Long term regulation of glycogen metabolizing enzymes by insulin in H4 hepatoma cells.

abstract：:Succinic acid monoethyl ester (EMS) is recently proposed as an insulinotropic agent for the treatment of non-insulin dependent diabetes mellitus. Oxidative stress has been suggested to be a contributory factor in the development and complications of diabetes. In the present study the effect of EMS and Metformin on pla...

journal_title：Molecular and cellular biochemistry

authors： Saravanan R,Pari L

更新日期：2007-02-01 00:00:00

abstract：:Brain membrane lipid fatty acid composition and consequently membrane fluidity change with increasing age. Intracellular fatty acid binding proteins (FABPs) such as heart H-FABP and the brain specific B-FABP, detected by immunoblotting of brain tissue, are thought to be involved in fatty acid uptake, metabolism, and d...

journal_title：Molecular and cellular biochemistry

authors： Pu L,Igbavboa U,Wood WG,Roths JB,Kier AB,Spener F,Schroeder F

更新日期：1999-08-01 00:00:00

abstract：:Heat-shock protein90 (HSP90) plays an essential role in maintaining stability and activity of its clients. HSP90 is involved in cell differentiation and survival in a variety of cell types. To elucidate the possible role of HSP90 in myogenic differentiation and cell survival, we examined the time course of changes in ...

journal_title：Molecular and cellular biochemistry

authors： Wagatsuma A,Shiozuka M,Kotake N,Takayuki K,Yusuke H,Mabuchi K,Matsuda R,Yamada S

更新日期：2011-12-01 00:00:00

abstract：:Ischemic heart disease is the leading cause of death for both men and women worldwide, accruing 7.4 million deaths in 2012. There has been a continued search for better cardioprotective modalities that would reduce myocardial ischemia-reperfusion injury. Among these attempts, a more convenient model of ischemic precon...

journal_title：Molecular and cellular biochemistry

authors： Gill R,Kuriakose R,Gertz ZM,Salloum FN,Xi L,Kukreja RC

更新日期：2015-04-01 00:00:00

abstract：:Fasting is accompanied by a decrease in collagen biosynthesis. The mechanism of this phenomenon involves inhibition of prolidase activity, an enzyme that plays a key role in upregulation of collagen metabolism. The mechanism of fasting-induced inhibition of prolidase activity is not known. Phosphoenolpyruvate (PEP) is...

journal_title：Molecular and cellular biochemistry

authors： Cechowska-Pasko M,Palka J,Bańkowski E

更新日期：2004-10-01 00:00:00

abstract：:Recently there has been a moderate resurgence in the use of flax-seed in a variety of ways including bread. The scientific basis of its use is very limited. There is some claim for beneficial effects in cancer and lupus nephritis. These claims could be due to its ability to scavenge oxygen radicals. However, its antio...

journal_title：Molecular and cellular biochemistry

authors： Prasad K

更新日期：1997-03-01 00:00:00

abstract：:Human cardiomyopathy has been extensively studied in the last decade, and knowledge of the functional and structural alterations of the heart has grown. However, understanding of the pathogenesis has come mostly from experimental studies. A number of work have been designed to elucidate if alterations of the contracti...

journal_title：Molecular and cellular biochemistry

authors： Veksler V,Ventura-Clapier R

更新日期：1994-04-01 00:00:00

abstract：:Molecular hydrogen (H2) is an agent with potential applications in oxidative stress-related and/or inflammatory disorders. H2 is usually administered by inhaling H2-containing air (HCA) or by oral intake of H2-rich water (HRW). Despite mounting evidence, the molecular mechanism underlying the therapeutic effects and t...

journal_title：Molecular and cellular biochemistry

authors： Sobue S,Yamai K,Ito M,Ohno K,Ito M,Iwamoto T,Qiao S,Ohkuwa T,Ichihara M

更新日期：2015-05-01 00:00:00

abstract：:In order to explore the role of cytochrome P-450 (CYP) 2E1 in schisandrin B (Sch B)-induced antioxidant and heat shock responses, the effects of Sch B treatment on hepatic mitochondrial glutathione antioxidant status (mtGAS) and heat shock protein (Hsp)25/70 expression were compared between wild-type and cyp2e1 knock-...

journal_title：Molecular and cellular biochemistry

authors： Chiu PY,Leung HY,Poon MK,Lee SS,Ko KM

更新日期：2006-12-01 00:00:00

abstract：:Recombinant COMP-Ang1, a chimera of angiopoietin-1 (Ang1), and a short coiled-coil domain of cartilage oligomeric matrix protein (COMP) can stimulate multiple cellular processes. Proliferative capacity of periodontal ligament (PDL) fibroblasts (PLFs) is important for maintaining PDL integrity and homeostasis. In this ...

journal_title：Molecular and cellular biochemistry

authors： Lim SS,Kook SH,Lee JC

更新日期：2016-05-01 00:00:00

abstract：:Previous studies reported that estrogen receptor β (ERβ) is localized to mitochondria, whereas little is known about the physiological functions of mitochondrial ERβ. In the present study, we explored the role of mitochondrial ERβ in regulating apoptosis using stable ERβ-expressing and ERβ knockdown cells lines. We fo...

journal_title：Molecular and cellular biochemistry

authors： Liang J,Xie Q,Li P,Zhong X,Chen Y

更新日期：2015-03-01 00:00:00

abstract：:Liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities were significantly decreased in both diabetic and fasted rats. Treatment of diabetic rats with insulin resulted in liver glucose 6-phosphate dehydrogenase and phosphogluconate dehydrogenase activities that were significantly greater ...

journal_title：Molecular and cellular biochemistry

authors： Martins RN,Stokes GB,Masters CL

更新日期：1986-05-01 00:00:00

abstract：:In rat cardiac sarcolemmal membranes a phosphoinositide-specific phospholipase C (PLC) was found to be present. The enzyme hydrolysed exogenous [3H-]phosphatidylinositol 4,5-biphosphate ([3H-]PtdIns(4,5)P2) in an optimized assay mixture containing 15 micrograms SL protein, 100 mM NaCl, 1 mM free Ca2+, 14 mM Na-cholate...

journal_title：Molecular and cellular biochemistry

authors： Meij JT,Panagia V

更新日期：1992-10-21 00:00:00

abstract：:Cytosolic purine nucleoside phosphorylase (PNPase) is a well known, and described enzyme which exists in a variety of organisms, both procaryotic and eucaryotic. More recently this enzyme was found in bovine liver mitochondria. The mitochondrial purine nucleoside phosphorylase was purified 63 fold and has a molecular ...

journal_title：Molecular and cellular biochemistry

authors： Haag R,Lewis RA

更新日期：1994-06-29 00:00:00

abstract：:Partial outlet obstruction of the rabbit urinary bladder results, initially, in a rapid increase in bladder mass and remodeling of the bladder wall. Previously, it was shown that this response was characterized by serosal growth (thickening) which was apparent after 1 day of obstruction, before any visible vasculariza...

journal_title：Molecular and cellular biochemistry

authors： Chichester P,Schröder A,Horan P,Levin RM

更新日期：2001-10-01 00:00:00

abstract：:High molecular weight, fully double-stranded RNA (dsRNA) has been recognized as the genetic material of many plant, animal, fungal, and bacterial viruses (Diplornaviruses): virusspecific dsRNA is also found in cells infected with single-stranded RNA viruses. DsRNA has identified in a variety of apparently normal eucar...

journal_title：Molecular and cellular biochemistry

authors： Libonati M,Carsana A,Furia A

更新日期：1980-08-16 00:00:00

abstract：:The aim of our study is to explore the regulation of C1QTNF1-AS1 on its target miR-221-3p/SOCS3 in human hepatocellular carcinoma (HCC). To explore the underlying molecular regulation of non-coding RNA for HCC, differentially expressed patterns of lncRNAs and genes were examined by RNA-seq. GO and KEGG pathway analysi...

journal_title：Molecular and cellular biochemistry

authors： Han W,Yu G,Meng X,Hong H,Zheng L,Wu X,Zhang D,Yan B,Ma Y,Li X,Wang Q

更新日期：2019-10-01 00:00:00

abstract：:Cyclic AMP (300 micron) activates phosphofructokinase from dialyzed haemolysates of mature rat erythrocytes. The main conclusions are: a) Cyclic AMP, at pH 7.1 and low concentrations of fructose-6-phosphate, is able to reverse the inhibition produced by different amounts of ATP (up to 1.5 mM). b) The cyclic nucleotide...

journal_title：Molecular and cellular biochemistry

authors： Pinilla M,Luque J

更新日期：1977-05-03 00:00:00

abstract：:The AP-1 consensus sequences (TGAGTCA) are the major 12-O-tetradecanoylphorbol113-acetate (TPA) responsive elements shared by several TPA inducible genes, such as c-sis, c-fos, c-myc, collagenase, stromelysin, hMTIIA and SV40. However, the role of AP-1 binding sites, which are present in the introns 3, 5, and 11 of OD...

journal_title：Molecular and cellular biochemistry

authors： Tseng CP,Verma AK

更新日期：1995-05-10 00:00:00

abstract：:Long-chain fatty acids (e.g. arachidonic acid) have been implicated in physiological control of insulin secretion. We previously reported histidine phosphorylation of at least two islet proteins (e.g., NDP kinase and the beta subunit of trimeric G-proteins), and suggested that such a signalling step may have regulator...

journal_title：Molecular and cellular biochemistry

authors： Kowluru A

更新日期：2004-11-01 00:00:00

abstract：:Fatty acid-binding proteins (FABP) are abundant cytosolic proteins whose levels is responsive to nutritional, endocrine, and a variety of pathological states. Although FABPs have been investigated in vitro for several decades, little is known of their physiological function. Liver L-FABP binds both fatty acids and cho...

journal_title：Molecular and cellular biochemistry

authors： Schroeder F,Jefferson JR,Powell D,Incerpi S,Woodford JK,Colles SM,Myers-Payne S,Emge T,Hubbell T,Moncecchi D

更新日期：1993-06-09 00:00:00

abstract：:Recent studies have shown that allogeneic bone marrow (BM)-mesenchymal stem cell transplantation (MSCT) appears to be effective in systemic lupus erythematosus (SLE) patients and lupus-prone mice, contrary to studies in syngeneic BM-MSCT. These studies indicated that the abnormalities of BM-MSCs may be involved in the...

journal_title：Molecular and cellular biochemistry

authors： Gu Z,Tan W,Feng G,Meng Y,Shen B,Liu H,Cheng C

更新日期：2014-02-01 00:00:00

abstract：:CDK11(p58), a G2/M-specific protein kinase, has been shown to be associated with apoptosis in many cell lines, with largely unknown mechanisms. Our previous study proved that CDK11(p58)-enhanced cycloheximide (CHX)-induced apoptosis in SMMC-7721 hepatocarcinoma cells. Here we report for the first time that ectopic exp...

journal_title：Molecular and cellular biochemistry

authors： Yun X,Wu Y,Yao L,Zong H,Hong Y,Jiang J,Yang J,Zhang Z,Gu J

更新日期：2007-10-01 00:00:00

abstract：:Tripeptide aminopeptidase (EC 3.4.11.4) was purified from bovine dental follicles by a series of chromatographies. Purified enzyme had a specific activity of 59.5 units per mg protein with L-prolyl-glycylglycine as substrate. The pH optimum was 8.0. The purified native enzyme had a Mr of 230,000 and was shown to be a ...

journal_title：Molecular and cellular biochemistry

authors： Hiraoka BY,Harada M

更新日期：1993-12-08 00:00:00

abstract：:Cytochrome c oxidase (COX), like other multi-subunit components of the respiratory chain, is controlled by both the nuclear and the mitochondrial genome. In order to find wether there is a close relationship between mRNAs encoded by the nucleus and by the mitochondrion, and between these mRNAs and enzyme activity, we ...

journal_title：Molecular and cellular biochemistry

authors： Gagnon J,Kurowski TT,Wiesner RJ,Zak R

更新日期：1991-09-18 00:00:00

abstract：:The clinical benefit of selective BRAF inhibitor therapies is limited by the emergence of drug resistance. Here, we investigated the molecular basis underlying the acquired resistance to a BRAF inhibitor by comparing the signaling pathways in the parental A375P cells and the resistant subline (A375P/Mdr). We demonstra...

journal_title：Molecular and cellular biochemistry

authors： Ahn JH,Lee M

更新日期：2014-07-01 00:00:00

abstract：:The effect of anti-regucalcin monoclonal antibody on neutral phoshatase activity in rat liver cytosol was investigated. Phosphotyrosine, phosphoserine, and phosphothreonine were used as the substrate toward phosphatase assay. Liver cytosolic phosphatase activity with three phosphoaminoacids was significantly increased...

journal_title：Molecular and cellular biochemistry

authors： Omura M,Yamaguchi M

更新日期：1999-07-01 00:00:00

abstract：:7,12-Dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis is widely preferred to assess the tumor-inhibiting efficacy of the medicinal plants or their constituents. The present study explores the tumor-inhibiting potential of esculetin by utilizing the status of lipid peroxidation by products (...

journal_title：Molecular and cellular biochemistry

authors： Selvasundaram R,Manoharan S,Buddhan R,Neelakandan M,Murali Naidu R

更新日期：2018-11-01 00:00:00

abstract：:Gram negative sepsis and septic shock continue to be a major medical problem, with a complex physiopathology and it is associated with high mortality. Although secretion of cytokines such as tumor necrosis factor-alpha by macrophages is the principal host mediator of septic shock, other characteristic functions of mac...

journal_title：Molecular and cellular biochemistry

authors： Víctor VM,Miñano M,Guayerbas N,Del Río M,Medina S,De la Fuente M

更新日期：1998-12-01 00:00:00

abstract：:In vivo administration of pyridine has been shown to increase the activity and content of several forms of cytochrome P450 by transcriptional and posttranscriptional mechanisms. The effect of pyridine on CYP1A and CYP2E1 isozymes was studied in a rat hepatocyte culture model. Hepatocytes were isolated from non-induced...

journal_title：Molecular and cellular biochemistry

authors： Wu D,Ramin SA,Cederbaum AI

更新日期：1997-08-01 00:00:00