00:00

abstract：BACKGROUND:Cotton (Gossypium spp.) is the most important natural fiber crop worldwide, and cottonseed oil is its most important byproduct. Phospholipid: diacylglycerol acyltransferase (PDAT) is important in TAG biosynthesis, as it catalyzes the transfer of a fatty acyl moiety from the sn-2 position of a phospholipid to...

journal_title：BMC genomics

authors： Zang X,Geng X,Ma L,Wang N,Pei W,Wu M,Zhang J,Yu J

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:In higher eukaryotes, small RNAs play a role in regulating gene expression. Overexpression (OE) lines of Arabidopsis thaliana purple acid phosphatase 2 (AtPAP2) were shown to grow faster and exhibit higher ATP and sugar contents. Leaf microarray studies showed that many genes involved in microRNAs (miRNAs) a...

journal_title：BMC genomics

authors： Liang C,Liu X,Sun Y,Yiu SM,Lim BL

更新日期：2014-02-10 00:00:00

abstract：BACKGROUND:Mitochondrial genomes of flowering plants (angiosperms) are highly dynamic in genome structure. The mitogenome of the earliest angiosperm Amborella is remarkable in carrying rampant foreign DNAs, in contrast to Liriodendron, the other only known early angiosperm mitogenome that is described as 'fossilized'. ...

journal_title：BMC genomics

authors： Dong S,Zhao C,Chen F,Liu Y,Zhang S,Wu H,Zhang L,Liu Y

更新日期：2018-08-14 00:00:00

abstract：BACKGROUND:Medicago truncatula has been chosen as a model species for genomic studies. It is closely related to an important legume, alfalfa. Transporters are a large group of membrane-spanning proteins. They deliver essential nutrients, eject waste products, and assist the cell in sensing environmental conditions by f...

journal_title：BMC genomics

authors： Miao Z,Li D,Zhang Z,Dong J,Su Z,Wang T

更新日期：2012-02-06 00:00:00

abstract：BACKGROUND:Major secondary metabolites, including flavonoids, caffeine, and theanine, are important components of tea products and are closely related to the taste, flavor, and health benefits of tea. Secondary metabolite biosynthesis in Camellia sinensis is differentially regulated in different tissues during growth a...

journal_title：BMC genomics

authors： Li CF,Zhu Y,Yu Y,Zhao QY,Wang SJ,Wang XC,Yao MZ,Luo D,Li X,Chen L,Yang YJ

更新日期：2015-07-29 00:00:00

abstract：BACKGROUND:Sequencing of the approximately 1.7 billion bases of the zebrafish genome is currently underway. To date, few high resolution genetic maps exist for the zebrafish genome, based mainly on single nucleotide polymorphisms (SNPs) and short microsatellite repeats. The desire to construct a higher resolution genet...

journal_title：BMC genomics

authors： Rouchka EC

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Genome-wide association studies have revealed associations between single-nucleotide polymorphisms (SNPs) and phenotypes such as disease symptoms and drug tolerance. To address the small sample size for rare variants, association studies tend to group gene or pathway level variants and evaluate the effect on...

journal_title：BMC genomics

authors： Hasegawa T,Kojima K,Kawai Y,Misawa K,Mimori T,Nagasaki M

更新日期：2016-09-21 00:00:00

abstract：BACKGROUND:Protein and mRNA levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency. These levels in rats increase sigmoidally with increasing dietary Se and reach defined plateaus at the Se requirement, making them sensitive biomarkers for...

journal_title：BMC genomics

authors： Raines AM,Sunde RA

更新日期：2011-01-12 00:00:00

abstract：BACKGROUND:Hepatitis C virus (HCV) is a rapidly evolving RNA virus that has been classified into seven genotypes. All HCV genotypes cause chronic hepatitis, which ultimately leads to liver diseases such as cirrhosis. The genotypes are unevenly distributed across the globe, with genotypes 1 and 3 being the most prevalen...

journal_title：BMC genomics

authors： Bull RA,Eltahla AA,Rodrigo C,Koekkoek SM,Walker M,Pirozyan MR,Betz-Stablein B,Toepfer A,Laird M,Oh S,Heiner C,Maher L,Schinkel J,Lloyd AR,Luciani F

更新日期：2016-03-17 00:00:00

abstract：BACKGROUND:Whole mitogenomes or short fragments (i.e., 300-700 bp of the cox1 gene) are the markers of choice for revealing within- and among-species genealogies. Protocols for sequencing and assembling mitogenomes include 'primer walking' or 'long PCR' followed by Sanger sequencing or Illumina short-read low-coverage ...

journal_title：BMC genomics

authors： Baeza JA

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:The ability to rapidly map millions of oligonucleotide fragments to a reference genome is crucial to many high throughput genomic technologies. RESULTS:We propose an intuitive and efficient algorithm, titled extreme MApping of OligoNucleotide (xMAN), to rapidly map millions of oligonucleotide fragments to a...

journal_title：BMC genomics

authors： Li W,Carroll JS,Brown M,Liu xS

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:The antitumor drug daunorubicin exerts some of its cytotoxic effects by binding to DNA and inhibiting the transcription of different genes. We analysed this effect in vivo at the transcriptome level using the budding yeast Saccharomyces cerevisiae as a model and sublethal (IC40) concentrations of the drug to...

journal_title：BMC genomics

authors： Rojas M,Casado M,Portugal J,Piña B

更新日期：2008-07-30 00:00:00

abstract：BACKGROUND:Elucidating the candidate genes and key metabolites responsible for pulp and peel coloration is essential for breeding pitaya fruit with new and improved appeal and high nutritional value. Here, we used transcriptome (RNA-Seq) and metabolome analysis (UPLC-MS/MS) to identify structural and regulatory genes a...

journal_title：BMC genomics

authors： Zhou Z,Gao H,Ming J,Ding Z,Lin X,Zhan R

更新日期：2020-10-22 00:00:00

abstract：BACKGROUND:Fitness epistasis, the interaction effect of genes at different loci on fitness, makes an important contribution to adaptive evolution. Although fitness interaction evidence has been observed in model organisms, it is more difficult to detect and remains poorly understood in human populations as a result of ...

journal_title：BMC genomics

authors： Ni X,Zhou M,Wang H,He KY,Broeckel U,Hanis C,Kardia S,Redline S,Cooper RS,Tang H,Zhu X

更新日期：2020-07-11 00:00:00

abstract：BACKGROUND:ATP binding cassette (ABC) systems are responsible for the import and export of a wide variety of molecules across cell membranes and comprise one of largest protein superfamilies found in prokarya, eukarya and archea. ABC systems play important roles in bacterial lifestyle, virulence and survival. In this s...

journal_title：BMC genomics

authors： Harland DN,Dassa E,Titball RW,Brown KA,Atkins HS

更新日期：2007-03-28 00:00:00

abstract：BACKGROUND:Small untranslated RNAs (sRNAs) seem to be far more abundant than previously believed. The number of sRNAs confirmed in E. coli through various approaches is above 70, with several hundred more sRNA candidate genes under biological validation. Although the total number of sRNAs in any one species is still un...

journal_title：BMC genomics

authors： Ulvé VM,Sevin EW,Chéron A,Barloy-Hubler F

更新日期：2007-12-19 00:00:00