Abstract:
Background:In Korea, the incidence of varicella has increased despite the introduction of a universal one-dose vaccination for children aged 12-15 months in 2005. A previous study demonstrated that the vaccine effectiveness was insufficient to prevent against varicella. We assessed the effect of the varicella vaccination on disease severity. Methods:Epidemiologic investigation of varicella cases in Seoul metropolitan area from 2015 to 2017 were used. Varicella-related symptoms such as rash were determined by the clinical practitioners. Disease severity of patients was assessed by the number of skin lesions and divided into mild (≤ 50) and moderate (51-249) to severe (≥ 250). Unconditional logistic regression analysis was performed and age was controlled. Results:Among a total of 1,008 varicella cases reported, 869 cases were breakthrough cases and 139 were unvaccinated cases. The risk for occurrence of moderate-to-severe disease in the breakthrough group was 0.57 times less than that of the unvaccinated group. Conclusion:These data suggest that national varicella vaccination may have a significant effect on attenuation of disease severity in children.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Lee YH,Choe YJ,Cho SI,Park H,Bang JH,Lee JKdoi
10.3346/jkms.2019.34.e83subject
Has Abstractpub_date
2019-03-07 00:00:00pages
e83issue
10eissn
1011-8934issn
1598-6357journal_volume
34pub_type
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