Abstract:
Background:We investigated the effects of gastric Helicobacter pylori infection on the daytime and overnight human oral microbiota. Methods:Twenty four volunteers were recruited. Ten tested positive for H. pylori infection by the Carbon-14 Urea Breath Test, and the rest were negative. Two oral swabs were collected: one immediately after waking up in the morning and before brushing teeth, and another in the evening before teeth-brushing. DNA extract acquired from each swab was subjected to Illumina sequencing of 16S rRNA gene amplicons. The microbial abundance and composition were analysed in relation to H. pylori infection status. Results:Helicobacter pylori-positive individuals had significant changes in the alpha and beta diversities in the daytime samples in comparison to those who were H. pylori negative. To identify which taxa could be significantly affected within the cohorts in the daytime, we employed the LEfSe method. When compared against UBT-negative samples, significantly higher abundances were detected in both Pseudomonas and Roseomonas, while Fusobacterium, Solobacterium, Haemophilus and Streptococcus were significantly decreased in the UBT-positive samples. Discussion:Our data demonstrated that H. pylori infection affects the human daytime oral microbiota. The hitherto undocumented changes of several bacterial genera due to H. pylori infection require more studies to examine their potential health effects on affected individuals.
journal_name
PeerJjournal_title
PeerJauthors
Chua EG,Chong JY,Lamichhane B,Webberley KM,Marshall BJ,Wise MJ,Tay CYdoi
10.7717/peerj.6336subject
Has Abstractpub_date
2019-01-28 00:00:00pages
e6336issn
2167-8359pii
6336journal_volume
7pub_type
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