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RNA Splicing: A New Paradigm in Host-Pathogen Interactions.

Abstract：

:RNA splicing brings diversity to the eukaryotic proteome. Different spliced variants of a gene may differ in their structure, function, localization, and stability influencing protein stoichiometry and physiological outcomes. Alternate spliced variants of different genes are known to associate with various chronic pathologies including cancer. Emerging evidence suggests precise regulation of splicing as fundamental to normal well-being. In this context, infection-induced alternative splicing has emerged as a new pivot of host function, which pathogenic microbes can alter-directly or indirectly-to tweak the host immune responses against the pathogen. The implications of these findings are vast, and although not explored much in the case of pathogenic infections, we present here examples from splicing mediated regulation of immune responses across a variety of conditions and explore how this fascinating finding brings a new paradigm to host-pathogen interactions.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Chauhan K,Kalam H,Dutt R,Kumar D

doi

10.1016/j.jmb.2019.03.001

subject

Has Abstract

pub_date

2019-04-05 00:00:00

pages

1565-1575

issue

8

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(18)30957-4

journal_volume

431

pub_type

杂志文章,评审

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