Abstract:
:Allergic rhinitis (AR) is a global health problem that appears in all age groups and affects approximately 15-30% of people. Baicalin has been used for the treatment of various allergic diseases, including AR. However, the metabolic mechanisms of AR and baicalin against AR have not been systematically studied. Here, ovalbumin-sensitized AR rats were used as a model, and animal behaviour, histological analysis, enzyme-linked immunosorbent assay (ELISA) and metabolomics were used to elucidate the mechanism of baicalin for AR. The results indicated that baicalin has a protective effect on AR rats by inhibiting the release of immunoglobulin E (IgE), histamine, interleukin-1 beta (IL-1β), interleukin-4 (IL-4), interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α). In addition, ovalbumin-induced AR included modulation of arachidonic acid, leukotriene A4 (LTA4), leukotriene B4 (LTB4), α-ketoglutaric acid, phosphatidylcholine PC (20 : 4/0 : 0), PC (16 : 0/0 : 0), citric acid, fumarate, malate, 3-methylhistidine, histamine and other amino acids that are involved in arachidonic acid, histidine metabolism, the TCA cycle and amino acid metabolism. Thus, AR could be alleviated or reversed by baicalin.
journal_name
R Soc Open Scijournal_title
Royal Society open scienceauthors
Chen S,Chen G,Shu S,Xu Y,Ma Xdoi
10.1098/rsos.181081subject
Has Abstractpub_date
2019-02-20 00:00:00pages
181081issue
2issn
2054-5703pii
rsos181081journal_volume
6pub_type
杂志文章abstract::Four kinds of functional ionic liquids (ILs) ([C3SO3Hnmp]HSO4), 1-(3-sulfopropyl)-1-methylpyrrolidone phosphate ([C3SO3Hnmp]H2PO4), 1-(3-sulfopropyl)-1-methylpyrrolidone p-toluene sulfonate ([C3SO3Hnmp]CH3SO3H) and 1-(3-sulfopropyl)-1-methylpyrrolidone methyl sulfonate ([C3SO3Hnmp]C6H6SO3H)) were prepared and the cata...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.190166
更新日期:2019-08-14 00:00:00
abstract::In this study, enzymatic hydrolysis and cationization with epoxypropyldodecyldimethylammonium chloride of wheat protein, an economic protein complex containing great amount of disulfide bonds, were conducted to improve properties such as solubility and disassociation behaviour for recovery of damaged hair when used in...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.171216
更新日期:2018-02-07 00:00:00
abstract::The current communication signifies the effect of oxygen vacancies (OVs) both qualitatively and quantitatively in multiferroic BiFe0.83Ni0.17O3 by an in-depth atomic-level investigation of its electronic structure and magnetization properties, and these materials have a variety of applications in spintronics, optoelec...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.170273
更新日期:2017-06-14 00:00:00
abstract::A novel alkyl lithium-based initiator with relatively large steric hindrance, tert-butyldimethylsiloxydimethylpropyl lithium (TBDMSODPrLi), was designed and synthesized. By using TBDMSODPrLi, hydroxyl-terminated polybutadiene (HTPB) was prepared via anionic polymerization. The macromolecular structure of HTPB was char...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.180156
更新日期:2018-05-30 00:00:00
abstract::The aim of this study was to compare young and adult sprinters on several biomechanical parameters that were previously highlighted as performance-related and to determine the behaviour of several muscle-tendon units (MTU) in the first stance phase following a block start in sprint running. The ground reaction force (...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.180332
更新日期:2018-06-13 00:00:00
abstract::Discs of gas and dust around million-year-old stars are a by-product of the star formation process and provide the raw material to form planets. Hence, their evolution and dispersal directly impact what type of planets can form and affect the final architecture of planetary systems. Here, we review empirical constrain...
journal_title:Royal Society open science
pub_type: 杂志文章,评审
doi:10.1098/rsos.170114
更新日期:2017-04-26 00:00:00
abstract::The mechanical properties of any substance are essential facts to understand its behaviour and make the maximum use of the particular substance. Rocks are indeed an important substance, as they are of significant use in the energy industry, specifically for fossil fuels and geothermal energy. Attenuation of seismic wa...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.170896
更新日期:2017-10-11 00:00:00
abstract::Racing pigeons are exposed to and act as carriers of diseases. Dietary protein requirement for their maintenance has not been determined experimentally despite their being domesticated for over 7000 years. A maintenance nitrogen (protein) requirement (MNR) for pigeons was determined in a balance study using diets cont...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.150408
更新日期:2016-03-23 00:00:00
abstract::The mesoporous silicate molecular sieves were synthesized with polyether F127 as the template by the aerosol-assisted method for loading and release of ibuprofen (IBU). The synthesized samples were characterized by scanning electron microscopy, transmission electron microscopy, X-ray diffraction and N2 adsorption-deso...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.200650
更新日期:2020-10-07 00:00:00
abstract::When we represent real-world systems as networks, the directions of links often convey valuable information. Finding module structures that respect link directions is one of the most important tasks for analysing directed networks. Although many notions of a directed module have been proposed, no consensus has been re...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160270
更新日期:2016-11-30 00:00:00
abstract::The recent availability of large-scale call detail record data has substantially improved our ability of quantifying human travel patterns with broad applications in epidemiology. Notwithstanding a number of successful case studies, previous works have shown that using different mobility data sources, such as mobile p...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160950
更新日期:2017-05-17 00:00:00
abstract::A shift-periodic map is a one-dimensional map from the real line to itself which is periodic up to a linear translation and allowed to have singularities. It is shown that iterative sequences xn+1 = F(x n ) generated by such maps display rich dynamical behaviour. The intege...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.191423
更新日期:2019-11-27 00:00:00
abstract::Building information modelling (BIM) can be applied to tunnel engineering to address a number of problems, including complex structure, extensive design, long construction cycle and increased security risks. To promote the development of tunnel engineering in China, this paper combines actual cases, including the Xing...
journal_title:Royal Society open science
pub_type: 杂志文章,评审
doi:10.1098/rsos.170174
更新日期:2017-08-02 00:00:00
abstract::A key challenge in the fabrication of ferromagnetically filled carbon nano-onions (CNOs) is the control of their thickness, dimensions and electric properties. Up to now literature works have mainly focused on the encapsulation of different types of ferromagnetic materials including α-Fe, Fe3C, Co, FeCo, FePd3 and oth...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.170981
更新日期:2018-01-17 00:00:00
abstract::The rigid structure of the mammalian trachea is functional to maintain constant patency and airflow during breathing, but no gas exchange takes place through its walls. The structure of the organ in dolphins shows increased rigidity of the tracheal cartilaginous rings and the presence of vascular lacunae in the submuc...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.171645
更新日期:2018-04-18 00:00:00
abstract::Sensitive, simple and green analytical methodology for simultaneous estimation of bambuterol and montelukast as a combined medication based on their native fluorescence character was developed. The method relies on synchronous spectrofluorimetry to solve the problem of the overlapping emission spectra of the studied d...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.201156
更新日期:2020-12-09 00:00:00
abstract::In several group-living species, individuals' social preferences are thought to be influenced by cooperation. For some societies with fission-fusion dynamics, sex-specific association patterns reflect sex differences in cooperation in within- and between-group contexts. In our study, we investigated this hypothesis fu...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.161081
更新日期:2017-05-03 00:00:00
abstract::This study investigated the chemical and nutritional profile and antioxidative properties of cultivated Coprinus comatus. Proximate analysis revealed that C. comatus is rich in carbohydrates, dietary fibres and proteins, and could also be a valuable source of phenolics. Additionally, fat content is low, consisting mai...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.200900
更新日期:2020-09-02 00:00:00
abstract::Recent works revealed that the energy required to control a complex network depends on the number of driving signals and the energy distribution follows an algebraic scaling law. If one implements control using a small number of drivers, e.g. as determined by the structural controllability theory, there is a high prob...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160064
更新日期:2016-04-20 00:00:00
abstract::Humans commonly engage in a variety of search behaviours, for example when looking for an object, a partner, information or a solution to a complex problem. The success or failure of a search strategy crucially depends on the structure of the environment and the constraints it imposes on the individuals. Here, we focu...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.190529
更新日期:2019-10-30 00:00:00
abstract::Provisioning wildlife for tourism is a controversial yet widespread practice. We analysed the residency patterns of juvenile whale sharks (Rhincodon typus) in Oslob, Philippines, where provisioning has facilitated a large shark-watching operation since 2011. We identified 208 individual sharks over three years, with a...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.170394
更新日期:2017-09-27 00:00:00
abstract::Ceratopsids are among the most ubiquitous dinosaur taxa from the Late Cretaceous terrestrial formations of the Western Interior of North America, comprising two subfamilies, Chasmosaurinae and Centrosaurinae. The Two Medicine Formation of northwestern Montana has produced numerous remains of centrosaurine dinosaurs, w...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.200284
更新日期:2020-04-29 00:00:00
abstract::We combined clinical, cytokine, genomic, methylation and dietary data from 43 young adult monozygotic twin pairs (aged 22-36 years, 53% female), where 25 of the twin pairs were substantially weight discordant (delta body mass index > 3 kg m-2). These measurements were originally taken as part of the TwinFat study, a s...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.200872
更新日期:2020-10-21 00:00:00
abstract::A two-dimensional molybdenum disulfide (MoS2)-based gas sensor was decorated with Pt nanoparticles (NPs) for high sensitivity and low limit of detection (LOD) for specific gases (NH3 and H2S). The two-dimensional MoS2 film was grown at 400°C using metal organic gas vapour deposition. To fabricate the MoS2 gas sensor, ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.181462
更新日期:2018-12-12 00:00:00
abstract::The characterization of diet for the giant manta ray Manta birostris has been problematic given their large-scale movement patterns and the difficulty in obtaining stomach contents from this species. The large majority of existing information is based on observational data limited to feeding events at the sea surface ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.160717
更新日期:2016-11-30 00:00:00
abstract::In this study, we investigated the extent to which adolescents who spend time playing violent video games exhibit higher levels of aggressive behaviour when compared with those who do not. A large sample of British adolescent participants (n = 1004) aged 14 and 15 years and an equal number of their carers were intervi...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.171474
更新日期:2019-02-13 00:00:00
abstract::Prior experience influences visual perception. For example, extended viewing of a moving stimulus results in the misperception of a subsequent stimulus's motion direction-the direction after-effect (DAE). There has been an ongoing debate regarding the locus of the neural mechanisms underlying the DAE. We know the mech...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.190114
更新日期:2019-03-27 00:00:00
abstract::Using a stochastic model, we investigate the probability of fixation, and the average time taken to achieve fixation, of a mutant in a population of wild-types. We do this in a context where the environment in which the competition takes place is subject to stochastic change. Our model takes into account interactions ...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.172176
更新日期:2018-03-21 00:00:00
abstract::There is increasing evidence that whale and dolphin watching activities have detrimental effects on targeted cetacean populations. In Egypt, spinner dolphins regularly occur in the resting areas of Samadai, Satayah and Qubbat'Isa reefs. In-water human interactions with dolphins are regulated with a time-area closure s...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.172044
更新日期:2018-04-25 00:00:00
abstract::This paper investigates the effect of contact geometry, temperature and displacement amplitude on the fretting behaviour of an aero-turbo oil lubricated cylinder-on-flat contact. To be effective, the lubricant needed both to penetrate the contact and then offer protection. Lubricant penetration into the fretting conta...
journal_title:Royal Society open science
pub_type: 杂志文章
doi:10.1098/rsos.150637
更新日期:2016-10-19 00:00:00