Abstract:
BACKGROUND:Quercetin is a polyphenol of great interest given its antioxidant activity and involvement in the immune response. Although quercetin has been well studied at the molecular level as a gene regulator and an activator of specific cellular pathways, not much attention has been given to its mechanism of action at the genome-wide level. The present study aims to characterize quercetin's interaction with cellular DNA and to show its subsequent effect on downstream transcription. RESULTS:Two massive parallel DNA-sequencing technologies were used: Chem-seq and RNA-seq. We demonstrate that upon binding to DNA or genome-associated proteins, quercetin acts as a cis-regulatory transcription factor for the expression of genes that are involved in the cell cycle, differentiation and development. CONCLUSIONS:Such findings could provide new and important insights into the mechanisms by which the dietary polyphenol quercetin influences cellular functions.
journal_name
BMC Genomicsjournal_title
BMC genomicsauthors
Atrahimovich D,Samson AO,Barsheshet Y,Vaya J,Khatib S,Reuveni Edoi
10.1186/s12864-019-5966-9subject
Has Abstractpub_date
2019-07-23 00:00:00pages
606issue
1issn
1471-2164pii
10.1186/s12864-019-5966-9journal_volume
20pub_type
杂志文章相关文献
BMC GENOMICS文献大全abstract:BACKGROUND:Congenital heart disease (CHD) is the leading non-infectious cause of death in infants. Monozygotic (MZ) twins share nearly all of their genetic variants before and after birth. Nevertheless, MZ twins are sometimes discordant for common complex diseases. The goal of this study is to identify genomic and epig...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4814-7
更新日期:2018-06-04 00:00:00
abstract:BACKGROUND:Dictyostelium discoideum is frequently subjected to environmental changes in its natural habitat, the forest soil. In order to survive, the organism had to develop effective mechanisms to sense and respond to such changes. When cells are faced with a hypertonic environment a complex response is triggered. It...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-8-123
更新日期:2007-05-21 00:00:00
abstract:BACKGROUND:Species of the family Vibrionaceae are ubiquitous in marine environments. Several of these species are important pathogens of humans and marine species. Evidence indicates that genetic exchange plays an important role in the emergence of new pathogenic strains within this family. Data from the sequenced geno...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-369
更新日期:2010-06-10 00:00:00
abstract:BACKGROUND:Several global transcriptomic and proteomic approaches have been applied in order to obtain new molecular insights on skeletal myogenesis, but none has generated any specific data on glycogenome expression, and thus on the role of glycan structures in this process, despite the involvement of glycoconjugates ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-483
更新日期:2009-10-20 00:00:00
abstract:BACKGROUND:Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells are not. The E1A gene determines oncogenic phenotype, is a transcriptional regulator and dysregulat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-10-67
更新日期:2009-02-06 00:00:00
abstract:BACKGROUND:Toxoplasmosis is caused by the apicomplexan parasite Toxoplasma gondii and can be acquired either congenitally or via the oral route. In the latter case, transmission is mediated by two distinct invasive stages, i.e., bradyzoites residing in tissue cysts or sporozoites contained in environmentally resistant ...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-183
更新日期:2013-03-15 00:00:00
abstract:BACKGROUND:The technological revolution in next-generation sequencing has brought unprecedented opportunities to study any organism of interest at the genomic or transcriptomic level. Transcriptome assembly is a crucial first step for studying the molecular basis of phenotypes of interest using RNA-Sequencing (RNA-Seq)...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2923-8
更新日期:2016-07-27 00:00:00
abstract:BACKGROUND:Dimethylsulfoniopropionate (DMSP) is a small sulphur compound which is produced in prodigious amounts in the oceans and plays a pivotal role in the marine sulfur cycle. Until recently, DMSP was believed to be synthesized exclusively by photosynthetic organisms; however we now know that corals and specific ba...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3959-0
更新日期:2017-08-14 00:00:00
abstract:BACKGROUND:Copy number variants (CNVs) have been shown to increase risk for physical anomalies, developmental, psychiatric and medical disorders. Some of them have been associated with changes in weight, height, and other physical traits. As most studies have been performed on children and young people, these effects o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-5292-7
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:By assaying hundreds of thousands of single nucleotide polymorphisms, genome wide association studies (GWAS) allow for a powerful, unbiased review of the entire genome to localize common genetic variants that influence health and disease. Although it is widely recognized that some correction for multiple tes...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-516
更新日期:2008-10-31 00:00:00
abstract:BACKGROUND:Thousands of intragenic long interspersed element 1 sequences (LINE-1 elements or L1s) reside within genes. These intragenic L1 sequences are conserved and regulate the expression of their host genes. When L1 methylation is decreased, either through chemical induction or in cancer, the intragenic L1 transcri...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-14-205
更新日期:2013-03-27 00:00:00
abstract:BACKGROUND:Precise identification of three-dimensional genome organization, especially enhancer-promoter interactions (EPIs), is important to deciphering gene regulation, cell differentiation and disease mechanisms. Currently, it is a challenging task to distinguish true interactions from other nearby non-interacting o...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-018-4459-6
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:RNA editing is an important mechanism that expands the diversity and complexity of genetic codes. The conversions of adenosine (A) to inosine (I) and cytosine (C) to uridine (U) are two prominent types of RNA editing in animals. The roles of RNA editing events have been implicated in important biological pat...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-4330-1
更新日期:2018-01-19 00:00:00
abstract:BACKGROUND:Several in vitro studies document the function of the transcriptional regulator TrmBL1 of Pyrococcus furiosus. These data indicate that the protein can act as repressor or activator and is mainly involved in transcriptional control of sugar uptake and in the switch between glycolysis and gluconeogenesis. The...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2360-0
更新日期:2016-01-08 00:00:00
abstract:BACKGROUND:Loaches of Cobitinae, widely distributed in Eurasian continent, have high economic, ornamental and scientific value. However, the phylogeny of Cobitinae fishes within genera or family level remains complex and controversial. Up to now, about 60 Cobitinae mitogenomes had been deposited in GenBank, but their i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-020-07360-w
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Butterflies and moths are emerging as model organisms in genetics and evolutionary studies. The family Hesperiidae (skippers) was traditionally viewed as a sister to other butterflies based on its moth-like morphology and darting flight habits with fast wing beats. However, DNA studies suggest that the famil...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1846-0
更新日期:2015-08-27 00:00:00
abstract:BACKGROUND:Microsatellites are highly abundant in eukaryotic genomes but their function and evolution are not yet well understood. Their elevated mutation rate makes them ideal markers of genetic difference, but high levels of unexplained heterogeneity in mutation rates among microsatellites at different genomic locati...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-9-49
更新日期:2008-01-28 00:00:00
abstract:BACKGROUND:Ramularia collo-cygni is a newly important, foliar fungal pathogen of barley that causes the disease Ramularia leaf spot. The fungus exhibits a prolonged endophytic growth stage before switching life habit to become an aggressive, necrotrophic pathogen that causes significant losses to green leaf area and he...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2928-3
更新日期:2016-08-09 00:00:00
abstract:BACKGROUND:We use an approach based on Factor Analysis to analyze datasets generated for transcriptional profiling. The method groups samples into biologically relevant categories, and enables the identification of genes and pathways most significantly associated to each phenotypic group, while allowing for the partici...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-6-109
更新日期:2005-08-17 00:00:00
abstract:BACKGROUND:Massively-parallel sequencing at depth is now enabling tumor heterogeneity and evolution to be characterized in unprecedented detail. Tracking these changes in clonal architecture often provides insight into therapeutic response and resistance. In complex cases involving multiple timepoints, standard visuali...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-3195-z
更新日期:2016-11-07 00:00:00
abstract:BACKGROUND:The Transcription Factor (TF) p63 is a master regulator of epidermal development and differentiation as evident from the remarkable skin phenotype of p63 mouse knockouts. Furthermore, ectopic expression of p63 alone is sufficient to convert simple epithelium into stratified epithelial tissues in vivo and p63...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-1042
更新日期:2014-11-29 00:00:00
abstract:BACKGROUND:Genomic characterization of rotavirus (RoV) has not been adopted at large-scale due to the complexity of obtaining sequences for all 11 segments, particularly when feces are used as starting material. METHODS:To overcome these limitations, we developed a novel RoV capture and genome sequencing method combin...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-017-3714-6
更新日期:2017-04-24 00:00:00
abstract:BACKGROUND:Intragenic tandem repeats occur throughout all domains of life and impart functional and structural variability to diverse translation products. Repeat proteins confer distinctive surface phenotypes to many unicellular organisms, including those with minimal genomes such as the wall-less bacterial monoderms,...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-11-430
更新日期:2010-07-13 00:00:00
abstract:BACKGROUND:Excretory/secretory proteins (ESPs) play a major role in parasitic infection as they are present at the host-parasite interface and regulate host immune system. In case of parasitic helminths, transcriptomics has been used extensively to understand the molecular basis of parasitism and for developing novel t...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-12-S3-S14
更新日期:2011-11-30 00:00:00
abstract:BACKGROUND:Harvest index (HI), the ratio of grain yield to total biomass, is considered as a measure of biological success in partitioning assimilated photosynthate to the harvestable product. While crop production can be dramatically improved by increasing HI, the underlying molecular genetic mechanism of HI in rapese...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1607-0
更新日期:2015-05-12 00:00:00
abstract:BACKGROUND:Insertion sequences (IS) are small transposable elements, commonly found in bacterial genomes. Identifying the location of IS in bacterial genomes can be useful for a variety of purposes including epidemiological tracking and predicting antibiotic resistance. However IS are commonly present in multiple copie...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1860-2
更新日期:2015-09-03 00:00:00
abstract:BACKGROUND:Non-coding RNAs (ncRNAs), which perform diverse regulatory roles, have been found in organisms from all superkingdoms of life. However, there have been limited numbers of studies on the functions of ncRNAs, especially in nonmodel organisms such as Kluyveromyces marxianus that is widely used in the field of i...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-016-2474-z
更新日期:2016-02-29 00:00:00
abstract:BACKGROUND:Mycobacterium abscessus complex, the third most frequent mycobacterial complex responsible for community- and health care-associated infections in developed countries, comprises of M. abscessus subsp. abscessus and M. abscessus subsp. bolletii reviously referred as Mycobacterium bolletii and Mycobacterium ma...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/1471-2164-15-359
更新日期:2014-05-12 00:00:00
abstract:BACKGROUND:Bixin or annatto is a commercially important natural orange-red pigment derived from lycopene that is produced and stored in seeds of Bixa orellana L. An enzymatic pathway for bixin biosynthesis was inferred from homology of putative proteins encoded by differentially expressed seed cDNAs. Some activities we...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-2065-4
更新日期:2015-10-28 00:00:00
abstract:BACKGROUND:The environmental light-dark cycle is the dominant cue that maintains 24-h biological rhythms in multicellular organisms. In Drosophila, light entrainment is mediated by the photosensitive protein CRYPTOCHROME, but the role and extent of transcription regulation in light resetting of the dipteran clock is ye...
journal_title:BMC genomics
pub_type: 杂志文章
doi:10.1186/s12864-015-1787-7
更新日期:2015-08-01 00:00:00